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Clinical Toxicology Volume 18, 1981 - Issue 1
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Research Article

Clinical Findings, Elimination Pharmacokinetics, and Tissue Drug Concentrations Following a Fatal Amitriptyline Intoxication

Harrell E. Hurst Therapeutics and Toxicology Laboratory Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, 40292
&
Charles H. Jarboe Therapeutics and Toxicology Laboratory Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky, 40292
Pages 119-125 | Published online: 25 Sep 2008

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Alan D. Woolf, Andrew R. Erdman, Lewis S. Nelson, E. Martin Caravati, Daniel J. Cobaugh, Lisa L. Booze, Paul M. Wax, Anthony S. Manoguerra, Elizabeth J. Scharman, Kent R. Olson, Peter A. Chyka, Gwenn Christianson & William G. Troutman. (2007) Tricyclic antidepressant poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 45:3, pages 203-233.
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Kennon Heard, Richard C. Dart, Gregory Bogdan, Gerald F. O'Malley, Keith K. Burkhart, J. Ward Donovan & Suzanne B. Ward. (2006) A Preliminary Study of Tricyclic Antidepressant (TCA) Ovine FAB for TCA Toxicity. Clinical Toxicology 44:3, pages 275-281.
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Charles H. Jarboe, Harrell E. Hurst, George C. Rodgers & John M. Metaxas. (1986) Toxicokinetics of Caffeine Elimination in an Infant. Journal of Toxicology: Clinical Toxicology 24:5, pages 415-428.
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F. J. Baud, A. Buisine, C. Bismuth, M. Galliot, E. Vicaut, R. Bourdon & P. E. Fournier. (1985) Arterio-Venous Plasma Concentration Differences in Amitriptyline Overdose. Journal of Toxicology: Clinical Toxicology 23:4-6, pages 391-406.
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Matthew V. Rudorfer. (1982) Cardiovascular Changes and Plasma Drug Levels after Amitriptyline Overdose. Journal of Toxicology: Clinical Toxicology 19:1, pages 67-78.
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Articles from other publishers (20)

Tejs Jansen, Lotte C. G. Hoegberg, Thomas Eriksen, Kim P. Dalhoff, Bo Belhage & Sys S. Johansen. (2019) Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion—a randomized controlled animal poisoning model. Naunyn-Schmiedeberg's Archives of Pharmacology 392:10, pages 1285-1292.
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Raimo A. Ketola & Pirkko Kriikku. (2019) Drug concentrations in post‐mortem specimens. Drug Testing and Analysis 11:9, pages 1338-1357.
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Zofia Tylutki, Aleksander Mendyk & Sebastian Polak. (2018) Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals. Journal of Pharmacokinetics and Pharmacodynamics 45:5, pages 663-677.
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Åse Marit Leere Øiestad, Ritva Karinen, Sidsel Rogde, Stian Nilsen, Kari-Beate Boye Eldor, Gerd-Wenche Brochmann, Marianne Arnestad, Elisabeth Leere Øiestad, Mariana Dadalto Peres, Lena Kristoffersen & Vigdis Vindenes. (2018) Comparative Study of Postmortem Concentrations of Antidepressants in Several Different Matrices. Journal of Analytical Toxicology 42:7, pages 446-458.
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F. Bévalot, N. Cartiser, C. Bottinelli, J. Guitton & L. Fanton. (2016) Analyse des xénobiotiques dans l’humeur vitrée en toxicologie médicolégale : revue de la littérature. La Revue de Médecine Légale 7:4, pages 153-179.
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Fabien Bévalot, Nathalie Cartiser, Charline Bottinelli, Laurent Fanton & Jérôme Guitton. (2015) Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review. Forensic Toxicology 34:1, pages 12-40.
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H K Ruben Thanacoody & Simon H L Thomas. (2005) Tricyclic Antidepressant Poisoning. Toxicological Reviews 24:3, pages 205-214.
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F Musshoff, S Padosch, S Steinborn & B Madea. (2004) Fatal blood and tissue concentrations of more than 200 drugs. Forensic Science International 142:2-3, pages 161-210.
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Henry Cohen, Robert S. Hoffman & Mary Ann Howland. (2016) Antidepressant Poisoning and Treatment: A Review and Case Illustration. Journal of Pharmacy Practice 10:4, pages 249-270.
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Laura Pimentel & Lori Trommer. (1994) Cyclic Antidepressant Overdoses. Emergency Medicine Clinics of North America 12:2, pages 533-547.
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Henry Cohen, Robert S. Hoffman & Mary Ann Howland. (2016) Cyclic Antidepressant Poisoning: A Review and Case Report. Journal of Pharmacy Practice 6:2, pages 89-102.
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David G. Jaimovich. (1993) Transport Management of the Patient With Acute Poisoning. Pediatric Clinics of North America 40:2, pages 407-430.
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H. Marty, O. Varoquaux, J. Fialip, P. Cordonnier, E. Duroux, C. Bulach, A. Eschalier, C. Advenier, M. Pays & P. Bastide. (2009) Compared plasma and brain pharmacokinetics of clomipramine and its metabolite demethylclomipramine in two strains of mice (NMRI and CD1). Fundamental & Clinical Pharmacology 6:2, pages 49-57.
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Larry R. Johnson. (1990) Tricyclic Antidepressant Toxicosis. Veterinary Clinics of North America: Small Animal Practice 20:2, pages 393-403.
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Curt M. Steinhart & Anthony L. Pearson-Shaver. (1988) Poisoning. Critical Care Clinics 4:4, pages 845-872.
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L. J. Perrot. (1988) Amitriptyline Overdose Versus Sudden Infant Death Syndrome in a Two-Month-Old White Female. Journal of Forensic Sciences 33:1, pages 12462J.
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N.J. Braden, J.E. Jackson & P.D. Walson. (1986) Tricyclic Antidepressant Overdose. Pediatric Clinics of North America 33:2, pages 287-297.
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P. Baumann, J. -M. Gaillard, M. Jonzier-Perey, C. Gerber & C. Bouras. (1984) Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies. Psychopharmacology 84:4, pages 489-495.
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Robert A. Curtis, Nicola Giacona, Donald Burrows, Jerry L. Bauman & Michael Schaffer. (2016) Fatal Maprotiline Intoxication. Drug Intelligence & Clinical Pharmacy 18:9, pages 716-720.
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H. Berlet, H. Noetzel, G. Quadbeck, W. Schlote, H. P. Schmitt & Günter UleH. Berlet, G. Quadbeck & G. Ule. 1983. Pathologie des Nervensystems II. Pathologie des Nervensystems II 251 656 .

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