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Research Article

Human Xylazine Overdose: A Comparative Review with Clonidine, Phenothiazines, and Tricyclic Antidepressants

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Pages 663-678 | Published online: 25 Sep 2008

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Noah S. Ball, Brittany M. Knable, Taylor A. Relich, Allyson N. Smathers, Michael R. Gionfriddo, Branden D. Nemecek, Courtney A. Montepara, Anthony J. Guarascio, Jordan R. Covvey & David E. Zimmerman. (2022) Xylazine poisoning: a systematic review. Clinical Toxicology 60:8, pages 892-901.
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Chang-Ming Liu, Ming-Jang Chiu, Cheng-Chung Fang & Wen-Jone Chen. (2007) Letter To The Editor: “Xylazine abuse: A rare cause of syncope”. Clinical Toxicology 45:3, pages 309-311.
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María Fátima Ramón, Salome Ballesteros, Rosa Martinez‐Arrieta, Jose M. Jorrecilla & Jose Cabrera. (2003) Volatile Substance and Other Drug Abuse Inhalation in Spain. Journal of Toxicology: Clinical Toxicology 41:7, pages 931-936.
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C.G. MacKintosh & G. Van Reenen. (1984) Comparison of yohimbine, 4-aminopyridine and doxapram antagonism of xylazine sedation in deer (Cervus elaphus). New Zealand Veterinary Journal 32:11, pages 181-184.
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Articles from other publishers (44)

Alex P. Focken, Jordan M. Woodsworth & Jennifer M. Loewen. (2023) Evaluation of the use of intranasal atipamezole to reverse the sedative effects of xylazine in dogs. Journal of Veterinary Emergency and Critical Care.
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Kimberly L. Sue & Kathryn Hawk. (2023) Clinical considerations for the management of xylazine overdoses and xylazine‐related wounds. Addiction.
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Andrew C. Holt, David M. Schwope, Kathy Le, Joshua P. Schrecker & Rebecca Heltsley. (2023) Widespread Distribution of Xylazine Detected Throughout the United States in Healthcare Patient Samples. Journal of Addiction Medicine 17:4, pages 468-470.
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Shahana Ayub, Shanli Parnia, Karuna Poddar, Anil K Bachu, Amanda Sullivan, Ali M Khan, Saeed Ahmed & Lakshit Jain. (2023) Xylazine in the Opioid Epidemic: A Systematic Review of Case Reports and Clinical Implications. Cureus.
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Stephanie Anne Deutsch & Allan R. De Jong. (2023) Xylazine Complicating Opioid Ingestions in Young Children. Pediatrics 151:1.
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Way Koon Teoh, Noor Zuhartini Md Muslim, Kah Haw Chang & Ahmad Fahmi Lim Abdullah. (2022) Abuse of Xylazine by Human and its Emerging Problems: A Review from Forensic Perspective. Malaysian Journal of Medicine and Health Sciences 18:4, pages 190-201.
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Kasrin Saisahas, Asamee Soleh, Kiattisak Promsuwan, Jenjira Saichanapan, Apichai Phonchai, Nabeesathul Sumayya Mohamed Sadiq, Way Koon Teoh, Kah Haw Chang, Ahmad Fahmi Lim Abdullah & Warakorn Limbut. (2022) Nanocoral-like Polyaniline-Modified Graphene-Based Electrochemical Paper-Based Analytical Device for a Portable Electrochemical Sensor for Xylazine Detection. ACS Omega 7:16, pages 13913-13924.
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Kasrin Saisahas, Asamee Soleh, Kiattisak Promsuwan, Apichai Phonchai, Nabeesathul Sumayya Mohamed Sadiq, Way Koon Teoh, Kah Haw Chang, Ahmad Fahmi Lim Abdullah & Warakorn Limbut. (2021) A portable electrochemical sensor for detection of the veterinary drug xylazine in beverage samples. Journal of Pharmaceutical and Biomedical Analysis 198, pages 113958.
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Jacqueline Nunez, Maura E. DeJoseph & James R. Gill. (2021) Xylazine, a Veterinary Tranquilizer, Detected in 42 Accidental Fentanyl Intoxication Deaths. American Journal of Forensic Medicine & Pathology 42:1, pages 9-11.
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Letícia Francine Mendes, Ângela Rodrigues Souza e Silva, Raphael Prata Bacil, Silvia Helena Pires Serrano, Lúcio Angnes, Thiago Regis Longo Cesar Paixão & William Reis de Araujo. (2019) Forensic electrochemistry: Electrochemical study and quantification of xylazine in pharmaceutical and urine samples. Electrochimica Acta 295, pages 726-734.
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Jatupon Krongvorakul, Saranya Auparakkitanon, Satariya Trakulsrichai, Pitsucha Sanguanwit, Jetjamnong Sueajai, Nantida Noumjad & Winai Wananukul. (2018) Use of Xylazine in Drug-Facilitated Crimes. Journal of Forensic Sciences 63:4, pages 1325-1330.
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Přemysl Mladěnka, Lenka Applová, Jiří Patočka, Vera Marisa Costa, Fernando Remiao, Jana Pourová, Aleš Mladěnka, Jana Karlíčková, Luděk Jahodář, Marie Vopršalová, Kurt J. Varner & Martin Štěrba. (2018) Comprehensive review of cardiovascular toxicity of drugs and related agents. Medicinal Research Reviews 38:4, pages 1332-1403.
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Xue Gao, Hao Guo, Yaoyu Du & Chaokang Gu. (2015) Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry. Journal of Analytical Toxicology 39:6, pages 444-450.
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A. J. Perrin. (2015) Intentional misuse of veterinary medications in human suicide. Journal of Veterinary Pharmacology and Therapeutics 38:3, pages 209-213.
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L.A. Silva-Torres, C. Vélez, J. Lyvia Alvarez, J.G. Ortiz & B. Zayas. (2014) Toxic effects of xylazine on endothelial cells in combination with cocaine and 6-monoacetylmorphine. Toxicology in Vitro 28:7, pages 1312-1319.
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Kazandra Ruiz-Colón, Carlos Chavez-Arias, José Eric Díaz-Alcalá & María A. Martínez. (2014) Xylazine intoxication in humans and its importance as an emerging adulterant in abused drugs: A comprehensive review of the literature. Forensic Science International 240, pages 1-8.
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Luz Silva-Torres, Christian Vel?z, Lyvia ?lvarez & Beatriz Zayas. (2014) Xylazine as a Drug of Abuse and Its Effects on the Generation of Reactive Species and DNA Damage on Human Umbilical Vein Endothelial Cells. Journal of Toxicology 2014, pages 1-8.
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Yong-Fu Xiao, Bingdi Wang, Xiaoli Wang, Fenglai Du, Michael Benzinou & Yi-Xin Jim Wang. (2013) Xylazine-induced reduction of tissue sensitivity to insulin leads to acute hyperglycemia in diabetic and normoglycemic monkeys. BMC Anesthesiology 13:1.
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Golo M.J. Meyer, Markus R. Meyer, Bernhard Mischo, Otto Schofer & Hans H. Maurer. (2013) Case report of accidental poisoning with the tranquilizer xylazine and the anesthetic ketamine confirmed by qualitative and quantitative toxicological analysis using GC‐MS and LC‐MS n . Drug Testing and Analysis 5:9-10, pages 785-789.
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J. C. Reyes, J. L. Negrón, H. M. Colón, A. M. Padilla, M. Y. Millán, T. D. Matos & R. R. Robles. (2012) The Emerging of Xylazine as a New Drug of Abuse and its Health Consequences among Drug Users in Puerto Rico. Journal of Urban Health 89:3, pages 519-526.
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