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Journal of Toxicology: Clinical Toxicology Volume 19, 1982 - Issue 1
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Research Article

Massive Intoxication with Acetaminophen and Propoxyphene: Unexpected Survival and Unusual Pharmacokinetics of Acetaminophen

Susan M. Pond Department of Clinical Pharmacology, Medical Service San Francisco General Hospital Medical Center, San Francisco, California, 94110
,
Theodore G. Tong Department of Clinical Pharmacy, Medical Service San Francisco General Hospital Medical Center, San Francisco, California, 94110
,
George A. Kaysen Department of Nephrology, Schools of Medicine and Pharmacy University of California at San Francisco, San Francisco, California, 94143
,
David J. Menke Department of Nephrology, Schools of Medicine and Pharmacy University of California at San Francisco, San Francisco, California, 94143
,
Raymond E. Galinsky Department of Pharmaceutics, School of Pharmacy State University of New York at Buffalo, Amherst, New York, 14260
,
Stephen M. Roberts Department of Pharmaceutics, School of Pharmacy State University of New York at Buffalo, Amherst, New York, 14260
&
Gerhard Levy Department of Pharmaceutics, School of Pharmacy State University of New York at Buffalo, Amherst, New York, 14260
 show all
Pages 1-16 | Published online: 25 Sep 2008

Citations (14)

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Daniel A. Spyker, Richard C. Dart, Luke Yip, Kate Reynolds, Scott Brittain & Mark Yarema. (2022) Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations. Clinical Toxicology 60:10, pages 1113-1121.
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S. Gosselin, D. N. Juurlink, J. T. Kielstein, M. Ghannoum, V. Lavergne, T. D. Nolin & R. S. Hoffman. (2014) Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup. Clinical Toxicology 52:8, pages 856-867.
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M. L. A. Sivilotti, D. N. Juurlink, J. S. Garland, I. Lenga, R. Poley, L. N. Hanly & M. Thompson. (2013) Antidote removal during haemodialysis for massive acetaminophen overdose. Clinical Toxicology 51:9, pages 855-863.
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Michael Bodmer & Andrew A. Monte. (2010) “Massive Acetaminophen Ingestion with Early Metabolic Acidosis and Coma: Treatment with IV NAC and Continuous Venovenous Hemodiafiltration” by Wiegand et al., Clin Toxicol (Phila) 48:156–159. Clinical Toxicology 48:9, pages 961-961.
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Timothy J. Wiegand, Mary Margaretten & Kent R. Olson. (2010) Massive acetaminophen ingestion with early metabolic acidosis and coma: treatment with IV NAC and continuous venovenous hemodiafiltration. Clinical Toxicology 48:2, pages 156-159.
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Articles from other publishers (9)

Ravindra Babu Pingili, Sridhar Vemulapalli, Manideep V. V. N. Gadamsetty, Divya Presingu, Ruthvik Katuri, Vijayalakshmi Rachamsetty & Naveen Babu Kilaru. (2023) Chlorzoxazone reduced the paracetamol-induced toxicity via competitive inhibition of CYP2E1-mediated metabolism. Future Journal of Pharmaceutical Sciences 9:1.
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Anoop D. Shah, David M. Wood & Paul I. Dargan. (2011) Understanding lactic acidosis in paracetamol (acetaminophen) poisoning. British Journal of Clinical Pharmacology 71:1, pages 20-28.
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Sidney Nelson & Sam Bruschi. 2007. Drug-Induced Liver Disease, Second Edition. Drug-Induced Liver Disease, Second Edition 353 388 .
Clifford Tan & Andis Graudins. (2006) Comparative pharmacokinetics of Panadol Extend and immediate-release paracetamol in a simulated overdose model. Emergency Medicine Australasia 18:4, pages 398-403.
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S.H.L. Thomas. (1993) Paracetamol (acetaminophen) poisoning. Pharmacology & Therapeutics 60:1, pages 91-120.
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Debra A Edwards, Susan F Fish, Michael J Lamson & Frederick H LovejoyJr.Jr.. (1986) Prediction of acetaminophren level from clinical history of overdose using a pharmacokinetic model. Annals of Emergency Medicine 15:11, pages 1314-1319.
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J. Vaněček. 1984. 91 99 .
Arvind K. Chaturvedi, N.G.S. Rao & Michael P. Hurly. (1983) Toxicological findings in a multi-drug death involving propoxyphene, caffeine, phenacetin, acetaminophen and salicylate. Forensic Science International 23:2-3, pages 255-264.
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Raymond E. Galinsky & Gerhard Levy. (1982) Effect of cimetidine on acetaminophen pharmacokinetics in rats. International Journal of Pharmaceutics 10:4, pages 301-306.
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