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Journal of Toxicology: Clinical Toxicology Volume 19, 1982 - Issue 8
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Research Article

The Pharmacokinetics of Prunasin, a Metabolite of Amygdalin

A. G. Rauws National Institute of Public Health, 3720 BA, Bilthoven, The Netherlands
,
M. Olling National Institute of Public Health, 3720 BA, Bilthoven, The Netherlands
&
A. Timmerman National Institute of Public Health, 3720 BA, Bilthoven, The Netherlands
Pages 851-856 | Published online: 25 Sep 2008

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Soon-Mi Shim & Hoonjeong Kwon. (2010) Metabolites of amygdalin under simulated human digestive fluids. International Journal of Food Sciences and Nutrition 61:8, pages 770-779.
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Vadivelan RamachandranKirankumar Rapindra HosalliInbakumar VijayakumarLalithkumar ManiRuchi TiwariGaurav Tiwari. (2022) A review on antitumor action of amygdalin on various types of cancers. Research Journal of Pharmacy and Technology, pages 5373-5380.
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Hassan Barakat, Thamer Aljutaily, Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Abdulkarim S. Almutairi, Saleh I. Alshimali & Ahmed A. H. Abdellatif. (2022) Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation. Biomolecules 12:10, pages 1514.
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Jakub Brozdowski, Boguslawa Waliszewska, Jakub Loffler, Metka Hudina, Robert Veberic & Maja Mikulic-Petkovsek. (2021) Composition of Phenolic Compounds, Cyanogenic Glycosides, Organic Acids and Sugars in Fruits of Black Cherry (Prunus serotina Ehrh.). Forests 12:6, pages 762.
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Xiao-Yan He, Li-Juan Wu, Wen-Xiang Wang, Pei-Jun Xie, Yun-Hui Chen & Fei Wang. (2020) Amygdalin - A pharmacological and toxicological review. Journal of Ethnopharmacology 254, pages 112717.
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Marek Halenár, Marí­na Medveďová, Simona Baldovská, Katarí­na Michalcová & Adriana Kolesárová. (2017) Co-administration of amygdalin and deoxynivalenol disrupted regulatory proteins linked to proliferation of porcine ovarian cells in vitro. Potravinarstvo Slovak Journal of Food Sciences 11:1, pages 503-509.
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Chao Liu, Xia Li, Honggai Yang, Xinhui Mao, Juan Wang & Wenyuan Gao. (2017) Effect of Natural β-Glucosidase Inhibitors in Reducing Toxicity of Amygdalin in Persicae Semen. Phytotherapy Research 31:5, pages 771-777.
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Roman A. Blaheta, Karen Nelson, Axel Haferkamp & Eva Juengel. (2016) Amygdalin, quackery or cure?. Phytomedicine 23:4, pages 367-376.
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George E. Burrows & Ronald J. Tyrl. 2012. Toxic Plants of North America. Toxic Plants of North America 1064 1094 .
Donald G. Barceloux. (2009) Cyanogenic Foods (Cassava, Fruit Kernels, and Cycad Seeds). Disease-a-Month 55:6, pages 336-352.
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Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 44 53 .
Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 760 767 .
Hoon-Jeong Kwon & Yong-Jin Jo. (2007) A Study on the Decomposition of Amygdalin Using an In Vitro Assay. Toxicological Research 23:1, pages 47-53.
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. (2007) Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to cyanogenic compounds as undesirable substances in animal feed. EFSA Journal 5:2, pages 434.
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. (2004) Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on hydrocyanic acid in flavourings and other food ingredients with flavouring properties. EFSA Journal 2:11, pages 105.
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Brent Wagner & William R. Galey. (2003) Kinetic analysis of hexose transport to determine the mechanism of amygdalin and prunasin absorption in the intestine. Journal of Applied Toxicology 23:5, pages 371-375.
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GJ Strugala, R. Stahl, B. Elsenhans, AG Rauws & W. Forth. (2016) Small-intestinal transfer mechanism of prunasin, the primary metabolite of the cyanogenic glycoside amygdalin. Human & Experimental Toxicology 14:11, pages 895-901.
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Ernst Steinegger & Rudolf HänselErnst Steinegger & Rudolf Hänsel. 1992. Pharmakognosie. Pharmakognosie 1 33 .
Ernst Steinegger & Rudolf HänselErnst Steinegger & Rudolf Hänsel. 1988. Lehrbuch der Pharmakognosie und Phytopharmazie. Lehrbuch der Pharmakognosie und Phytopharmazie 1 33 .
Gerhard J. Strugala, Adalbert G. Rauws & Rembert Elbers. (1986) Intestinal first pass metabolism of amygdalin in the rat in vitro. Biochemical Pharmacology 35:13, pages 2123-2128.
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R.A. Frakes, R.P. Sharma & C.C. Willhite. (1986) Comparative metabolism of linamarin and amygdalin in hamsters. Food and Chemical Toxicology 24:5, pages 417-420.
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W. Majak, M.A. Pass, A.D. Muir & L.M. Rode. (1984) Absorption of 3-nitropropanol (Miserotoxin aglycone) from the compound stomach of cattle. Toxicology Letters 23:1, pages 9-15.
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