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Journal of Toxicology: Clinical Toxicology Volume 24, 1986 - Issue 1
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Research Article

Serum Osmolal Gap and Ethanol Concentration: A Simple and Accurate Formula

Robert J. Geller Department of Internal Medicine, University of Virginia Medical Center, Charlottesville, VA, 22908
,
Daniel A. Spyker Department of Internal Medicine, University of Virginia Medical Center, Charlottesville, VA, 22908
,
David A. Herold Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, 22908
&
David E. Bruns Department of Pathology, University of Virginia Medical Center, Charlottesville, VA, 22908
Pages 77-84 | Published online: 25 Sep 2008

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K. Berend & A. J. Duits. (2019) The role of the clinical laboratory in diagnosing acid–base disorders. Critical Reviews in Clinical Laboratory Sciences 56:3, pages 147-169.
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S. D. Carstairs, J. R. Suchard, T. Smith, L. V. Simon, C. J. Kalynych, M. Shimada & D. A. Tanen. (2013) Contribution of serum ethanol concentration to the osmol gap: a prospective volunteer study. Clinical Toxicology 51:5, pages 398-401.
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Alexander Garrard, Dawn R. Sollee, Ryan C. Butterfield, Laura Johannsen, Adam Wood & Roger L. Bertholf. (2012) Validation of a pre-existing formula to calculate the contribution of ethanol to the osmolar gap. Clinical Toxicology 50:7, pages 562-566.
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Articles from other publishers (12)

Jeevan Dhanarisi, Tanita Maria Tzotzolaki, Ana‐Mariya D. Vasileva, Matti A. Kjellberg, Hanna Hakulinen, Paula Vanninen, Indika Gawarammana, Fahim Mohamed, Knut Erik Hovda & Michael Eddleston. (2021) Osmolal and anion gaps after acute self‐poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study. Basic & Clinical Pharmacology & Toxicology 130:2, pages 320-327.
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Minhtri K. Nguyen, Lu Song, Liyo Kao, Kevin Tong, Maria J. De La Cruz, Giancarlo Rodriguez, Minh-Kevin Nguyen, Dai-Scott Nguyen & Ira Kurtz. (2020) Is the Osmolal Concentration of Ethanol Greater Than Its Molar Concentration?. Frontiers in Medicine 6.
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Matthew D Krasowski, Rebecca M Wilcoxon & Joel Miron. (2012) A retrospective analysis of glycol and toxic alcohol ingestion: utility of anion and osmolal gaps. BMC Clinical Pathology 12:1.
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Loralie Langman, Laura Bechtel & Christopher P. Holstege. 2012. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 1109 1188 .
Mitchell G. Scott, Vicky A. LeGrys & Joshua L. Hood. 2012. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 807 835 .
Peter L Platteborze, Petrie M Rainey & Geoffrey S Baird. (2011) Ketoacidosis with Unexpected Serum Isopropyl Alcohol. Clinical Chemistry 57:10, pages 1361-1364.
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John Krahn & Annu Khajuria. (2006) Osmolality Gaps: Diagnostic Accuracy and Long-Term Variability. Clinical Chemistry 52:4, pages 737-739.
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A. Khajuria & J. Krahn. (2005) Osmolality revisited—Deriving and validating the best formula for calculated osmolality. Clinical Biochemistry 38:6, pages 514-519.
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Roy A Purssell, Larry D Lynd & Yoshikata Koga. (2004) The Use of the Osmole Gap as a Screening Test for the Presence of Exogenous Substances. Toxicological Reviews 23:3, pages 189-202.
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Roy A. Purssell, Morris Pudek, Jeffrey Brubacher & Riyad B. Abu-Laban. (2001) Derivation and validation of a formula to calculate the contribution of ethanol to the osmolal gap. Annals of Emergency Medicine 38:6, pages 653-659.
Crossref
RJ Flanagan. (2012) SI units‐‐common sense not dogma is needed.. British Journal of Clinical Pharmacology 39:6, pages 589-594.
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S.B. Rosalki. 1994. Scientific Foundations of Biochemistry in Clinical Practice. Scientific Foundations of Biochemistry in Clinical Practice 121 143 .

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