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Research Article

Baclofen Overdose with Cardiac Conduction Abnormalities: Case Report and Review of the Literature

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Pages 321-328 | Published online: 25 Sep 2008

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Chin-Tse Peng, Jiin Ger, Chen-Chang Yang, Wei-Jen Tsai, Jou-Fang Deng & Michael J. Bullard. (1998) Prolonged Severe Withdrawal Symptoms After Acute-on-Chronic Baclofen Overdose. Journal of Toxicology: Clinical Toxicology 36:4, pages 359-363.
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Raymond J. Roberge, Thomas G. Martin, Michael Hodgman, John G. Benitez & Jay E. Brunswick. (1994) Supraventricular Tachyarrhythmia Associated with Baclofen Overdose. Journal of Toxicology: Clinical Toxicology 32:3, pages 291-297.
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Articles from other publishers (29)

L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson & A. R. Lingford-Hughes. (2022) FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study. Trials 23:1.
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Jia W Romito, Emily R Turner, John A Rosener, Landon Coldiron, Ashutosh Udipi, Linsey Nohrn, Jacob Tausiani & Bryan T Romito. (2021) Baclofen therapeutics, toxicity, and withdrawal: A narrative review. SAGE Open Medicine 9, pages 205031212110221.
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Sahar Farhat, Tarek El Halabi, Achraf Makki, Samir F. Atweh, Wassim Nasreddine & Ahmad Beydoun. (2020) Coma With Absent Brainstem Reflexes and a Burst Suppression on EEG Secondary to Baclofen Toxicity. Frontiers in Neurology 11.
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David Boels, Caroline Victorri‐Vigneau, Marie Grall‐Bronnec, Ali Touré, Anais Garnier, Alain Turcant & Gaël Le Roux. (2017) Baclofen and Alcohol‐Dependent Patients: A Real Risk of Severe Self‐Poisoning. Basic & Clinical Pharmacology & Toxicology 121:4, pages 353-359.
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Dalvir Gill, Kamalpreet Mann & Kan Liu. (2017) QT Prolongation by Baclofen Overdose. American Journal of Therapeutics 24:5, pages e625-e627.
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Adam Zeman, Serge Hoefeijzers, Fraser Milton, Michaela Dewar, Melanie Carr & Claire Streatfield. (2016) The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain – A detailed case report. Cortex 74, pages 9-19.
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Louise Bendix Kiel, Lotte Christine Groth Hoegberg, Tejs Jansen, John Asger Petersen & Kim Peder Dalhoff. (2015) A Nationwide Register-Based Survey of Baclofen Toxicity. Basic & Clinical Pharmacology & Toxicology 116:5, pages 452-456.
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Roxanna Khorzad, Justine A. Lee, Megan Whelan, Ahna G. Brutlag, Elizabeth P. Martin, Lee T. Miyahara & Lynn R. Hovda. (2012) Baclofen toxicosis in dogs and cats: 145 cases (2004–2010). Journal of the American Veterinary Medical Association 241:8, pages 1059-1064.
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Guido F. Weißhaar, Marc Hoemberg, Katja Bender, Ursula Bangen, Peter Herkenrath, Frank Eifinger, Markus Rothschild, Bernhard Roth & André Oberthuer. (2012) Baclofen intoxication: a “fun drug” causing deep coma and nonconvulsive status epilepticus—a case report and review of the literature. European Journal of Pediatrics 171:10, pages 1541-1547.
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Gyanendra Kumar, Kinshuk Sahaya, Munish Kumar Goyal, Manjamalai Sivaraman & Pradeep Kumar Sahota. (2010) Electroencephalographic abnormalities in baclofen-induced encephalopathy. Journal of Clinical Neuroscience 17:12, pages 1594-1596.
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. 2009. Meyler's Side Effects of Drugs Used in Anesthesia. Meyler's Side Effects of Drugs Used in Anesthesia 179 264 .
MATTHEW D. SZTAJNKRYCER. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 695 702 .
Geoffrey C. WallAmy WasiakGreg A. Hicklin. (2006) An Initially Unsuspected Case of Baclofen Overdose. American Journal of Critical Care 15:6, pages 611-613.
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Nicola Y Leung, Ian M Whyte & Geoffrey K Isbister. (2006) Baclofen overdose: Defining the spectrum of toxicity. Emergency Medicine Australasia 18:1, pages 77-82.
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Angela F. Slaughter, Sarah M. Roddy, Barbara A. Holshouser & Shamel A. Abd-Allah. (2006) Magnetic Resonance Spectroscopy and Electroencephalography in Baclofen Coma. Pediatric Neurology 34:2, pages 151-155.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 408 413 .
Ronald N. Yeh, Michele M. Nypaver, Thomas J. Deegan & Rita Ayyangar. (2004) Baclofen toxicity in an 8-year-old with an intrathecal baclofen pump. The Journal of Emergency Medicine 26:2, pages 163-167.
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Alessandro Dario & Giustino Tomei. (2004) A Benefit-Risk Assessment of Baclofen in Severe Spinal Spasticity. Drug Safety 27:11, pages 799-818.
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Glenn D Ritchie, Mary E Hulme & John RossiIIIIII. (2003) Treatment of spontaneous and chemically induced EEG paroxysms in the Fischer-344 rat with traditional antiepileptic drugs or AED+CGP 35348 polytherapy. Progress in Neuro-Psychopharmacology and Biological Psychiatry 27:5, pages 847-862.
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Ming-Tao Yang, Wang-Tso Lee, Li-Wen Chu & Yu-Zen Shen. (2003) Anti-epileptic drugs-induced de novo absence seizures. Brain and Development 25:1, pages 51-56.
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Eric P. Bastings & Amelito Malapira. 2002. Clinical Evaluation and Management of Spasticity. Clinical Evaluation and Management of Spasticity 103 124 .
NJ McDonald, MS Festa & B Wilkins. (2001) Teenage coma. Journal of Paediatrics and Child Health 37:4, pages 395-396.
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DENISE CHAPPLE, DAVID JOHNSON & RUTH CONNORS. (2001) Baclofen overdose in two siblings. Pediatric Emergency Care 17:2, pages 110-112.
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Darlene R VanDierendonk & Daniel J Dire. (1999) Baclofen and ethanol ingestion: a case report. The Journal of Emergency Medicine 17:6, pages 989-993.
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Daniel V. Hecht & Karin Allenspach. (2007) Presumptive Baclofen Intoxication in a Dog. Journal of Veterinary Emergency and Critical Care 8:1, pages 49-54.
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David A. Hosford & Ying Wang. (2005) Utility of the Lethargic ( lh/lh ) Mouse Model of Absence Seizures in Predicting the Effects of Lamotrigine, Vigabatrin, Tiagabine, Gabapentin, and Topiramate Against Human Absence Seizures . Epilepsia 38:4, pages 408-414.
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L. Saltuari, M.J. Marosi, M. Kofler & G. Bauer. (1992) Statusepilepticus complicating intrathecal baclofen overdose. The Lancet 339:8789, pages 373-374.
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