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Journal of Toxicology: Clinical Toxicology Volume 25, 1987 - Issue 6
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Research Article

Primary Hypogonadism Associated with O,P′ DDD (mitotane) Therapy

Mario Sparagana Medical and Research Services Veterans Administration Hospital, Hines, Illinois, 60141; Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois, 60153
Pages 463-472 | Published online: 25 Sep 2008

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Alison C. Nimrod & William H. Benson. (1996) Environmental Estrogenic Effects of Alkylphenol Ethoxylates. Critical Reviews in Toxicology 26:3, pages 335-364.
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Federica Innocenti, Sara Di Persio, Marilena Taggi, Roberta Maggio, Pina Lardo, Vincenzo Toscano, Rita Canipari, Elena Vicini & Antonio Stigliano. (2023) Effect of Mitotane on Male Gonadal Function. Cancers 15:12, pages 3234.
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Marta Bianchini, Giulia Puliani, Alfonsina Chiefari, Marilda Mormando, Rosa Lauretta & Marialuisa Appetecchia. (2021) Metabolic and Endocrine Toxicities of Mitotane: A Systematic Review. Cancers 13:19, pages 5001.
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Malene Elbæk Vikner, Jesper Krogh, Gedske Daugaard & Mikkel Andreassen. (2020) Metabolic and hormonal side effects of mitotane treatment for adrenocortical carcinoma: A retrospective study in 50 Danish patients. Clinical Endocrinology 94:2, pages 141-149.
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Rosa Maria Paragliola, Francesco Torino, Giampaolo Papi, Pietro Locantore & Alfredo Pontecorvi. (2018) Role of Mitotane in Adrenocortical Carcinoma – Review and State of the art. European Endocrinology 14:2, pages 62.
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Daniele Santi & Giovanni Corona. 2017. Endocrinology of the Testis and Male Reproduction. Endocrinology of the Testis and Male Reproduction 687 747 .
Daniele Santi & Giovanni Corona. 2017. Thyroid Diseases. Thyroid Diseases 1 62 .
Vasileios Chortis, Angela E. Taylor, Petra Schneider, Jeremy W. Tomlinson, Beverly A. Hughes, Donna M. O'Neil, Rossella Libé, Bruno Allolio, Xavier Bertagna, Jérôme Bertherat, Felix Beuschlein, Martin Fassnacht, Niki Karavitaki, Massimo Mannelli, Franco Mantero, Giuseppe Opocher, Emilio Porfiri, Marcus Quinkler, Mark Sherlock, Massimo Terzolo, Peter Nightingale, Cedric H. L. Shackleton, Paul M. Stewart, Stefanie Hahner & Wiebke Arlt. (2013) Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5α-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement. The Journal of Clinical Endocrinology & Metabolism 98:1, pages 161-171.
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Vassilios Papadopoulos. 2007. The Leydig Cell in Health and Disease. The Leydig Cell in Health and Disease 393 413 .
. 2004. Sax's Dangerous Properties of Industrial Materials. Sax's Dangerous Properties of Industrial Materials.
. 2004. Sax's Dangerous Properties of Industrial Materials. Sax's Dangerous Properties of Industrial Materials.
Leonardo Rizzo, H. Pablo Curutchet & Oscar D. Bruno. (2002) Long-Term Survival in a Patient With a Feminizing Adrenal Carcinoma. The Endocrinologist 12:1, pages 13-16.
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C.W. Breuner, D.H. Jennings, M.C. Moore & M. Orchinik. (2000) Pharmacological Adrenalectomy with Mitotane. General and Comparative Endocrinology 120:1, pages 27-34.
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