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Journal of Toxicology: Clinical Toxicology Volume 26, 1988 - Issue 1-2
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Research Article

Citric, malic and succinic acids as possible alternatives to deferoxamine in aluminum toxicity

José L. Domingo Laboratory of Toxicology & Biochemistry, School of Medicine University of Barcelona, San Llorenç, 21, 43201-Reus, Spain
,
Mercedes Gómez Laboratory of Toxicology & Biochemistry, School of Medicine University of Barcelona, San Llorenç, 21, 43201-Reus, Spain
,
Juan M. Llobet Laboratory of Toxicology & Biochemistry, School of Medicine University of Barcelona, San Llorenç, 21, 43201-Reus, Spain
&
Jacinto Corbella School of Medicine, University of Barcelona, Spain
Pages 67-79 | Published online: 25 Sep 2008

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Amylee Amos & Bashar Khiatah. (2022) Mechanisms of Action of Nutritionally Rich Hibiscus sabdariffa's Therapeutic Uses in Major Common Chronic Diseases: A Literature Review. Journal of the American Nutrition Association 41:1, pages 116-124.
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RobertA. Yokel. (1994) Aluminum chelation: Chemistry, clinical, and experimental studies and the search for alternatives to desferrioxamine. Journal of Toxicology and Environmental Health 41:2, pages 131-174.
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Guy E Abraham & Jorge D Flechas. (1992) Management of Fibromyalgia: Rationale for the Use of Magnesium and Malic Acid. Journal of Nutritional Medicine 3:1, pages 49-59.
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Mark M. Jones. (1991) New Developments in Therapeutic Chelating Agents as Antidotes for Metal Poisoning. Critical Reviews in Toxicology 21:3, pages 209-233.
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José L. Domingo. (1989) The use of chelating agents in the treatment of aluminum overload. Journal of Toxicology: Clinical Toxicology 27:6, pages 355-367.
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Articles from other publishers (22)

Mehmet Enes ARSLAN. (2021) Anticarcinogenic properties of malic acid on glioblastoma cell line through necrotic cell death mechanism. MANAS Journal of Engineering 9:1, pages 22-29.
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Su-Jin Jung, Woo-Lim Kim, Byung-Hyun Park, Seung-Ok Lee & Soo-Wan Chae. (2020) Effect of toxic trace element detoxification, body fat reduction following four-week intake of the Wellnessup diet: a three-arm, randomized clinical trial. Nutrition & Metabolism 17:1.
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A. V. Klein & H. Kiat. (2015) Detox diets for toxin elimination and weight management: a critical review of the evidence. Journal of Human Nutrition and Dietetics 28:6, pages 675-686.
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Margaret E. Sears & Stephen J. Genuis. (2012) Environmental Determinants of Chronic Disease and Medical Approaches: Recognition, Avoidance, Supportive Therapy, and Detoxification. Journal of Environmental and Public Health 2012, pages 1-15.
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Stephen J Genuis. (2010) Elimination of persistent toxicants from the human body. Human & Experimental Toxicology 30:1, pages 3-18.
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Michael J. Schneider, David M. Brady & Stephen M. Perle. (2006) Commentary: Differential Diagnosis of Fibromyalgia Syndrome: Proposal of a Model and Algorithm for Patients Presenting with the Primary Symptom of Chronic Widespread Pain. Journal of Manipulative and Physiological Therapeutics 29:6, pages 493-501.
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Swaran J.S Flora, Ashish Mehta, Kiran Satsangi, Gurusamy M Kannan & Manju Gupta. (2003) Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 134:3, pages 319-328.
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Roger Deloncle, Bernard Fauconneau, Alain Piriou, François Huguet & Olivier Guillard. (2002) Aluminum l-glutamate complex in rat brain cortex: in vivo prevention of aluminum deposit by magnesium d-aspartate. Brain Research 946:2, pages 247-252.
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M Amélia Santos. (2002) Hydroxypyridinone complexes with aluminium. In vitro/vivo studies and perspectives. Coordination Chemistry Reviews 228:2, pages 187-203.
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Marilyne Venturini-Soriano & Guy Berthon. (2001) Aluminum speciation studies in biological fluids. Journal of Inorganic Biochemistry 85:2-3, pages 143-154.
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M.P. Sauvant, D. Pepin & J. Guillot. (1999) Effects of Humic Substances and Phenolic Compounds on the In Vitro Toxicity of Aluminium. Ecotoxicology and Environmental Safety 44:1, pages 47-55.
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Sandra Desroches, Fabrice Biron & Guy Berthon. (1999) Aluminum speciation studies in biological fluids Part 5. A quantitative investigation of Al(III) complex equilibria with desferrioxamine, 2,3-dihydroxybenzoic acid, Tiron, CP20 (L1), and CP94 under physiological conditions, and computer-aided assessment of the aluminum-mobilizing capacities of these ligands in vivo. Journal of Inorganic Biochemistry 75:1, pages 27-35.
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Mercedes Gómez, Jose L. Esparza, Jose L. Domingo, Pramod K. Singh & Mark M. Jones. (1998) Comparative aluminium mobilizing actions of deferoxamine and four 3-hydroxypyrid-4-ones in aluminium-loaded rats. Toxicology 130:2-3, pages 175-181.
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Marilyne Venturini-Soriano & Guy Berthon. (1998) Aluminum speciation studies in biological fluids. Part 4. A new investigation of aluminum–succinate complex formation under physiological conditions, and possible implications for aluminum metabolism and toxicity. Journal of Inorganic Biochemistry 71:3-4, pages 135-145.
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Mercedes Gómez, Jose L. Esparza, Jose L. Domingo, Jacinto Corbella, Pramod K. Singh & Mark M. Jones. (2009) Aluminium Distribution and Excretion: A Comparative Study of a Number of Chelating Agents in Rats. Pharmacology & Toxicology 82:6, pages 295-300.
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Guy Berthon. (1996) Chemical speciation studies in relation to aluminium metabolism and toxicity. Coordination Chemistry Reviews 149, pages 241-280.
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Arthur E. Martell & Robert D. HancockArthur E. Martell & Robert D. Hancock. 1996. Metal Complexes in Aqueous Solutions. Metal Complexes in Aqueous Solutions 149 197 .
Richard M. Kettler, Donald A. Palmer & David J. Wesolowski. (1995) Dissociation quotients of succinic acid in aqueous sodium chloride media to 225�C. Journal of Solution Chemistry 24:1, pages 65-87.
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R. Schmidt, K. Bohm, W. Vater & E. Unger. (1991) Aluminium induced osteomalacia and encephalopathy - an aberration of the tubulin assembly into microtubules (MTs) by Al3+?. Progress in Histochemistry and Cytochemistry 23:1-4, pages 355-364.
Crossref
Alfred Haug & Biao Shi. 1991. Plant-Soil Interactions at Low pH. Plant-Soil Interactions at Low pH 839 850 .
Biao Shi & Alfred Haug. (2006) Aluminum Uptake by Neuroblastoma Cells. Journal of Neurochemistry 55:2, pages 551-558.
Crossref
J.L. Domingo, M. Gomez, J.M. Llobet & J. Corbella. (1988) PARENTERAL CITRIC ACID FOR ALUMINIUM INTOXICATION. The Lancet 332:8624, pages 1362-1363.
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