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Research Article

Characterization of 4-Aminopyridine in Overdose

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Pages 583-587 | Published online: 25 Sep 2008

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Scott Weir, Risa Torkin & Herbert R. Henney III. (2013) Pharmacokinetic profile of dalfampridine extended release: clinical relevance in patients with multiple sclerosis. Current Medical Research and Opinion 29:12, pages 1627-1636.
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Sheryl R. Haut, E. Jay Bienen & Aaron Miller. (2012) Clinical overview of the seizure risk of dalfampridine . Expert Opinion on Drug Safety 11:4, pages 651-657.
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Keith C Hayes. (2011) Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis. Neuropsychiatric Disease and Treatment 7, pages 229-239.
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Hillel Panitch & Angela Applebee. (2011) Treatment of walking impairment in multiple sclerosis: an unmet need for a disease-specific disability. Expert Opinion on Pharmacotherapy 12:10, pages 1511-1521.
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Keith C Hayes. (2007) Fampridine-SR for multiple sclerosis and spinal cord injury. Expert Review of Neurotherapeutics 7:5, pages 453-461.
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Yesim Tuncok, Sebnem Apaydin, Ayse Gelal, Mehmet Ates & Hulya Guven. (1998) The Effects of 4-Aminopyridine and Bay K 8644 on Verapamil-Induced Cardiovascular Toxicity in Anesthetized Rats. Journal of Toxicology: Clinical Toxicology 36:4, pages 301-307.
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Winai Wananukul, Daniel E. Keyler & Paul R. Pentel. (1996) Effect of Calcium Chloride and 4-Aminopyridine Therapy on Desipramine Toxicity in Rats. Journal of Toxicology: Clinical Toxicology 34:5, pages 499-506.
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Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede & Manisha Patel. (2023) Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability. Redox Biology 67, pages 102895.
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Guan‐Hsun Wang, Ai‐Yu Chuang, Yi‐Chen Lai, Hsin‐I Chen, Shu‐Wei Hsueh & Ya‐Chin Yang. (2022) Pre‐synaptic and post‐synaptic A‐type K + channels regulate glutamatergic transmission and switching of the network into epileptiform oscillations . British Journal of Pharmacology 179:14, pages 3754-3777.
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Eveline Van Looy, Annelies Van Dycke & Ludo Vanopdenbosch. (2021) Two related cases of super‐refractory status epilepticus due to 4‐aminopyridine intoxication and an overview of the literature. Epileptic Disorders 23:3, pages 527-530.
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Lauren K. Shawn. 2017. Case Studies in Medical Toxicology. Case Studies in Medical Toxicology 181 187 .
Philippe E. Hantson. 2017. Critical Care Toxicology. Critical Care Toxicology 447 473 .
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Andrew R. Blight, Herbert R. HenneyIIIIII & Ron Cohen. (2014) Development of dalfampridine, a novel pharmacologic approach for treating walking impairment in multiple sclerosis. Annals of the New York Academy of Sciences 1329:1, pages 33-44.
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Anne-Michelle Ruha & Michael Levine. (2014) Central Nervous System Toxicity. Emergency Medicine Clinics of North America 32:1, pages 205-221.
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Maria Ballesta M?ndez, Vincent van Pesch, Arnaud Capron & Philippe Hantson. (2014) Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose. Case Reports in Neurological Medicine 2014, pages 1-4.
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Saurabh K. Sinha & Sushant K. Shrivastava. (2013) Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory. Bioorganic & Medicinal Chemistry Letters 23:10, pages 2984-2989.
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Saurabh K. Sinha & Sushant K. Shrivastava. (2012) Synthesis and evaluation of some new 4-aminopyridine derivatives as a potent antiamnesic and cognition enhancing drugs. Medicinal Chemistry Research 21:12, pages 4395-4402.
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Andrew M. King, Nathan B. Menke, Kenneth D. Katz & Anthony F. Pizon. (2012) 4-Aminopyridine Toxicity: a Case Report and Review of the Literature. Journal of Medical Toxicology 8:3, pages 314-321.
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Saam Sedehizadeh, Michael Keogh & Paul Maddison. (2012) The Use of Aminopyridines in Neurological Disorders. Clinical Neuropharmacology 35:4, pages 191-200.
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David R. Cornblath, E. Jay Bienen & Andrew R. Blight. (2012) The Safety Profile of Dalfampridine Extended Release in Multiple Sclerosis Clinical Trials. Clinical Therapeutics 34:5, pages 1056-1069.
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Riyi Shi & Wenjing Sun. (2011) Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons钾通道阻滞剂可以有效修复受伤轴突的冲动传导. Neuroscience Bulletin 27:1, pages 36-44.
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M.A. Sahraian, A.H. Maghzi, M. Etemadifar & A. Minagar. (2011) Dalfampridine: Review of its Efficacy in Improving Gait in Patients with Multiple Sclerosis. Journal of Central Nervous System Disease 3, pages JCNSD.S4868.
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Gary Leung, Wenjing Sun, Sarah Brookes, Daniel Smith & Riyi Shi. (2011) Potassium channel blocker, 4-aminopyridine-3-methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis. Experimental Neurology 227:1, pages 232-235.
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A. L. Hopkins & J. Clarke. (2010) Episodic cerebellar dysfunction in a bichon frise: a canine case of episodic ataxia?. Journal of Small Animal Practice 51:8, pages 444-446.
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Andis Graudins & Kathy Ka Ling Wong. (2010) Comparative Hemodynamic Effects of Levosimendan Alone and in Conjunction with 4-Aminopyridine or Calcium Chloride in a Rodent Model of Severe Verapamil Poisoning. Journal of Medical Toxicology 6:2, pages 85-93.
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William Smith, Suzanne Swan, Thomas Marbury & Herbert HenneyIIIIII. (2013) Single‐Dose Pharmacokinetics of Sustained‐Release Fampridine (Fampridine‐SR) in Healthy Volunteers and Adults With Renal Impairment. The Journal of Clinical Pharmacology 50:2, pages 151-159.
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Wenjing SunDaniel Smith, Yan Fu, Ji-Xin Cheng, Steven Bryn, Richard Borgens & Riyi Shi. (2010) Novel Potassium Channel Blocker, 4-AP-3-MeOH, Inhibits Fast Potassium Channels and Restores Axonal Conduction in Injured Guinea Pig Spinal Cord White Matter. Journal of Neurophysiology 103:1, pages 469-478.
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Craig Smith, Sathapana Kongsamut, Hongge Wang, Junzhi Ji, Jiesheng Kang & David Rampe. (2009) In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative . Clinical and Experimental Pharmacology and Physiology 36:11, pages 1104-1109.
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N. J. OLBY, D. T. SMITH, J. HUMPHREY, K. SPINAPOLICE, N. PARKE, P. M. MEHTA, D. DISE & M. PAPICH. (2009) Pharmacokinetics of 4-aminopyridine derivatives in dogs. Journal of Veterinary Pharmacology and Therapeutics 32:5, pages 485-491.
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Timothy Vollmer & Herbert R. HenneyIIIIII. (2009) Pharmacokinetics and tolerability of single escalating doses of fampridine sustained-release tablets in patients with multiple sclerosis: A phase I–II, open-label trial. Clinical Therapeutics 31:10, pages 2206-2214.
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Timothy Vollmer, Andrew R. Blight & Herbert R. HenneyIIIIII. (2009) Steady-state pharmacokinetics and tolerability of orally administered fampridine sustained-Release 10-mg tablets in patients with multiple sclerosis: A 2-week, open-label, follow-up study. Clinical Therapeutics 31:10, pages 2215-2223.
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Wenjing Sun, Daniel Smith, Steven Bryn, Richard Borgens & Riyi Shi. (2009) N-(4-pyridyl) methyl carbamate inhibits fast potassium currents in guinea pig dorsal root ganglion cells. Journal of the Neurological Sciences 277:1-2, pages 114-118.
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Kiyoaki Kobayashi, Yukio Nishizawa, Kohei Sawada, Hiroo Ogura & Masayuki Miyabe. (2008) K+-Channel Openers Suppress Epileptiform Activities Induced by 4-Aminopyridine in Cultured Rat Hippocampal Neurons. Journal of Pharmacological Sciences 108:4, pages 517-528.
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J.M. McBride, D.T. Smith, S.R. Byrn, R.B. Borgens & R. Shi. (2007) 4-Aminopyridine derivatives enhance impulse conduction in guinea-pig spinal cord following traumatic injury. Neuroscience 148:1, pages 44-52.
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A. N. Boiko, T. T. Batysheva, O. V. Matvievskaya, T. M. Manevich & E. I. Gusev. (2007) Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage. Neuroscience and Behavioral Physiology 37:3, pages 221-228.
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Keith C. Hayes. (2006) The Use of 4‐Aminopyridine (Fampridine) in Demyelinating Disorders. CNS Drug Reviews 10:4, pages 295-316.
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K. C. Hayes, M. A. Katz, J. G. Devane, J. T. C. Hsieh, D. L. Wolfe, P. J. Potter & A. R. Blight. (2003) Pharmacokinetics of an Immediate-Release Oral Formulation of Fampridine (4-Aminopyridine) in Normal Subjects and Patients with Spinal Cord Injury. The Journal of Clinical Pharmacology 43:4, pages 379-385.
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Larissa Velez, Farshad Shirazi, Collin Goto, Greene Shepherd & Brett A. Roth. (2003) Opisthotonic Posturing With Neuromuscular Irritability Attributable to 4-Aminopyridine Ingestion by a Healthy Pediatric Patient. Pediatrics 111:1, pages e82-e84.
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D.L. Wolfe, K.C. Hayes, J.T.C. Hsieh & P.J. Potter. (2001) Effects of 4-Aminopyridine on Motor Evoked Potentials in Patients with Spinal Cord Injury: A Double-Blinded, Placebo-Controlled Crossover Trial. Journal of Neurotrauma 18:8, pages 757-771.
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