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Journal of Toxicology: Clinical Toxicology Volume 34, 1996 - Issue 2
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Research Article

Pharmacokinetics of Extended Relief vs Regular Release Tylenol in Simulated Human Overdose

Christine M. Stork New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
,
Sean Rees New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
,
Mary Ann Howland New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
,
Lawrence Kaplan New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
,
Lewis Goldfrank New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
&
Robert S. Hoffman New York City Poison Control Center, Bellevue Hospital Center, New York; St John's University College of Pharmacy and Allied Health Professions, New York
Pages 157-162 | Published online: 25 Sep 2008

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A. L. Chiew & N. A. Buckley. (2023) Comment on: “population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations”. Clinical Toxicology 61:2, pages 139-140.
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Daniel A. Spyker, Richard C. Dart, Luke Yip, Kate Reynolds, Scott Brittain & Mark Yarema. (2022) Population pharmacokinetic analysis of acetaminophen overdose with immediate release, extended release and modified release formulations. Clinical Toxicology 60:10, pages 1113-1121.
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S. Gosselin, D. N. Juurlink, J. T. Kielstein, M. Ghannoum, V. Lavergne, T. D. Nolin & R. S. Hoffman. (2014) Extracorporeal treatment for acetaminophen poisoning: Recommendations from the EXTRIP workgroup. Clinical Toxicology 52:8, pages 856-867.
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Susan Bartels, Marco Sivilotti, Deborah Crosby & Julie Richard. (2008) Are recommended doses of acetaminophen hepatotoxic for recently abstinent alcoholics? A randomized trial. Clinical Toxicology 46:3, pages 243-249.
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Patrick J Amar & Eugene R Schiff. (2007) Acetaminophen safety and hepatotoxicity – where do we go from here?. Expert Opinion on Drug Safety 6:4, pages 341-355.
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Anthony R. Temple, Joseph M. Lynch, Jason Vena, Joanna F. Auiler & Cathy K. Gelotte. (2007) Aminotransferase activities in healthy subjects receiving three-day dosing of 4, 6, or 8 grams per day of acetaminophen. Clinical Toxicology 45:1, pages 36-44.
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Richard C. Dart, Andrew R. Erdman, Kent R. Olson, Gwenn Christianson, Anthony S. Manoguerra, Peter A. Chyka, E. Martin Caravati, Paul M. Wax, Daniel C. Keyes, Alan D. Woolf, Elizabeth J. Scharman, Lisa L. Booze & William G. Troutman. (2006) Acetaminophen Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management. Clinical Toxicology 44:1, pages 1-18.
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Marco L. A Sivilotti, Angela M. Good, Mark C. Yarema, David N. Juurlink & David W. Johnson. (2005) A New Predictor of Toxicity Following Acetaminophen Overdose Based on Pretreatment Exposure. Clinical Toxicology 43:4, pages 229-234.
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Articles from other publishers (13)

Tony Burda & Todd Sigg. (2012) Double Peak and Prolonged Absorption After Large Acetaminophen Extended Release and Diphenhydramine Ingestion. American Journal of Therapeutics 19:2, pages e101-e104.
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Darren M RobertsNicholas A Buckley. (2008) Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended‐release formulation. Medical Journal of Australia 188:5, pages 310-311.
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. (2006) Bioequivalence of Tylicol ER Tablet to Tylenol ® ER Tablet (Acetaminophen 650 mg) . Journal of Korean Pharmaceutical Sciences 36:3, pages 201-207.
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B. G. Leshnower. (2006) Role of acetaminophen in acute myocardial infarction. AJP: Heart and Circulatory Physiology 290:6, pages H2424-H2431.
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Richard C Dart, Jody L Green & Gregory M Bogdan. (2005) The Safety Profile of Sustained Release Paracetamol During Therapeutic Use and Following Overdose. Drug Safety 28:11, pages 1045-1056.
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Binh T. Ly, Aaron B. Schneir & Richard F. Clark. (2004) In reply:. Annals of Emergency Medicine 44:6, pages 669-670.
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Babak Mokhlesi & Thomas Corbridge. (2003) Toxicology in the critically ill patient. Clinics in Chest Medicine 24:4, pages 689-711.
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Matthew Q Bromer & Martin Black. (2003) Acetaminophen hepatotoxicity. Clinics in Liver Disease 7:2, pages 351-367.
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Babak Mokhlesi, Jerrold B. Leikin, Patrick Murray & Thomas C. Corbridge. (2003) Adult Toxicology in Critical Carea. Chest 123:3, pages 897-922.
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Fiona C. Baker, Helen S. Driver, Janice Paiker, Geoffrey G. Rogers & Duncan Mitchell. (2002) Acetaminophen does not affect 24-h body temperature or sleep in the luteal phase of the menstrual cycle. Journal of Applied Physiology 92:4, pages 1684-1691.
Crossref
J. Meyer & U. Karst. (2001) Determination of paracetamol (acetaminophen) by HPLC with post-column enzymatic derivatization and fluorescence detection. Chromatographia 54:3-4, pages 163-167.
Crossref
Edward W Cetarukcol, Richard C Dartcol, Katherine M Hurlbutcol, Rivka S Horowitzcol & Richard Shihcol. (1997) Tylenol Extended Relief Overdose. Annals of Emergency Medicine 30:1, pages 104-108.
Crossref
Teresa Rivera-Penera, Roberto Gugig, Judy Davis, Sue McDiarmid, Jorge Vargas, Philip Rosenthal, William Berquist, Melvin B. Heyman & Marvin E. Ament. (1997) Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity. The Journal of Pediatrics 130:2, pages 300-304.
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