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Journal of Toxicology: Clinical Toxicology Volume 34, 1996 - Issue 3
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Research Article

Pharmacokinetics Following a Loading Plus a Continuous Infusion of Pralidoxime Compared with the Traditional Short Infusion Regimen in Human Volunteers

Joseph J. Medicis University Hospital, State University of New York, Health Science Center at Syracuse, New York City Poison Control Center, New York
,
Christine M. Stork St John's University, Jamaica
,
Mary Ann Howland St John's University, Jamaica
,
Robert S. Hoffman Bellevue Hospital Center and New York University Medical Center, New York, New York
&
Lewis R. Goldfrank University Hospital, State University of New York, Health Science Center at Syracuse, New York City Poison Control Center, New York
Pages 289-295 | Published online: 25 Sep 2008

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Tae Oh Jeong, Jae Baek Lee, Young Ho Jin & Jae Chol Yoon. (2015) Respiratory arrest caused by accidental rapid pralidoxime infusion. Clinical Toxicology 53:4, pages 412-412.
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Lewis Nelson, Lewis S. Nelson, Jeanmarie Perrone, Francis DeRoos, Christine Stork & Robert S. Hoffman. (2001) Aldicarb Poisoning by an Illicit Rodenticide Imported into the United States: Tres Pasitos. Journal of Toxicology: Clinical Toxicology 39:5, pages 447-452.
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Schexnayder Stephen, James Laura, Kearns Gregory & Farrar Henry. (1998) The Pharmacokinetics of Continuous Infusion Pralidoxime in Children with Organophosphate Poisoning. Journal of Toxicology: Clinical Toxicology 36:6, pages 549-555.
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Joseph J. Medicis, Christine M. Stork, Mary Ann Howland, Robert S. Hoffman & Lewis R. Godlfrank. (1997) What Target Pralidoxime Concentration?-Author's Reply. Journal of Toxicology: Clinical Toxicology 35:2, pages 229-230.
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Andrew Dawson, Nick Buckley & Ian Whyte. (1997) What Target Pralidoxime Concentration?. Journal of Toxicology: Clinical Toxicology 35:2, pages 227-228.
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Articles from other publishers (36)

Lin-Na Xie, Jie Shao, Chun-Hua Huang, Feng Li, Dan Xu, Balaraman Kalyanaraman & Ben-Zhan Zhu. (2019) An unusual double radical homolysis mechanism for the unexpected activation of the aldoxime nerve-agent antidotes by polyhalogenated quinoid carcinogens under normal physiological conditions. Free Radical Biology and Medicine 130, pages 1-7.
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Erin Gallagher, Il Minn, Janice E. Chambers & Peter C. Searson. (2016) In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids and Barriers of the CNS 13:1.
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Subham Banerjee, Pronobesh Chattopadhyay, Animesh Ghosh, Aseem Bhatnagar & Vijay Veer. (2014) Pharmacokinetic and biodistribution study of eserine and pralidoxime chloride in rabbits following a single application of a transdermal patch. European Journal of Drug Metabolism and Pharmacokinetics 41:3, pages 219-230.
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Andrew M. King & Cynthia K. Aaron. (2015) Organophosphate and Carbamate Poisoning. Emergency Medicine Clinics of North America 33:1, pages 133-151.
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Abby M. Bailey, Stephanie N. Baker, Regan A. Baum, Hannah E. Chandler & Kyle A. Weant. (2014) Being Prepared. Advanced Emergency Nursing Journal 36:1, pages 22-33.
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Sung Phil ChungHyung-Keun Roh. (2013) Antidote for organophosphate insecticide poisoning: atropine and pralidoxime. Journal of the Korean Medical Association 56:12, pages 1057.
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Christopher P. Holstege & Heather A. Borek. (2012) Toxidromes. Critical Care Clinics 28:4, pages 479-498.
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Harald John & Marc-Michael Blum. (2012) Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM). Drug Testing and Analysis 4:3-4, pages 179-193.
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Robert S. Hoffman, Maria Mercurio-Zappala, Nicole Bouchard, Padinjarekuttu Ravikumar & Lewis Goldfrank. (2013) Preparing for Chemical Terrorism: A Study of the Stability of Expired Pralidoxime (2-PAM). Disaster Medicine and Public Health Preparedness 6:1, pages 20-25.
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Nick A Buckley, Michael Eddleston, Yi Li, Marc Bevan & Jane Robertson. (2011) Oximes for acute organophosphate pesticide poisoning. Cochrane Database of Systematic Reviews.
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Pascal Houzé, Donald E. Mager, Patricia Risède & Frédéric J. Baud. (2010) Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity. Toxicological Sciences 116:2, pages 660-672.
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Cynthia K. Aaron, James W. Rhee & Bram A. Dolcourt. 2010. Rosen's Emergency Medicine – Concepts and Clinical Practice. Rosen's Emergency Medicine – Concepts and Clinical Practice 2052 2060 .
Wayne R. Snodgrass. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 1295 1311 .
Maya Kayouka, Pascal Houzé, Patricia Risède, Marcel Debray & Frederic J. Baud. (2009) Acute renal failure alters the kinetics of pralidoxime in rats. Toxicology Letters 184:1, pages 61-66.
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David T. Lawrence & Mark A. Kirk. (2007) Chemical Terrorism Attacks: Update on Antidotes. Emergency Medicine Clinics of North America 25:2, pages 567-595.
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CYNTHIA K. AARON. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 1171 1184 .
Kirti S Pawar, Ramesh R Bhoite, Chandrakant P Pillay, Sujata C Chavan, Dhananjay S Malshikare & Saraswati G Garad. (2006) Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial. The Lancet 368:9553, pages 2136-2141.
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John V. Peter, John L. Moran & Petra Graham. (2006) Oxime therapy and outcomes in human organophosphate poisoning: An evaluation using meta-analytic techniques. Critical Care Medicine 34:2, pages 502-510.
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Timothy C. Marrs & J. Allister Vale. 2006. Toxicology of Organophosphate & Carbamate Compounds. Toxicology of Organophosphate & Carbamate Compounds 715 733 .
J.C. Ríos, G. Repetto, I. Galleguillos, A. Jos, A. del Peso & M. Repetto. (2005) High concentrations of pralidoxime are needed for the adequate reactivation of human erythrocyte acetylcholinesterase inhibited by dimethoate in vitro. Toxicology in Vitro 19:7, pages 893-897.
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Claudia L. Barthold & Joshua G. Schier. (2005) Organic Phosphorus Compounds—Nerve Agents. Critical Care Clinics 21:4, pages 673-689.
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Christopher P. Holstege & Stephen G. Dobmeier. (2005) Nerve agent toxicity and treatment. Current Treatment Options in Neurology 7:2, pages 91-98.
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Nick Buckley, Michael Eddleston & Ladislaus Szinicz. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Eran Kozer, Amnon Mordel, Shmuael Bar Haim, Mordechei Bulkowstein, Matitiahu Berkovitch & Yedidia Bentur. (2005) Pediatric poisoning from trimedoxime (TMB4) and atropine automatic injectors. The Journal of Pediatrics 146:1, pages 41-44.
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Pascal Houz?Stephen W. Borron, Fran?ois Scherninski, Bernard Bousquet, Bernard Gourmel & Fr?d?ric Baud. (2005) Measurement of serum pralidoxime methylsulfate (Contrathion?) by high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B 814:1, pages 149-154.
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Abdolkarim Pajoumand, Shahin Shadnia, Ali Rezaie, Mahboobeh Abdi & Mohammad Abdollahi. (2016) Benefits of magnesium sulfate in the management of acute human poisoning by organophosphorus insecticides. Human & Experimental Toxicology 23:12, pages 565-569.
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Guillermo Burillo-Putze, Robert S Hoffman, Mary Ann Howland & Antonio Duenas-Laita. (2004) Late administration of pralidoxime in organophosphate (fenitrothion) poisoning. The American Journal of Emergency Medicine 22:4, pages 327-328.
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Sage W. Wiener & Robert S. Hoffman. (2016) Nerve Agents: A Comprehensive Review. Journal of Intensive Care Medicine 19:1, pages 22-37.
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Christopher P. Holstege & Alexander B. Baer. (2004) Insecticides. Current Treatment Options in Neurology 6:1, pages 17-23.
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Peter Eyer. (2003) The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning. Toxicological Reviews 22:3, pages 165-190.
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Tai C. Kwong. (2002) Organophosphate Pesticides: Biochemistry and Clinical Toxicology. Therapeutic Drug Monitoring 24:1, pages 144-149.
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A M Tsatsakis, G K Bertsias, V Liakou, I N Mammas, I Stiakakis & G N Tzanakakis. (2016) Severe fenthion intoxications due to ingestion and inhalation with survival outcome. Human & Experimental Toxicology 21:1, pages 49-54.
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Wayne R. Snodgrass. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 589 602 .
Martin K Johnson, Dag Jacobsen, Tim J Meredith, Peter Eyer, Andrew J Heath, David A Ligtenstein, Tim C Marrs, Ladislaus Szinicz, J Allister Vale & John A Haines. (2001) Evaluation of antidotes for poisoning by organophosphorus pesticides. Emergency Medicine 12:1, pages 22-37.
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H. Thiermann, L. Szinicz, F. Eyer, F. Worek, P. Eyer, N. Felgenhauer & T. Zilker. (1999) Modern strategies in therapy of organophosphate poisoning. Toxicology Letters 107:1-3, pages 233-239.
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Christopher P. Holstege, Mark Kirk & Frederick R. Sidell. (1997) CHEMICAL WARFARE. Critical Care Clinics 13:4, pages 923-942.
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