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Research Article

Delayed Peak Serum Valproic Acid in Massive Divalproex Overdose—Treatment with Charcoal Hemoperfusion

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Pages 335-341 | Published online: 25 Sep 2008

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Lotte C. G. Hoegberg, Greene Shepherd, David M. Wood, Jami Johnson, Robert S. Hoffman, E. Martin Caravati, Wui Ling Chan, Silas W. Smith, Kent R. Olson & Sophie Gosselin. (2021) Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose. Clinical Toxicology 59:12, pages 1196-1227.
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Marc Ghannoum, Martin Laliberté, Thomas D. Nolin, Robert MacTier, Valery Lavergne, Robert S. Hoffman & Sophie Gosselin. (2015) Extracorporeal treatment for valproic acid poisoning: Systematic review and recommendations from the EXTRIP workgroup. Clinical Toxicology 53:5, pages 454-465.
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Ruben H.K. Thanacoody. (2009) Extracorporeal elimination in acute valproic acid poisoning. Clinical Toxicology 47:7, pages 609-616.
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Philippe E.R. Lheureux & Philippe Hantson. (2009) Carnitine in the treatment of valproic acid-induced toxicity. Clinical Toxicology 47:2, pages 101-111.
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Anthony S. Manoguerra, Andrew R. Erdman, Alan D. Woolf, Peter A. Chyka, E. Martin Caravati, Elizabeth J. Scharman, Lisa L. Booze, Gwenn Christianson, Lewis S. Nelson, Daniel J. Cobaugh & William G. Troutman. (2008) Valproic acid poisoning: An evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 46:7, pages 661-676.
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Matthew D. Sztajnkrycer. (2002) Valproic Acid Toxicity: Overview and Management. Journal of Toxicology: Clinical Toxicology 40:6, pages 789-801.
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Henry A. Spiller, Henry Spiller, Edward P. Krenzelok, Wendy Klein-Schwartz, Mark L. Winter, Julie A. Weber, Dawn R. Sollee & Stacy A. Bangh. (2000) Multicenter Case Series of Valproic Acid Ingestion: Serum Concentrations and Toxicity. Journal of Toxicology: Clinical Toxicology 38:7, pages 755-760.
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Articles from other publishers (25)

Antonio E. Muñiz. (2017) Valproic Acid Overdose Review of a Case With Electrocardiographic Changes. The Journal of Emergency Medicine 53:3, pages 333-338.
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B. Tate Cutshall, Samarth P. Shah, Megan A. Van Berkel, Shanise Patterson, L. Jeff Harris & Jessica V. Rivera. (2017) Should Pharmacies Be Included in Medication Reconciliation? A Report of Recurrent Valproic Acid Toxicity. Clinical Practice and Cases in Emergency Medicine 1:2, pages 122-125.
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Wojciech Jawień, Jolanta Wilimowska, Małgorzata Kłys & Wojciech Piekoszewski. (2017) Population pharmacokinetic modelling of valproic acid and its selected metabolites in acute VPA poisoning. Pharmacological Reports 69:2, pages 340-349.
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Wayne R. Snodgrass & Chia Wei Hsu. 2017. Critical Care Toxicology. Critical Care Toxicology 1083 1094 .
Wayne R. Snodgrass & Chia Wei Hsu. 2016. Critical Care Toxicology. Critical Care Toxicology 1 12 .
Dror Weiner, Vered Nir, Adi Klein-Kremer & Eiass Kassem. (2013) Chronic Valproic Acid Intoxication. Pediatric Emergency Care 29:6, pages 756-757.
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Matthew W. Hedge. (2012) Miscellaneous Central Nervous System Intoxicants. Critical Care Clinics 28:4, pages 587-600.
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R. Kumar, R.M. Reddy, P.S. Sinha, J. Tirkey, M.K. Singh & B.C. Prasad. (2010) Impact of Leguminous Biomulching on Soil Properties, Leaf Yield and Cocoon Productivity of Tropical Tasarculture under Rain-Fed Conditions. Journal of Entomology 7:4, pages 219-226.
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Jinhee Jung, Eunkyung Eo & Ki-ok Ahn. (2008) A case of hemoperfusion and l-carnitine management in valproic acid overdose. The American Journal of Emergency Medicine 26:3, pages 388.e3-388.e4.
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Abhishek Katiyar & Cynthia Aaron. (2007) Case files of the Children’s Hospital of Michigan Regional Poison Control Center: The use of carnitine for the management of acute valproic acid toxicity. Journal of Medical Toxicology 3:3, pages 129-138.
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Jolanta Wilimowska, Ewa Florek & Wojciech Piekoszewski. (2006) Disposition of Valproic Acid in Self-Poisoned Adults. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 99:1, pages 22-26.
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Chunhui Deng, Ning Li, Jie Ji, Bei Yang, Gengli Duan & Xiangmin Zhang. (2006) Development of water-phase derivatization followed by solid-phase microextraction and gas chromatography/mass spectrometry for fast determination of valproic acid in human plasma. Rapid Communications in Mass Spectrometry 20:8, pages 1281-1287.
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N. V. S. Ramakrishna, K. N. Vishwottam, S. Manoj, M. Koteshwara, M. Santosh, J. Chidambara & B. Ravi Kumar. (2005) Liquid chromatography/electrospray ionization mass spectrometry method for the quantification of valproic acid in human plasma. Rapid Communications in Mass Spectrometry 19:14, pages 1970-1978.
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Mark A. Perazella, Ziyad Al Aly, Praveen Yalamanchili & Esther Gonzalez. (2008) Extracorporeal Management of Valproic Acid Toxicity: A Case Report and Review of the Literature. Seminars in Dialysis 18:1, pages 62-66.
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V Minville, C Roche Tissot & K Samii. (2004) Épuration extrarénale, supplémentation en L-carnitine et intoxication à l’acide valproïque. Annales Françaises d'Anesthésie et de Réanimation 23:4, pages 357-360.
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Geoffrey K. Isbister, Corrine R. Balit, Ian M. Whyte & Andrew Dawson. (2003) Valproate overdose: a comparative cohort study of self poisonings. British Journal of Clinical Pharmacology 55:4, pages 398-404.
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Frank LoVecchio, Daniel Thole & Terri Bagnasco. (2008) Delayed Absorption of Valproic Acid, Resulting in Coma. Academic Emergency Medicine 9:12, pages 1464-1464.
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Frank LoVecchio, Daniel Thole & Terri Bagnasco. (2002) Delayed Absorption of Valproic Acid, Resulting in Coma. Academic Emergency Medicine 9:12, pages 1464-1464.
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Marianne Ingels, Jon Beauchamp, Richard F. Clark & Saralyn R. Williams. (2002) Delayed valproic acid toxicity: A retrospective case series. Annals of Emergency Medicine 39:6, pages 616-621.
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Marilena Minari, Umberto Maggiore, Dante Tagliavini, Carlo Rotelli, Aderville Cabassi, Salvatore David & Enrico Fiaccadori. (2002) Severe acute valproic acid intoxication successfully treated with hemodiafiltration without hemoperfusion. Annals of Emergency Medicine 39:2, pages 204-205.
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Lisa K. Hicks & Philip A. McFarlane. (2001) Valproic acid overdose and haemodialysis. Nephrology Dialysis Transplantation 16:7, pages 1483-1486.
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Jeffrey Reynold Brubacher, Payam Dahghani & Douglas McKnight. (1999) Delayed toxicity following ingestion of enteric-coated divalproex sodium (epival). The Journal of Emergency Medicine 17:3, pages 463-467.
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Lin Z. Johnson, Ileana Martinez, Miguel C. Fern?ndez, Charles P. Davis & Balakuntalam S. Kasinath. (1999) Successful treatment of valproic acid overdose with hemodialysis. American Journal of Kidney Diseases 33:4, pages 786-789.
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