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Journal of Toxicology: Clinical Toxicology Volume 36, 1998 - Issue 6
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Research Article

The Pharmacokinetics of Continuous Infusion Pralidoxime in Children with Organophosphate Poisoning

Schexnayder Stephen University of Arkansas for Medical Sciences, (SS, LPJ, HCF);Correspondence [email protected]. uams.edu
,
James Laura Arkansas Children’s Hospital, Little Rock, Arkansas (SS, LPJ, HCF);
,
Kearns Gregory University of Missouri–Kansas City (GLK) and The Claildren’s
&
Farrar Henry Mercy Hospital, Kansas City, Missouri (GLK)
Pages 549-555 | Published online: 25 Sep 2008

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Nabeel I. Uwaydah, Stephen L. Hoskins, Stephen P. Bruttig, Henry Farrar, Nick C. Copper, Donald J. Deyo, Michael A. Dubick & George C. Kramer. (2016) Intramuscular versus Intraosseous Delivery of Nerve Agent Antidote Pralidoxime Chloride in Swine. Prehospital Emergency Care 20:4, pages 485-492.
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Daniel L. Sudakin, Michael E. Mullins, B. Zane Horowitz, Virginia Abshier & Lynda Letzig. (2000) Intermediate Syndrome After Malathion Ingestion Despite Continuous Infusion of Pralidoxime. Journal of Toxicology: Clinical Toxicology 38:1, pages 47-50.
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Articles from other publishers (32)

Najmiddin Mamadjonov, Yong Hun Jung, Kyung Woon Jeung, Hyoung Youn Lee, Byung Kook Lee, Chun Song Youn, In Seok Jeong, Tag Heo & Yong Il Min. (2021) Pralidoxime improves the hemodynamics and survival of rats with peritonitis-induced sepsis. PLOS ONE 16:4, pages e0249794.
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Erin Gallagher, Il Minn, Janice E. Chambers & Peter C. Searson. (2016) In vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs). Fluids and Barriers of the CNS 13:1.
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Rita HumeniukDionna Green. (2015) Medical Countermeasures Development for Neonates. NeoReviews 16:12, pages e701-e707.
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Andrew M. King & Cynthia K. Aaron. (2015) Organophosphate and Carbamate Poisoning. Emergency Medicine Clinics of North America 33:1, pages 133-151.
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Xue Tang, Ruilan Wang, Hui Xie, Jiachang Hu & Wenbiao Zhao. (2013) Repeated pulse intramuscular injection of pralidoxime chloride in severe acute organophosphorus pesticide poisoning. The American Journal of Emergency Medicine 31:6, pages 946-949.
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Harald John & Marc-Michael Blum. (2012) Review of UV spectroscopic, chromatographic, and electrophoretic methods for the cholinesterase reactivating antidote pralidoxime (2-PAM). Drug Testing and Analysis 4:3-4, pages 179-193.
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Willemijn van Heel & Said Hachimi-Idrissi. (2011) Accidental organophosphate insecticide intoxication in children: a reminder. International Journal of Emergency Medicine 4:1.
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Anna M. Fan. 2011. Anticholinesterase Pesticides. Anticholinesterase Pesticides 541 566 .
Pascal Houzé, Donald E. Mager, Patricia Risède & Frédéric J. Baud. (2010) Pharmacokinetics and Toxicodynamics of Pralidoxime Effects on Paraoxon-Induced Respiratory Toxicity. Toxicological Sciences 116:2, pages 660-672.
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M.A. Bocanegra, I. Campanario, M.L. Moreno Perulero, F. Araujo & C. Encinas Barrios. (2009) Pralidoxima en intoxicación por organofosforados: a propósito de dos casos en pediatría. Farmacia Hospitalaria 33:6, pages 336-337.
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L. Marruecos-Sant & J.C. Martín-Rubí. (2007) Uso de oximas en la intoxicación por organofosforados. Medicina Intensiva 31:5, pages 258-260.
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CYNTHIA K. AARON. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 1171 1184 .
I.M. Abdullat, A.H. Battah & K.A. Hadidi. (2006) The use of serial measurement of plasma cholinesterase in the management of acute poisoning with organophosphates and carbamates. Forensic Science International 162:1-3, pages 126-130.
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David P. BettenRais B. Vohra, Matthew D. Cook, Michael J. Matteucci & Richard F. Clark. (2016) Antidote Use in the Critically Ill Poisoned Patient. Journal of Intensive Care Medicine 21:5, pages 255-277.
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Derek S. Wheeler, Renuka Mehta, Lyle E. FisherJrJr, Joseph E. Segeleon & Anthony L. Pearson-Shaver. (2006) A Tale of Two Sisters. Pediatric Emergency Care 22:3, pages 197-200.
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Timothy C. Marrs & J. Allister Vale. 2006. Toxicology of Organophosphate & Carbamate Compounds. Toxicology of Organophosphate & Carbamate Compounds 715 733 .
Claudia L. Barthold & Joshua G. Schier. (2005) Organic Phosphorus Compounds—Nerve Agents. Critical Care Clinics 21:4, pages 673-689.
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Christopher P. Holstege & Stephen G. Dobmeier. (2005) Nerve agent toxicity and treatment. Current Treatment Options in Neurology 7:2, pages 91-98.
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Christopher P. Holstege & Alexander B. Baer. (2004) Insecticides. Current Treatment Options in Neurology 6:1, pages 17-23.
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Joshua S. Rotenberg & Jonathan Newmark. (2003) Nerve Agent Attacks on Children: Diagnosis and Management. Pediatrics 112:3, pages 648-658.
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Peter Eyer. (2003) The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning. Toxicological Reviews 22:3, pages 165-190.
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Fred M. Henretig, Theodore J. Cieslak & Edward M. EitzenJrJr. (2002) Biological and chemical terrorism. The Journal of Pediatrics 141:3, pages 311-326.
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L.I.G. Worthley. (2002) Clinical Toxicology: Part II. Diagnosis and Management of Uncommon Poisonings. Critical Care and Resuscitation 4:3, pages 216-230.
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C Paget, S Menard, I Wroblewski, J.P Gout, V Danel & M Bost. (2002) Intoxication aiguë par organophosphorés à la suite de l’utilisation d’un insecticide comme shampooing anti-poux. Archives de Pédiatrie 9:9, pages 913-916.
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A M Tsatsakis, G K Bertsias, V Liakou, I N Mammas, I Stiakakis & G N Tzanakakis. (2016) Severe fenthion intoxications due to ingestion and inhalation with survival outcome. Human & Experimental Toxicology 21:1, pages 49-54.
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Bev-Lorraine True & Robert H. DreisbachBev-Lorraine True & Robert H. Dreisbach. 2001. Dreisbach’s HANDBOOK of POISONING. Dreisbach’s HANDBOOK of POISONING 172 198 .
Ron Ben Abraham, Avi A. Weinbroum, Valery Rudick & Gideon Paret. (2008) Perioperative care of children with nerve agent intoxication. Pediatric Anesthesia 11:6, pages 643-649.
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P.T. Haywood & L. Karalliedde. (2000) Management of poisoning due to organophosphorus compounds. Current Anaesthesia & Critical Care 11:6, pages 331-337.
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J.M Rousseau, M Rüttimann & L Brinquin. (2000) Intoxications aiguës par neurotoxiques organophosphorés : insecticides et armes chimiques. Annales Françaises d'Anesthésie et de Réanimation 19:8, pages 588-598.
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Martin K Johnson, Dag Jacobsen, Tim J Meredith, Peter Eyer, Andrew J Heath, David A Ligtenstein, Tim C Marrs, Ladislaus Szinicz, J Allister Vale & John A Haines. (2001) Evaluation of antidotes for poisoning by organophosphorus pesticides. Emergency Medicine 12:1, pages 22-37.
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L.I.G. Worthley. (1999) “If you don’t look for Canaries you won’t find them”. Critical Care and Resuscitation 1:4, pages 335-337.
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L. Karalliedde. (1999) Organophosphorus poisoning and anaesthesia. Anaesthesia 54:11, pages 1073-1088.
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