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Journal of Toxicology: Clinical Toxicology Volume 36, 1998 - Issue 6
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Research Article

Loss of Consciousness from Acute Quetiapine Overdosage

Timothy J. Harmon Pittsburgh Poison Center, Children's Hospital of Pittsburgh and University of Pittsburgh Medical Center Toxicology Treatment Program, Pittsburgh, PennsylvaniaCorrespondence[email protected]
,
John G. Benitez Pittsburgh Poison Center, Children's Hospital of Pittsburgh and University of Pittsburgh Medical Center Toxicology Treatment Program, Pittsburgh, Pennsylvania
,
Edward P. Krenzelok Pittsburgh Poison Center, Children's Hospital of Pittsburgh and University of Pittsburgh Medical Center Toxicology Treatment Program, Pittsburgh, Pennsylvania
&
Ernesto Cortes-Belen Pittsburgh Poison Center, Children's Hospital of Pittsburgh and University of Pittsburgh Medical Center Toxicology Treatment Program, Pittsburgh, Pennsylvania
Pages 599-602 | Published online: 25 Sep 2008

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Florian Eyer, Rudolf Pfab, Norbert Felgenhauer, Tim Strubel, Bernd Saugel & Thomas Zilker. (2011) Clinical and analytical features of severe suicidal quetiapine overdoses – a retrospective cohort study. Clinical Toxicology 49:9, pages 846-853.
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Annalisa Capuano, Simona Ruggiero, Francesco Vestini, Benedetta Ianniello, Concetta Rafaniello, Francesco Rossi & Armida Mucci. (2011) Survival from coma induced by an intentional 36-g overdose of extended-release quetiapine. Drug and Chemical Toxicology 34:4, pages 475-477.
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Pamela L Smithburger, Amy L Seybert, Michael J Armahizer & Sandra L Kane-Gill. (2010) QT prolongation in the intensive care unit: commonly used medications and the impact of drug–drug interactions. Expert Opinion on Drug Safety 9:5, pages 699-712.
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Daniel J. Cobaugh, Andrew R. Erdman, Lisa L. Booze, Elizabeth J. Scharman, Gwenn Christianson, Anthony S. Manoguerra, E. Martin Caravati, Peter A. Chyka, Alan D. Woolf, Lewis S. Nelson & William G. Troutman. (2007) Atypical antipsychotic medication poisoning: An evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 45:8, pages 918-942.
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Robert G. Hendrickson$suffix/text()$suffix/text() & Anthony P. Morocco$suffix/text()$suffix/text(). (2003) Quetiapine Cross-Reactivity Among Three Tricyclic Antidepressant Immunoassays. Journal of Toxicology: Clinical Toxicology 41:2, pages 105-108.
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Michael J. Burns. (2001) The Pharmacology and Toxicology of Atypical Antipsychotic Agents. Journal of Toxicology: Clinical Toxicology 39:1, pages 1-14.
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Articles from other publishers (39)

Elisabetta Bertol, Fabio Vaiano, Antonina Argo, Stefania Zerbo, Claudia Trignano, Simone Protani & Donata Favretto. (2021) Overdose of Quetiapine—A Case Report with QT Prolongation. Toxics 9:12, pages 339.
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Filippo MILANO, Stefania URSO & Enrico DE DOMINICIS. (2021) Toxicological and histopathological findings in a suicidal quetiapine overdose. Minerva Medicolegale 140:4.
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Yusuf S. Althobaiti. (2021) Quetiapine-Induced Place Preference in Mice: Possible Dopaminergic Pathway. Pharmaceuticals 14:2, pages 156.
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Michael Chen, Hassaan Gomaa, Alonso Cortez-Resendiz, Christopher Martin, Andrew Francis & Alfredo Bellon. (2020) Quetiapine and Wolff-Parkinson-White Syndrome. Case Reports in Psychiatry 2020, pages 1-4.
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Raj K S Badhan & Hannah Macfarlane. (2020) Quetiapine dose optimisation during gestation: a pharmacokinetic modelling study. Journal of Pharmacy and Pharmacology 72:5, pages 670-681.
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Elise Peridy, Jean-François Hamel, Anne-Lise Rolland, Bénédicte Gohier & David Boels. (2019) Quetiapine Poisoning and Factors Influencing Severity. Journal of Clinical Psychopharmacology 39:4, pages 312-317.
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Rhome L. Hughes. (2018) Fatal combination of mitragynine and quetiapine – a case report with discussion of a potential herb-drug interaction. Forensic Science, Medicine and Pathology 15:1, pages 110-113.
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Hong Joon Lee, Jin-Sung Choi, Bok Hee Choi & Sang June Hahn. (2018) Effects of norquetiapine, the active metabolite of quetiapine, on cloned hERG potassium channels. Neuroscience Letters 664, pages 66-73.
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Bradley L. Demeter & Michael J. Burns. 2017. Critical Care Toxicology. Critical Care Toxicology 907 933 .
Bradley L. Demeter & Michael J. Burns. 2016. Critical Care Toxicology. Critical Care Toxicology 1 27 .
Louise Skov, Sys Stybe Johansen & Kristian Linnet. (2015) Postmortem Quetiapine Reference Concentrations in Brain and Blood. Journal of Analytical Toxicology 39:7, pages 557-561.
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Louise Skov, Sys Stybe Johansen & Kristian Linnet. (2015) Postmortem Femoral Blood Reference Concentrations of Aripiprazole, Chlorprothixene, and Quetiapine. Journal of Analytical Toxicology 39:1, pages 41-44.
Crossref
Bradley L. Demeter & Michael J. Burns. 2016. Critical Care Toxicology. Critical Care Toxicology 1 27 .
Amar Bavle & Chittaranjan Andrade. (2013) Prolonged, self-administration of ultra-high doses of quetiapine. Indian Journal of Psychiatry 55:4, pages 404.
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Masaru Umeda, Miyuki Nakamatsu, Rie Arii, Hideyuki Yoshida & Ryuichi Fuchi. (2013) A case report of severe overdose of valproate, quetiapine, and promethazine treated with direct hemoperfusion. Nihon Toseki Igakkai Zasshi 46:1, pages 125-129.
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Engin Deniz Arslan, Ali Demir, Fevzi Yilmaz, Cemil Kavalci, Evvah Karakilic & Elif Çelikel. (2013) Treatment of Quetiapine Overdose with Intravenous Lipid Emulsion. The Keio Journal of Medicine 62:2, pages 53-57.
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Nasim Aghaienia, Nancy C. Brahm, Kyla M. Lussier & Nicole B. Washington. (2011) Probable Quetiapine-Mediated Prolongation of the QT Interval. Journal of Pharmacy Practice 24:5, pages 506-512.
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T. Zilker. (2010) Intoxikationen als Ursachen von BewusstseinsstörungenPoisoning as cause of disturbance of consciousness. Intensivmedizin und Notfallmedizin 47:2, pages 101-108.
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Ayumi Fujita, Kenji Aratake, Yugo Minagawa, Takeshi Nishida, Hitoshi Tanaka, Shigeki Tomojiri & Kenji Hara. (2010) A case of Quetiapine overdose in which the analyses of biological specimens were possible. Nihon Kyukyu Igakukai Zasshi 21:9, pages 811-816.
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Mary A. Wittler & Eric J. Lavonas. 2010. Rosen's Emergency Medicine – Concepts and Clinical Practice. Rosen's Emergency Medicine – Concepts and Clinical Practice 2042 2046 .
Hock Heng Tan, Jason Hoppe & Kennon Heard. (2009) A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. The American Journal of Emergency Medicine 27:5, pages 607-616.
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Adeline Ngo, Michael Ciranni & Kent R. Olson. (2008) Acute Quetiapine Overdose in Adults: A 5-Year Retrospective Case Series. Annals of Emergency Medicine 52:5, pages 541-547.
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Michael Bodmer, Thilo Burkard, Oliver Kummer, Ralf Beyrau, Stephan Krähenbühl & Manuel Haschke. (2008) Pharmacokinetics and Pharmacodynamics of Quetiapine in a Patient with a Massive Overdose. Therapeutic Drug Monitoring 30:4, pages 553-556.
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Sara Brown & Rachel Sweeney. (2007) Overdose and Treatment of Quetiapine Ingestions. Journal of Emergency Nursing 33:6, pages 582-584.
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MICHAEL LEVINE & MICHAEL J. BURNS. 2007. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose 703 720 .
Paul M Strachan & Brian A Benoff. (2006) Mental Status Change, Myoclonus, Electrocardiographic Changes, and Acute Respiratory Distress Syndrome Induced by Quetiapine Overdose. Pharmacotherapy 26:4, pages 578-582.
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Seema Jabeen, Stephanie I Polli & David R Gerber. (2016) Acute Respiratory Failure with a Single Dose of Quetiapine Fumarate. Annals of Pharmacotherapy 40:3, pages 559-562.
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Andréanne Précourt, Magdalena Dunewicz, Geneviève Grégoire & David R Williamson. (2005) Multiple Complications and Withdrawal Syndrome Associated with Quetiapine/Venlafaxine Intoxication. Annals of Pharmacotherapy 39:1, pages 153-156.
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Seeth Vivek. (2004) No QT interval prolongation associated with quetiapine overdose. The American Journal of Emergency Medicine 22:4, pages 330.
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Richard P. Smith, Ben N. Puckett, Jennifer Crawford & Richard L. Elliott. (2004) Quetiapine Overdose and Severe Rhabdomyolysis. Journal of Clinical Psychopharmacology 24:3, pages 343.
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Corrine R Balit, Geoffrey K Isbister, L.Peter Hackett & Ian M Whyte. (2003) Quetiapine poisoning. Annals of Emergency Medicine 42:6, pages 751-758.
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D. M. Taylor. (2003) Antipsychotics and QT prolongation. Acta Psychiatrica Scandinavica 107:2, pages 85-95.
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Glenn Catalano, Maria C. Catalano, Rachel E. Agustines, Erin M. Dolan & Khatija N. Paperwalla. (2002) Pediatric Quetiapine Overdose: A Case Report and Literature Review. Journal of Child and Adolescent Psychopharmacology 12:4, pages 355-361.
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. 2001. Dreisbach's Handbook of Poisoning. Dreisbach's Handbook of Poisoning 390 421 .
Vernon M PaisJrJr & Philip J Ayvazian. (2001) Priapism from quetiapine overdose: first report and proposal of mechanism. Urology 58:3, pages 462.
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ELIZABETH S. JACOBS, DANIEL P. DICKSTEIN & ERICA L. LIEBELT. (2001) Novel psychotropic medications in children: New toxicities to master. Pediatric Emergency Care 17:3, pages 226-231.
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Mercedes Galdós Barroso, Mariano Ulla Anés, Salvador Martínez Vicente & Javier Arozemena Baquerizo. (2001) Intoxicación por quetiapina. Medicina Clínica 117:16, pages 638-639.
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Vikram Dev & Joher Raniwalla. (2000) Quetiapine. Drug Safety 23:4, pages 295-307.
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Fredric M Hustey. (1999) Acute quetiapine poisoning. The Journal of Emergency Medicine 17:6, pages 995-997.
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