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Research Articles

Endothelial cell damage following sulfur mustard exposure in rabbits and its association with the delayed-onset ocular lesions

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Pages 115-123 | Received 20 Jun 2012, Accepted 30 Jul 2012, Published online: 30 Oct 2012

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Satyendra K. Singh, Joshua A. Klein, Holly N. Wright & Neera Tewari-Singh. (2021) Phosgene oxime: a highly toxic urticant and emerging chemical threat. Toxicology Mechanisms and Methods 31:4, pages 288-292.
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Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Eliezer Fishbine, Rachel Brandeis, Joseph Turetz, Adina Amir, Ariel Gore & Tamar Kadar. (2014) The Beneficial Effects of Doxycycline, An Inhibitor of Matrix Metalloproteinases, on Sulfur Mustard-Induced Ocular Pathologies Depend on the Injury Stage. Current Eye Research 39:8, pages 803-812.
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Vered Horwitz, Maayan Cohen, Ariel Gore, Rellie Gez, Hila Gutman, Tamar Kadar, Shlomit Dachir & Shai Kendler. (2023) Predicting clinical outcome of sulfur mustard induced ocular injury using machine learning model. Experimental Eye Research 236, pages 109671.
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Hamid Alemi, Shima Dehghani, Katayoon Forouzanfar, Pier Luigi Surico, Akitomo Narimatsu, Aytan Musayeva, Sina Sharifi, Shudan Wang, Thomas H. Dohlman, Jia Yin, Yihe Chen & Reza Dana. (2023) Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Experimental Eye Research 236, pages 109657.
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Mohammad Soleimani, Bita Momenaei, Alireza Baradaran-Rafii, Kasra Cheraqpour, Seungwon An, Mohammad Javad Ashraf, Farshad Abedi, Mohammad Ali Javadi & Ali R. Djalilian. (2023) Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management. Cornea 42:6, pages 776-786.
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Hamid Alemi, Shima Dehghani, Aytan Musayeva, Amirreza Nadari, Akitomo Narimatsu, Sina Sharifi, Katayoun Forouzanfar, Shudan Wang, Thomas H. Dohlman, Jia Yin, Yihe Chen & Reza Dana. (2023) Insights into mustard gas keratopathy: Characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Experimental Eye Research, pages 109495.
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Okoyeocha OM. Ebenezar, Andrew Roney, Dinesh G. Goswami, J. Mark Petrash, Dodd Sledge, András M. Komáromy, Karen T. Liby & Neera Tewari-Singh. (2023) Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice. Experimental Eye Research 230, pages 109440.
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Ariel Gore, Tamar Kadar, Maayan Cohen, Hila Gutman, Rellie Gez, Shlomit Dachir & Vered Horwitz. (2023) The use of aflibercept (VEGF trap) in mitigating sulfur mustard-induced corneal neovascularization in a rabbit model. Toxicology Reports 10, pages 206-215.
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Nishant R. Sinha, Ratnakar Tripathi, Praveen K. Balne, Sydney L. Green, Prashant R. Sinha, Filiz Bunyak, Elizabeth A. Giuliano, Shyam S. Chaurasia & Rajiv R. Mohan. (2022) Time-dependent in situ structural and cellular aberrations in rabbit cornea in vivo after mustard gas exposure. Experimental Eye Research 224, pages 109247.
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Laurie B. Joseph, Marion K. Gordon, Peihong Zhou, Rita A. Hahn, Hamdi Lababidi, Claire R. Croutch, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2022) Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Experimental and Molecular Pathology 128, pages 104807.
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Tamar Kadar, Vered Horwitz, Maayan Cohen, Inbal Egoz, Hila Gutman, Relli Gez & Shlomit Dachir. (2022) Limbal stem cell deficiency (LSCD) in rats and mice following whole body exposure to sulfur mustard (SM) vapor. Experimental Eye Research 223, pages 109195.
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Allison Fuchs, Elizabeth A. Giuliano, Nishant R. Sinha & Rajiv R. Mohan. (2021) Ocular toxicity of mustard gas: A concise review. Toxicology Letters 343, pages 21-27.
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Ariel Gore, Tamar Kadar, Shlomit Dachir & Vered Horwitz. (2021) Therapeutic measures for sulfur mustard-induced ocular injury. Toxicology Letters 340, pages 58-66.
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Matthew D. McGraw, So‐Young Kim, Carl W. White & Livia A. Veress. (2020) Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure . Annals of the New York Academy of Sciences 1479:1, pages 223-233.
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Neera Tewari-Singh. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 197 202 .
Vered Horwitz, Inbar Cohen-Gihon, Inbal Egoz, Shlomit Dachir, Maayan Cohen, Liat Cohen, Hila Gutman, Rellie Gez, Tamar Kadar, Ariel Gore, Adi Beth-Din, Anat Zvi, Galia Zaide & Ofir Israeli. (2019) A comprehensive analysis of corneal mRNA levels during sulfur mustard induced ocular late pathology in the rabbit model using RNA sequencing. Experimental Eye Research 184, pages 201-212.
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Dinesh G. Goswami, Rama Kant, Neera Tewari-Singh & Rajesh Agarwal. (2018) Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology Letters 293, pages 127-132.
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Dinesh Giri Goswami, Rajesh Agarwal & Neera Tewari-Singh. (2018) Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. Toxicology Letters 293, pages 112-119.
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Ariel Gore, Vered Horwitz, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Tamar Kadar & Shlomit Dachir. (2018) Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model. Experimental Eye Research 171, pages 183-191.
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Yunes Panahi, Seyyed Mahdi Rajaee & Amirhossein Sahebkar. (2017) Ocular Effects of Sulfur Mustard and Therapeutic Approaches. Journal of Cellular Biochemistry 118:11, pages 3549-3560.
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Dinesh G. Goswami, Neera Tewari-Singh & Rajesh Agarwal. (2016) Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences 1374:1, pages 193-201.
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Annette Schmidt, Dirk Steinritz, Horst Thiermann, Viktor Meineke & Michael Abend. (2016) Alteration of miRNA expression in early endothelial cells after exposure with sub-lethal sulfur mustard concentrations. Toxicology Letters 244, pages 88-94.
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Mostafa Ghanei & Amin Saburi. 2015. Basic and Clinical Toxicology of Mustard Compounds. Basic and Clinical Toxicology of Mustard Compounds 171 212 .
Ruijin Zheng, Iris Po, Vladimir Mishin, Adrienne T. Black, Diane E. Heck, Debra L. Laskin, Patrick J. Sinko, Donald R. Gerecke, Marion K. Gordon & Jeffrey D. Laskin. (2013) The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard. Toxicology and Applied Pharmacology 272:2, pages 345-355.
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