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Research Articles

Development of a mouse model for sulfur mustard-induced ocular injury and long-term clinical analysis of injury progression

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Pages 140-149 | Received 31 Jul 2012, Accepted 15 Sep 2012, Published online: 30 Oct 2012

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Melad Sabzevare, Farshad Yazdani, Ali Karami, Mohaddese Haddadi, Hossein Aghamollaei & Alireza Shahriary. (2021) The effect of N-acetyl cysteine and doxycycline on TNF-α-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide. Immunopharmacology and Immunotoxicology 43:4, pages 452-460.
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Vered Horwitz, Maayan Cohen, Ariel Gore, Rellie Gez, Hila Gutman, Tamar Kadar, Shlomit Dachir & Shai Kendler. (2023) Predicting clinical outcome of sulfur mustard induced ocular injury using machine learning model. Experimental Eye Research 236, pages 109671.
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Hamid Alemi, Shima Dehghani, Katayoon Forouzanfar, Pier Luigi Surico, Akitomo Narimatsu, Aytan Musayeva, Sina Sharifi, Shudan Wang, Thomas H. Dohlman, Jia Yin, Yihe Chen & Reza Dana. (2023) Insights into mustard gas keratopathy- characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Experimental Eye Research 236, pages 109657.
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Hamid Alemi, Shima Dehghani, Aytan Musayeva, Amirreza Nadari, Akitomo Narimatsu, Sina Sharifi, Katayoun Forouzanfar, Shudan Wang, Thomas H. Dohlman, Jia Yin, Yihe Chen & Reza Dana. (2023) Insights into mustard gas keratopathy: Characterizing corneal layer-specific changes in mice exposed to nitrogen mustard. Experimental Eye Research, pages 109495.
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Ezigbobiara Umejiego, Ricky Paramo, Alexander Zafiris, Elias Mullane, Paola Bargagna-Mohan & Royce Mohan. (2023) A corneo-retinal hypercitrullination axis underlies ocular injury to nitrogen mustard. Experimental Eye Research, pages 109485.
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Patrick McNutt. (2023) Progress towards a standardized model of ocular sulfur mustard injury for therapeutic testing. Experimental Eye Research 228, pages 109395.
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Ariel Gore, Tamar Kadar, Maayan Cohen, Hila Gutman, Rellie Gez, Shlomit Dachir & Vered Horwitz. (2023) The use of aflibercept (VEGF trap) in mitigating sulfur mustard-induced corneal neovascularization in a rabbit model. Toxicology Reports 10, pages 206-215.
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Laurie B. Joseph, Marion K. Gordon, Peihong Zhou, Rita A. Hahn, Hamdi Lababidi, Claire R. Croutch, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2022) Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Experimental and Molecular Pathology 128, pages 104807.
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Neha Mishra & Rajesh Agarwal. (2022) Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics. Experimental Eye Research 223, pages 109209.
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Tamar Kadar, Vered Horwitz, Maayan Cohen, Inbal Egoz, Hila Gutman, Relli Gez & Shlomit Dachir. (2022) Limbal stem cell deficiency (LSCD) in rats and mice following whole body exposure to sulfur mustard (SM) vapor. Experimental Eye Research 223, pages 109195.
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Dinesh G. Goswami, Neha Mishra, Rama Kant, Chapla Agarwal, Claire R. Croutch, Robert W. Enzenauer, Mark J. Petrash, Neera Tewari-Singh & Rajesh Agarwal. (2021) Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits. PLOS ONE 16:10, pages e0258503.
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Allison Fuchs, Elizabeth A. Giuliano, Nishant R. Sinha & Rajiv R. Mohan. (2021) Ocular toxicity of mustard gas: A concise review. Toxicology Letters 343, pages 21-27.
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Ariel Gore, Tamar Kadar, Shlomit Dachir & Vered Horwitz. (2021) Therapeutic measures for sulfur mustard-induced ocular injury. Toxicology Letters 340, pages 58-66.
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Clémence Bonnet, JoAnn S. Roberts & Sophie X. Deng. (2021) Limbal stem cell diseases. Experimental Eye Research 205, pages 108437.
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Mohd Tayyab Adil & Jonathan J. Henry. (2021) Understanding cornea epithelial stem cells and stem cell deficiency: Lessons learned using vertebrate model systems. genesis 59:1-2.
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Robert D. Causey, Jeffrey A. Koenig, Jeffrey J. Autrey, Kevin J. McGowan, Amber M. Gomez, John G. Lehman & Albert L. Ruff. (2020) Development of mouse models for the study of chloropicrin and hydrogen fluoride ocular injury. Annals of the New York Academy of Sciences 1479:1, pages 65-74.
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Patrick M. McNutt, Tracey A. Hamilton, Megan E. Lyman & Marian R. Nelson. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 567 588 .
Vered Horwitz, Inbar Cohen-Gihon, Inbal Egoz, Shlomit Dachir, Maayan Cohen, Liat Cohen, Hila Gutman, Rellie Gez, Tamar Kadar, Ariel Gore, Adi Beth-Din, Anat Zvi, Galia Zaide & Ofir Israeli. (2019) A comprehensive analysis of corneal mRNA levels during sulfur mustard induced ocular late pathology in the rabbit model using RNA sequencing. Experimental Eye Research 184, pages 201-212.
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Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Hillel Buch, Tamar Kadar & Ariel Gore. (2018) Differential expression of corneal and limbal cytokines and chemokines throughout the clinical course of sulfur mustard induced ocular injury in the rabbit model. Experimental Eye Research 177, pages 145-152.
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Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y. Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R. Djalilian & Edward J. Holland. (2018) Current and emerging therapies for corneal neovascularization. The Ocular Surface 16:4, pages 398-414.
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Georgia Charkoftaki, James V. Jester, David C. Thompson & Vasilis Vasiliou. (2018) Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. The Ocular Surface 16:1, pages 154-162.
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Qihua Le, Jianjiang Xu & Sophie X. Deng. (2018) The diagnosis of limbal stem cell deficiency. The Ocular Surface 16:1, pages 58-69.
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Neera Tewari-Singh, Dinesh G Goswami, Rama Kant, David A AmmarDileep Kumar, Robert W EnzenauerRobert P Casillas, Claire R Croutch, J Mark PetrashRajesh Agarwal. (2017) Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicological Sciences 160:2, pages 420-428.
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Dinesh G. Goswami, Neera Tewari-Singh & Rajesh Agarwal. (2016) Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences 1374:1, pages 193-201.
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Patrick M. McNutt, Kaylie M. Tuznik, Elliot J. Glotfelty, Marian R. Nelson, Megan E. Lyman & Tracey A. Hamilton. (2016) Contributions of tissue‐specific pathologies to corneal injuries following exposure to SM vapor. Annals of the New York Academy of Sciences 1374:1, pages 132-143.
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Dinesh G. Goswami, Neera Tewari-Singh, Deepanshi Dhar, Dileep Kumar, Chapla Agarwal, David A. Ammar, Rama Kant, Robert W. Enzenauer, J. Mark Petrash & Rajesh Agarwal. (2016) Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea 35:2, pages 257-266.
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K.M. Gronkiewicz, E.A. Giuliano, K. Kuroki, F. Bunyak, A. Sharma, L.B.C. Teixeira, C.W. Hamm & R.R. Mohan. (2016) Development of a novel in vivo corneal fibrosis model in the dog. Experimental Eye Research 143, pages 75-88.
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Patrick M. McNutt & Tracey L. Hamilton. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 535 555 .
Yi-Zhou Mei, Xiao-Rui Zhang, Ning Jiang, Jun-Ping Cheng, Feng Liu, Pan Zheng, Wen-Xia Zhou & Yong-Xiang Zhang. (2014) The injury progression of T lymphocytes in a mouse model with subcutaneous injection of a high dose of sulfur mustard. Military Medical Research 1:1.
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