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Research Article

Retinol: Safety Considerations for its Use in Cosmetic Products

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Pages 169-185 | Published online: 27 Sep 2008

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P. P. Fu, S.-H. Cheng, L. Coop, Q. Xia, S. J. Culp, W. H. Tolleson, W. G. Wamer & P. C. Howard. (2003) Photoreaction, Phototoxicity, and Photocarcinogenicity of Retinoids. Journal of Environmental Science and Health, Part C 21:2, pages 165-197.
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Maria Laura Ermini, Maria Summa, Agata Zamborlin, Valentina Frusca, Ana Katrina Mapanao, Enrico Mugnaioli, Rosalia Bertorelli & Valerio Voliani. (2023) Copper nano-architecture topical cream for the accelerated recovery of burnt skin. Nanoscale Advances 5:4, pages 1212-1219.
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Sarah Tozer, Cian O'Mahony, Jen Hannah, John O'Brien, Seamus Kelly, Kirstin Kosemund-Meynen & Camilla Alexander-White. (2019) Aggregate exposure modelling of vitamin A from cosmetic products, diet and food supplements. Food and Chemical Toxicology 131, pages 110549.
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Mary D. Boudreau, Frederick A. Beland, Robert P. Felton, Peter P. Fu, Paul C. Howard, Paul W. Mellick, Brett T. Thorn & Greg R. Olson. (2017) Photo-co-carcinogenesis of Topically Applied Retinyl Palmitate in SKH-1 Hairless Mice. Photochemistry and Photobiology 93:4, pages 1096-1114.
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Jun Bae Lee, Dong Ryeol Lee, Nak Cho Choi, Jihui Jang, Chun Ho Park, Moung Seok Yoon, Miyoung Lee, Kyoungae Won, Jae Sung Hwang & B. Moon Kim. (2015) Efficient dermal delivery of retinyl palmitate: Progressive polarimetry and Raman spectroscopy to evaluate the structure and efficacy. European Journal of Pharmaceutical Sciences 78, pages 111-120.
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F. Jason Duncan, Kathleen A. Silva, Charles J. Johnson, Benjamin L. King, Jin P. Szatkiewicz, Sonya P. Kamdar, David E. Ong, Joseph L. Napoli, Jinshan Wang, Lloyd E. KingJr.Jr., David A. Whiting, Kevin J. McElwee, John P. Sundberg & Helen B. Everts. (2013) Endogenous Retinoids in the Pathogenesis of Alopecia Areata. Journal of Investigative Dermatology 133:2, pages 334-343.
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Helen B. Everts. (2012) Endogenous retinoids in the hair follicle and sebaceous gland. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821:1, pages 222-229.
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Nan Mei, Jiaxiang Hu, Qingsu Xia, Peter P. Fu, Martha M. Moore & Tao Chen. (2010) Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells. Toxicology in Vitro 24:2, pages 439-444.
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Eric K. Dufour, James Whitwell, Gerhard J. Nohynek, David Kirkland & Herv? Toutain. (2009) Retinyl palmitate is non-genotoxic in Chinese hamster ovary cells in the dark or after pre-irradiation or simultaneous irradiation with UV light. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 672:1, pages 21-26.
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Peter P. Fu, Qingsu Xia, Mary D. Boudreau, Paul C. Howard, William H. Tolleson & Wayne G. Wamer. 2007. Vitamin A. Vitamin A 223 256 .
Jian Yan, Wayne G Wamer, Paul C Howard, Mary D Boudreau & Peter P Fu. (2016) Levels of retinyl palmitate and retinol in the stratum corneum, epidermis, and dermis of female SKH-1 mice topically treated with retinyl palmitate. Toxicology and Industrial Health 22:4, pages 181-191.
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G.J. Nohynek, W.J.A. Meuling, W.H.J. Vaes, R.S. Lawrence, S. Shapiro, S. Schulte, W. Steiling, J. Bausch, E. Gerber, H. Sasa & H. Nau. (2006) Repeated topical treatment, in contrast to single oral doses, with Vitamin A-containing preparations does not affect plasma concentrations of retinol, retinyl esters or retinoic acids in female subjects of child-bearing age. Toxicology Letters 163:1, pages 65-76.
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Ella L. Toombs. (2005) Cosmetics in the Treatment of Acne Vulgaris. Dermatologic Clinics 23:3, pages 575-581.
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