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Journal of Toxicology: Toxin Reviews Volume 18, 1999 - Issue 1
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Original

Membrane Channel activity and Translocation of Tetanus and Botulinum Neurotoxins

Frank J. Lebeda Department of Cell Biology and Biochemistry, Toxinology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD, 21702-5011
&
Bal Ram Singh Department of Chemistry, University of Massachusetts at Dartmouth, North Dartmouth, MA, 02747
Pages 45-76 | Published online: 24 Sep 2010

Citations (17)

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Read on this site (1)

Shuowei Cai, Bal Ram Singh & Shashi Sharma. (2007) Botulism Diagnostics: From Clinical Symptoms to in vitro Assays. Critical Reviews in Microbiology 33:2, pages 109-125.
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Articles from other publishers (16)

James SwearengenStephen Greenbaum & Frank Lebeda. 2012. Biodefense Research Methodology and Animal Models, Second Edition. Biodefense Research Methodology and Animal Models, Second Edition 311 332 .
Frank J. Lebeda, Zygmunt F. Dembek & Michael Adler. (2012) Kinetic and Reaction Pathway Analysis in the Application of Botulinum Toxin A for Wound Healing. Journal of Toxicology 2012, pages 1-9.
Crossref
Frank J. Lebeda, Regina Z. Cer, Uma Mudunuri, Robert Stephens, Bal Ram Singh & Michael Adler. (2010) The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins. Toxins 2:5, pages 978-997.
Crossref
Shashi Sharma, Uma Basavanna & Hem Shukla. (2009) Protein Domain Analysis of C. botulinum Type A Neurotoxin and Its Relationship with Other Botulinum Serotypes. Toxins 2:1, pages 1-9.
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Frank J. Lebeda, Michael Adler, Keith Erickson & Yaroslav Chushak. (2008) Onset dynamics of type A botulinum neurotoxin-induced paralysis. Journal of Pharmacokinetics and Pharmacodynamics 35:3.
Crossref
Sweta Parikh & Bal Ram Singh. (2007) Comparative Membrane Channel Size and Activity of Botulinum Neurotoxins A and E. The Protein Journal 26:1, pages 19-28.
Crossref
Shuowei Cai, Roshan Kukreja, Sue Shoesmith, Tzuu-Wang Chang & Bal Ram Singh. (2006) Botulinum Neurotoxin Light Chain Refolds at Endosomal pH for its Translocation. The Protein Journal 25:7-8, pages 455-462.
Crossref
Bal Ram Singh. (2009) Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting. Neurotoxicity Research 9:2-3, pages 73-92.
Crossref
Yu Zhou, Sean Foss, Paul Lindo, Hemanta Sarkar & Bal Ram Singh. (2005) Hemagglutinin‐33 of type A botulinum neurotoxin complex binds with synaptotagmin II. The FEBS Journal 272:11, pages 2717-2726.
Crossref
John L. Middlebrook. (2005) Production of vaccines against leading biowarfare toxins can utilize DNA scientific technology. Advanced Drug Delivery Reviews 57:9, pages 1415-1423.
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Yu Zhou & Bal Ram Singh. (2004) Cloning, high-level expression, single-step purification, and binding activity of His6-tagged recombinant type B botulinum neurotoxin heavy chain transmembrane and binding domain. Protein Expression and Purification 34:1, pages 8-16.
Crossref
Frank J. Lebeda. (2004) BotDB: A database resource for the clostridial neurotoxins. Movement Disorders 19:S8, pages S35-S41.
Crossref
Fen-Ni Fu, David D Busath & Bal Ram Singh. (2002) Spectroscopic analysis of low pH and lipid-induced structural changes in type A botulinum neurotoxin relevant to membrane channel formation and translocation. Biophysical Chemistry 99:1, pages 17-29.
Crossref
M Byrne. (2000) Development of vaccines for prevention of botulism. Biochimie 82:9-10, pages 955-966.
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Li & Bal Ram Singh. (2000) Spectroscopic Analysis of pH-Induced Changes in the Molecular Features of Type A Botulinum Neurotoxin Light Chain. Biochemistry 39:21, pages 6466-6474.
Crossref
Leonard A. Smith. (1998) Development of recombinant vaccines for botulinum neurotoxin. Toxicon 36:11, pages 1539-1548.
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