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Review Articles

Tryptophan as an evolutionarily conserved signal to brain serotonin: Molecular evidence and psychiatric implications

, , , & , PhD
Pages 258-268 | Received 30 Mar 2007, Published online: 18 Nov 2009

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Wenjun Zhu, Yuwen Fan, Qiang Xu, Xinxin Liu, Bin Heng, Wenge Yang & Yonghong Hu. (2019) Saturated Solubility and Thermodynamic Evaluation of l -Tryptophan in Eight Pure Solvents and Three Groups of Binary Mixed Solvents by the Gravimetric Method at T = 278.15–333.15 K . Journal of Chemical & Engineering Data 64:9, pages 4154-4168.
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R.A. Yadav, M. Yogesha, Bhoopendra Yadav & C. Santhosh. (2018) Conformational and vibrational investigations of L-Tryptophan zwitterion. Journal of Molecular Structure 1171, pages 867-879.
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Svante Winberg, Erik Höglund & Øyvind Øverli. 2016. Biology of Stress in Fish - Fish Physiology. Biology of Stress in Fish - Fish Physiology 35 74 .
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G. G. von Polier & F. D. Zepf. (2014) Physiosomatic complaints, immune-inflammatory pathways, and serotonin-related mood symptoms: relevance for tryptophan-related challenge procedures and clinical considerations with respect to the DSM-V. Acta Psychiatrica Scandinavica 129:2, pages 98-99.
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Crossref
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E. Russo, F. Scicchitano, R. Citraro, R. Aiello, C. Camastra, P. Mainardi, S. Chimirri, E. Perucca, G. Donato & G. De Sarro. (2012) Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis. Neuroscience 226, pages 282-288.
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Taro Kishi, Hiroshi Ichinose, Reiji Yoshimura, Yasuhisa Fukuo, Tsuyoshi Kitajima, Toshiya Inada, Hiroshi Kunugi, Tadafumi Kato, Takeo Yoshikawa, Hiroshi Ujike, Giovanna M. Musso, Wakako Umene-Nakano, Jun Nakamura, Norio Ozaki & Nakao Iwata. (2012) GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder. Journal of Affective Disorders 142:1-3, pages 315-322.
Crossref
Efrain C Azmitia. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Martina M. Hughes, Angela Carballedo, Declan M. McLoughlin, Francesco Amico, Andrew Harkin, Thomas Frodl & Thomas J. Connor. (2012) Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain, Behavior, and Immunity 26:6, pages 979-987.
Crossref
Tomasz Kocki, Sebastian Wnuk, Renata Kloc, Janusz Kocki, Björn Owe-Larsson & Ewa M. Urbanska. (2011) New insight into the antidepressants action: modulation of kynurenine pathway by increasing the kynurenic acid/3-hydroxykynurenine ratio. Journal of Neural Transmission 119:2, pages 235-243.
Crossref
Mikaela I. Nichkova, Han Huisman, Paul M. Wynveen, David T. Marc, Kelly L. Olson & Gottfried H. Kellermann. (2011) Evaluation of a novel ELISA for serotonin: urinary serotonin as a potential biomarker for depression. Analytical and Bioanalytical Chemistry 402:4, pages 1593-1600.
Crossref
E.C. Azmitia. 2012. Encyclopedia of Human Behavior. Encyclopedia of Human Behavior 396 405 .
L. Trabace, M. Zotti, M.G. Morgese, P. Tucci, M. Colaianna, S. Schiavone, P. Avato & V. Cuomo. (2011) Estrous cycle affects the neurochemical and neurobehavioral profile of carvacrol-treated female rats. Toxicology and Applied Pharmacology 255:2, pages 169-175.
Crossref
Antonio Preti. (2011) Animal model and neurobiology of suicide. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:4, pages 818-830.
Crossref
Rita Citraro, Francesca Scicchitano, Salvatore De Fazio, Riccardo Raggio, Paolo Mainardi, Emilio Perucca, Giovambattista De Sarro & Emilio Russo. (2011) Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy. Epilepsy Research 95:1-2, pages 60-69.
Crossref
A.R. Del Angel-Meza, A.J. Dávalos-Marín, L.L. Ontiveros-Martinez, G.G. Ortiz, C. Beas-Zarate, V. Chaparro-Huerta, B.M. Torres-Mendoza & O.K. Bitzer-Quintero. (2011) Protective effects of tryptophan on neuro-inflammation in rats after administering lipopolysaccharide. Biomedicine & Pharmacotherapy 65:3, pages 215-219.
Crossref
Igor Branchi. (2011) The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology 36:3, pages 339-351.
Crossref
Sylvia Navailles, Bernard Bioulac, Christian Gross & Philippe De Deurwaerdère. (2011) Chronic L-DOPA therapy alters central serotonergic function and L-DOPA-induced dopamine release in a region-dependent manner in a rat model of Parkinson's disease. Neurobiology of Disease 41:2, pages 585-590.
Crossref
Cornelia Kiank, Jan-Philip Zeden, Solveig Drude, Grazyna Domanska, Gerhard Fusch, Winfried Otten & Christine Schuett. (2010) Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans. PLoS ONE 5:7, pages e11825.
Crossref
Nikoletta Dobos, Jakob Korf, Paul G.M. Luiten & Ulrich L.M. Eisel. (2010) Neuroinflammation in Alzheimer's Disease and Major Depression. Biological Psychiatry 67:6, pages 503-504.
Crossref

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