250
Views
49
CrossRef citations to date
0
Altmetric
Original Articles

Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions

, , , , , , & show all
Pages 17-25 | Received 26 Sep 2011, Accepted 15 Nov 2011, Published online: 09 Mar 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Bella Schanzer, Ana Maria Rivas-Grajales, Aamir Khan & Sanjay J Mathew. (2019) Novel investigational therapeutics for generalized anxiety disorder (GAD). Expert Opinion on Investigational Drugs 28:11, pages 1003-1012.
Read now
Michael G. Gottschalk & Katharina Domschke. (2017) Genetics of generalized anxiety disorder and related traits. Dialogues in Clinical Neuroscience 19:2, pages 159-168.
Read now
S. Notzon, K. Domschke, K. Holitschke, C. Ziegler, V. Arolt, P. Pauli, A. Reif, J. Deckert & P. Zwanzger. (2016) Attachment style and oxytocin receptor gene variation interact in influencing social anxiety. The World Journal of Biological Psychiatry 17:1, pages 76-83.
Read now
Fabian Streit, Leila Haddad, Torsten Paul, Josef Frank, Axel Schäfer, Jörg Nikitopoulos, Ceren Akdeniz, Florian Lederbogen, Jens Treutlein, Stephanie Witt, Andreas Meyer-Lindenberg, Marcella Rietschel, Peter Kirsch & Stefan Wüst. (2014) A functional variant in the neuropeptide S receptor 1 gene moderates the influence of urban upbringing on stress processing in the amygdala. Stress 17:4, pages 352-361.
Read now

Articles from other publishers (45)

Chen Song, Zhi-chen Zhu, Chuan-chuan Liu, Wen-xin Yun, Zhi-yuan Wang, Guan-yi Lu, Rui Song, Ning Wu, Jin Li & Fei Li. (2023) Neuropeptide S Receptor variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner. Neuropharmacology, pages 109771.
Crossref
Valery V. Gafarov, Elena A. Gromova, Vladimir N. Maksimov, Igor V. Gagulin & Almira V. Gafarova. 2022. Circadian Rhythm - New Insights Into Physiological and Pathological Implications. Circadian Rhythm - New Insights Into Physiological and Pathological Implications.
Hannah L. Peter, Marina Giglberger, Josef Frank, Fabian Streit, Sandra Zänkert, Ludwig Kreuzpointner, Marcella Rietschel, Brigitte M. Kudielka & Stefan Wüst. (2022) The association between genetic variability in the NPS/NPSR1 system and chronic stress responses: A gene-environment-(quasi-) experiment. Psychoneuroendocrinology 144, pages 105883.
Crossref
Megan Ryan & Rebecca Ryznar. (2022) The Molecular Basis of Resilience: A Narrative Review. Frontiers in Psychiatry 13.
Crossref
Mehmet Bülbül & Osman Sinen. (2022) The influence of early-life and adulthood stressors on brain neuropeptide-S system. Neuropeptides 92, pages 102223.
Crossref
Marwa AzabMarwa Azab. 2022. An Update on Anxiety Disorders. An Update on Anxiety Disorders 1 46 .
Ann-Marie Tobinski & Virginie Rappeneau. (2021) Role of the Neuropeptide S System in Emotionality, Stress Responsiveness and Addiction-Like Behaviours in Rodents: Relevance to Stress-Related Disorders. Pharmaceuticals 14:8, pages 780.
Crossref
Xabier Bengoetxea, Lena Goedecke, Jasmin Remmes, Peter Blaesse, Thomas Grosch, Jörg Lesting, Hans-Christian Pape & Kay Jüngling. (2021) Human-Specific Neuropeptide S Receptor Variants Regulate Fear Extinction in the Basal Amygdala of Male and Female Mice Depending on Threat Salience. Biological Psychiatry 90:3, pages 145-155.
Crossref
Ahmet Oguzhan Bicakci, Pei-Ling Tsai, Evelyn Kahl, Dana Mayer & Markus Fendt. (2021) Dissociative Effects of Neuropeptide S Receptor Deficiency and Nasal Neuropeptide S Administration on T-Maze Discrimination and Reversal Learning. Pharmaceuticals 14:7, pages 643.
Crossref
Rainer K. Reinscheid, Fabrizio Mafessoni, Annika Lüttjohann, Kay Jüngling, Hans-Christian Pape & Stefan Schulz. (2021) Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality. Peptides 138, pages 170506.
Crossref
Aftab Ahmad, Fahad Almsned, Pasha Ghazal, Malik Waqar Ahmed, M. Saleet Jafri & Habib Bokhari. (2020) Neuropeptide S receptor gene Asn107 polymorphism in obese male individuals in Pakistan. PLOS ONE 15:12, pages e0243205.
Crossref
Miriam A. Schiele, Katharina Herzog, Leonie Kollert, Christoph Schartner, Elisabeth J. Leehr, Joscha Böhnlein, Jonathan Repple, Karoline Rosenkranz, Tina B. Lonsdorf, Udo Dannlowski, Peter Zwanzger, Andreas Reif, Paul Pauli, Jürgen Deckert & Katharina Domschke. (2020) Extending the vulnerability–stress model of mental disorders: three-dimensional NPSR1 × environment × coping interaction study in anxiety . The British Journal of Psychiatry 217:5, pages 645-650.
Crossref
Malgorzata H. Kolodziejczyk & Markus Fendt. (2020) Corticosterone Treatment and Incubation Time After Contextual Fear Conditioning Synergistically Induce Fear Memory Generalization in Neuropeptide S Receptor-Deficient Mice. Frontiers in Neuroscience 14.
Crossref
Rashelle J. Musci, Jura L. Augustinavicius & Heather Volk. (2019) Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications. Current Psychiatry Reports 21:9.
Crossref
Osama Y. Alshogran, Laith N. AL-Eitan, Shoroq M. Altawalbeh, Amani A. Khalil, Mohammad A.Y. Alqudah, Ashraf O. Oweis, Hatem A. Aman & Hussein H. Alhawari. (2019) Investigating the Contribution of NPSR1, IL-6 and BDNF Polymorphisms to Depressive and Anxiety Symptoms in Hemodialysis Patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry 94, pages 109657.
Crossref
Xiujin Lin, Jianbo Liu, Xuan Zeng, Shengjie Zhang, Yuli Pan & Junduan Wu. (2019) Effects of the neuropeptide S receptor gene on the mediating effect of somatization on the association between life-event scores and psychological distress. Journal of Affective Disorders 246, pages 738-744.
Crossref
Johanna Gechter, Carolin Liebscher, Maximilian J. Geiger, André Wittmann, Florian Schlagenhauf, Ulrike Lueken, Hans-Ulrich Wittchen, Bettina Pfleiderer, Volker Arolt, Tilo Kircher, Benjamin Straube, Jürgen Deckert, Heike Weber, Martin J. Herrmann, Andreas Reif, Katharina Domschke & Andreas Ströhle. (2019) Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls. NeuroImage: Clinical 24, pages 102029.
Crossref
Thomas Grund & Inga D. Neumann. (2018) Brain neuropeptide S: via GPCR activation to a powerful neuromodulator of socio-emotional behaviors. Cell and Tissue Research 375:1, pages 123-132.
Crossref
Qianqian He, Zhongxia Shen, Lie Ren, Xing Wang, Mincai Qian, Jianying Zhu & Xinhua Shen. (2018) Association of NPSR1 rs324981 polymorphism and treatment response to antidepressants in Chinese Han population with generalized anxiety disorder. Biochemical and Biophysical Research Communications 504:1, pages 137-142.
Crossref
M. A. Schiele & K. Domschke. (2018) Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders. Genes, Brain and Behavior 17:3, pages e12423.
Crossref
Jung-Ah Min, Heon-Jeong Lee, Seung-Hwan Lee, Young-Min Park, Seung-Gul Kang, Young-Gyu Park & Jeong-Ho Chae. (2017) RORA Polymorphism Interacts with Childhood Maltreatment in Determining Anxiety Sensitivity by Sex: A Preliminary Study in Healthy Young Adults . Clinical Psychopharmacology and Neuroscience 15:4, pages 402-406.
Crossref
Christiane E. Angermann, Mathias Kaspar, Almuth Marx, Sarah Kittel-Schneider, Dominik Menhofer, Stefan Störk, Georg Ertl, Katharina Domschke, Jürgen Deckert & Andreas Reif. (2017) A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study. European Journal of Heart Failure 19:3, pages 314-323.
Crossref
Fabian Streit, Ceren Akdeniz, Leila Haddad, Robert Kumsta, Sonja Entringer, Josef Frank, Ilona S. Yim, Sandra Zänkert, Stephanie H. Witt, Peter Kirsch, Marcella Rietschel & Stefan Wüst. (2017) Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses. Psychoneuroendocrinology 76, pages 49-56.
Crossref
Miriam A. Schiele, Christiane Ziegler, Karoline Holitschke, Christoph Schartner, Brigitte Schmidt, Heike Weber, Andreas Reif, Marcel Romanos, Paul Pauli, Peter Zwanzger, Jürgen Deckert & Katharina Domschke. (2016) Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study. Journal of Neural Transmission 123:8, pages 895-904.
Crossref
A S Howe, H N Buttenschøn, A Bani-Fatemi, E Maron, T Otowa, A Erhardt, E B Binder, N O Gregersen, O Mors, D P Woldbye, K Domschke, A Reif, J Shlik, S Kõks, Y Kawamura, A Miyashita, R Kuwano, K Tokunaga, H Tanii, J W Smoller, T Sasaki, D Koszycki & V De Luca. (2015) Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways. Molecular Psychiatry 21:5, pages 665-679.
Crossref
Michael G. Gottschalk & Katharina Domschke. (2016) Novel developments in genetic and epigenetic mechanisms of anxiety. Current Opinion in Psychiatry 29:1, pages 32-38.
Crossref
Justin P. Smith, Melissa A. Prince, Justin K. Achua, James M. Robertson, Raymond T. Anderson, Patrick J. Ronan & Cliff H. Summers. (2016) Intensity of anxiety is modified via complex integrative stress circuitries. Psychoneuroendocrinology 63, pages 351-361.
Crossref
M. Peskin & G. Zalsman. 2016. Positive Mental Health, Fighting Stigma and Promoting Resiliency for Children and Adolescents. Positive Mental Health, Fighting Stigma and Promoting Resiliency for Children and Adolescents 79 90 .
Anne Guhn, Katharina Domschke, Laura D. Müller, Thomas Dresler, Florian Eff, Juliane Kopf, Jürgen Deckert, Andreas Reif & Martin J. Herrmann. (2015) Neuropeptide S receptor gene variation and neural correlates of cognitive emotion regulation. Social Cognitive and Affective Neuroscience 10:12, pages 1730-1737.
Crossref
Katharina Domschke, Atae Akhrif, Marcel Romanos, Christina Bajer, Margrit Mainusch, Juliane Winkelmann, Claus Zimmer & Susanne Neufang. (2015) Neuropeptide S Receptor Gene Variation Differentially Modulates Fronto-Limbic Effective Connectivity in Childhood and Adolescence. Cerebral Cortex, pages bhv259.
Crossref
Tillmann Ruland, Katharina Domschke, Valerie Schütte, Maxim Zavorotnyy, Harald Kugel, Swantje Notzon, Nadja Vennewald, Patricia Ohrmann, Volker Arolt, Bettina Pfleiderer & Peter Zwanzger. (2015) Neuropeptide S receptor gene variation modulates anterior cingulate cortex Glx levels during CCK-4 induced panic. European Neuropsychopharmacology 25:10, pages 1677-1682.
Crossref
Kariina Laas, Diva Eensoo, Marika Paaver, Klaus-Peter Lesch, Andreas Reif & Jaanus Harro. (2015) Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn 107 Ile) with impulsivity and hyperactivity . Journal of Psychopharmacology 29:8, pages 878-883.
Crossref
James M. Robertson, Melissa A. Prince, Justin K. Achua, Russ E. Carpenter, David H. Arendt, Justin P. Smith, Torrie L. Summers, Tangi R. Summers & Cliff H. Summers. (2015) Nuance and behavioral cogency: How the Visible Burrow System inspired the Stress-Alternatives Model and conceptualization of the continuum of anxiety. Physiology & Behavior 146, pages 86-97.
Crossref
Susanne Neufang, Maximilian J. Geiger, György A. Homola, Marina Mahr, Atae Akhrif, Johannes Nowak, Andreas Reif, Marcel Romanos, Jürgen Deckert, László Solymosi & Katharina Domschke. (2015) Modulation of prefrontal functioning in attention systems by NPSR1 gene variation. NeuroImage 114, pages 199-206.
Crossref
Kariina Laas, Andreas Reif, Kirsti Akkermann, Evelyn Kiive, Katharina Domschke, Klaus-Peter Lesch, Toomas Veidebaum & Jaanus Harro. (2015) Neuropeptide S receptor gene variant and environment: contribution to alcohol use disorders and alcohol consumption. Addiction Biology 20:3, pages 605-616.
Crossref
Ulrike Schmidt, Gerd-Dieter Willmund, Florian Holsboer, Carsten T. Wotjak, J?rgen Gallinat, Jens T. Kowalski & Peter Zimmermann. (2015) Searching for non-genetic molecular and imaging PTSD risk and resilience markers: Systematic review of literature and design of the German Armed Forces PTSD biomarker study. Psychoneuroendocrinology 51, pages 444-458.
Crossref
Maximilian J. Geiger, Susanne Neufang, Dan J. Stein & Katharina Domschke. (2014) Arousal and the attentional network in panic disorder. Human Psychopharmacology: Clinical and Experimental 29:6, pages 599-603.
Crossref
Eduard Maron & Jakov Shlik. 2014. The Wiley Handbook of Anxiety Disorders. The Wiley Handbook of Anxiety Disorders 213 232 .
Kariina Laas, Andreas Reif, Evelyn Kiive, Katharina Domschke, Klaus-Peter Lesch, Toomas Veidebaum & Jaanus Harro. (2013) A functional NPSR1 gene variant and environment shape personality and impulsive action: A longitudinal study . Journal of Psychopharmacology 28:3, pages 227-236.
Crossref
K. Domschke. (2013) Anxiety disorders: genetic mechanisms. e-Neuroforum 4:3, pages 71-78.
Crossref
Norbert Sachser, Sylvia Kaiser & Michael B. Hennessy. (2013) Behavioural profiles are shaped by social experience: when, how and why. Philosophical Transactions of the Royal Society B: Biological Sciences 368:1618, pages 20120344.
Crossref
Christian Beste, Carsten Konrad, Christina Uhlmann, Volker Arolt, Peter Zwanzger & Katharina Domschke. (2013) Neuropeptide S receptor (NPSR1) gene variation modulates response inhibition and error monitoring. NeuroImage 71, pages 1-9.
Crossref
Sara V. Tupak, Andreas Reif, Paul Pauli, Thomas Dresler, Martin J. Herrmann, Katharina Domschke, Clara Jochum, Elisabeth Haas, Christian Baumann, Heike Weber, Andreas J. Fallgatter, Jürgen Deckert & Ann-Christine Ehlis. (2013) Neuropeptide S receptor gene: Fear-specific modulations of prefrontal activation. NeuroImage 66, pages 353-360.
Crossref
Thomas Dresler, Anne Guhn, Sara V. Tupak, Ann-Christine Ehlis, Martin J. Herrmann, Andreas J. Fallgatter, Jürgen Deckert & Katharina Domschke. (2012) Revise the revised? New dimensions of the neuroanatomical hypothesis of panic disorder. Journal of Neural Transmission 120:1, pages 3-29.
Crossref
Katharina Domschke, Benedikt Klauke, Bernward Winter, Agnes Gajewska, Martin J. Herrmann, Bodo Warrings, Andreas Mühlberger, Katherina Wosnitza, Andrea Dlugos, Swantje Naunin, Kathrin Nienhaus, Manfred Fobker, Christian Jacob, Volker Arolt, Paul Pauli, Andreas Reif, Peter Zwanzger & Jürgen Deckert. (2012) Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation. Psychopharmacology 222:3, pages 533-541.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.