Advanced search
Publication Cover
The World Journal of Biological Psychiatry Volume 14, 2013 - Issue 7
Submit an article Journal homepage
864
Views
67
CrossRef citations to date
0
Altmetric
Research Article

Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study

Christiane MontagDepartment of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, GermanyCorrespondence[email protected]
,
Eva-Maria BrockmannDepartment of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany
,
Martin BayerlDepartment of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany
,
Dan RujescuDepartment of Psychiatry, University of Munich (LMU), Munich, Germany
,
Daniel J. MüllerNeurogenetics Section, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
&
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Mitte, Berlin, Germany
Pages 500-508 | Received 15 Jul 2011, Accepted 06 Mar 2012, Published online: 31 May 2012

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Miho Ota, Sumiko Yoshida, Masanori Nakata, Toshihiko Yada & Hiroshi Kunugi. (2018) The effects of adjunctive intranasal oxytocin in patients with schizophrenia. Postgraduate Medicine 130:1, pages 122-128.
Read now

Articles from other publishers (66)

Jinbao Wei, Huanrui Zheng, Guokai Li, Zichun Chen, Gengjing Fang & Jianying Yan. (2023) Involvement of oxytocin receptor deficiency in psychiatric disorders and behavioral abnormalities. Frontiers in Cellular Neuroscience 17.
Crossref
Ulises Ríos, Javier Morán, Jimena Hermosilla, René González, Paulina Muñoz, Marcelo Arancibia, Luisa Herrera, Juan Pablo Jiménez & Pablo R. Moya. (2023) The interaction of the oxytocin receptor gene and child abuse subtypes on social cognition in euthymic patients with bipolar disorder type I. Frontiers in Psychiatry 14.
Crossref
Cristina Cuesta‐Marti, Friederike Uhlig, Begoña Muguerza, Niall Hyland, Gerard Clarke & Harriët Schellekens. (2023) Microbes, oxytocin and stress: Converging players regulating eating behavior. Journal of Neuroendocrinology.
Crossref
Hannah M. Heseding, Kirsten Jahn, Christian K. Eberlein, Jelte Wieting, Hannah B. Maier, Phileas J. Proskynitopoulos, Alexander Glahn, Stefan Bleich, Helge Frieling & Maximilian Deest. (2022) Distinct promoter regions of the oxytocin receptor gene are hypomethylated in Prader-Willi syndrome and in Prader-Willi syndrome associated psychosis. Translational Psychiatry 12:1.
Crossref
Donatella Marazziti, Phuoc-Tan Diep, Sue Carter & Manuel Glauco Carbone. (2022) Oxytocin: An Old Hormone, a Novel Psychotropic Drug and its Possible Use in Treating Psychiatric Disorders. Current Medicinal Chemistry 29:35, pages 5615-5687.
Crossref
Lei Guo, Yang-Jian Qi, Hong Tan, Dan Dai, Rawien Balesar, Arja Sluiter, Joop van Heerikhuize, Shao-Hua Hu, Dick F. Swaab & Ai-Min Bao. (2022) Different oxytocin and corticotropin-releasing hormone system changes in bipolar disorder and major depressive disorder patients. eBioMedicine 84, pages 104266.
Crossref
Yan-Hong Piao, Yin Cui, Fatima Zahra Rami, Ling Li, Maryam Karamikheirabad, Shi Hyun Kang, Sung-Wan Kim, Jung Jin Kim, Bong Ju Lee & Young-Chul Chung. (2022) Methylome-wide Association Study of Patients with Recent-onset Psychosis. Clinical Psychopharmacology and Neuroscience 20:3, pages 462-473.
Crossref
Kah Kheng Goh, Cynthia Yi-An Chen, Tzu-Hua Wu, Chun-Hsin Chen & Mong-Liang Lu. (2022) Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction. International Journal of Molecular Sciences 23:13, pages 7092.
Crossref
Eryn L. Werry & Michael Kassiou. 2022. Oxytocin. Oxytocin 231 245 .
Victoria Burmester, Dasha Nicholls, Alexis Buckle, Boban Stanojevic & Marta Crous-Bou. (2021) Review of eating disorders and oxytocin receptor polymorphisms. Journal of Eating Disorders 9:1.
Crossref
Adriano Winterton, Francesco Bettella, Ann-Marie G. de Lange, Marit Haram, Nils Eiel Steen, Lars T. Westlye, Ole A. Andreassen & Daniel S. Quintana. (2021) Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank. Translational Psychiatry 11:1.
Crossref
JingJing Niu, Jenny Tong & James E. Blevins. (2021) Oxytocin as an Anti-obesity Treatment. Frontiers in Neuroscience 15.
Crossref
Neeru Bhatt. 2021. Oxytocin and Health. Oxytocin and Health.
Kah Kheng Goh, Chun-Hsin Chen & Hsien-Yuan Lane. (2021) Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment. International Journal of Molecular Sciences 22:4, pages 2146.
Crossref
Nayna Sanathara, Lamees Alhassen, Ilias Marmouzi, Mohammad Khoudari, Joseph Phan, Wedad Alhassen, Olivier Civelli & Amal Alachkar. (2021) Oxytocin-MCH circuit regulates monosynaptic inputs to MCH neurons and modulates social recognition memory. Neuropharmacology 184, pages 108423.
Crossref
Md. Abdul Aziz, Tahmina Akter, Md. Abdul Barek & Mohammad Safiqul Islam. 2021. Autism Spectrum Disorder and Alzheimer's Disease. Autism Spectrum Disorder and Alzheimer's Disease 153 164 .
Min Zhang, Na Liu, Haocheng Chen & Ning Zhang. (2020) Oxytocin receptor gene, childhood maltreatment and borderline personality disorder features among male inmates in China. BMC Psychiatry 20:1.
Crossref
Yue Qin, Jujiao Kang, Zeyu Jiao, Yi Wang, Jiucun Wang, Hongyan Wang, Jianfeng Feng, Li Jin, Fei Wang & Xiaohong Gong. (2020) Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia. Translational Psychiatry 10:1.
Crossref
Agnieszka Potasiewicz, Malgorzata Holuj, Ewa Litwa, Kinga Gzielo, Lucyna Socha, Piotr Popik & Agnieszka Nikiforuk. (2020) Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies. Neuropharmacology 170, pages 108040.
Crossref
M. Giralt-López, S. Miret, J. Soler, S. Campanera, M. Parellada, L. Fañanás & M. Fatjó-Vilas. (2020) The role of schizotypal traits and the OXTR gene in theory of mind in schizophrenia: A family-based study . European Psychiatry 63:1.
Crossref
Minji Bang, Jee In Kang, Se Joo Kim, Jin Young Park, Kyung Ran Kim, Su Young Lee, Kyungmee Park, Eun Lee, Seung-Koo Lee & Suk Kyoon An. (2019) Reduced DNA Methylation of the Oxytocin Receptor Gene Is Associated With Anhedonia-Asociality in Women With Recent-Onset Schizophrenia and Ultra-high Risk for Psychosis. Schizophrenia Bulletin 45:6, pages 1279-1290.
Crossref
Ellen R. Bradley, Alison Seitz, Andrea N. Niles, Katherine P. Rankin, Daniel H. Mathalon, Aoife O'Donovan & Joshua D. Woolley. (2019) Oxytocin increases eye gaze in schizophrenia. Schizophrenia Research 212, pages 177-185.
Crossref
Peiyan Ni, Yang Tian, Xiaochu Gu, Linghui Yang, Jinxue Wei, Yingcheng Wang, Liansheng Zhao, Yamin Zhang, Chengcheng Zhang, Liping Li, Xiangdong Tang, Xiaohong Ma, Xun Hu & Tao Li. (2019) Plasma neuropeptides as circulating biomarkers of multifactorial schizophrenia. Comprehensive Psychiatry 94, pages 152114.
Crossref
Tuğba Kalyoncu, Burcu Özbaran, Sezen Köse & Hüseyin Onay. (2017) Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD. Journal of Attention Disorders 23:7, pages 702-711.
Crossref
Yong Liu, Huai Tao, Xiudeng Yang, Kai Huang, Xianghui Zhang & Cunyan Li. (2019) Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients. Frontiers in Psychiatry 10.
Crossref
Hae Won Kim, Jee In Kang, Suk Kyoon An & Se Joo Kim. (2018) Oxytocin receptor gene variants are associated with emotion recognition and resilience, but not with false‐belief reasoning performance in healthy young Korean volunteers. CNS Neuroscience & Therapeutics 25:4, pages 519-526.
Crossref
Teodor T. Postolache, Laura Bosque‐Plata, Serge Jabbour, Michael Vergare, Rongling Wu & Claudia Gragnoli. (2019) Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180:3, pages 186-203.
Crossref
C. Luckhaus, G. Juckel & R. Hurlemann. (2018) Oxytocin bei SchizophrenieOxytocin in schizophrenia. Der Nervenarzt 90:3, pages 277-284.
Crossref
Eline J. Kraaijenvanger, Yujie He, Hannah Spencer, Alicia K. Smith, Peter A. Bos & Marco P.M. Boks. (2019) Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies. Neuroscience & Biobehavioral Reviews 96, pages 127-142.
Crossref
Sara M. Freeman, Julie Ngo, Bhavdeep Singh, Megan Masnaghetti, Karen L. Bales & James E. Blevins. (2018) Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain. Neuroscience 392, pages 241-251.
Crossref
Vera Flasbeck, Dirk Moser, Robert Kumsta & Martin Brüne. (2018) The OXTR Single-Nucleotide Polymorphism rs53576 Moderates the Impact of Childhood Maltreatment on Empathy for Social Pain in Female Participants: Evidence for Differential Susceptibility. Frontiers in Psychiatry 9.
Crossref
Andre B. Veras, Mara Getz, Robert C. Froemke, Antonio Egidio Nardi, Gilberto Sousa Alves, Julie Walsh-Messinger, Moses V. Chao, Thorsten M. Kranz & Dolores Malaspina. (2018) Rare missense coding variants in oxytocin receptor ( OXTR ) in schizophrenia cases are associated with early trauma exposure, cognition and emotional processing. Journal of Psychiatric Research 97, pages 58-64.
Crossref
Fevzi Tuna Ocakoğlu, Sezen Köse, Burcu Özbaran & Hüseyin Onay. (2018) The oxytocin receptor gene polymorphism -rs237902- is associated with the severity of autism spectrum disorder: A pilot study. Asian Journal of Psychiatry 31, pages 142-149.
Crossref
Xiudeng Yang, Yamei Tang, Qinling Wei, Bing Lang, Huai Tao, Xianghui Zhang, Yong Liu & Aiguo Tang. (2017) Up-regulated expression of oxytocin mRNA in peripheral blood lymphocytes from first-episode schizophrenia patients. Oncotarget 8:45, pages 78882-78889.
Crossref
Ellen R. Bradley & Joshua D. Woolley. (2017) Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward. Neuroscience & Biobehavioral Reviews 80, pages 36-56.
Crossref
Erin L. Reinl, Zane A. Goodwin, Nandini Raghuraman, Grace Y. Lee, Erin Y. Jo, Beakal M. Gezahegn, Meghan K. Pillai, Alison G. Cahill, Cristina de Guzman Strong & Sarah K. England. (2017) Novel oxytocin receptor variants in laboring women requiring high doses of oxytocin. American Journal of Obstetrics and Gynecology 217:2, pages 214.e1-214.e8.
Crossref
C Davis, K Patte, C Zai & J L Kennedy. (2017) Polymorphisms of the oxytocin receptor gene and overeating: the intermediary role of endophenotypic risk factors. Nutrition & Diabetes 7:5, pages e279-e279.
Crossref
Daniel S. Quintana, Ingrid Dieset, Torbjørn Elvsåshagen, Lars T. Westlye & Ole A. Andreassen. (2017) Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders. Frontiers in Neuroendocrinology 45, pages 1-10.
Crossref
Philipp Toepfer, Christine Heim, Sonja Entringer, Elisabeth Binder, Pathik Wadhwa & Claudia Buss. (2017) Oxytocin pathways in the intergenerational transmission of maternal early life stress. Neuroscience & Biobehavioral Reviews 73, pages 293-308.
Crossref
Donald R. Williams & Paul-Christian B?rkner. (2017) Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis. Psychoneuroendocrinology 75, pages 141-151.
Crossref
Marit Haram, Francesco Bettella, Christine Lycke Brandt, Daniel S. Quintana, Mari Nerhus, Thomas Bjella, Srdjan Djurovic, Lars T. Westlye, Ole A. Andreassen, Ingrid Melle & Martin Tesli. (2018) Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders. BJPsych Open 2:6, pages 353-358.
Crossref
Stefanie Uhrig, Natalie Hirth, Laura Broccoli, Martina von Wilmsdorff, Manfred Bauer, Clemens Sommer, Mathias Zink, Johann Steiner, Thomas Frodl, Berend Malchow, Peter Falkai, Rainer Spanagel, Anita C. Hansson & Andrea Schmitt. (2016) Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study. Schizophrenia Research 177:1-3, pages 59-66.
Crossref
Amanda Crider & Anilkumar Pillai. (2016) The Neurobiological Basis for Social Affiliation in Autism Spectrum Disorder and Schizophrenia. Current Behavioral Neuroscience Reports 3:2, pages 154-164.
Crossref
Paul D. Shilling & David Feifel. (2016) Potential of Oxytocin in the Treatment of Schizophrenia. CNS Drugs 30:3, pages 193-208.
Crossref
Ruth Feldman, Mikhail Monakhov, Maayan Pratt & Richard P. Ebstein. (2016) Oxytocin Pathway Genes: Evolutionary Ancient System Impacting on Human Affiliation, Sociality, and Psychopathology. Biological Psychiatry 79:3, pages 174-184.
Crossref
Adele Romano, Bianca Tempesta, Maria Vittoria Micioni Di Bonaventura & Silvana Gaetani. (2016) From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders. Frontiers in Neuroscience 9.
Crossref
Tyler B. Grove, Kyle J. Burghardt, A. Zarina Kraal, Ryan J. Dougherty, Stephan F. Taylor & Vicki L. Ellingrod. (2016) Oxytocin Receptor <b><i>(OXTR)</i></b> Methylation and Cognition in Psychotic Disorders. Complex Psychiatry 2:3, pages 151-160.
Crossref
Min Jung Koh, Wonji Kim, Jee In Kang, Kee Namkoong & Se Joo Kim. (2015) Lack of Association between Oxytocin Receptor (OXTR) Gene Polymorphisms and Alexithymia: Evidence from Patients with Obsessive-Compulsive Disorder. PLOS ONE 10:11, pages e0143168.
Crossref
Cali F. Bartholomeusz, Eleni P. Ganella, Izelle Labuschagne, Chad Bousman & Christos Pantelis. (2015) Effects of oxytocin and genetic variants on brain and behaviour: Implications for treatment in schizophrenia. Schizophrenia Research 168:3, pages 614-627.
Crossref
Megan Elizabeth Rich & Heather Kingsley Caldwell. (2015) A Role for Oxytocin in the Etiology and Treatment of Schizophrenia. Frontiers in Endocrinology 6.
Crossref
Marit Haram, Martin Tesli, Francesco Bettella, Srdjan Djurovic, Ole Andreas Andreassen & Ingrid Melle. (2015) Association between Genetic Variation in the Oxytocin Receptor Gene and Emotional Withdrawal, but not between Oxytocin Pathway Genes and Diagnosis in Psychotic Disorders. Frontiers in Human Neuroscience 9.
Crossref
Kerstin Uvnäs-Moberg, Linda Handlin & Maria Petersson. (2015) Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Frontiers in Psychology 5.
Crossref
Heather K. Caldwell & H. Elliott Albers. 2016. Behavioral Neuroscience of Motivation. Behavioral Neuroscience of Motivation 51 103 .
A. Abu-Akel, M. Fischer-Shofty, Y. Levkovitz, J. Decety & S. Shamay-Tsoory. (2014) The role of oxytocin in empathy to the pain of conflictual out-group members among patients with schizophrenia. Psychological Medicine 44:16, pages 3523-3532.
Crossref
Michael C. Davis, William P. Horan, Erika L. Nurmi, Shemra Rizzo, Wendy Li, Catherine A. Sugar & Michael F. Green. (2014) Associations between oxytocin receptor genotypes and social cognitive performance in individuals with schizophrenia. Schizophrenia Research 159:2-3, pages 353-357.
Crossref
Cort A. Pedersen. (2014) Schizophrenia and alcohol dependence: Diverse clinical effects of oxytocin and their evolutionary origins. Brain Research 1580, pages 102-123.
Crossref
Orna Levran, Matthew Randesi, Yi Li, John Rotrosen, Jurg Ott, Miriam Adelson & Mary Jeanne Kreek. (2014) Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans. Annals of Human Genetics 78:4, pages 290-298.
Crossref
Mark J. Millan, Kevin Fone, Thomas Steckler & William P. Horan. (2014) Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. European Neuropsychopharmacology 24:5, pages 645-692.
Crossref
R Feldman, A Vengrober & R P Ebstein. (2014) Affiliation buffers stress: cumulative genetic risk in oxytocin–vasopressin genes combines with early caregiving to predict PTSD in war-exposed young children. Translational Psychiatry 4:3, pages e370-e370.
Crossref
Marit Haram, Martin Tesli, Ingrid Dieset, Nils Eiel Steen, Jan Ivar Røssberg, Srdjan Djurovic, Ole A. Andreassen & Ingrid Melle. (2014) An Attempt to Identify Single Nucleotide Polymorphisms Contributing to Possible Relationships between Personality Traits and Oxytocin-Related Genes. Neuropsychobiology 69:1, pages 25-30.
Crossref
Rachel Bachner-Melman & Richard P. Ebstein. 2014. Clinical Neuroendocrinology. Clinical Neuroendocrinology 53 68 .
Cumhur Tas, Elliot C. Brown, Cristina Gonzalez & Martin Brüne. 2014. Social Cognition and Metacognition in Schizophrenia. Social Cognition and Metacognition in Schizophrenia 301 312 .
David M. Cochran, Yael Dvir & Jean A. Frazier. (2013) “Autism-plus” Spectrum Disorders. Child and Adolescent Psychiatric Clinics of North America 22:4, pages 609-627.
Crossref
Nina de LacyBryan H. King. (2013) Revisiting the Relationship Between Autism and Schizophrenia: Toward an Integrated Neurobiology. Annual Review of Clinical Psychology 9:1, pages 555-587.
Crossref
Christiane Montag, Eva-Maria Brockmann, Anja Lehmann, Daniel J. Müller, Dan Rujescu & Jürgen Gallinat. (2012) Association between Oxytocin Receptor Gene Polymorphisms and Self-Rated ‘Empathic Concern’ in Schizophrenia. PLoS ONE 7:12, pages e51882.
Crossref
Hidenori Yamasue, Jason R. Yee, René Hurlemann, James K. Rilling, Frances S. Chen, Andreas Meyer-Lindenberg & Heike Tost. (2012) Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction. The Journal of Neuroscience 32:41, pages 14109-14117a.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.