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The World Journal of Biological Psychiatry Volume 18, 2017 - Issue 6
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Review Article

Strategies to mitigate dissociative and psychotomimetic effects of ketamine in the treatment of major depressive episodes: a narrative review

Matthew D. CooperMedical Sciences, Dalhousie University, Halifax, NS, Canada; ;Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada;
,
Joshua D. RosenblatMood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; ;Department of Psychiatry, University of Toronto, Toronto, ON, Canada;
,
Danielle S. ChaMood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; ;Institute of Medical Science, University of Toronto, Toronto, ON, Canada;
,
Yena LeeMood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada;
,
Ron KakarMood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; ;Department of Psychiatry, Western University, London and Windsor, ON, Canada;
&
Roger S. McIntyreMood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; ;Department of Psychiatry, University of Toronto, Toronto, ON, Canada; ;Department of Pharmacology, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]
Pages 410-423 | Received 30 Jul 2015, Accepted 16 Dec 2015, Published online: 16 Mar 2016

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Kyle T. Greenway, Nicolas Garel, Lisa Jerome & Allison A. Feduccia. (2020) Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments. Expert Review of Clinical Pharmacology 13:6, pages 655-670.
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Paul Glue, Colleen Loo, Anthony Rodgers, Verònica Gálvez, Andrew A. Somogyi & Philip B. Mitchell. (2017) Comments on Cooper et al.’s review on strategies to mitigate dissociative and psychotomimetic effects from ketamine when used as a fast-acting antidepressant. The World Journal of Biological Psychiatry 18:6, pages 489-489.
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Articles from other publishers (24)

Andres A. Avellaneda Ojeda, Benjamin Li & Ronak Patel. (2023) Substance-Induced Psychotic Disorder. Psychiatric Annals 53:4, pages 166-170.
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Isabela Karina Silva Dias, Juliano Kosuge da Silva, Saulo Rogério Gomes Júnior, Thomas Henrique Neves dos Santos & Sabrina Thalita dos Reis Faria. (2022) Uso da cetamina na depressão resistente ao tratamento: uma revisão sistemática. Jornal Brasileiro de Psiquiatria 71:3, pages 247-252.
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Aiste Lengvenyte, Robertas Strumila, Emilie Olié & Philippe Courtet. (2022) Ketamine and esketamine for crisis management in patients with depression: Why, whom, and how?. European Neuropsychopharmacology 57, pages 88-104.
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Alessio Fiorentini, Filippo Cantù, Camilla Crisanti, Guido Cereda, Lucio Oldani & Paolo Brambilla. (2021) Substance-Induced Psychoses: An Updated Literature Review. Frontiers in Psychiatry 12.
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Michael D. Banov, Rachel E. Landrum, Michelle B. Moore & Steven T. Szabo. (2021) Switching to Intranasal Esketamine Maintains the Antidepressant Response to Intravenous Racemic Ketamine Administration. Journal of Clinical Psychopharmacology 41:5, pages 594-599.
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Ya-Ting Wang, Xiao-Le Wang, Si-Tong Feng, Nai-Hong Chen, Zhen-Zhen Wang & Yi Zhang. (2021) Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression. Pharmacological Research 171, pages 105761.
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Felicia Ceban, Joshua D. Rosenblat, Kevin Kratiuk, Yena Lee, Nelson B. Rodrigues, Hartej Gill, Mehala Subramaniapillai, Flora Nasri, Leanna M. W. Lui, Orly Lipsitz, Anil Kumar, Jung Goo Lee, Edmond H. Chau, Bing Cao, Kangguang Lin, Roger C. Ho, Rodrigo B. Mansur, Jennifer Swainson & Roger S. McIntyre. (2021) Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders. CNS Drugs 35:9, pages 925-934.
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Rosa Estrada-Reyes, Daniel B. Quero-Chávez, Citlali Trueta, Armida Miranda, Marcela Valdés-Tovar, Salvador Alarcón-Elizalde, Julián Oikawa-Sala, Jesús Argueta, Luis A. Constantino-Jonapa, Jesús Muñoz-Estrada, Margarita L. Dubocovich & Gloria Benítez-King. (2021) Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice. International Journal of Molecular Sciences 22:17, pages 9225.
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Rodrigo P. Mello, Mariana V.F. Echegaray, Ana Paula Jesus-Nunes, Gustavo C. Leal, Guilherme M. Magnavita, Flávia Vieira, Ana Teresa Caliman-Fontes, Manuela Telles, Lívia N.F. Guerreiro-Costa, Breno Souza-Marques, Igor D. Bandeira, Cassio Santos-Lima, Roberta F. Marback, Fernanda S. Correia-Melo, Acioly L.T. Lacerda & Lucas C. Quarantini. (2021) Trait dissociation as a predictor of induced dissociation by ketamine or esketamine in treatment-resistant depression: Secondary analysis from a randomized controlled trial. Journal of Psychiatric Research 138, pages 576-583.
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Eric P. McMullen, Yena Lee, Orly Lipsitz, Leanna M. W. Lui, Maj Vinberg, Roger Ho, Nelson B. Rodrigues, Joshua D. Rosenblat, Bing Cao, Hartej Gill, Kayla M. Teopiz, Danielle S. Cha & Roger S. McIntyre. (2021) Strategies to Prolong Ketamine’s Efficacy in Adults with Treatment-Resistant Depression. Advances in Therapy 38:6, pages 2795-2820.
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Nelson B. Rodrigues, Roger S. McIntyre, Orly Lipsitz, Yena Lee, Danielle S. Cha, Margarita Shekotikhina, Maj Vinberg, Hartej Gill, Mehala Subramaniapillai, Kevin Kratiuk, Kangguang Lin, Roger Ho, Rodrigo B. Mansur & Joshua D. Rosenblat. (2021) A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions. Journal of Affective Disorders 282, pages 160-164.
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Athira K V, Arathy S Mohan & Sumana Chakravarty. (2020) Rapid acting antidepressants in the mTOR pathway: Current evidence. Brain Research Bulletin 163, pages 170-177.
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Abdullah Mohammed Ramadan & Islam Ahmed Mansour. (2020) Could ketamine be the answer to treating treatment-resistant major depressive disorder?. General Psychiatry 33:5, pages e100227.
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Joshua D. Manduca, Rachel-Karson Thériault, Olivia O.F. Williams, Duncan J. Rasmussen & Melissa L. Perreault. (2020) Transient Dose-dependent Effects of Ketamine on Neural Oscillatory Activity in Wistar-Kyoto Rats. Neuroscience 441, pages 161-175.
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J.M. Witkin, J. Kranzler, K. Kaniecki, P. Popik, J.L. Smith, K. Hashimoto & J. Sporn. (2020) R-(−)-ketamine modifies behavioral effects of morphine predicting efficacy as a novel therapy for opioid use disorder1. Pharmacology Biochemistry and Behavior 194, pages 172927.
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Yamin Yao, Peijun Ju, Hongmei Liu, Xiaohui Wu, Zhiang Niu, Yuncheng Zhu, Chen Zhang & Yiru Fang. (2020) Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats. Psychopharmacology 237:5, pages 1421-1433.
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David S. Mathai, Matthew J. Meyer, Eric A. Storch & Thomas R. Kosten. (2020) The relationship between subjective effects induced by a single dose of ketamine and treatment response in patients with major depressive disorder: A systematic review. Journal of Affective Disorders 264, pages 123-129.
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Katrina Witt, Jennifer Potts, Anna Hubers, Michael F Grunebaum, James W Murrough, Colleen Loo, Andrea Cipriani & Keith Hawton. (2019) Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials. Australian & New Zealand Journal of Psychiatry 54:1, pages 29-45.
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Lesley J. Scott. (2019) Intranasal esketamine in treatment-resistant depression: a profile of its use. Drugs & Therapy Perspectives 35:11, pages 536-545.
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Renee-Marie Ragguett, Jocelyn K. Tamura & Roger S. McIntyre. (2019) Keeping up with the clinical advances: depression. CNS Spectrums 24:S1, pages 25-37.
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Francesco Bartoli, Cristina Crocamo & Giuseppe Carrà. (2019) Ketamine for suicidal ideation treatment: Available evidence remains convincing. Neuroscience & Biobehavioral Reviews 99, pages 1-2.
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Jennifer L. Jones, Camilo F. Mateus, Robert J. Malcolm, Kathleen T. Brady & Sudie E. Back. (2018) Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review. Frontiers in Psychiatry 9.
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Vincent Chin-Hung Chen, Chao-Yu Shen, Sophie Hsin-Yi Liang, Zhen-Hui Li, Ming-Hong Hsieh, Yeu-Sheng Tyan, Mong-Liang Lu, Yena Lee, Roger S. McIntyre & Jun-Cheng Weng. (2017) Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders. PeerJ 5, pages e3147.
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Chen Zheng, Zhi H. Qiao, Meng Z. Hou, Nan N. Liu, Bin Fu, Ran Ding, Yuan Y. Li, Liang P. Wei, Ai L. Liu & Hui Shen. (2017) GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice. Frontiers in Aging Neuroscience 9.
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