479
Views
56
CrossRef citations to date
0
Altmetric
Research Article

Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape

, , , , , , , , , & show all
Pages 789-803 | Received 28 Oct 2010, Accepted 22 Jul 2011, Published online: 24 Oct 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Taylor E. Henson, Jana Navratilova, Alan H. Tennant, Karen D. Bradham, Kim R. Rogers & Michael F. Hughes. (2019) In vitro intestinal toxicity of copper oxide nanoparticles in rat and human cell models. Nanotoxicology 13:6, pages 795-811.
Read now
Luisa Mancuso & Giacomo Cao. (2014) Acute toxicity test of CuO nanoparticles using human mesenchymal stem cells. Toxicology Mechanisms and Methods 24:7, pages 449-454.
Read now
Gemma Janer, Elisabet Fernández-Rosas, Ezequiel Mas del Molino, David González-Gálvez, Gemma Vilar, Carmen López-Iglesias, Valentina Ermini & Socorro Vázquez-Campos. (2014) In vitro toxicity of functionalised nanoclays is mainly driven by the presence of organic modifiers. Nanotoxicology 8:3, pages 279-294.
Read now

Articles from other publishers (53)

Yifan ChengXiaojing MaTrevor FranklinRong YangCarmen I. Moraru. (2023) Mechano-Bactericidal Surfaces: Mechanisms, Nanofabrication, and Prospects for Food Applications. Annual Review of Food Science and Technology 14:1, pages 449-472.
Crossref
Wanting Hu, Chenlong Wang, Dan Gao & Qionglin Liang. (2022) Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract. Journal of Applied Toxicology 43:1, pages 32-46.
Crossref
Marine C. N. M. Blackman, Tania Capeloa, Justin D. Rondeau, Luca X. Zampieri, Zohra Benyahia, Justine A. Van de Velde, Maude Fransolet, Evangelos P. Daskalopoulos, Carine Michiels, Christophe Beauloye & Pierre Sonveaux. (2022) Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells. Cancers 14:18, pages 4371.
Crossref
Ninell P. Mortensen, Maria Moreno Caffaro, Klinton Davis, Shyam Aravamudhan, Susan J. Sumner & Timothy R. Fennell. (2022) Investigation of eight cellulose nanomaterials’ impact on Differentiated Caco-2 monolayer integrity and cytotoxicity. Food and Chemical Toxicology 166, pages 113204.
Crossref
Penelope A. Rice. 2022. Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems. Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems 277 351 .
Tania Capeloa, Joanna Krzystyniak, Donatienne d’Hose, Amanda Canas Rodriguez, Valery L. Payen, Luca X. Zampieri, Justine A. Van de Velde, Zohra Benyahia, Erica Pranzini, Thibaut Vazeille, Maude Fransolet, Caroline Bouzin, Davide Brusa, Carine Michiels, Bernard Gallez, Michael P. Murphy, Paolo E. Porporato & Pierre Sonveaux. (2022) MitoQ Inhibits Human Breast Cancer Cell Migration, Invasion and Clonogenicity. Cancers 14:6, pages 1516.
Crossref
Jevin Büttner, Thomas Schneider, Martin Westermann & Michael Glei. (2022) Artificial Digestion of Polydisperse Copper Oxide Nanoparticles: Investigation of Effects on the Human In Vitro Intestinal Co-Culture Model Caco-2/HT29-MTX. Toxics 10:3, pages 130.
Crossref
Victor C. Ude, David M. Brown, Vicki Stone & Helinor J. Johnston. (2021) Time dependent impact of copper oxide nanomaterials on the expression of genes associated with oxidative stress, metal binding, inflammation and mucus secretion in single and co-culture intestinal in vitro models. Toxicology in Vitro 74, pages 105161.
Crossref
Xiaoqi Tao, Xulin Wan, Di Wu, Erqun Song & Yang Song. (2021) A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage. Journal of Hazardous Materials 411, pages 125134.
Crossref
Alessia Bertero, Graziano Colombo, Cristina Cortinovis, Virginia Bassi, Elisa Moschini, Nicholas Bellitto, Maria Chiara Perego, Marco Albonico, Emanuela Astori, Isabella Dalle‐Donne, Aharon Gedanken, Ilana Perelshtein, Paride Mantecca & Francesca Caloni. (2020) In vitro copper oxide nanoparticle toxicity on intestinal barrier. Journal of Applied Toxicology 41:2, pages 291-302.
Crossref
Yiqing Zhu, Jian Ding, Yi Shi, Yong Fang, Peng Li, Fengjiao Fan, Jian Wu & Qiuhui Hu. (2020) Deciphering the role of selenium‐enriched rice protein hydrolysates in the regulation of Pb 2+ ‐induced cytotoxicity: an in vitro Caco‐2 cell model study . International Journal of Food Science & Technology 56:1, pages 420-428.
Crossref
Tatiana Andreani, Verónica Nogueira, Ana Gavina, Saul Fernandes, José Luís Rodrigues, Vera V. Pinto, Maria José Ferreira, Amélia M. Silva, Carlos M. Pereira & Ruth Pereira. (2020) Ecotoxicity to Freshwater Organisms and Cytotoxicity of Nanomaterials: Are We Generating Sufficient Data for Their Risk Assessment?. Nanomaterials 11:1, pages 66.
Crossref
Mohamed F. Attia, Roman Akasov, Frank Alexis & Daniel C. Whitehead. (2020) Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells. ACS Biomaterials Science & Engineering 6:12, pages 6671-6679.
Crossref
Zahid Hussain, Hnin Ei Thu, Mohamed Haider, Shahzeb Khan, Mohammad Sohail, Fahad Hussain, Farman Matloob Khan, Muhammad Asim Farooq & Ahmad Nazrun Shuid. (2020) A review of imperative concerns against clinical translation of nanomaterials: Unwanted biological interactions of nanomaterials cause serious nanotoxicity. Journal of Drug Delivery Science and Technology 59, pages 101867.
Crossref
Chaolu Chen, Chaoshuang Ye, Jianmei Xia, Yong Zhou & Ruijin Wu. (2020) Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton. Life Sciences 254, pages 117681.
Crossref
Xiaoying Zou, Shiwei Cheng, Bo You & Changting Yang. (2020) Bio-mediated synthesis of copper oxide nanoparticles using Pogestemon benghalensis extract for treatment of the esophageal cancer in nursing care. Journal of Drug Delivery Science and Technology 58, pages 101759.
Crossref
Jinxing Li, Yuchao Song, Rolf David Vogt, Yuankun Liu, Jipeng Luo & Tingqiang Li. (2020) Bioavailability and cytotoxicity of Cerium- (IV), Copper- (II), and Zinc oxide nanoparticles to human intestinal and liver cells through food. Science of The Total Environment 702, pages 134700.
Crossref
Ninell P. Mortensen, Maria Moreno Caffaro, Purvi R. Patel, Md Jamal Uddin, Shyam Aravamudhan, Susan J. Sumner & Timothy R. Fennell. (2020) Investigation of twenty metal, metal oxide, and metal sulfide nanoparticles' impact on differentiated Caco-2 monolayer integrity. NanoImpact 17, pages 100212.
Crossref
Victor C. Ude, David M. Brown, Vicki Stone & Helinor J. Johnston. (2019) Using 3D gastrointestinal tract in vitro models with microfold cells and mucus secreting ability to assess the hazard of copper oxide nanomaterials. Journal of Nanobiotechnology 17:1.
Crossref
Zahra Nakhaeepour, Mansour Mashreghi, Maryam M. Matin, Ali NakhaeiPour & Mohammad Reza Housaindokht. (2019) Multifunctional CuO nanoparticles with cytotoxic effects on KYSE30 esophageal cancer cells, antimicrobial and heavy metal sensing activities. Life Sciences 234, pages 116758.
Crossref
Chaolu Chen, Yong Zhou, Changchang Hu, Yinfeng Wang, Zhuqing Yan, Zhi Li & Ruijin Wu. (2019) Mitochondria and oxidative stress in ovarian endometriosis. Free Radical Biology and Medicine 136, pages 22-34.
Crossref
Victor C. Ude, David M. Brown, Krystyna Maciaszek, Vicki Stone & Helinor J. Johnston. (2019) Comparing the sensitivity of different intestinal Caco-2 in vitro monocultures and co-cultures to amorphous silicon dioxide nanomaterials and the clay montmorillonite. NanoImpact 15, pages 100165.
Crossref
Alyona Sukhanova, Svetlana Bozrova, Pavel Sokolov, Mikhail Berestovoy, Alexander Karaulov & Igor Nabiev. (2018) Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties. Nanoscale Research Letters 13:1.
Crossref
Laura Vila, Alba García-Rodríguez, Constanza Cortés, Ricard Marcos & Alba Hernández. (2018) Assessing the effects of silver nanoparticles on monolayers of differentiated Caco-2 cells, as a model of intestinal barrier. Food and Chemical Toxicology 116, pages 1-10.
Crossref
Christian Riebeling, Jean-Pascal Piret, Bénédicte Trouiller, Inge Nelissen, Christelle Saout, Olivier Toussaint & Andrea Haase. (2018) A guide to nanosafety testing: Considerations on cytotoxicity testing in different cell models. NanoImpact 10, pages 1-10.
Crossref
Jun Zhang, Zhen Zou, Bin Wang, Ge Xu, Qiong Wu, Yuchan Zhang, Zhiyi Yuan, Xi Yang & Chao Yu. (2018) Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death. Biomaterials 161, pages 228-239.
Crossref
Nadja R. Brun, Bjørn E. V. Koch, Mónica Varela, Willie J. G. M. PeijnenburgHerman P. Spaink & Martina G. Vijver. (2018) Nanoparticles induce dermal and intestinal innate immune system responses in zebrafish embryos. Environmental Science: Nano 5:4, pages 904-916.
Crossref
Victor C. Ude, David M. Brown, Luca Viale, Nilesh Kanase, Vicki Stone & Helinor J. Johnston. (2017) Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration. Particle and Fibre Toxicology 14:1.
Crossref
Eleonore Fröhlich. (2017) Role of omics techniques in the toxicity testing of nanoparticles. Journal of Nanobiotechnology 15:1.
Crossref
Mireille Chevallet, Giulia Veronesi, Alexandra Fuchs, Elisabeth Mintz, Isabelle Michaud-Soret & Aurélien Deniaud. (2017) Impact of labile metal nanoparticles on cellular homeostasis. Current developments in imaging, synthesis and applications. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:6, pages 1566-1577.
Crossref
Jean-Pascal Piret, Olesja M. Bondarenko, Matthew S. P. Boyles, Martin Himly, Ana R. Ribeiro, Federico Benetti, Caroline Smal, Braulio Lima, Annegret Potthoff, Monica Simion, Elise Dumortier, Paulo Emilio C. Leite, Luciene Bottentuit Balottin, José Mauro Granjeiro, Angela Ivask, Anne Kahru, Isabella Radauer-Preiml, Ulrike Tischler, Albert Duschl, Christelle Saout, Sergio Anguissola, Andrea Haase, An Jacobs, Inge Nelissen, Superb K. Misra & Olivier Toussaint. (2016) Pan-European inter-laboratory studies on a panel of in vitro cytotoxicity and pro-inflammation assays for nanoparticles. Archives of Toxicology 91:6, pages 2315-2330.
Crossref
Evelien Frijns, Sandra Verstraelen, Linda Corinna Stoehr, Jo Van Laer, An Jacobs, Jan Peters, Kristof Tirez, Matthew Samuel Powys Boyles, Mark Geppert, Pierre Madl, Inge Nelissen, Albert Duschl & Martin Himly. (2017) A Novel Exposure System Termed NAVETTA for In Vitro Laminar Flow Electrodeposition of Nanoaerosol and Evaluation of Immune Effects in Human Lung Reporter Cells. Environmental Science & Technology 51:9, pages 5259-5269.
Crossref
Silvia Gabriella Ciappellano, Erik Tedesco, Marco Venturini & Federico Benetti. (2016) In vitro toxicity assessment of oral nanocarriers. Advanced Drug Delivery Reviews 106, pages 381-401.
Crossref
Aleksandr Käkinen, Anne Kahru, Helen Nurmsoo, Anna-Liisa Kubo & Olesja M. Bondarenko. (2016) Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli : Effect of sonication energy and test environment. Toxicology in Vitro 36, pages 172-179.
Crossref
Lucie Brisson, Piotr Bański, Martina Sboarina, Coralie Dethier, Pierre Danhier, Marie-Joséphine Fontenille, Vincent F. Van Hée, Thibaut Vazeille, Morgane Tardy, Jorge Falces, Caroline Bouzin, Paolo E. Porporato, Raphaël Frédérick, Carine Michiels, Tamara Copetti & Pierre Sonveaux. (2016) Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer. Cancer Cell 30:3, pages 418-431.
Crossref
Christiane Beer. 2016. Nanomedicine. Nanomedicine 279 310 .
Matthew S. P. Boyles, Christina Ranninger, Roland Reischl, Marc Rurik, Richard Tessadri, Oliver Kohlbacher, Albert Duschl & Christian G. Huber. (2016) Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Particle and Fibre Toxicology 13:1.
Crossref
Anastasia Georgantzopoulou, Tommaso Serchi, Sébastien Cambier, Céline C. Leclercq, Jenny Renaut, Jia Shao, Marcin Kruszewski, Esther Lentzen, Patrick Grysan, Santhana Eswara, Jean-Nicolas Audinot, Servane Contal, Johanna Ziebel, Cédric Guignard, Lucien Hoffmann, AlberTinka J. Murk & Arno C. Gutleb. (2016) Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium. Particle and Fibre Toxicology 13:1.
Crossref
M. Best, G. Phillips, C. Fowler, J. Rowland & J. Elsom. (2015) Characterisation and cytotoxic screening of metal oxide nanoparticles putative of interest to oral healthcare formulations in non-keratinised human oral mucosa cells in vitro. Toxicology in Vitro 30:1, pages 402-411.
Crossref
Ylva Rodhe, Sara Skoglund, Inger Odnevall Wallinder, Zuzana Potácová & Lennart Möller. (2015) Copper-based nanoparticles induce high toxicity in leukemic HL60 cells. Toxicology in Vitro 29:7, pages 1711-1719.
Crossref
Tina Ramskov, Marie-Noële Croteau, Valery E. Forbes & Henriette Selck. (2015) Biokinetics of different-shaped copper oxide nanoparticles in the freshwater gastropod, Potamopyrgus antipodarum. Aquatic Toxicology 163, pages 71-80.
Crossref
Sarah Triboulet, Catherine Aude-Garcia, Lucie Armand, Véronique Collin-Faure, Mireille Chevallet, Hélène Diemer, Adèle Gerdil, Fabienne Proamer, Jean-Marc Strub, Aurélie Habert, Nathalie Herlin, Alain Van Dorsselaer, Marie Carrière & Thierry Rabilloud. (2015) Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages. PLOS ONE 10:4, pages e0124496.
Crossref
Gao Chen, Zhu Lianqin, Zhu Fenghua, Zheng Fang, Song Mingming & Huang Kai. (2015) Comparative evaluation of nano-CuO crossing Caco-2 cell monolayers and cellular uptake. Journal of Nanoparticle Research 17:4.
Crossref
Lingxiangyu Li, María Luisa Fernández-Cruz, Mona Connolly, Michael Schuster & José María Navas. (2015) Dissolution and aggregation of Cu nanoparticles in culture media: effects of incubation temperature and particles size. Journal of Nanoparticle Research 17:1.
Crossref
Vladan Bernard, Ondřej Zobač, Jiří Sopoušek & Vojtěch Mornstein. (2014) AgCu Bimetallic Nanoparticles under Effect of Low Intensity Ultrasound: The Cell Viability Study In Vitro. Journal of Cancer Research 2014, pages 1-6.
Crossref
Paolo E. Porporato, Valéry L. Payen, Jhudit Pérez-Escuredo, Christophe J. De Saedeleer, Pierre Danhier, Tamara Copetti, Suveera Dhup, Morgane Tardy, Thibaut Vazeille, Caroline Bouzin, Olivier Feron, Carine Michiels, Bernard Gallez & Pierre Sonveaux. (2014) A Mitochondrial Switch Promotes Tumor Metastasis. Cell Reports 8:3, pages 754-766.
Crossref
Jean-Pascal Piret, Jorge Mejia, Stéphane Lucas, Christos C. Zouboulis, Christelle Saout & Olivier Toussaint. (2014) Sonicated and stirred copper oxide nanoparticles induce similar toxicity and pro-inflammatory response in N-hTERT keratinocytes and SZ95 sebocytes. Journal of Nanoparticle Research 16:4.
Crossref
Martine Cuillel, Mireille Chevallet, Peggy Charbonnier, Caroline Fauquant, Isabelle Pignot-Paintrand, Josiane Arnaud, Doris Cassio, Isabelle Michaud-Soret & Elisabeth Mintz. (2014) Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions. Nanoscale 6:3, pages 1707-1715.
Crossref
Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti & François Rossi. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems 481 499 .
Olesja Bondarenko, Katre Juganson, Angela Ivask, Kaja Kasemets, Monika Mortimer & Anne Kahru. (2013) Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review. Archives of Toxicology 87:7, pages 1181-1200.
Crossref
Sebastiano Di Bucchianico, Maria Rita Fabbrizi, Superb K. Misra, Eugenia Valsami-Jones, Deborah Berhanu, Paul Reip, Enrico Bergamaschi & Lucia Migliore. (2013) Multiple cytotoxic and genotoxic effects induced in vitro by differently shaped copper oxide nanomaterials. Mutagenesis 28:3, pages 287-299.
Crossref
Kaja Kasemets, Sandra Suppi, Kai Künnis-Beres & Anne Kahru. (2013) Toxicity of CuO Nanoparticles to Yeast Saccharomyces cerevisiae BY4741 Wild-Type and Its Nine Isogenic Single-Gene Deletion Mutants . Chemical Research in Toxicology 26:3, pages 356-367.
Crossref
M. Calatayud, V. Devesa & D. Vélez. (2013) Differential toxicity and gene expression in Caco-2 cells exposed to arsenic species. Toxicology Letters 218:1, pages 70-80.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.