855
Views
50
CrossRef citations to date
0
Altmetric
Original Article

Molecular mechanism of silver nanoparticles in human intestinal cells

, , , &
Pages 852-860 | Received 13 Aug 2014, Accepted 21 Oct 2014, Published online: 21 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Muriel Mercier-Bonin, Bernard Despax, Patrice Raynaud, Eric Houdeau & Muriel Thomas. (2018) Mucus and microbiota as emerging players in gut nanotoxicology: The example of dietary silver and titanium dioxide nanoparticles. Critical Reviews in Food Science and Nutrition 58:6, pages 1023-1032.
Read now
Laura Vila, Ricard Marcos & Alba Hernández. (2017) Long-term effects of silver nanoparticles in caco-2 cells. Nanotoxicology 11:6, pages 771-780.
Read now
Meike van der Zande, Anna K. Undas, Evelien Kramer, Marco P. Monopoli, Ruud J. Peters, David Garry, Elsa C. Antunes Fernandes, Peter J. Hendriksen, Hans J.P. Marvin, Ad A. Peijnenburg & Hans Bouwmeester. (2016) Different responses of Caco-2 and MCF-7 cells to silver nanoparticles are based on highly similar mechanisms of action. Nanotoxicology 10:10, pages 1431-1441.
Read now

Articles from other publishers (47)

Nguyen Hoang Anh, Young Jin Min, Truong Thi My Nhung, Nguyen Phuoc Long, Seunghyeon Han, Sun Jo Kim, Cheol Woon Jung, Young Cheol Yoon, Yun Pyo Kang, Sang Ki Park & Sung Won Kwon. (2023) Unveiling potentially convergent key events related to adverse outcome pathways induced by silver nanoparticles via cross-species omics-scale analysis. Journal of Hazardous Materials 459, pages 132208.
Crossref
Bruno Lamas, Laurence Chevalier, Eric Gaultier, Christel Cartier, Laurent Weingarten, Xavier Blanc, Paola Fisicaro, Caroline Oster, Johanna Noireaux, Lauris Evariste, Natalia Martins Breyner & Eric Houdeau. (2023) The food additive titanium dioxide hinders intestinal production of TGF-β and IL-10 in mice, and long-term exposure in adults or from perinatal life blocks oral tolerance to ovalbumin. Food and Chemical Toxicology 179, pages 113974.
Crossref
Chelsea Cary & Phoebe Stapleton. (2023) Determinants and mechanisms of inorganic nanoparticle translocation across mammalian biological barriers. Archives of Toxicology 97:8, pages 2111-2131.
Crossref
A. F. P. Allwin Mabes Raj, Maja Bauman, Nena Dimitrušev, Lamiaa M. A. Ali, Mélanie Onofre, Magali Gary-Bobo, Jean-Olivier Durand, Aleksandra Lobnik & Aljoša Košak. (2023) Superparamagnetic Spinel-Ferrite Nano-Adsorbents Adapted for Hg2+, Dy3+, Tb3+ Removal/Recycling: Synthesis, Characterization, and Assessment of Toxicity. International Journal of Molecular Sciences 24:12, pages 10072.
Crossref
Jiaming Bi, Chuzi Mo, Siwei Li, Mingshu Huang, Yunhe Lin, Peiyan Yuan, Zhongjun Liu, Bo Jia & Shuaimei Xu. (2023) Immunotoxicity of metal and metal oxide nanoparticles: from toxic mechanisms to metabolism and outcomes. Biomaterials Science 11:12, pages 4151-4183.
Crossref
Mengying Qi, Xudong Wang, Jiahao Chen, Yin Liu, Yun Liu, Jianbo Jia, Lingxiangyu Li, Tongtao Yue, Lirong Gao, Bing Yan, Bin Zhao & Ming Xu. (2023) Transformation, Absorption and Toxicological Mechanisms of Silver Nanoparticles in the Gastrointestinal Tract Following Oral Exposure. ACS Nano 17:10, pages 8851-8865.
Crossref
Maryam Vazifedust & Ali Mandegary. 2023. Nanopharmacology and Nanotoxicology: Clinical Implications and Methods. Nanopharmacology and Nanotoxicology: Clinical Implications and Methods 239 268 .
Wanting Hu, Chenlong Wang, Dan Gao & Qionglin Liang. (2022) Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract. Journal of Applied Toxicology 43:1, pages 32-46.
Crossref
Chittatosh Pal, Abhinandan Kumar & Subrata Majumder. (2022) Fabrication of ssDNA functionalized MoS nanoflakes based label-free electrochemical biosensor for explicit silver ion detection at sub-pico molar level . Colloids and Surfaces A: Physicochemical and Engineering Aspects 655, pages 130241.
Crossref
V. Chandrakala, Valmiki Aruna & Gangadhara Angajala. (2022) Review on metal nanoparticles as nanocarriers: current challenges and perspectives in drug delivery systems. Emergent Materials 5:6, pages 1593-1615.
Crossref
Shuyuan Wang, Xing Kang, Harri Alenius, Sunny Hei Wong, Piia Karisola & Hani El-Nezami. (2022) Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis. Food and Chemical Toxicology 169, pages 113368.
Crossref
Penelope A. Rice. 2022. Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems. Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems 277 351 .
Adelaide Sousa, Tracey D. Bradshaw, Daniela Ribeiro, Eduarda Fernandes & Marisa Freitas. (2022) Pro-inflammatory effects of silver nanoparticles in the intestine. Archives of Toxicology 96:6, pages 1551-1571.
Crossref
Peizheng Xiong, Xiangming Huang, Naijing Ye, Qunwen Lu, Gang Zhang, Shunlin Peng, Hongbo Wang & Yiyao Liu. (2022) Cytotoxicity of Metal‐Based Nanoparticles: From Mechanisms and Methods of Evaluation to Pathological Manifestations. Advanced Science 9:16, pages 2106049.
Crossref
Lan-Min Wang, Yu-Ting Wang & Wan-Xi Yang. (2021) Engineered nanomaterials induce alterations in biological barriers: focus on paracellular permeability. Nanomedicine 16:30, pages 2725-2741.
Crossref
Ana Rufino, Ana Ramalho, Adelaide Sousa, José Ferreira de Oliveira, Paulo Freitas, Manuel Gómez, Yolanda Piñeiro-Redondo, José Rivas, Félix Carvalho, Eduarda Fernandes & Marisa Freitas. (2021) Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles. Molecules 26:21, pages 6610.
Crossref
N.A. Bhaskaran & L. Kumar. (2021) Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems. Journal of Controlled Release 336, pages 16-39.
Crossref
Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra & Dario Greco. (2021) Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials. Scientific Data 8:1.
Crossref
Ming Jiang, Jing Jin, Xiaohui Ye, Jing Wang, Hongbo Shen, Jie Zhen & Yinong Zhou. (2021) Construction of Lycetin Nanocarriers and Its Effect on the Proliferation and Apoptosis of Hepatocellular Carcinoma Cells by Regulating Nuclear Factor E2 Related Factor/Antioxidant Response Element Pathway. Journal of Nanoscience and Nanotechnology 21:2, pages 1054-1060.
Crossref
Kévin Gillois, Charlotte Stoffels, Mathilde Leveque, Isabelle Fourquaux, Justine Blesson, Valérie Mils, Sébastien Cambier, Julien Vignard, Hélène Terrisse, Gladys Mirey, Jean-Nicolas Audinot, Vassilia Theodorou, Marie-Hélène Ropers, Hervé Robert & Muriel Mercier-Bonin. (2021) Repeated exposure of Caco-2 versus Caco-2/HT29-MTX intestinal cell models to (nano)silver in vitro: Comparison of two commercially available colloidal silver products. Science of The Total Environment 754, pages 142324.
Crossref
Kuppan Gokulan, Katherine Williams, Sarah Orr & Sangeeta Khare. (2020) Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability. International Journal of Molecular Sciences 22:1, pages 9.
Crossref
Isabela Medeiros de Oliveira, Mônica Degraf Cavallin, Deborah Elzita do Carmo Corrêa, Amanda Razera, Danielle Dobner Mariano, Francine Ferreira, Marco Aurélio Romano & Renata Marino Romano. (2020) Proteomic Profiles of Thyroid Gland and Gene Expression of the Hypothalamic–Pituitary–Thyroid Axis Are Modulated by Exposure to AgNPs during Prepubertal Rat Stages. Chemical Research in Toxicology 33:10, pages 2605-2622.
Crossref
Madeleine Polet, Laurie Laloux, Sébastien Cambier, Johanna Ziebel, Arno C. Gutleb & Yves-Jacques Schneider. (2020) Soluble silver ions from silver nanoparticles induce a polarised secretion of interleukin-8 in differentiated Caco-2 cells. Toxicology Letters 325, pages 14-24.
Crossref
Laurie Laloux, Donika Kastrati, Sébastien Cambier, Arno C. Gutleb & Yves‐Jacques Schneider. (2020) The Food Matrix and the Gastrointestinal Fluids Alter the Features of Silver Nanoparticles. Small 16:21, pages 1907687.
Crossref
Sivasankari Marimuthu, Arul Jayanthi Antonisamy, Sankar Malayandi, Karthikeyan Rajendran, Pei-Chien Tsai, Arivalagan Pugazhendhi & Vinoth Kumar Ponnusamy. (2020) Silver nanoparticles in dye effluent treatment: A review on synthesis, treatment methods, mechanisms, photocatalytic degradation, toxic effects and mitigation of toxicity. Journal of Photochemistry and Photobiology B: Biology 205, pages 111823.
Crossref
Ganesan Raja, Yoon-Kwan Jang, Jung-Soo Suh, Heon-Su Kim, Sang Hyun Ahn & Tae-Jin Kim. (2020) Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review. Cancers 12:3, pages 664.
Crossref
Angela A.M. Kämpfer, Patricia Urbán, Rita La Spina, Isaac Ojea Jiménez, Nilesh Kanase, Vicki Stone & Agnieszka Kinsner-Ovaskainen. (2020) Ongoing inflammation enhances the toxicity of engineered nanomaterials: Application of an in vitro co-culture model of the healthy and inflamed intestine. Toxicology in Vitro 63, pages 104738.
Crossref
Li Fu, Aiwu Wang, Kefeng Xie, Jiangwei Zhu, Fei Chen, Henggang Wang, Huaiwei Zhang, Weitao Su, Zhenguang Wang, Cangtao Zhou & Shuangchen Ruan. (2020) Electrochemical detection of silver ions by using sulfur quantum dots modified gold electrode. Sensors and Actuators B: Chemical 304, pages 127390.
Crossref
Kar Xin Lee, Kamyar Shameli, Shaza Eva Mohamad, Yen Pin Yew, Eleen Dayana Mohamed Isa, Hooi-Yeen Yap, Wei Ling Lim & Sin-Yeang Teow. (2019) Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action. Nanomaterials 9:10, pages 1423.
Crossref
Zhangjian Chen, Di Zhou, Yun Wang, Lin Zhao, Guiping Hu, Jiaxing Liu, Huimin Feng, Changmao Long, Tenglong Yan, Shupei Zhou & Guang Jia. (2018) Combined effect of titanium dioxide nanoparticles and glucose on the cardiovascular system in young rats after oral administration. Journal of Applied Toxicology 39:4, pages 590-602.
Crossref
Solmaz Ghojavand, Fatemeh Bagheri & Hamzeh Mesrian Tanha. (2019) Integrative meta-analysis of publically available microarray datasets of several epithelial cell lines identifies biological processes affected by silver nanoparticles exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 216, pages 67-74.
Crossref
Ako Rezaei, Amjad Farzinpour, Asaad Vaziry & Ali Jalili. (2018) Effects of Silver Nanoparticles on Hematological Parameters and Hepatorenal Functions in Laying Japanese Quails. Biological Trace Element Research 185:2, pages 475-485.
Crossref
Laura Vila, Alba García-Rodríguez, Constanza Cortés, Ricard Marcos & Alba Hernández. (2018) Assessing the effects of silver nanoparticles on monolayers of differentiated Caco-2 cells, as a model of intestinal barrier. Food and Chemical Toxicology 116, pages 1-10.
Crossref
Loretta Müller, Selina K. Steiner, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Barbara Rothen-Rutishauser & Philipp Latzin. (2017) Exposure to silver nanoparticles affects viability and function of natural killer cells, mostly via the release of ions. Cell Biology and Toxicology 34:3, pages 167-176.
Crossref
Sotirios I. Sinis, Chrissi Hatzoglou, Konstantinos I. Gourgoulianis & Sotirios G. Zarogiannis. (2018) Carbon Nanotubes and Other Engineered Nanoparticles Induced Pathophysiology on Mesothelial Cells and Mesothelial Membranes. Frontiers in Physiology 9.
Crossref
Sabine Juling, Linda Böhmert, Dajana Lichtenstein, Axel Oberemm, Otto Creutzenberg, Andreas F. Thünemann, Albert Braeuning & Alfonso Lampen. (2018) Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats. Food and Chemical Toxicology 113, pages 255-266.
Crossref
Hans Bouwmeester, Meike van der Zande & Mark A. Jepson. (2017) Effects of food‐borne nanomaterials on gastrointestinal tissues and microbiota. WIREs Nanomedicine and Nanobiotechnology 10:1.
Crossref
Sabine Juling, Alicia Niedzwiecka, Linda Böhmert, Dajana Lichtenstein, Sören Selve, Albert Braeuning, Andreas F. Thünemann, Eberhard Krause & Alfonso Lampen. (2017) Protein Corona Analysis of Silver Nanoparticles Links to Their Cellular Effects. Journal of Proteome Research 16:11, pages 4020-4034.
Crossref
Lili Wang, Huanwen Wu, Li Wang, Hui Zhang, Junliang Lu, Zhiyong Liang & Tonghua Liu. (2017) Asporin promotes pancreatic cancer cell invasion and migration by regulating the epithelial-to-mesenchymal transition (EMT) through both autocrine and paracrine mechanisms. Cancer Letters 398, pages 24-36.
Crossref
Mi-Ran Go, Song-Hwa Bae, Hyeon-Jin Kim, Jin Yu & Soo-Jin Choi. (2017) Interactions between Food Additive Silica Nanoparticles and Food Matrices. Frontiers in Microbiology 8.
Crossref
Laurie Laloux, Madeleine Polet & Yves-Jacques Schneider. 2017. Nanotechnology in Agriculture and Food Science. Nanotechnology in Agriculture and Food Science 311 332 .
Mark A. Jepson & Hans Bouwmeester. 2017. Adverse Effects of Engineered Nanomaterials. Adverse Effects of Engineered Nanomaterials 381 396 .
Gero Benckiser. 2017. Nanotechnology. Nanotechnology 19 31 .
Yi Cao, Juan Li, Fang Liu, Xiyue Li, Qin Jiang, Shanshan Cheng & Yuxiu Gu. (2016) Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review. Environmental Toxicology and Pharmacology 46, pages 206-210.
Crossref
Pedro M. Costa & Bengt Fadeel. (2016) Emerging systems biology approaches in nanotoxicology: Towards a mechanism-based understanding of nanomaterial hazard and risk. Toxicology and Applied Pharmacology 299, pages 101-111.
Crossref
Christie McCracken, Prabir K. Dutta & W. James Waldman. (2016) Critical assessment of toxicological effects of ingested nanoparticles. Environmental Science: Nano 3:2, pages 256-282.
Crossref
Sybille van den Brule, Jérôme Ambroise, Hélène Lecloux, Clément Levard, Romain Soulas, Pieter-Jan De Temmerman, Mihaly Palmai-Pallag, Etienne Marbaix & Dominique Lison. (2016) Dietary silver nanoparticles can disturb the gut microbiota in mice. Particle and Fibre Toxicology 13:1.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.