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Acta Orthopaedica Volume 82, 2011 - Issue 6

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Research Article

Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

A randomized controlled trial

Jamie S McConnell Royal National Orthopaedic Hospital, Stanmore, MiddlesexCorrespondence[email protected]

Sandeep Shewale Monklands Hospital, Airdrie

Niall A Munro Golden Jubilee National Hospital, Clydebank, UK

Kalpesh Shah Golden Jubilee National Hospital, Clydebank, UK

Angela H Deakin Golden Jubilee National Hospital, Clydebank, UK

Andrew WG Kinninmonth Golden Jubilee National Hospital, Clydebank, UK

Pages 660-663 | Received 09 Dec 2010, Accepted 21 Jun 2011, Published online: 17 Oct 2011

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https://doi.org/10.3109/17453674.2011.623568

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David A. Bloom, Charles C. Lin, Joseph E. Manzi, Edward S. Mojica, Zachary L. Telgheder, Cary B. Chapman & Sanjit R. Konda. (2023) The Efficacy of Tranexamic Acid for the Treatment of Traumatic Hip Fractures: A Network Meta-Analysis. Journal of Orthopaedic Trauma 37:7, pages 341-345.
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Antonio Ziranu, Cesare Meschini, Davide De Marco, Giuseppe Sircana, Maria Serena Oliva, Giusepp Rovere, Andrea Corbingi, Raffaele Vitiello, Giulio Maccauro & Enrico Pola. (2022) Prevention of postoperative anemia in hip hemiarthroplasty for femoral neck fractures: comparison between local haemostatic agents. Orthopedic Reviews 14:6.
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Davide Reale, Luca Andriolo, Safa Gursoy, Murat Bozkurt, Giuseppe Filardo & Stefano Zaffagnini. (2021) Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials. BioMed Research International 2021, pages 1-14.
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Giuseppe Sircana, Michele Cauteruccio, Maria Serena Oliva, Nicola Piccirillo, Elisa Pesare, Felice Minutillo & Antonio Ziranu. (2020) Fibrin sealant reduces need for transfusions after hip hemiarthroplasty for femoral neck fractures. Injury 51, pages S23-S27.
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Ishaan Swarup, Joseph Nguyen, Chris Edmonds, Emily Dodwell & David Scher. (2020) Effect of Intravenous Aminocaproid Acid on Blood Loss and Transfusion Requirements After Bilateral Varus Rotational Osteotomy: A Double-blind, Placebo-controlled Randomized Trial. Journal of Pediatric Orthopaedics 40:6, pages e454-e459.
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Mohamed Sukeik, Sattar Alshryda, James Powell & Fares S. Haddad. (2020) The effect of tranexamic acid on wound complications in primary total Hip Arthroplasty: A meta-analysis. The Surgeon 18:1, pages 53-61.
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Zhihu Zhao, Jianxiong Ma & Xinlong Ma. (2019) Comparative efficacy and safety of different hemostatic methods in total hip arthroplasty: a network meta-analysis. Journal of Orthopaedic Surgery and Research 14:1.
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Wen-qiang Xin, Ya-long Gao, Jun Shen & Xin-yu Yang. (2019) Intravenous tranexamic acid reduces blood transfusions in revision total hip arthroplasty: a meta-analysis. Journal of Comparative Effectiveness Research 8:11, pages 917-928.
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Marcos Jordan, Xavier Aguilera, José Carlos González, Pablo Castillón, Mónica Salomó, José Antonio Hernández, Leonardo Ruiz, José Maria Mora, Pilar Camacho-Carrasco, Salvi Prat-Fabregat, Alba Bosch, Ainhoa Rodriguez-Arias & María José Martínez-Zapata. (2018) Prevention of postoperative bleeding in hip fractures treated with prosthetic replacement: efficacy and safety of fibrin sealant and tranexamic acid. A randomised controlled clinical trial (TRANEXFER study). Archives of Orthopaedic and Trauma Surgery 139:5, pages 597-604.
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Jeffrey Yates, Iris Perelman, Simonne Khair, Joshua Taylor, Jacinthe Lampron, Alan Tinmouth & Elianna Saidenberg. (2019) Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta-analysis. Transfusion 59:2, pages 806-824.
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Kannan Sridharan & Gowri Sivaramakrishnan. (2018) Tranexamic acid in total hip arthroplasty: Mixed treatment comparisons of randomized controlled trials and cohort studies. Journal of Orthopaedics 15:1, pages 81-88.
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Zhihu Zhao, Xinlong Ma, Jianxiong Ma, Xiaolei Sun, Fengbo Li & Jianwei Lv. (2018) A Systematic Review and Meta-analysis of the Topical Administration of Fibrin Sealant in Total Hip Arthroplasty. Scientific Reports 8:1.
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Pei Zhang, Yuan Liang, Pengtao Chen, Yongchao Fang, Jinshan He & Jingcheng Wang. (2017) Combined application versus topical and intravenous application of tranexamic acid following primary total hip arthroplasty: a meta-analysis. BMC Musculoskeletal Disorders 18:1.
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Jianxi Zhu, Yong Zhu, Pengfei Lei, Min Zeng, Weiping Su & Yihe Hu. (2017) Efficacy and safety of tranexamic acid in total hip replacement. Medicine 96:52, pages e9552.
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Aatif Mahmood, Seif Sawalha, Aaron Borbora, Gunasekaran Kumar & Viju Peter. (2017) Tranexamic acid versus fibrin sealant in primary total hip replacement: a comparative study. European Journal of Orthopaedic Surgery & Traumatology 27:7, pages 923-928.
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Kannan Sridharan & Gowri Sivaramakrishnan. (2017) Tranexamic acid in total hip arthroplasty: A recursive cumulative meta-analysis of randomized controlled trials and assessment of publication bias. Journal of Orthopaedics 14:3, pages 323-328.
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Meiguang Qiu, Xuming Zhang, Hongru Cai, Zhixian Xu & Hao Lin. (2017) The impact of hemocoagulase for improvement of coagulation and reduction of bleeding in fracture-related hip hemiarthroplasty geriatric patients: A prospective, single-blinded, randomized, controlled study. Injury 48:4, pages 914-919.
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Jaclyn A. Boyle & Mate M. Soric. (2016) Impact of Tranexamic Acid in Total Knee and Total Hip Replacement. Journal of Pharmacy Practice 30:1, pages 89-93.
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Zhen-yang Hou, Yi-ling Sun, Tao Pang, Dong Lv, Biao Zhu, Zhen Li, Xing-yu Chai, Zheng-wen Xu & Chang-zheng Su. (2017) Effects of two different tranexamic acid administration methods on perioperative blood loss in total hip arthroplasty: study protocol for a prospective, open-label, randomized, controlled clinical trial. Clinical Trials in Orthopedic Disorders 2:2, pages 63.
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Gustavus Lemos Ribeiro Melo, Daniel Souza Lages, João Lopo Madureira Junior, Guilherme de Paula Pellucci & João Wagner Junqueira Pellucci. (2017) The use of tranexamic acid in patients submitted to primary total hip arthroplasty: an evaluation of its impact in different administration protocols. Revista Brasileira de Ortopedia (English Edition) 52, pages 34-39.
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Zhiyuan Wang, Lin Xiao, Hao Guo, Guanghui Zhao & Jianbing Ma. (2017) The efficiency and safety of fibrin sealant for reducing blood loss in primary total hip arthroplasty: A systematic review and meta-analysis. International Journal of Surgery 37, pages 50-57.
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Steven J Edwards, Fay Crawford, Michelle Helena van Velthoven, Andrea Berardi, George Osei-Assibey, Mariana Bacelar, Fatima Salih & Victoria Wakefield. (2016) The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms. Health Technology Assessment 20:94, pages 1-224.
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Pei Zhang, Yuan Liang, Pengtao Chen, Yongchao Fang, Jinshan He & Jingcheng Wang. (2016) Intravenous versus topical tranexamic acid in primary total hip replacement. Medicine 95:50, pages e5573.
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Jie Li, Hong-biao Li, Xi-cheng Zhai, Qin-lei, Xin-qiang Jiang & Zhen-hua Zhang. (2016) Topical use of topical fibrin sealant can reduce the need for transfusion, total blood loss and the volume of drainage in total knee and hip arthroplasty: A systematic review and meta-analysis of 1489 patients. International Journal of Surgery 36, pages 127-137.
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Joseph T. Moskal & Susan G. Capps. (2016) Meta-analysis of Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty. Orthopedics 39:5.
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Fuqiang Gao, Jinhui Ma, Wei Sun, Wanshou Guo, Zirong Li & Weiguo Wang. (2016) Topical fibrin sealant versus intravenous tranexamic acid for reducing blood loss following total knee arthroplasty: A systematic review and meta-analysis. International Journal of Surgery 32, pages 31-37.
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Changde Wang, Pengde Kang, Jun Ma, Chen Yue, Jinwei Xie & Fuxing Pei. (2016) Single-dose tranexamic acid for reducing bleeding and transfusions in total hip arthroplasty: A double-blind, randomized controlled trial of different doses. Thrombosis Research 141, pages 119-123.
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Jinwei Xie, Jun Ma, Chen Yue, Pengde Kang & Fuxing Pei. (2015) Combined use of Intravenous and Topical Tranexamic Acid following Cementless Total Hip Arthroplasty: A Randomised Clinical Trial. HIP International 26:1, pages 36-42.
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J. Stuart Melvin, Louis S. Stryker & Rafael J. Sierra. (2015) Tranexamic Acid in Hip and Knee Arthroplasty. Journal of the American Academy of Orthopaedic Surgeons 23:12, pages 732-740.
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Fei Huang, Yunfeng Wu, Zongsheng Yin, Guangwen Ma & Jun Chang. (2018) A Systematic Review and Meta-Analysis of the Use of Antifibrinolytic Agents in Total Hip Arthroplasty. HIP International 25:6, pages 502-509.
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Richard P. NadeauJames L. HowardDouglas D.R. Naudie. (2015) Antifibrinolytic Therapy for Perioperative Blood Conservation in Lower-Extremity Primary Total Joint Arthroplasty. JBJS Reviews 3:6.
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C.E. Pinzón-Florez, K.M. Vélez Cañas & D.M. Díaz Quijano. (2015) Efficiency of tranexamic acid in perioperative blood loss in hip arthroplasty: A systematic literature review and meta-analysis. Revista Española de Anestesiología y Reanimación (English Edition) 62:5, pages 253-264.
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C.E. Pinzón-Florez, K.M. Vélez Cañas & D.M. Díaz Quijano. (2015) Efectividad del ácido tranexámico en las pérdidas sanguíneas perioperatorias en la artroplastia de cadera: revisión sistemática de la literatura y metaanálisis. Revista Española de Anestesiología y Reanimación 62:5, pages 253-264.
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Herv? Hourlier, Nicolas Reina & Peter Fennema. (2015) Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial. Archives of Orthopaedic and Trauma Surgery 135:4, pages 465-471.
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Mahdi Motififard, Mohammad Ali Tahririan, Mehdi Saneie, Sajad Badiei & Amin Nemati. (2015) Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial. Journal of Blood Transfusion 2015, pages 1-5.
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Chih-Hsiang Chang, Yuhan Chang, Dave W. Chen, Steve W. N. Ueng & Mel S. Lee. (2014) Topical Tranexamic Acid Reduces Blood Loss and Transfusion Rates Associated With Primary Total Hip Arthroplasty. Clinical Orthopaedics & Related Research 472:5, pages 1552-1557.
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Ben Young & Parvez Moondi. (2014) A questionnaire-based survey investigating the current use of tranexamic acid in traumatic haemorrhage and elective hip and knee arthroplasty. JRSM Open 5:2, pages 204253331351694.
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Mohammad R. Rasouli, Luiz Sérgio Marcelino Gomes, Brian Parsley, Wael Barsoum, Hari Bezwada, James Cashman, Julio Garcia, William Hamilton, Eric Hume, Tae Kyun Kim, Rajesh Malhotra, Stavros G. Memtsoudis, Alvin Ong, Fabio Orozco, Douglas E. Padgett, Ricardo J. Reina, Marco Teloken, Emmanuel Thienpont & Jonathan H. Waters. (2014) Blood Conservation. The Journal of Arthroplasty 29:2, pages 65-70.
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Anas Saleh, Mark Hebeish, Mario Farias-Kovac, Alison K. Klika, Preetesh Patel, Juan Suarez & Wael K. Barsoum. (2014) Use of Hemostatic Agents in Hip and Knee Arthroplasty. JBJS Reviews 2:1.
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Fei Huang, Dan Wu, Guangwen Ma, Zongsheng Yin & Qing Wang. (2014) The use of tranexamic acid to reduce blood loss and transfusion in major orthopedic surgery: a meta-analysis. Journal of Surgical Research 186:1, pages 318-327.
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Rajiv Gandhi, Heather MK Evans, Safiyyah R Mahomed & Nizar N Mahomed. (2013) Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis. BMC Research Notes 6:1.
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X. Aguilera, M.J. Martinez-Zapata, A. Bosch, G. Urrútia, J.C. González, M. Jordan, I. Gich, R.M. Maymó, N. Martínez, J.C. Monllau, F. Celaya & J.A. Fernández. (2013) Efficacy and Safety of Fibrin Glue and Tranexamic Acid to Prevent Postoperative Blood Loss in Total Knee Arthroplasty. Journal of Bone and Joint Surgery 95:22, pages 2001-2007.
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James L. Nutt, Kleomenis Papanikolaou & Catherine F. Kellett. (2013) (ii) Complications of total hip arthroplasty. Orthopaedics and Trauma 27:5, pages 272-276.
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Gerhardt Konig, Brian R. Hamlin & Jonathan H. Waters. (2013) Topical Tranexamic Acid Reduces Blood Loss and Transfusion Rates in Total Hip and Total Knee Arthroplasty. The Journal of Arthroplasty 28:9, pages 1473-1476.
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Xin-die Zhou, Li-jiang Tao, Jin Li & Li-dong Wu. (2013) Do we really need tranexamic acid in total hip arthroplasty? A meta-analysis of nineteen randomized controlled trials. Archives of Orthopaedic and Trauma Surgery 133:7, pages 1017-1027.
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Francesco Falez, Antonio Meo, Gabriele Panegrossi, Fabio Favetti, Filippo La Cava & Filippo Casella. (2013) Blood loss reduction in cementless total hip replacement with fibrin spray or bipolar sealer: a randomised controlled trial on ninety five patients. International Orthopaedics 37:7, pages 1213-1217.
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Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

A randomized controlled trial

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Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray

A randomized controlled trial

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