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Original Article

Antibiotic Prophylaxis in Open and Closed Fractures: A Controlled Clinical Trial

Pages 57-62 | Received 20 Apr 1981, Published online: 08 Jul 2009

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Seppo Vainionpää, Jarkko Vasenius & Pentti Rokkanen. (1990) Benzylpenicillin ineffective for open fractures: Prospective study of 60 cases. Acta Orthopaedica Scandinavica 61:2, pages 158-160.
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Articles from other publishers (43)

Kevin M. Klifto, Alexandria C. Rydz, Sonali Biswas, C. Scott Hultman, Detlev ErdmannBrett T. Phillips. (2023) Evidence-Based Medicine: Systemic Perioperative Antibiotic Prophylaxis for Prevention of Surgical-Site Infections in Plastic and Reconstructive Surgery. Plastic & Reconstructive Surgery 152:6, pages 1154e-1182e.
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M Candela Andrade, I De Rus Aznar, M Brunnberg & P Slunsky. (2023) Indications for the removal of implants after fracture healing: A comparison between human and veterinary medicine. Veterinární medicína.
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James K-K Chan, Alexander L Aquilina, Sharon R Lewis, Jeremy N Rodrigues, Xavier L Griffin & Jagdeep Nanchahal. (2022) Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs. Cochrane Database of Systematic Reviews 2022:4.
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Stuart D. Miller, Bryan Bean & Lew C. Schon. 2020. Antimicrobial Combination Devices. Antimicrobial Combination Devices 75 88 .
Rico EisnerNorman LippmannChristoph JostenArne C. RodloffDaniel Behrendt. (2020) Development of the Bacterial Spectrum and Antimicrobial Resistance in Surgical Site Infections of Trauma Patients. Surgical Infections 21:8, pages 684-693.
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Hannah C. Johnson, Abby M. Bailey, Regan A. Baum, Stephanie B. Justice & Kyle A. Weant. (2019) Compliance and Related Outcomes of Prophylactic Antibiotics in Traumatic Open Fractures. Hospital Pharmacy 55:3, pages 193-198.
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S. K. Rai, S. K. Nath, Manoj Kashid & Sunitkumar Wani. (2019) PRIMARY UNREAMED NAILING IN GRADE I, II AND IIIA OPEN FRACTURES OF THE TIBIA SHAFT: A PROSPECTIVE STUDY OF THE OUTCOMES IN 80 PATIENTS. Journal of Musculoskeletal Research 21:03n04, pages 1850015.
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Sambit Acharya, Mallika Sengupta, Soma Sarkar, Atreyi Chakroborty, Aniruddha Sengupta & Manideepa Sengupta. (2018) PRESENCE AND SIGNIFICANCE OF MICRO-ORGANISMS IN OPEN FRACTURES. Journal of Evolution of Medical and Dental Sciences 7:14, pages 1782-1785.
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Rajesh K Rajnish, Uttam C Saini,Udai Cheema,. (2017) Open Fractures of the Ankle: Management Options and Factors influencing Outcomes. Journal of Foot and Ankle Surgery (Asia Pacific) 4:2, pages 69-76.
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Juergen MessnerCostas PapakostidisPeter V. GiannoudisNikolaos K. Kanakaris. (2017) Duration of Administration of Antibiotic Agents for Open Fractures: Meta-Analysis of the Existing Evidence. Surgical Infections 18:8, pages 854-867.
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Yaping Chang, Sean Alexander Kennedy, Mohit Bhandari, Luciane Cruz Lopes, Cristiane de Cássia Bergamaschi, Maria Carolina de Oliveira e Silva, Neera Bhatnagar, S. Mohsen Mousavi, Saqib Khurshid, Brad Petrisor, Melody Ren, Sukhmani K. Sodhi, Reza Donald Mirza & Gordon H. Guyatt. (2015) Effects of Antibiotic Prophylaxis in Patients with Open Fracture of the Extremities. JBJS Reviews 3:6.
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Jeffrey Manway & Peter Highlander. (2014) Open Fractures of the Foot and Ankle. Foot & Ankle Specialist 8:1, pages 59-64.
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Sheng-Gen Xu, Zhao-Guang Mao, Bin-Sheng Liu, Hui-Hua Zhu & Hui-Lin Pan. (2015) Evaluating the use of antibiotic prophylaxis during open reduction and internal fixation surgery in patients at low risk of surgical site infection. Injury 46:2, pages 184-188.
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Kyle A. Weant, Abby M. Bailey, Regan A. Baum & Stephanie B. Justice. (2015) Antibiotic Prophylaxis for Open Fractures in the Emergency Department. Advanced Emergency Nursing Journal 37:1, pages 23-29.
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Geoffrey D. HanniganNicholas PulosElizabeth A. GriceSamir Mehta. (2015) Current Concepts and Ongoing Research in the Prevention and Treatment of Open Fracture Infections. Advances in Wound Care 4:1, pages 59-74.
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Daniele Poole, Arturo Chieregato, Martin Langer, Bruno Viaggi, Emiliano Cingolani, Paolo Malacarne, Francesca Mengoli, Giuseppe Nardi, Ennio Nascimben, Luigi Riccioni, Ilaria Turriziani, Annalisa Volpi, Carlo Coniglio & Giovanni Gordini. (2014) Systematic Review of the Literature and Evidence-Based Recommendations for Antibiotic Prophylaxis in Trauma: Results from an Italian Consensus of Experts. PLoS ONE 9:11, pages e113676.
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Daniel J Jordan, Marco Malahias, Wasim Khan & Sandip Hindocha. (2014) The Ortho-Plastic Approach to Soft Tissue Management in Trauma. The Open Orthopaedics Journal 8:1, pages 399-408.
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Lauren Rodriguez, Hee Soo Jung, James A. Goulet, Ashley Cicalo, David A. Machado-Aranda & Lena M. Napolitano. (2014) Evidence-based protocol for prophylactic antibiotics in open fractures. Journal of Trauma and Acute Care Surgery 77:3, pages 400-408.
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O’Brien C.L, Menon M & Jomha N.M. (2014) Controversies in the Management of Open Fractures. The Open Orthopaedics Journal 8:1, pages 178-184.
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P. J. SHARR & R. E. BUCKLEY. (2014) Current Concepts Review: Open Tibial Fractures. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 81:2, pages 95-107.
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R. Walton, J. Manara, S. E. Elamin, I. Braithwaite & E. Wood. (2014) Immediate Care of Open Extremity Fractures: Where Can We Improve?. BioMed Research International 2014, pages 1-6.
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Cyril Mauffrey, Kyros Ipaktchi & James C. Beazley. 2014. Management of Musculoskeletal Injuries in the Trauma Patient. Management of Musculoskeletal Injuries in the Trauma Patient 197 223 .
Carla C. Saveli, Steven J. Morgan, Robert W. Belknap, Erin Ross, Philip F. Stahel, George W. Chaus, David J. Hak, Walter L. Biffl, Bryan Knepper & Connie S. Price. (2013) Prophylactic Antibiotics in Open Fractures. Journal of Orthopaedic Trauma 27:10, pages 552-557.
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Cyril Mauffrey, James R. Bailey, Richard J. Bowles, Connie Price, Duke Hasson, David J. Hak & Philip F. Stahel. (2012) Acute Management of Open Fractures: Proposal of a New Multidisciplinary Algorithm. Orthopedics 35:10, pages 877-881.
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James Lee Pace, Mininder S. Kocher & David L. Skaggs. (2012) Evidence-based Review. Journal of Pediatric Orthopaedics 32:Supplement 2, pages S123-S127.
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S. Grote, H. Polzer, W.C. Prall, S. Gill, S. Shafizadeh, M. Banerjee, B. Bouillon & H. Bäthis. (2012) Prävention von Infektionen bei offenen Frakturen heutePrevention of infection in the current treatment of open fractures. Der Orthopäde 41:1, pages 32-42.
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Carla C. Saveli, Robert W. Belknap, Steven J. Morgan & Connie S. Price. (2011) The Role of Prophylactic Antibiotics in Open Fractures in an Era of Community-acquired Methicillin-resistant Staphylococcus aureus . Orthopedics 34:8, pages 611-616.
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Clinton K. Murray, William T. Obremskey, Joseph R. Hsu, Romney C. Andersen, Jason H. Calhoun, Jon C. Clasper, Timothy J. Whitman, Thomas K. Curry, Mark E. Fleming, Joseph C. Wenke & James R. Ficke. (2011) Prevention of Infections Associated With Combat-Related Extremity Injuries. Journal of Trauma: Injury, Infection & Critical Care 71:2, pages S235-S257.
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William J Gillespie & Geert HIM Walenkamp. (2010) Antibiotic prophylaxis for surgery for proximal femoral and other closed long bone fractures. Cochrane Database of Systematic Reviews.
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Craig M. Rodner, Bruce D. Browner & Ed Pesanti. 2009. Skeletal Trauma. Skeletal Trauma 589 614 .
Kevin B. Cleveland. 2008. Campbell's Operative Orthopaedics. Campbell's Operative Orthopaedics 675 694 .
Kara L. Birrer, Tram Cat, Lisa Hall & Asad Patanwala. (2017) Use of Hypertonic 7.5% Sodium Chloride (NaCl) Solution in Patients with Traumatic Brain Injuries Trauma: Antibiotics in Open Fractures: Sedation Update: Time for a Change?. Hospital Pharmacy 42:5, pages 411-417.
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Carl J. HauserCharles A. AdamsJr.Jr. & Soumitra R. Eachempati. (2006) Prophylactic Antibiotic Use in Open Fractures: An Evidence-Based Guideline. Surgical Infections 7:4, pages 379-405.
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Brett A. Miles, Jason K. Potter & Edward EllisIIIIII. (2006) The Efficacy of Postoperative Antibiotic Regimens in the Open Treatment of Mandibular Fractures: A Prospective Randomized Trial. Journal of Oral and Maxillofacial Surgery 64:4, pages 576-582.
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J. Gaudias. 2006. Practice of Intramedullary Locked Nails. Practice of Intramedullary Locked Nails 277 281 .
Richard A Gosselin, Ian Roberts & William J Gillespie. (2004) Antibiotics for preventing infection in open limb fractures. Cochrane Database of Systematic Reviews 2010:1.
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J. Jason Hoth, Glen A. Franklin, Nicole A. Stassen, Stephen M. Girard, Roman J. Rodriguez & Jorge L. Rodriguez. (2003) Prophylactic Antibiotics Adversely Affect Nosocomial Pneumonia in Trauma Patients. The Journal of Trauma: Injury, Infection, and Critical Care 55:2, pages 249-254.
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William J Gillespie & Geert Walenkamp. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
J. Evrard. (1995) Antibioprophylaxie des fractures ouvertesAntibiotic prophylaxis in open fractures. European Journal of Orthopaedic Surgery & Traumatology 5:1, pages 15-19.
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Anthony N. Acello, George F. Wallace & Nicholas M. Pachuda. (1995) Treatment of open fractures of the foot and ankle: A preliminary report. The Journal of Foot and Ankle Surgery 34:4, pages 329-346.
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R. Koole & P. Egyedi. (1987) Postoperative contamination of mandibular osteotomy sites with saliva. International Journal of Oral and Maxillofacial Surgery 16:5, pages 554-558.
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DAVID L. HOLMBERG. (2008) The Use of Prophylactic Penicillin in Orthopedic Surgery: A Clinical Trial. Veterinary Surgery 14:2, pages 160-165.
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E. Simchen, H. Stein, T.G. Sacks, M. Shapiro & J. Michel. (1984) Multivariate analysis of determinants of postoperative wound infection in orthopaedic patients. Journal of Hospital Infection 5:2, pages 137-146.
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