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Original Article

Dose-dependent stimulation of bone induction by basic fibroblast growth factor in rats

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Pages 481-484 | Received 09 Feb 1991, Accepted 08 Jun 1991, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Per T Prisell, Per Aspenberg, Bo Wikstrom, Torsten Wredmark & Gunnar Norstedt. (1997) Insulin-like growth factor I increases bone formation in old or corticosteroid treated rats. Acta Orthopaedica Scandinavica 68:6, pages 586-592.
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Jian-Sheng Wang. (1996) Basic fibroblast growth factor for stimulation of bone formation in osteoinductive or conductive implants. Acta Orthopaedica Scandinavica 67:sup269, pages 1-33.
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Jian Sheng Wang & Per Aspenberg. (1996) Basic fibroblast growth factor infused at different times during bone graft incorporation Titanium chamber study in rats. Acta Orthopaedica Scandinavica 67:3, pages 229-236.
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Yvette S Bland, Matthew A Critchlow & Doreen E Ashhurst. (1995) Exogenous fibroblast growth factors-1 and -2 do not accelerate fracture healing in the rabbit. Acta Orthopaedica Scandinavica 66:6, pages 543-548.
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Jian Sheng Wang & Per Aspenberg. (1994) Basic fibroblast growth factor increases allograf incorporation: Bone chamber study in rats. Acta Orthopaedica Scandinavica 65:1, pages 27-31.
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Jian-Sheng Wang & Per Aspenberg. (1993) Basic fibroblast growth factor and bone induction in rats. Acta Orthopaedica Scandinavica 64:5, pages 557-561.
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Per Aspenberg, Elizabeth Wang & Karl-Göran Wang. (1992) Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not. Acta Orthopaedica Scandinavica 63:6, pages 619-622.
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Articles from other publishers (47)

Yue Cai, Xuexin Tan, Li Zhao, Ran Zhang, Tong Zhu, Yang Du & Xukai Wang. (2022) Withdrawal: Synthesis of a Novel bFGF/nHAP/COL Bone Tissue Engineering Scaffold for Mandibular Defect Regeneration in a Rabbit Model [Journal of Hard Tissue Biology 27(1) Vol.27, 2018, pp 85-94]. Journal of Hard Tissue Biology 31:1, pages 61-61.
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Wataru Saito, Kentaro Uchida, Osamu Matsushita, Gen Inoue, Hiroyuki Sekiguchi, Jun Aikawa, Hisako Fujimaki & Masashi Takaso. (2015) Acceleration of callus formation during fracture healing using basic fibroblast growth factor-kidney disease domain-collagen-binding domain fusion protein combined with allogenic demineralized bone powder. Journal of Orthopaedic Surgery and Research 10:1.
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Shigeto Ikemura, Masahiro Hasegawa, Takahiro Iino, Keiichi Miyamoto, Kyoko Imanaka-Yoshida, Toshimichi Yoshida & Akihiro Sudo. (2015) Effect of tenascin-C on the repair of full-thickness osteochondral defects of articular cartilage in rabbits. Journal of Orthopaedic Research 33:4, pages 563-571.
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Atsushi Kimura, Yuji Kabasawa, Yasuhiko Tabata, Kazuhiro Aoki, Keiichi Ohya & Ken Omura. (2014) Gelatin Hydrogel as a Carrier of Recombinant Human Fibroblast Growth Factor-2 During Rat Mandibular Distraction. Journal of Oral and Maxillofacial Surgery 72:10, pages 2015-2031.
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Tae-Hyun Kim, Jung-Ju Kim & Hae-Won Kim. (2013) Basic fibroblast growth factor-loaded, mineralized biopolymer-nanofiber scaffold improves adhesion and proliferation of rat mesenchymal stem cells. Biotechnology Letters 36:2, pages 383-390.
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Akira SAITO, Emiko SAITO, Yoshinori KUBOKI, Mariko KIMURA, Toshinori NAKAJIMA, Fumihiko YUGE, Tsuyoshi KATO, Yoshiyuki HONMA, Tomomi TAKAHASHI & Noboru OHATA. (2013) Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs. Dental Materials Journal 32:2, pages 256-262.
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Hidetsugu Maehara, Shinichi Sotome, Toshitaka Yoshii, Ichiro Torigoe, Yuichi Kawasaki, Yumi Sugata, Masato Yuasa, Masahiro Hirano, Naomi Mochizuki, Masanori Kikuchi, Kenichi Shinomiya & Atsushi Okawa. (2010) Repair of large osteochondral defects in rabbits using porous hydroxyapatite/collagen (HAp/Col) and fibroblast growth factor-2 (FGF-2). Journal of Orthopaedic Research 28:5, pages 677-686.
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A. Gigante, A. Busilacchi, S. Cecconi & F. Greco. (2010) Fattori di crescita e cartilagineGrowth factors and cartilage. Archivio di Ortopedia e Reumatologia 120:3-4, pages 12-14.
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Xiupeng Wang, Atsuo Ito, Yu Sogo, Xia Li, Hideo Tsurushima & Ayako Oyane. (2009) Ascorbate–apatite composite and ascorbate–FGF-2–apatite composite layers formed on external fixation rods and their effects on cell activity in vitro. Acta Biomaterialia 5:7, pages 2647-2656.
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Kanayama Keiichi, Kitago Mitsunobu, Shiraki Masafumi, Doi Yutaka & Shibutani Toshiaki. (2009) Induction of new bone by basic FGF-loaded porous carbonate apatite implants in femur defects in rats. Clinical Oral Implants Research 20:6, pages 560-565.
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Yasumasa Akagawa, Takayasu Kubo, Katsunori Koretake, Kazuhiko Hayashi, Kazuya Doi, Ayumu Matsuura, Koji Morita, Ryou Takeshita, Quan Yuan & Yasuhiko Tabata. (2009) Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor–gelatin hydrogel complex with varying biodegradation rates. Journal of Prosthodontic Research 53:1, pages 41-47.
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Uwe Maus, Stefan Andereya, Jörg A. K. Ohnsorge, Sascha Gravius, Christian H. Siebert & Christopher Niedhart. (2008) A bFGF/TCP-composite inhibits bone formation in a sheep model. Journal of Biomedical Materials Research Part B: Applied Biomaterials 85B:1, pages 87-92.
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Ting Ma, Jesse Gutnick, Brent Salazar, Meegan D. Larsen, Eiji Suenaga, Sebastien Zilber, Zhinong Huang, James Huddleston, R. Lane Smith & Stuart Goodman. (2007) Modulation of allograft incorporation by continuous infusion of growth factors over a prolonged duration in vivo. Bone 41:3, pages 386-392.
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Kazuhiko HAYASHI, Takayasu KUBO, Kazuya DOI, Yasuhiko TABATA & Yasumasa AKAGAWA. (2007) Development of New Drug Delivery System for Implant Bone Augmentation Using a basic Fibroblast Growth Factor-gelatin Hydrogel Complex. Dental Materials Journal 26:2, pages 170-177.
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Xinhua Lin, Louis A. Peña, Paul O. Zamora, Sarah L. Campion & Kazuyuki Takahashi. (2006) Augmentation of demineralized bone matrix (DBM) mineralization by a synthetic growth factor mimetic. Journal of Orthopaedic Research 24:11, pages 2051-2058.
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Maria Giovanna Sabbieti, Luigi Marchetti, Maria Gabriella Gabrielli, Maura Menghi, Stefano Materazzi, Giovanna Menghi, Lawrence G. Raisz & Marja M. Hurley. (2004) Prostaglandins differently regulate FGF-2 and FGF receptor expression and induce nuclear translocation in osteoblasts via MAPK kinase. Cell and Tissue Research 319:2, pages 267-278.
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Christopher Niedhart, Uwe Maus, Oliver Miltner, Hans G. Gräber, Fritz U. Niethard & Christian H. Siebert. (2004) The effect of basic fibroblast growth factor on bone regeneration when released from a novel in situ setting tricalcium phosphate cement . Journal of Biomedical Materials Research Part A 69A:4, pages 680-685.
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Hiroshi TanakaHiroshi MizokamiEiichi ShiigiHidenori MurataHiroyoshi OgasaTakatomo MineSinya Kawai. (2004) Effects of Basic Fibroblast Growth Factor on the Repair of Large Osteochondral Defects of Articular Cartilage in Rabbits: Dose–Response Effects and Long-Term Outcomes. Tissue Engineering 10:3-4, pages 633-641.
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Yoichiro MURATA. (2004) Effects of Basic Fibroblast Growth Factor (bFGF) on the Bone Grafting. Yamaguchi Medical Journal 53:1, pages 55-65.
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Stuart B. Goodman, Yong Song, Juh Yung Yoo, Nora Fox, Michael C.D. Trindade, Glen Kajiyama, Ting Ma, Donald Regula, Jim Brown & R. Lane Smith. (2003) Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles. Journal of Biomedical Materials Research 65A:4, pages 454-461.
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Janine M. Orban, Kacey G. Marra & Jeffrey O. Hollinger. (2002) Composition Options for Tissue-Engineered Bone. Tissue Engineering 8:4, pages 529-539.
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Kazuma Fujimura, Kazuhisa Bessho, Yasunori Okubo, Kenji Kusumoto, Natsuki Segami & Tadahiko Iizuka. (2002) The effect of fibroblast growth factor-2 on the osteoinductive activity of recombinant human bone morphogenetic protein-2 in rat muscle. Archives of Oral Biology 47:8, pages 577-584.
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Edward J Calabrese & Linda A Baldwin. (2002) Applications of hormesis in toxicology, risk assessment and chemotherapeutics. Trends in Pharmacological Sciences 23:7, pages 331-337.
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T. Sobue, T. Gravely, A. Hand, Y. K. Min, C. Pilbeam, L. G. Raisz, X. Zhang, D. Larocca, R. Florkiewicz & M. M. Hurley. (2002) Regulation of Fibroblast Growth Factor 2 and Fibroblast Growth Factor Receptors by Transforming Growth Factor β in Human Osteoblastic MG-63 Cells. Journal of Bone and Mineral Research 17:3, pages 502-512.
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Marja M. Hurley, Pierre J. Marie & Robert Z. Florkiewicz. 2002. Principles of Bone Biology. Principles of Bone Biology 825 XXXII .
T. Sobue, X. Zhang, R.Z. Florkiewicz & M.M. Hurley. (2001) Interleukin-1 Regulates FGF-2 mRNA and Localization of FGF-2 Protein in Human Osteoblasts. Biochemical and Biophysical Research Communications 286:1, pages 33-40.
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Douglas J. Mackenzie, Richard Sipe, Dave Buck, Wilson Burgess & Jeffrey Hollinger. (2001) Recombinant Human Acidic Fibroblast Growth Factor and Fibrin Carrier Regenerates Bone. Plastic and Reconstructive Surgery 107:4, pages 989-996.
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Lentsha Nathaniel Ramoshebi & Ugo Ripamonti. (2000) Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-β1. The Anatomical Record 259:1, pages 97-107.
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G Zellin & A Linde. (2000) Effects of recombinant human fibroblast growth factor-2 on osteogenic cell populations during orthopic osteogenesis in vivo. Bone 26:2, pages 161-168.
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Jay R. Lieberman. 2000. Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine. Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine 43 56 .
David L. Cochran & John M. Wozney. (2007) Biological mediators for periodontal regeneration. Periodontology 2000 19:1, pages 40-58.
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M. G. SabbietiL. MarchettiC. AbreuA. MonteroA. R. Hand, L. G. RaiszM. M. Hurley. (1999) Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone. Endocrinology 140:1, pages 434-444.
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T. Kimoto, R. Hosokawa, T. Kubo, M. Maeda, A. Sano & Y. Akagawa. (2016) Continuous Administration of Basic Fibroblast Growth Factor (FGF-2) Accelerates Bone Induction on Rat Calvaria— An Application of a New Drug Delivery System. Journal of Dental Research 77:12, pages 1965-1969.
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L.Steven Beck, Rita L. Wong, Leo DeGuzman, Wyne P. Lee, Boonsri Ongpipattanakul & Tue H. Nguyen. (1998) Combination of Bone Marrow and TGF-β1 Augment the Healing of Critical-Sized bone Defects. Journal of Pharmaceutical Sciences 87:11, pages 1379-1386.
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Takashi Kato, Hiroshi Kawaguchi, Keigo Hanada, Ikuo Aoyama, Yoshiyuki Hiyama, Toshiyuki Nakamura, Kazuya Kuzutani, Makoto Tamura, Takahide Kurokawa & Kozo Nakamura. (2005) Single local injection of recombinant fibroblast growth factor‐2 stimulates healing of segmental bone defects in rabbits. Journal of Orthopaedic Research 16:6, pages 654-659.
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Jung U. Yoo & Brian Johnstone. (1998) The Role of Osteochondral Progenitor Cells in Fracture Repair. Clinical Orthopaedics and Related Research 355S, pages S73-S81.
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Göran Zellin, Per Alberius & Anders Linde. (1998) Autoclaved Bone for Craniofacial Reconstruction: Effects of Supplementation with Bone Marrow or Recombinant Human Fibroblast Growth Factor-2. Plastic & Reconstructive Surgery 102:3, pages 792-800.
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H. Winet & J. Y. Bao. (1998) Fibroblast growth factor-2 alters the effect of eroding polylactide-polyglycolide on osteogenesis in the bone chamber. Journal of Biomedical Materials Research 40:4, pages 567-576.
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Norio Amizuka, Marie Yamada, Jun-Ichi Watanabe, Kazuto Hoshi, Mariko Fukushi, Kimimitsu Oda, Yukio Ikehara & Hidehiro Ozawa. (1998) Morphological examination of bone synthesis via direct administration of basic fibroblast growth factor into rat bone marrow. Microscopy Research and Technique 41:4, pages 313-322.
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Jay R. Lieberman, Lu Q. Le, Lilly Wu, Gerald A. M. Finerman, Arnie Berk, Owen N. Witte & Sharon Stevenson. (2005) Regional gene therapy with a BMP‐2‐producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. Journal of Orthopaedic Research 16:3, pages 330-339.
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F. Debiais, M. Hott, A. M. Graulet & P. J. Marie. (1998) The Effects of Fibroblast Growth Factor-2 on Human Neonatal Calvaria Osteoblastic Cells Are Differentiation Stage Specific. Journal of Bone and Mineral Research 13:4, pages 645-654.
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John L. Andreshak, Steven I. Rabin, Avinash G. Patwardhan & Frederick H. Wezeman. (1997) Tibial segmental defect repair: Chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor. The Anatomical Record 248:2, pages 198-204.
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Pedro Cuevas, Victor de Paz, Begoña Cuevas, Jesus Marin-Martinez, Manuel Picon-Molina, Antonio Fernández-Pereira & Guillermo Giménez-Gallego. (1997) Osteopromotion for cranioplasty: An experimental study in rats using acidic fibroblast growth factor. Surgical Neurology 47:3, pages 242-246.
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N. R. Kübler. (2013) Osteoinduktion und- reparationOsteoinduction and bone restoration. Oral and Maxillofacial Surgery 1:1-6, pages 2-25.
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Jian-Sheng Wang & Per Aspenberg. (1996) Basic Fibroblast Growth Factor Promotes Bone Ingrowth in Porous Hydroxyapatite. Clinical Orthopaedics and Related Research 333, pages 252???260.
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Jian‐Sheng Wang & Per Aspenberg. (2005) Basic fibroblast growth factor enhances bone‐graft incorporation: Dose and time dependence in rats. Journal of Orthopaedic Research 14:2, pages 316-323.
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Lynn L. H. Huang-Lee, Julia H. Wu & Marcel E. Nimni. (1994) Effects of hyaluronan on collagen fibrillar matrix contraction by fibroblasts. Journal of Biomedical Materials Research 28:1, pages 123-132.
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