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Original Article

Pathways of aggrecan processing in joint tissues Implications for disease mechanism and monitoring

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Pages 26-32 | Published online: 08 Jul 2009

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Read on this site (2)

James F. Nishimuta & Marc E. Levenston. (2017) Adipokines induce catabolism of newly synthesized matrix in cartilage and meniscus tissues. Connective Tissue Research 58:3-4, pages 246-258.
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Kathryn G. Vogel. (1996) The Effect of Compressive Loading on Proteoglycan Turnover in Cultured Fetal Tendon. Connective Tissue Research 34:3, pages 227-237.
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Articles from other publishers (35)

Susanne Rein, Veit Krenn, Elisabet Hagert, Marc Garcia-Elias, Alex Lluch, Thomas Kremer & Manuel Semisch. (2021) Degeneration of the articular disc in the human triangular fibrocartilage complex. Archives of Orthopaedic and Trauma Surgery 141:4, pages 699-708.
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Carrie H-Y Ling, Janice H. Lai, Ivan J. Wong & Marc E. Levenston. (2016) Bovine meniscal tissue exhibits age- and interleukin-1 dose-dependent degradation patterns and composition-function relationships. Journal of Orthopaedic Research 34:5, pages 801-811.
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V. Krenn, B. Kurz, M.G. Krukemeyer, P. Knoess, M. Jakobs, C. Poremba & G. Möllenhoff. (2010) Histopathologischer Degenerations-Score des FaserknorpelsHistopathological degeneration score of fibrous cartilage. Zeitschrift für Rheumatologie 69:7, pages 644-652.
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V. Krenn, P. Knöß, W. Rüther, M. Jakobs, M. Otto, M.G. Krukemeyer, A. Heine, G. Möllenhoff & B. Kurz. (2010) Meniskusdegenerationsscore und NITEGE-ExpressionMeniscal degeneration score and NITEGE expression. Der Orthopäde 39:5, pages 475-485.
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Angelika K. Lemke, John D. Sandy, Henning Voigt, Rita Dreier, Jennifer H. Lee, Alan J. Grodzinsky, Rolf Mentlein, Jakob Fay, Michael Schünke & Bodo Kurz. (2010) Interleukin-1α treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell and Tissue Research 340:1, pages 179-188.
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Christopher G. WilsonJames F. NishimutaMarc E. Levenston. (2009) Chondrocytes and Meniscal Fibrochondrocytes Differentially Process Aggrecan During De Novo Extracellular Matrix Assembly . Tissue Engineering Part A 15:7, pages 1513-1522.
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Joan M. Lemire, Carrie Patis, Leslie B. Gordon, John D. Sandy, Bryan P. Toole & Anthony S. Weiss. (2006) Aggrecan expression is substantially and abnormally upregulated in Hutchinson–Gilford Progeria Syndrome dermal fibroblasts. Mechanisms of Ageing and Development 127:8, pages 660-669.
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M.A. Pratta, J.L. Su, M.A. Leesnitzer, A. Struglics, S. Larsson, L.S. Lohmander & S. Kumar. (2006) Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments. Osteoarthritis and Cartilage 14:7, pages 702-713.
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J.D. Sandy. (2006) A contentious issue finds some clarity: on the independent and complementary roles of aggrecanase activity and MMP activity in human joint aggrecanolysis. Osteoarthritis and Cartilage 14:2, pages 95-100.
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A. Struglics, S. Larsson, M.A. Pratta, S. Kumar, M.W. Lark & L.S. Lohmander. (2006) Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis and Cartilage 14:2, pages 101-113.
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DANIEL-HENRI MANICOURT, JEAN-PIERRE DEVOGELAER & EUGENE J.-M. A. THONAR. 2006. Dynamics of Bone and Cartilage Metabolism. Dynamics of Bone and Cartilage Metabolism 421 449 .
Kotaro Sugimoto, Tomoko Iizawa, Hosami Harada, Kazuyo Yamada, Mutsumi Katsumata & Masaaki Takahashi. (2004) Cartilage degradation independent of MMP/aggrecanases. Osteoarthritis and Cartilage 12:12, pages 1006-1014.
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Hidefumi OSHITA, John D. SANDYKiichi SUZUKI, Atsushi AKAIKE, Yun BAITomohiro SASAKI & Katsuji SHIMIZU. (2004) Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochemical Journal 382:1, pages 253-259.
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Tom Samiric, Mirna Z Ilic & Christopher J Handley. (2004) Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon. Matrix Biology 23:2, pages 127-140.
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W Yuan, R.T Matthews, J.D Sandy & P.E Gottschall. (2002) Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Neuroscience 114:4, pages 1091-1101.
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Wolfgang Eger, Barbara L. Schumacher, Jürgen Mollenhauer, Klaus E. Kuettner & Ada A. Cole. (2002) Human knee and ankle cartilage explants: Catabolic differences. Journal of Orthopaedic Research 20:3, pages 526-534.
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Michele L. Lemons, John D. Sandy, Douglas K. Anderson & Dena R. Howland. (2001) Intact Aggrecan and Fragments Generated by Both Aggrecanse and Metalloproteinase-Like Activities Are Present in the Developing and Adult Rat Spinal Cord and Their Relative Abundance Is Altered by Injury. The Journal of Neuroscience 21:13, pages 4772-4781.
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Mireille N. Vankemmelbeke, Ingunn Holen, Anthony G. Wilson, Mirna Z. Ilic, Christopher J. Handley, Gregory S. Kelner, Melody Clark, Changlu Liu, Richard A. Maki, David Burnett & David J. Buttle. (2001) Expression and activity of ADAMTS-5 in synovium. European Journal of Biochemistry 268:5, pages 1259-1268.
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Michael A. Pratta, Micky D. Tortorella & Elizabeth C. Arner. (2000) Age-related Changes in Aggrecan Glycosylation Affect Cleavage by Aggrecanase. Journal of Biological Chemistry 275:50, pages 39096-39102.
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Christine Hörber, Frank H. Büttner, Christopher Kern, Gerno Schmiedeknecht & Eckart Bartnik. (2000) Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site.. Matrix Biology 19:6, pages 533-543.
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Paula M. Ragan, Vicki I. Chin, Han-Hwa K. Hung, Koichi Masuda, Eugene J.-M.A. Thonar, Elizabeth C. Arner, Alan J. Grodzinsky & John D. Sandy. (2000) Chondrocyte Extracellular Matrix Synthesis and Turnover Are Influenced by Static Compression in a New Alginate Disk Culture System. Archives of Biochemistry and Biophysics 383:2, pages 256-264.
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Amanda J. Fosang, Karena Last, Heather Stanton, David B. Weeks, Ian K. Campbell, Timothy E. Hardingham & Rosalind M. Hembry. (2000) Generation and Novel Distribution of Matrix Metalloproteinase-derived Aggrecan Fragments in Porcine Cartilage Explants. Journal of Biological Chemistry 275:42, pages 33027-33037.
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Kouji Kuno, Yasunori Okada, Hiroto Kawashima, Hiroyuki Nakamura, Masayuki Miyasaka, Hiroshi Ohno & Kouji Matsushima. (2000) ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Letters 478:3, pages 241-245.
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Mirna Z Ilic, Mireille N Vankemmelbeke, Ingunn Holen, David J Buttle, H Clem Robinson & Christopher J Handley. (2000) Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity. Matrix Biology 19:3, pages 257-265.
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Micky D. Tortorella, Michael Pratta, Rui-Qin Liu, Julian Austin, O.Harold Ross, Ilgar Abbaszade, Tim Burn & Elizabeth Arner. (2000) Sites of Aggrecan Cleavage by Recombinant Human Aggrecanase-1 (ADAMTS-4). Journal of Biological Chemistry 275:24, pages 18566-18573.
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Parth Patwari, Bodo Kurz, John D. Sandy & Alan J. Grodzinsky. (2000) Mannosamine Inhibits Aggrecanase-Mediated Changes in the Physical Properties and Biochemical Composition of Articular Cartilage. Archives of Biochemistry and Biophysics 374:1, pages 79-85.
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Ilgar Abbaszade, Rui-Qin Liu, Fude Yang, Stuart A. Rosenfeld, O. Harold Ross, John R. Link, Dawn M. Ellis, Micky D. Tortorella, Michael A. Pratta, Jeannine M. Hollis, Richard Wynn, Jodie L. Duke, Henry J. George, Milton C. HillmanJr.Jr., Kathleen Murphy, Barbara H. Wiswall, Robert A. Copeland, Carl P. Decicco, Robert Bruckner, Hideaki Nagase, Yoshifumi Itoh, Robert C. Newton, Ronald L. Magolda, James M. Trzaskos, Gregory F. Hollis, Elizabeth C. Arner & Timothy C. Burn. (1999) Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family. Journal of Biological Chemistry 274:33, pages 23443-23450.
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John D. Sandy, Vivian Thompson, Christie Verscharen & Dan Gamett. (1999) Chondrocyte-Mediated Catabolism of Aggrecan: Evidence for a Glycosylphosphatidylinositol-Linked Protein in the Aggrecanase Response to Interleukin-1 or Retinoic Acid. Archives of Biochemistry and Biophysics 367:2, pages 258-264.
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THOMAS M. QUINN, ADRIAN A. MAUNG, ALAN J. GRODZINSKY, ERNST B. HUNZIKER & JOHN D. SANDY. (1999) Physical and Biological Regulation of Proteoglycan Turnover around Chondrocytes in Cartilage Explants: Implications for Tissue Degradation and Repair. Annals of the New York Academy of Sciences 878:1 INHIBITION OF, pages 420-441.
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Elizabeth C. Arner, Michael A. Pratta, James M. Trzaskos, Carl P. Decicco & Micky D. Tortorella. (1999) Generation and Characterization of Aggrecanase. Journal of Biological Chemistry 274:10, pages 6594-6601.
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Mireille N. Vankemmelbeke, Mirna Z. Ilic, Christopher J. Handley, C.Graham Knight & David J. Buttle. (1999) Coincubation of Bovine Synovial or Capsular Tissue with Cartilage Generates a Soluble “Aggrecanase” Activity. Biochemical and Biophysical Research Communications 255:3, pages 686-691.
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Amanda J. Fosang. 1999. Metalloproteinases as Targets for Anti-Inflammatory Drugs. Metalloproteinases as Targets for Anti-Inflammatory Drugs 117 143 .
Thomas M. Quinn, Alan J. Grodzinsky, Ernst B. Hunziker & John D. Sandy. (1998) Effects of injurious compression on matrix turnover around individual cells in calf articular cartilage explants. Journal of Orthopaedic Research 16:4, pages 490-499.
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Thomas M. Hering, John Kollar & Tru D. Huynh. (1997) Complete Coding Sequence of Bovine Aggrecan: Comparative Structural Analysis. Archives of Biochemistry and Biophysics 345:2, pages 259-270.
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Lawrence J. Bonassar, John D. Sandy, Michael W. Lark, Anna H.K. Plaas, Eliot H. Frank & Alan J. Grodzinsky. (1997) Inhibition of Cartilage Degradation and Changes in Physical Properties Induced by IL-1β and Retinoic Acid Using Matrix Metalloproteinase Inhibitors. Archives of Biochemistry and Biophysics 344:2, pages 404-412.
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