283
Views
63
CrossRef citations to date
0
Altmetric
Original Article

BMP-2 for intramuscular bone induction:Effect in squirrel monkeys is dependent on implantation site

&
Pages 3-6 | Received 17 Jun 1995, Accepted 28 Oct 1995, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Olof Sandberg, Pernilla Eliasson, Therese Andersson, Fredik Agholme & Per Aspenberg. (2012) Etanercept does not impair healing in rat models of tendon or metaphyseal bone injury. Acta Orthopaedica 83:3, pages 305-310.
Read now
Sébastien A. Gittens & Hasan Uludag. (2001) Growth Factor Delivery for Bone Tissue Engineering. Journal of Drug Targeting 9:6, pages 407-429.
Read now
Charlotte Jeppsson, Hans Saveland, Urban Rydholm & Per Aspen Berg. (1999) OP-1 for cervical spine fusion: Bridging bone in only 1 of 4 rheumatoid patients but prednisolone did not inhibit bone induction in rats. Acta Orthopaedica Scandinavica 70:6, pages 559-563.
Read now
Gerhard Herr, Carl-Heinz Hartwig, Cornelia Boll & Wolfgang Küsswetter. (1996) Ectopic bone formation by composites of BMP and metal implants in rats. Acta Orthopaedica Scandinavica 67:6, pages 606-610.
Read now
Charlotte Jeppsson & Per Aspenberg. (1996) BMP-2 can inhibit bone healing: Bone-chamber study in rabbits. Acta Orthopaedica Scandinavica 67:6, pages 589-592.
Read now

Articles from other publishers (58)

Chen Chen, Matthew Rehnama, Soyon Kim, Chung‐Sung Lee, Xiao Zhang, Tara Aghaloo, Jiabing Fan & Min Lee. (2021) Enhanced Osteoinductivity of Demineralized Bone Matrix with Noggin Suppression in Polymer Matrix. Advanced Biology 5:1, pages 2000135.
Crossref
Bing WangSimone MastrogiacomoFang YangJinlong ShaoMarianne Meng Ann OngNattharee ChanchareonsookJohn A. JansenX. Frank WalboomersNa Yu. (2019) Application of BMP-Bone Cement and FGF-Gel on Periodontal Tissue Regeneration in Nonhuman Primates. Tissue Engineering Part C: Methods 25:12, pages 748-756.
Crossref
Darilis Suárez-GonzálezJae Sung LeeAlisha DiggsYan LuBrett NemkeMark MarkelScott J. HollisterWilliam L. Murphy. (2014) Controlled Multiple Growth Factor Delivery from Bone Tissue Engineering Scaffolds via Designed Affinity. Tissue Engineering Part A 20:15-16, pages 2077-2087.
Crossref
M. Reza Sanaei, Jalila Abu, Mojgan Nazari, Mohd Zuki A.B. & Zeenathul N. Allaudin. (2013) Qualitative and quantitative evaluation of avian demineralized bone matrix in heterotopic beds. Veterinary Surgery 42:8, pages 963-970.
Crossref
Matti Scholz, Philipp Schleicher, Andreas Sewing, Michael Gelinsky & Frank Kandziora. (2013) Cyclic-RGD Is as Effective as rhBMP-2 in Anterior Interbody Fusion of the Sheep Cervical Spine. Spine 38:2, pages E59-E65.
Crossref
M.E. Draenert, K.-H. Kunzelmann, F. Forriol, R. Hickel & K. Draenert. (2013) Primary cancellous bone formation with BMP and micro-chambered beads. Bone 52:1, pages 465-473.
Crossref
Kenneth P.H. Pritzker & Matthew J. Kessler. 2012. Nonhuman Primates in Biomedical Research. Nonhuman Primates in Biomedical Research 629 697 .
Miao Zhou, Xin Peng, Chi Mao, Fang Xu, Min Hu & Guang-yan Yu. (2010) Primate mandibular reconstruction with prefabricated, vascularized tissue-engineered bone flaps and recombinant human bone morphogenetic protein-2 implanted in situ. Biomaterials 31:18, pages 4935-4943.
Crossref
Ziyad S. Haidar, Reggie C. Hamdy & Maryam Tabrizian. (2010) Biocompatibility and safety of a hybrid core–shell nanoparticulate OP-1 delivery system intramuscularly administered in rats. Biomaterials 31:10, pages 2746-2754.
Crossref
L DI SILVIO & P JAYAKUMAR. 2009. Cellular Response to Biomaterials. Cellular Response to Biomaterials 313 343 .
Svenja-Yvonne Bauer, Ulrich Brehm, Richard Stangl & Matthias M?nzberg. (2009) Supraspinatussehnenrupturen Typ Bateman III und IV im Alter ? eine operative Option?Supraspinatus tear type Bateman III and IV? in the elderly An operative option?. Obere Extremit?t 3:4, pages 203-213.
Crossref
Knut N. Leknes, Jie Yang, Mohammed Qahash, Giuseppe Polimeni, Cristiano Susin & Ulf M. E. Wikesjö. (2008) Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-2: radiographic observations. Clinical Oral Implants Research 19:10, pages 1027-1033.
Crossref
Daniel S. Mulconrey, Keith H. Bridwell, Jennifer Flynn, Geoffrey A. Cronen & Peter S. Rose. (2008) Bone Morphogenetic Protein (RhBMP-2) as a Substitute for Iliac Crest Bone Graft in Multilevel Adult Spinal Deformity Surgery. Spine 33:20, pages 2153-2159.
Crossref
Yasunori Hasegawa, Shuichi Sato, Tadahiro Takayama, Masakazu Murai, Naoto Suzuki & Koichi Ito. (2008) Short‐Term Effects of rhBMP‐2–Enhanced Bone Augmentation Beyond the Skeletal Envelope Within a Titanium Cap in Rabbit Calvarium. Journal of Periodontology 79:2, pages 348-354.
Crossref
Hossein Hosseinkhani, Tony Azzam, Hisatoshi Kobayashi, Yosuke Hiraoka, Hitoyata Shimokawa, Abraham J. Domb & Yasuhiko Tabata. (2006) Bone Tissue Engineering Through a Combination of 3-Dimensional Tissue Engineered Scaffold and Transfected Mesenchymal Stem Cells. Tissue Engineering 0:0, pages 060928122958004.
Crossref
Ui-Won Jung, Seong-Yong Choi, Eun-Kyoung Pang, Chang-Sung Kim, Seong-Ho Choi & Kyoo-Sung Cho. (2006) The Effect of Varying the Particle Size of Beta Tricalcium Phosphate Carrier of Recombinant Human Bone Morphogenetic Protein-4 on Bone Formation in Rat Calvarial Defects. Journal of Periodontology 77:5, pages 765-772.
Crossref
Francis H. Shen, Dino Samartzis & Howard S. An. (2005) Cell technologies for spinal fusion. The Spine Journal 5:6, pages S231-S239.
Crossref
Yukio Nakamura, Shigeyuki Wakitani, Naoto Saito & Kunio Takaoka. (2005) Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells. Journal of Bone and Mineral Metabolism 23:6, pages 426-434.
Crossref
Hajime Tsuda, Takuro Wada, Toshihiko Yamashita & Hirofumi Hamada. (2005) Enhanced osteoinduction by mesenchymal stem cells transfected with a fiber-mutant adenoviral BMP2 gene. The Journal of Gene Medicine 7:10, pages 1322-1334.
Crossref
Scott J. Luhmann, Keith H. Bridwell, Ivan Cheng, Toshihiro Imamura, Lawrence G. Lenke & Mario Schootman. (2005) Use of Bone Morphogenetic Protein-2 for Adult Spinal Deformity. Spine 30:Supplement, pages S110-S117.
Crossref
Yukio Nakamura, Keiji Tensho, Hiroyuki Nakaya, Masashi Nawata, Takahiro Okabe & Shigeyuki Wakitani. (2005) Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice. Bone 36:3, pages 399-407.
Crossref
Dino Samartzis, Nitin Khanna, Francis H. Shen & Howard S. An. (2005) Update on bone morphogenetic proteins and their application in spine surgery1. Journal of the American College of Surgeons 200:2, pages 236-248.
Crossref
Eun-Kyoung Pang, Se-Ung Im, Chang-Sung Kim, Seong-Ho Choi, Jung-Kiu Chai, Chong-Kwan Kim, Soo-Boo Han & Kyoo-Sung Cho. (2004) Effect of Recombinant Human Bone Morphogenetic Protein-4 Dose on Bone Formation in a Rat Calvarial Defect Model. Journal of Periodontology 75:10, pages 1364-1370.
Crossref
Hiroo Maeda, Akihiko Sano & Keiji Fujioka. (2004) Controlled release of rhBMP-2 from collagen minipellet and the relationship between release profile and ectopic bone formation. International Journal of Pharmaceutics 275:1-2, pages 109-122.
Crossref
B. Wildemann, F. Kandziora, G. Krummrey, N. Palasdies, N.P. Haas, M. Raschke & G. Schmidmaier. (2004) Local and controlled release of growth factors (combination of IGF-I and TGF-beta I, and BMP-2 alone) from a polylactide coating of titanium implants does not lead to ectopic bone formation in sheep muscle. Journal of Controlled Release 95:2, pages 249-256.
Crossref
Mia Jullig, Wei V. Zhang & N. Susan Stott. (2004) Gene therapy in orthopaedic surgery: the current status. ANZ Journal of Surgery 74:1-2, pages 46-54.
Crossref
Naoto Saito, Hiroshi Horiuchi, Narumichi Murakami, Jun Takahashi, Takao Okada, Kazutoshi Nozaki & Kunio Takaoka. 2003. Tissue Engineering And Novel Delivery Systems. Tissue Engineering And Novel Delivery Systems.
Yukio Nakamura, Shigeyuki Wakitani, Jun Nakayama, Shinji Wakabayashi, Hiroshi Horiuchi & Kunio Takaoka. (2003) Temporal and Spatial Expression Profiles of BMP Receptors and Noggin During BMP-2-Induced Ectopic Bone Formation. Journal of Bone and Mineral Research 18:10, pages 1854-1862.
Crossref
F. Kandziora, R. Pflugmacher, M. Scholz, J. Schäfer, G. Schollmeier, G. Schmidmaier, G. Duda, M. Raschke & N. P. Haas. (2002) Dose-dependent effects of combined IGF-I and TGF-β1 application in a sheep cervical spine fusion model. European Spine Journal 12:5, pages 464-473.
Crossref
Narumichi Murakami, Naoto Saito, Jun Takahashi, Hiroshi Ota, Hiroshi Horiuchi, Masashi Nawata, Takao Okada, Kazutoshi Nozaki & Kunio Takaoka. (2003) Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier. Biomaterials 24:13, pages 2153-2159.
Crossref
Naoto Saito & Kunio Takaoka. (2003) New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials 24:13, pages 2287-2293.
Crossref
Hajime Tsuda, Takuro Wada, Yoshinori Ito, Hiroaki Uchida, Hironari Dehari, Kiminori Nakamura, Katsunori Sasaki, Masayoshi Kobune, Toshihiko Yamashita & Hirofumi Hamada. (2003) Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector. Molecular Therapy 7:3, pages 354-365.
Crossref
Scott D. Boden. (2002) Overview of the Biology of Lumbar Spine Fusion and Principles for Selecting a Bone Graft Substitute. Spine 27:Supplement, pages S26-S31.
Crossref
Kazuma Fujimura, Kazuhisa Bessho, Yasunori Okubo, Kenji Kusumoto, Natsuki Segami & Tadahiko Iizuka. (2002) The effect of fibroblast growth factor-2 on the osteoinductive activity of recombinant human bone morphogenetic protein-2 in rat muscle. Archives of Oral Biology 47:8, pages 577-584.
Crossref
Frank Kandziora, Hermann Bail, Gerhard Schmidmaier, Georg Schollmeier, Matti Scholz, Christian Knispel, Timo Hiller, Robert Pflugmacher, Thomas Mittlmeier, Michael Raschke & Norbert P. Haas. (2002) Bone morphogenetic protein—2 application by a poly(d,l-lactide)—coated interbody cage: in vivo results of a new carrier for growth factors. Journal of Neurosurgery: Spine 97:1, pages 40-48.
Crossref
K Kusumoto, K Bessho, K Fujimura, J Akioka, Y Okubo, Y Wang, T Iizuka & Y Ogawa. (2016) Osteoinduction by Recombinant Human Bone Morphogenetic Protein-2 in Muscles of Non-Human Primates. Journal of International Medical Research 30:3, pages 251-259.
Crossref
Dimitris N. Tatakis, Alexander Koh, Lisa Jin, John M. Wozney, Michael D. Rohrer & Ulf M. E. Wikesjö. (2002) Peri‐implant bone regeneration using recombinant human bone morphogenetic protein‐2 in a canine model: a dose‐response study. Journal of Periodontal Research 37:2, pages 93-100.
Crossref
H. Terheyden, C. Knak, S. Jepsen, S. Palmie & D.R. Rueger. (2001) Mandibular reconstruction with a prefabricated vascularized bone graft using recombinant human osteogenic protein-1: an experimental study in miniature pigs. Part I: Prefabrication. International Journal of Oral and Maxillofacial Surgery 30:5, pages 373-379.
Crossref
Brian R. Subach, Regis W. Haid, Gerald E. Rodts & Michael G. Kaiser. (2001) Bone morphogenetic protein in spinal fusion: overview and clinical update. Neurosurgical Focus 10:4, pages 1-6.
Crossref
H Horiuchi, N Saito, T Kinoshita, S Wakabayashi, T Tsutsumimoto & K Takaoka. (2001) Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline. Bone 28:3, pages 290-294.
Crossref
Ester Vögelin, Neil F. Jones, Jerry I. Huang, John H. Brekke & Jeffrey M. Toth. (2000) Practical Illustrations in Tissue Engineering: Surgical Considerations Relevant to the Implantation of Osteoinductive Devices. Tissue Engineering 6:4, pages 449-460.
Crossref
Scott D. Boden. (2000) Biology of Lumbar Spine Fusion and Use of Bone Graft Substitutes: Present, Future, and Next Generation. Tissue Engineering 6:4, pages 383-399.
Crossref
Liu Hong, Yasuhiko Tabata, Susumu Miyamoto, Masaya Yamamoto, Keisuke Yamada, Nobuo Hashimoto & Yoshito Ikada. (2000) Bone regeneration at rabbit skull defects treated with transforming growth factor—β1 incorporated into hydrogels with different levels of biodegradability. Journal of Neurosurgery 92:2, pages 315-325.
Crossref
Scott D. Boden, Thomas A. Zdeblick, Harvinder S. Sandhu & Stephen E. Heim. (2000) The Use of rhBMP-2 in Interbody Fusion Cages. Spine 25:3, pages 376-381.
Crossref
Thomas Engstrand, Aaron Daluiski, Matthew E. Bahamonde, Hakan Melhus & Karen M. Lyons. (2000) Transient Production of Bone Morphogenetic Protein 2 by Allogeneic Transplanted Transduced Cells Induces Bone Formation. Human Gene Therapy 11:1, pages 205-211.
Crossref
Kirk P. Andriano, Bhagya Chandrashekar, Kathleen McEnery, Richard L. Dunn, Katie Moyer, Catherine M. Balliu, Kathleen M. Holland, Steven Garrett & William E. Huffer. (2000) Preliminaryin vivo studies on the osteogenic potential of bone morphogenetic proteins delivered from an absorbable puttylike polymer matrix. Journal of Biomedical Materials Research 53:1, pages 36-43.
Crossref
Cato T. Laurencin, Mohamed Attawia & Mark D. Borden. (1999) Advancements in tissue engineered bone substitutes. Current Opinion in Orthopedics 10:6, pages 445-451.
Crossref
Nancy M. P. Lamerigts, Pieter Buma, Per Aspenberg, B Willem Schreurs & Tom J.J.H. Slooff. (1999) Role of Growth Factors in the Incorporation of Unloaded Bone Allografts in the Goat. Clinical Orthopaedics and Related Research 368, pages 260???270.
Crossref
Scott D. Boden. (1999) Bioactive Factors for Bone Tissue Engineering. Clinical Orthopaedics and Related Research 367, pages S84-S94.
Crossref
Naoto Saito, Takao Okada, Shigeyuki Toba, Shimpei Miyamoto & Kunio Takaoka. (1999) New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers. Journal of Biomedical Materials Research 47:1, pages 104-110.
Crossref
B. D. Boyan, C. H. Lohmann, A. Somers, G. G. Niederauer, J. M. Wozney, D. D. Dean, D. L. Carnes & Z. Schwartz. (1999) Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinductionin vivo. Journal of Biomedical Materials Research 46:1, pages 51-59.
Crossref
Masatsugu Isobe, Yasuharu Yamazaki, Masahiro Mori & Teruo Amagasa. (1999) Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2. Journal of Oral and Maxillofacial Surgery 57:6, pages 695-698.
Crossref
K. Kawasaki, M. Aihara, J. Honmo, S. Sakurai, Y. Fujimaki, K. Sakamoto, E. Fujimaki, J.M. Wozney & A. Yamaguchi. (1998) Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin. Bone 23:3, pages 223-231.
Crossref
Eric E. Johnson & Marshall R. Urist. (1998) One-Stage Lengthening of Femoral Nonunion Augmented With Human Bone Morphogenetic Protein. Clinical Orthopaedics and Related Research 347, pages 105???116.
Crossref
Teruo ITOH, Manabu MOCHIZUKI, Kaoru FUDA, Ryohei NISHIMURA, Satoru MATSUNAGA, Tsuyoshi KADOSAWA & Nobuo SASAKI. (1998) Femoral Nonunion Fracture Treated with Recombinant Human Bone Morphogenetic Protein-2 in a Dog.. Journal of Veterinary Medical Science 60:4, pages 535-538.
Crossref
Teruo ITOH, Manabu MOCHIZUKI, Ryohei NISHIMURA, Satoru MATSUNAGA, Tsuyoshi KADOSAWA, Satoshi KOKUBO, Syoji YOKOTA & Nobuo SASAKI. (1998) Repair of Ulnar Segmental Defect by Recombinant Human Bone Morphogenetic Protein-2 in Dogs.. Journal of Veterinary Medical Science 60:4, pages 451-458.
Crossref
Kenneth P.H. Pritzker & Matt J. Kessler. 1998. Nonhuman Primates in Biomedical Research. Nonhuman Primates in Biomedical Research 415 459 .
John H. Brekke & Jeffrey M. Toth. (1998) Principles of tissue engineering applied to programmable osteogenesis. Journal of Biomedical Materials Research 43:4, pages 380-398.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.