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Original Article

BMP-2 can inhibit bone healing: Bone-chamber study in rabbits

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Pages 589-592 | Received 05 Feb 1996, Accepted 03 Sep 1996, Published online: 08 Jul 2009

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Read on this site (4)

Per Aspenberg. (2011) Under-reported complications related to BMP use in spine surgery. Acta Orthopaedica 82:5, pages 511-512.
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Per Aspenberg. (2005) Drugs and fracture repair. Acta Orthopaedica 76:6, pages 741-748.
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Charlotte Jeppsson, Mathias Bostrom & Per Aspenberg. (1999) Intraosseous BMP implants in rabbits Inhibitory effect on bone formation. Acta Orthopaedica Scandinavica 70:1, pages 77-83.
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Per Aspenberg & Carina Forslund. (1999) Enhanced tendon healing with GDF 5 and 6. Acta Orthopaedica Scandinavica 70:1, pages 51-54.
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Articles from other publishers (26)

Jietao Xu, Shorouk Fahmy-Garcia, Marinus A. Wesdorp, Nicole Kops, Lucia Forte, Claudio De Luca, Massimiliano Maraglino Misciagna, Laura Dolcini, Giuseppe Filardo, Margot Labberté, Karin Vancíková, Joeri Kok, Bert van Rietbergen, Joachim Nickel, Eric Farrell, Pieter A. J. Brama & Gerjo J. V. M. van Osch. (2023) Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair: In Vitro, Ex Vivo and In Vivo Evaluation. Journal of Functional Biomaterials 14:2, pages 111.
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Jing-Ying Chen, Ying-Sui Sun, Diem Thuy Nguyen, Chia-Fei Liu & Her-Hsiung Huang. (2022) Surface characterizations and cell growth of rough zirconia surfaces immobilized with different BMP-2 concentrations using natural crosslinker genipin. Materials & Design 223, pages 111216.
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Akihiro Mikai, Mitsuaki Ono, Ikue Tosa, Ha Thi Thu Nguyen, Emilio Satoshi Hara, Shuji Nosho, Aya Kimura-Ono, Kumiko Nawachi, Takeshi Takarada, Takuo Kuboki & Toshitaka Oohashi. (2020) BMP-2/β-TCP Local Delivery for Bone Regeneration in MRONJ-Like Mouse Model. International Journal of Molecular Sciences 21:19, pages 7028.
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Ha Thi Nguyen, Mitsuaki Ono, Yasutaka Oida, Emilio Satoshi Hara, Taishi Komori, Kentaro Akiyama, Ha Thi Thu Nguyen, Kyaw Thu Aung, Hai Thanh Pham, Ikue Tosa, Takeshi Takarada, Koichi Matsuo, Toshihide Mizoguchi, Toshitaka Oohashi & Takuo Kuboki. (2019) Bone Marrow Cells Inhibit BMP-2-Induced Osteoblast Activity in the Marrow Environment. Journal of Bone and Mineral Research 34:2, pages 327-332.
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Yan Bai, Guangfu Yin, Zhongbing Huang, Xiaoming Liao, Xianchun Chen, Yadong Yao & Ximing Pu. (2013) Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering. International Immunopharmacology 16:2, pages 214-223.
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Shin-Hee Jun, Eun-Jung Lee, Tae-Sik Jang, Hyoun-Ee Kim, Jun-Hyeog Jang & Young-Hag Koh. (2013) Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. Journal of Materials Science: Materials in Medicine 24:3, pages 773-782.
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Aaron W. James, Janette N. Zara, Xinli Zhang, Asal Askarinam, Raghav Goyal, Michael Chiang, Wei Yuan, Le Chang, Mirko Corselli, Jia Shen, Shen Pang, David Stoker, Ben Wu, Kang Ting, Bruno Péault & Chia Soo. (2012) Perivascular Stem Cells: A Prospectively Purified Mesenchymal Stem Cell Population for Bone Tissue Engineering. Stem Cells Translational Medicine 1:6, pages 510-519.
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Kristofer E. Chenard, Chad M. Teven, Tong-Chuan He & Russell R. Reid. (2012) Bone Morphogenetic Proteins in Craniofacial Surgery: Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy. Journal of Biomedicine and Biotechnology 2012, pages 1-14.
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Dominique Le Nen, Alain Fabre & Frédéric DubranaL. Obert, A. Couesmes, J. Pauchot, P. Garbuio & Y. Tropet. 2012. Réparations tissulaires à la jambe. Réparations tissulaires à la jambe 101 117 .
María D. Cuenca-López, José L. Peris, Mireia García-Roselló, Carlos Atienza, Jaime Prat, José Becerra & José A. Andrades. (2010) Action of recombinant human BMP-2 on fracture healing in rabbits is dependent on the mechanical environment. Journal of Tissue Engineering and Regenerative Medicine 4:7, pages 543-552.
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Steve Minear, Philipp Leucht, Samara Miller & Jill A Helms. (2010) rBMP represses Wnt signaling and influences skeletal progenitor cell fate specification during bone repair. Journal of Bone and Mineral Research 25:6, pages 1196-1207.
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Felicity R A J Rose, Qingpu Hou & Richard O C Oreffo. (2004) Delivery systems for bone growth factors — the new players in skeletal regeneration. Journal of Pharmacy and Pharmacology 56:4, pages 415-427.
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Z. L. Shi, P. H. Chua, K. G. Neoh, E. T. Kang & W. Wang. (2018) Bioactive Titanium Implant Surfaces with Bacterial Inhibition and Osteoblast Function Enhancement Properties. The International Journal of Artificial Organs 31:9, pages 777-785.
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Gerjon Hannink, Per Aspenberg, B Willem Schreurs & Pieter Buma. (2006) High Doses of OP-1 Inhibit Fibrous Tissue Ingrowth in Impaction Grafting. Clinical Orthopaedics and Related Research 452, pages 250-259.
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Jürgen Becker, Axel Kirsch, Frank Schwarz, Maria Chatzinikolaidou, Daniel Rothamel, Vojislav Lekovic & Herbert Peter Jennissen. (2006) Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs. Clinical Oral Investigations 10:3, pages 217-224.
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L. Obert, F. Deschaseaux & P. Garbuio. (2005) Critical analysis and efficacy of BMPs in long bones non-union. Injury 36:3, pages S38-S42.
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Nikitas Sykaras, Anthony M. Iacopino, Robert G. Triplett & Victoria A. Marker. (2004) Effect of recombinant human bone morphogenetic protein-2 on the osseointegration of dental implants: a biomechanics study. Clinical Oral Investigations 8:4, pages 196-205.
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Margaret A. McGee, David M. Findlay, Donald W. Howie, Angelo Carbone, Peter Ward, Roumen Stamenkov, Tara T. Page, Warrick J. Bruce, Corinna I. Wildenauer & Carol Toth. (2006) The use of OP‐1 in femoral impaction grafting in a sheep model. Journal of Orthopaedic Research 22:5, pages 1008-1015.
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Vera Luginbuehl, Lorenz Meinel, Hans P Merkle & Bruno Gander. (2004) Localized delivery of growth factors for bone repair. European Journal of Pharmaceutics and Biopharmaceutics 58:2, pages 197-208.
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D. R. Sumner, T. M. Turner, R. M. Urban, T. Turek, H. Seeherman & J. M. Wozney. (2006) Locally delivered rhBMP‐2 enhances bone ingrowth and gap healing in a canine model. Journal of Orthopaedic Research 22:1, pages 58-65.
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M. Wiemann, H. P. Jennissen, H. Rumpf, L. Winkler, M. Chatzinikolaidou, I. Schmitz & D. Bingmann. (2002) A reporter‐cell assay for the detection of BMP‐2 immobilized on porous and nonporous materials. Journal of Biomedical Materials Research 62:1, pages 119-127.
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P.B Malafaya, G.A Silva, E.T Baran & R.L Reis. (2002) Drug delivery therapies I. Current Opinion in Solid State and Materials Science 6:4, pages 283-295.
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S. Kujala, T. Raatikainen, J. Ryhänen, O. Kaarela & P. Jalovaara. (2016) Composite Implant of Native Bovine Bone Morphogenetic Protein (BMP) and Biocoral in the Treatment of Scaphoid Nonunions — A Preliminary Study. Scandinavian Journal of Surgery 91:2, pages 186-190.
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Nikitas Sykaras, Robert G. Triplett, Martha E. Nunn, Anthony M. Iacopino & Lynne A. Opperman. (2001) Effect of recombinant human bone morphogenetic protein‐2 on bone regeneration and osseointegration of dental implants. Clinical Oral Implants Research 12:4, pages 339-349.
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Robert L. Vonau, Mathias P. G. Bostrom, Per Aspenberg & Andrew E. Sams. (2001) Combination of Growth Factors Inhibits Bone Ingrowth in the Bone Harvest Chamber. Clinical Orthopaedics and Related Research 386, pages 243-251.
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John H. Brekke & Jeffrey M. Toth. (1998) Principles of tissue engineering applied to programmable osteogenesis. Journal of Biomedical Materials Research 43:4, pages 380-398.
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