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Amyotrophic Lateral Sclerosis Volume 11, 2010 - Issue 1-2
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Original Article

Combined structural and neurochemical evaluation of the corticospinal tract in amyotrophic lateral sclerosis

Timothy Pyra The Faculty of Medicine and Dentistry,
,
Benjamin Hui The Division of Neurology, Department of Medicine, University of Toronto,
,
Chris Hanstock Department of Biomedical Engineering, The University of Alberta,
,
Luis Concha Department of Biomedical Engineering, The University of Alberta,
,
John C.T. Wong The Department of Medicine, University of British Columbia,
,
Christian Beaulieu Department of Biomedical Engineering, The University of Alberta,
,
Wendy Johnston Division of Neurology, Department of Medicine,
&
Sanjay Kalra Division of Neurology, Department of Medicine,; Department of Biomedical Engineering, The University of Alberta,Correspondence[email protected]
 show all
Pages 157-165 | Received 18 Nov 2008, Accepted 16 Jan 2009, Published online: 26 Feb 2010

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Arens Taga & Nicholas J. Maragakis. (2018) Current and emerging ALS biomarkers: utility and potential in clinical trials. Expert Review of Neurotherapeutics 18:11, pages 871-886.
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Federica Agosta, Edoardo Gioele Spinelli & Massimo Filippi. (2018) Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses. Expert Review of Neurotherapeutics 18:5, pages 395-406.
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Thomas M. Jenkins, Christine Burness, Daniel J. Connolly, D. Ganesh Rao, Nigel Hoggard, Susan Mawson, Christopher J. McDermott, Iain D. Wilkinson & Pamela J. Shaw. (2013) A prospective pilot study measuring muscle volumetric change in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:5-6, pages 414-423.
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Daniel Ta, Abdullah IshaqueOjas SrivastavaChris HanstockPeter SeresDean T. EurichCollin LukHannah BriembergRichard Frayne, Angela L. GengeSimon J. GrahamLawrence KorngutLorne ZinmanSanjay Kalra. (2021) Progressive Neurochemical Abnormalities in Cognitive and Motor Subgroups of Amyotrophic Lateral Sclerosis. Neurology 97:8.
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Zhuozhi Dai, Sanjay Kalra, Dennell Mah, Peter Seres, Hongfu Sun, Renhua Wu & Alan H. Wilman. (2020) Amide signal intensities may be reduced in the motor cortex and the corticospinal tract of ALS patients. European Radiology 31:3, pages 1401-1409.
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Ovidiu C. Andronesi, Katharine Nicholson, Kourosh Jafari-Khouzani, Wolfgang Bogner, Jing Wang, James Chan, Eric A. Macklin, Mark Levine-Weinberg, Christopher Breen, Michael A. Schwarzschild, Merit Cudkowicz, Bruce R. Rosen, Sabrina Paganoni & Eva-Maria Ratai. (2020) Imaging Neurochemistry and Brain Structure Tracks Clinical Decline and Mechanisms of ALS in Patients. Frontiers in Neurology 11.
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Suvi Häkkinen, Stephanie A. Chu & Suzee E. Lee. (2020) Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis. Neurobiology of Disease 145, pages 105063.
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Foteini Christidi, Efstratios Karavasilis, Michail Rentzos, Georgios Velonakis, Vasiliki Zouvelou, Sofia Xirou, Georgios Argyropoulos, Ioannis Papatriantafyllou, Varvara Pantolewn, Panagiotis Ferentinos, Nikolaos Kelekis, Ioannis Seimenis, Ioannis Evdokimidis & Peter Bede. (2019) Hippocampal pathology in amyotrophic lateral sclerosis: selective vulnerability of subfields and their associated projections. Neurobiology of Aging 84, pages 178-188.
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Sanjay Kalra. (2019) Magnetic Resonance Spectroscopy in ALS. Frontiers in Neurology 10.
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Nick S. Verber, Stephanie R. Shepheard, Matilde Sassani, Harry E. McDonough, Sophie A. Moore, James J. P. Alix, Iain D. Wilkinson, Tom M. Jenkins & Pamela J. Shaw. (2019) Biomarkers in Motor Neuron Disease: A State of the Art Review. Frontiers in Neurology 10.
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I. S. Bakulin, A. V. Chervyakov, E. I. Kremneva, R. N. Konovalov & M. N. Zakharova. (2019) Structural and Functional Neuroimaging in Amyotrophic Lateral Sclerosis. Human Physiology 44:8, pages 844-854.
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Foteini Christidi, Efstratios Karavasilis, Michail Rentzos, Nikolaos Kelekis, Ioannis Evdokimidis & Peter Bede. (2018) Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis. Frontiers in Neurology 9.
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Abdullah Ishaque, Dennell Mah, Peter Seres, Collin Luk, Dean Eurich, Wendy Johnston, Yee-Hong Yang & Sanjay Kalra. (2018) Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology 5:11, pages 1350-1361.
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Miguel Mazón, Juan Francisco Vázquez Costa, Amadeo Ten-Esteve & Luis Martí-Bonmatí. (2018) Imaging Biomarkers for the Diagnosis and Prognosis of Neurodegenerative Diseases. The Example of Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience 12.
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Julio Acosta-Cabronero, Judith Machts, Stefanie Schreiber, Susanne Abdulla, Katja Kollewe, Susanne Petri, Nicola Spotorno, Joern Kaufmann, Hans-Jochen Heinze, Reinhard Dengler, Stefan Vielhaber & Peter J. Nestor. (2018) Quantitative Susceptibility MRI to Detect Brain Iron in Amyotrophic Lateral Sclerosis. Radiology 289:1, pages 195-203.
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Mohamad J. AlshikhoNicole R. ZürcherMarco L. LoggiaPaul CernasovDaniel B. ChondeDavid Izquierdo GarciaJulia E. YasekOluwaseun AkejuCiprian CatanaBruce R. RosenMerit E. CudkowiczJacob M. HookerNazem Atassi. (2016) Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis. Neurology 87:24, pages 2554-2561.
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G. Grolez, C. Moreau, V. Danel-Brunaud, C. Delmaire, R. Lopes, P. F. Pradat, M. M. El Mendili, L. Defebvre & D. Devos. (2016) The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review. BMC Neurology 16:1.
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Tima R Stuchevskaya, Dmitriy I Rudenko, Valery M Kazakov, Olga F Pozdnyakova, Alexandr V Pozdnyakov, Alexandr A Skoromets & Leonid A Tyutin. (2016) Signs of MRI affection of brain in сlassical Amyotrophic Lateral Sclerosis patients. Pediatrician (St. Petersburg) 7:2, pages 69-78.
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Chaoyang Zhou, Xiaofei Hu, Jun Hu, Minglong Liang, Xuntao Yin, Lin Chen, Jiuquan Zhang & Jian Wang. (2016) Altered Brain Network in Amyotrophic Lateral Sclerosis: A Resting Graph Theory-Based Network Study at Voxel-Wise Level. Frontiers in Neuroscience 10.
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Rouzbeh Maani, Yee-Hong Yang, Derek Emery & Sanjay Kalra. (2016) Cerebral Degeneration in Amyotrophic Lateral Sclerosis Revealed by 3-Dimensional Texture Analysis. Frontiers in Neuroscience 10.
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Akash P. Kansagra, John-Paul J. Yu, Arindam R. Chatterjee, Leon Lenchik, Daniel S. Chow, Adam B. Prater, Jean Yeh, Ankur M. Doshi, C. Matthew Hawkins, Marta E. Heilbrun, Stacy E. Smith, Martin Oselkin, Pushpender Gupta & Sayed Ali. (2016) Big Data and the Future of Radiology Informatics. Academic Radiology 23:1, pages 30-42.
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Varan Govind. 2016. Magnetic Resonance Spectroscopy of Degenerative Brain Diseases. Magnetic Resonance Spectroscopy of Degenerative Brain Diseases 121 150 .
Esther Verstraete & Bradley R. Foerster. (2015) Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 403-416.
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N. Weiduschat, X. Mao, J. Hupf, N. Armstrong, G. Kang, D.J. Lange, H. Mitsumoto & D.C. Shungu. (2014) Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique. Neuroscience Letters 570, pages 102-107.
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Bradley R. Foerster, Ruth C. Carlos, Ben A. Dwamena, Brian C. Callaghan, Myria Petrou, Richard A. E. Edden, Mona A. Mohamed, Robert C. Welsh, Peter B. Barker, Eva L. Feldman & Martin G. Pomper. (2014) Multimodal MRI as a diagnostic biomarker for amyotrophic lateral sclerosis . Annals of Clinical and Translational Neurology 1:2, pages 107-114.
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Xenia Kobeleva & Susanne Petri. (2013) Barriers to novel therapeutics in amyotrophic lateral sclerosis. Neurodegenerative Disease Management 3:6, pages 525-537.
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Aleksandar Ignjatović, Zorica Stević, Slobodan Lavrnić, Marko Daković & Goran Bačić. (2013) Brain iron MRI: A biomarker for amyotrophic lateral sclerosis. Journal of Magnetic Resonance Imaging 38:6, pages 1472-1479.
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Bradley R. Foerster, Robert C. Welsh & Eva L. Feldman. (2013) 25 years of neuroimaging in amyotrophic lateral sclerosis. Nature Reviews Neurology 9:9, pages 513-524.
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Jasna Furtula, Birger Johnsen, Jesper Frandsen, Anders Rodell, Peter Broegger Christensen, Kirsten Pugdahl & Anders Fuglsang-Frederiksen. (2013) Upper motor neuron involvement in amyotrophic lateral sclerosis evaluated by triple stimulation technique and diffusion tensor MRI. Journal of Neurology 260:6, pages 1535-1544.
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Alok Kumar, Devlina Ghosh & R. L. Singh. (2013) Amyotrophic Lateral Sclerosis and Metabolomics: Clinical Implication and Therapeutic Approach. Journal of Biomarkers 2013, pages 1-15.
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Justin Y. Kwan, Avner Meoded, Laura E. Danielian, Tianxia Wu & Mary Kay Floeter. (2013) Structural imaging differences and longitudinal changes in primary lateral sclerosis and amyotrophic lateral sclerosis. NeuroImage: Clinical 2, pages 151-160.
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Bradley R. Foerster, Ben A. Dwamena, Myria Petrou, Ruth C. Carlos, Brian C. Callaghan & Martin G. Pomper. (2012) Diagnostic Accuracy Using Diffusion Tensor Imaging in the Diagnosis of ALS. Academic Radiology 19:9, pages 1075-1086.
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Martin R TurnerFederica Agosta, Peter Bede, Varan Govind, Dorothée Lulé & Esther Verstraete. (2012) Neuroimaging in amyotrophic lateral sclerosis. Biomarkers in Medicine 6:3, pages 319-337.
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Varan Govind, Khema R. Sharma, Andrew A. Maudsley, Kristopher L. Arheart, Gaurav Saigal & Sulaiman Sheriff. (2012) Comprehensive Evaluation of Corticospinal Tract Metabolites in Amyotrophic Lateral Sclerosis Using Whole-Brain 1H MR Spectroscopy. PLoS ONE 7:4, pages e35607.
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M. Filippi, F. Agosta, S. Abrahams, F. Fazekas, J. Grosskreutz, S. Kalra, J. Kassubek, V. Silani, M. R. Turner & J. C. Masdeu. 2011. European Handbook of Neurological Management. European Handbook of Neurological Management 199 211 .
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N. Sudharshan, C. Hanstock, B. Hui, T. Pyra, W. Johnston & S. Kalra. (2011) Degeneration of the Mid-Cingulate Cortex in Amyotrophic Lateral Sclerosis Detected In Vivo with MR Spectroscopy. American Journal of Neuroradiology 32:2, pages 403-407.
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Sumei Wang, Elias R. Melhem, Harish Poptani & John H. Woo. (2011) Neuroimaging in Amyotrophic Lateral Sclerosis. Neurotherapeutics 8:1, pages 63-71.
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F. Agosta, A. Chiò, M. Cosottini, N. De Stefano, A. Falini, M. Mascalchi, M.A. Rocca, V. Silani, G. Tedeschi & M. Filippi. (2010) The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis. American Journal of Neuroradiology 31:10, pages 1769-1777.
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