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Amyotrophic Lateral Sclerosis Volume 11, 2010 - Issue 3

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ORIGINAL ARTICLE

TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread

Aaron Bodansky Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA

Jae Mun ‘Hugo’ Kim Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA

Lynne Tempest Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA

Amit Velagapudi Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA

Ryan Libby Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA

John Ravits Translational Research Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USACorrespondence[email protected]

Pages 321-327 | Received 26 Oct 2009, Accepted 04 Jan 2010, Published online: 12 Mar 2010

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https://doi.org/10.3109/17482961003602363

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Lindsey R. Hayes & Petr Kalab. (2022) Emerging Therapies and Novel Targets for TDP-43 Proteinopathy in ALS/FTD. Neurotherapeutics 19:4, pages 1061-1084.
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Katarina Milicevic, Branislava Rankovic, Pavle R. Andjus, Danijela Bataveljic & Dragomir Milovanovic. (2022) Emerging Roles for Phase Separation of RNA-Binding Proteins in Cellular Pathology of ALS. Frontiers in Cell and Developmental Biology 10.
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Manoj Kumar Jaiswal. 2022. TDP-43 and Neurodegeneration. TDP-43 and Neurodegeneration 1 26 .

Piero Andrea Temussi, Gian Gaetano Tartaglia & Annalisa Pastore. (2021) The seesaw between normal function and protein aggregation: How functional interactions may increase protein solubility. BioEssays 43:6, pages 2100031.
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Juliana Ferreira Vasques, Rosalia Mendez-Otero & Fernanda Gubert. (2020) Modeling ALS using iPSCs: is it possible to reproduce the phenotypic variations observed in patients in vitro ? . Regenerative Medicine 15:7, pages 1919-1933.
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Ginevra Begani Provinciali, Nicola Pieroni, Inna Bukreeva, Michela Fratini, Lorenzo Massimi, Laura Maugeri, Francesca Palermo, Fabrizio Bardelli, Alberto Mittone, Alberto Bravin, Giuseppe Gigli, Francesco Gentile, Andrea Fossaghi, Nilo Riva, Angelo Quattrini & Alessia Cedola. (2020) X-ray phase contrast tomography for the investigation of amyotrophic lateral sclerosis. Journal of Synchrotron Radiation 27:4, pages 1042-1048.
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Haley Yost, Riya Patel, Anders Kipp & Tanea T. Reed. 2005. Bailey's Industrial Oil and Fat Products. Bailey's Industrial Oil and Fat Products 1 29 .

Yevgeniya A. Abramzon, Pietro Fratta, Bryan J. Traynor & Ruth Chia. (2020) The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Frontiers in Neuroscience 14.
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Britt A. Berning & Adam K. Walker. (2019) The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD. Frontiers in Neuroscience 13.
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Martin Madill, Katya McDonagh, Jun Ma, Alice Vajda, Paul McLoughlin, Timothy O?Brien, Orla Hardiman & Sanbing Shen. (2017) Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms. Molecular Brain 10:1.
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S. Shellikeri, V. Karthikeyan, R. Martino, S.E. Black, L. Zinman, J. Keith & Y. Yunusova. (2017) The neuropathological signature of bulbar-onset ALS: A systematic review. Neuroscience & Biobehavioral Reviews 75, pages 378-392.
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Matthew F. Burkhardt, Fernando J. Martinez, Sarah Wright, Carla Ramos, Dmitri Volfson, Michael Mason, Jeff Garnes, Vu Dang, Jeffery Lievers, Uzma Shoukat-Mumtaz, Rita Martinez, Hui Gai, Robert Blake, Eugeni Vaisberg, Marica Grskovic, Charles Johnson, Stefan Irion, Jessica Bright, Bonnie Cooper, Leane Nguyen, Irene Griswold-Prenner & Ashkan Javaherian. (2013) A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells. Molecular and Cellular Neuroscience 56, pages 355-364.
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Clotilde Lagier-Tourenne, Magdalini Polymenidou, Kasey R Hutt, Anthony Q Vu, Michael Baughn, Stephanie C Huelga, Kevin M Clutario, Shuo-Chien Ling, Tiffany Y Liang, Curt Mazur, Edward Wancewicz, Aneeza S Kim, Andy Watt, Sue Freier, Geoffrey G Hicks, John Paul Donohue, Lily Shiue, C Frank Bennett, John Ravits, Don W Cleveland & Gene W Yeo. (2012) Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nature Neuroscience 15:11, pages 1488-1497.
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Iqbal El-Assaad, Jeremy A. Bari, Koji Yasuda, Thomas J. Divers, Brian A. Summers, Alexander Lahunta & Hussni Mohammed. (2012) Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker. Veterinary Research Communications.
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Magdalini Polymenidou, Clotilde Lagier-Tourenne, Kasey R. Hutt, C. Frank Bennett, Don W. Cleveland & Gene W. Yeo. (2012) Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Research 1462, pages 3-15.
Crossref

Jean-Luc C Mougeot, Zhen Li, Andrea E Price, Fred A Wright & Benjamin R Brooks. (2011) Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway. BMC Medical Genomics 4:1.
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Petra Steinacker, Lubin Fang, Jens Kuhle, Axel Petzold, Hayrettin Tumani, Albert C. Ludolph, Markus Otto & Johannes Brettschneider. (2011) Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis. PLoS ONE 6:8, pages e23600.
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Nicole F. Liachko, Chris R. Guthrie & Brian C. Kraemer. (2010) Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy . The Journal of Neuroscience 30:48, pages 16208-16219.
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Ian RA Mackenzie, Rosa Rademakers & Manuela Neumann. (2010) TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. The Lancet Neurology 9:10, pages 995-1007.
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TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread

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TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread

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