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Journal of Dietary Supplements Volume 7, 2010 - Issue 4
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Research Article

The Anti-Inflammatory and Antinociceptive Properties of the Chloroform Fraction From Phyllanthus niruri Plant Is Mediated via the Peripheral Nervous System

Ifeoma Chinwude Obidike Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.Correspondence[email protected]
, MPharm,
Oluwakanyinsola Adeola Salawu Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
,
Mary Ndukuba Ifeoma Chinwude Obidike, Oluwakanyinsola Adeola Salawu, and Mary Ndukuba are affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
,
Charles Ogbonnaya Okoli Charles Ogbonnaya Okoli is affiliated with the Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu, Nigeria.
&
Uche Alex Osunkwo Uche Alex Osunkwo is affiliated with the Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria.
Pages 341-350 | Published online: 11 Oct 2010

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Oluwaseun Ruth Alara, Nour Hamid Abdurahman, Moses Oludayo Tade & Hassan Alsaggaf Ali. (2022) Thermodynamics and kinetic studies for the microwave-enhanced extraction of phenolics from Phyllanthus niruri leaves. Chemical Engineering Communications 0:0, pages 1-9.
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Maliheh Safavi, Mohammadreza Shams-Ardakani & Alireza Foroumadi. (2015) Medicinal plants in the treatment of Helicobacter pylori infections. Pharmaceutical Biology 53:7, pages 939-960.
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Thapanee Roengrit, Panakaporn Wannanon, Piyapong Prasertsri, Yupaporn Kanpetta, Bung-orn Sripanidkulchai & Naruemon Leelayuwat. (2014) Antioxidant and anti-nociceptive effects of Phyllanthus amarus on improving exercise recovery in sedentary men: a randomized crossover (double-blind) design. Journal of the International Society of Sports Nutrition 11:1.
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C. O. Okoli, A. C. Nwezza & A. C. Ezike. (2014) Extracts of Phyllanthus niruri Aerial Parts Suppress Acute and Chronic Inflammation in Murine Models. Journal of Herbs, Spices & Medicinal Plants 20:3, pages 256-268.
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Articles from other publishers (10)

Muhammad Radzi Abu Hassan, Rosaida Hj Md Said, Zalwani Zainuddin, Haniza Omar, Siti Maisarah Md Ali, Siti Aishah Aris & Huan-Keat Chan. (2023) Effects of one-year supplementation with Phyllanthus niruri on fibrosis score and metabolic markers in patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. Heliyon 9:6, pages e16652.
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Manish V. Patel, Mansi M. Patel, Kalapi B. Patel, Pankaj V. Chhayani, Martin Mittwede, Daniel Scheidbach & Shivenarain N. Gupta. (2022) A randomized placebo-compared study on the efficacy of classical ayurvedic pharmaceutical form versus aqueous alcoholic extracts of Phyllanthus niruri Linn. Plus Sida cordifolia Linn. in patients of diabetic sensory polyneuropathy. Journal of Ayurveda and Integrative Medicine 13:3, pages 100619.
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Verônyca Gonçalves Paula, Larissa Lopes Cruz, Letícia Barros Sene, Thamires Ballarini Gratão, Thaigra Sousa Soares, Rafaianne Queiroz Moraes-Souza, Débora Cristina Damasceno & Gustavo Tadeu Volpato. (2020) Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy. Journal of Ethnopharmacology 254, pages 112728.
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Patrick Amoateng, Emmanuel Quansah, Thomas K. Karikari, Alex Asase, Dorcas Osei-Safo, Kennedy Kwami Edem Kukuia, Isaac Kingsley Amponsah & Alexander K. Nyarko. (2018) Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana. Evidence-Based Complementary and Alternative Medicine 2018, pages 1-14.
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Chinyere Benardette Chinaka Ikpa, U.C. Okoro, Collins I. Ubochi, Kieran O. Nwanorh & Samuel O. Onoja. (2016) Preliminary Screening for Anti-Inflammatory, Anti-Nociceptive and Antioxidant Activities of Five New Synthesized Paratoluene Sulphonamide Derivatives of Amino Acids. International Journal of Pharmacology, Phytochemistry and Ethnomedicine 5, pages 74-78.
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Rafael C. Dutra, Maria M. Campos, Adair R.S. Santos & João B. Calixto. (2016) Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacological Research 112, pages 4-29.
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Nathanael Y S Lee, William K S Khoo, Mohammad Akmal Adnan, Tanes Prasat Mahalingam, Anne R Fernandez & Kamalan Jeevaratnam. (2016) The pharmacological potential of Phyllanthus niruri . Journal of Pharmacy and Pharmacology 68:8, pages 953-969.
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Ezenyi Ifeoma Chinwude, Kulkarni Roshan, Joshi Swati, Salawu Oluwakanyinsola Adeola & Emeje Martins. (2014) Identification of sitosteryl glucoside palmitate in a chloroform-derived fraction of Phyllanthus niruri with antiplasmodial and peripheral antinociceptive properties. Asian Pacific Journal of Tropical Biomedicine 4:9, pages 707-713.
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Nelli Giribabu, Pasupuleti Visweswara Rao, Korla Praveen Kumar, Sekaran Muniandy, Somesula Swapna Rekha & Naguib Salleh. (2014) Aqueous Extract of Phyllanthus niruri Leaves Displays In Vitro Antioxidant Activity and Prevents the Elevation of Oxidative Stress in the Kidney of Streptozotocin-Induced Diabetic Male Rats . Evidence-Based Complementary and Alternative Medicine 2014, pages 1-10.
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Jeverson Moreira, Luiz Carlos Klein-Júnior, Valdir Cechinel Filho & Fátima de Campos Buzzi. (2013) Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae). Journal of Ethnopharmacology 146:1, pages 318-323.
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