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RESEARCH ARTICLE

Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement

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Pages 270-280 | Received 28 Oct 2012, Accepted 13 Feb 2013, Published online: 10 May 2013

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Muhmmad Nadeem Akhtar, Rabia Saeed, Farhan Saeed, Aasma Asghar, Samia Ghani, Huda Ateeq, Aftab Ahmed, Amara Rasheed, Muhammad Afzaal, Marwa Waheed, Bilal Hussain & Mohd Asif Shah. (2023) Silymarin: a review on paving the way towards promising pharmacological agent. International Journal of Food Properties 26:1, pages 2256-2272.
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Articles from other publishers (28)

Anirban Goutam Mukherjee & Abilash Valsala Gopalakrishnan. (2023) The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review. Ecotoxicology and Environmental Safety 252, pages 114614.
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Marek Szymański, Piotr Domaracki, Angelika Szymańska, Tomasz Wandtke, Robert Szyca, Łukasz Brycht, Karolina Wasilow & Wojciech Jan Skorupski. (2022) The Role and Place of Antioxidants in the Treatment of Male Infertility Caused by Varicocele. Journal of Clinical Medicine 11:21, pages 6391.
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Hissah Ahmed Alturki, Hany Amin Elsawy & Ademola Clement Famurewa. (2022) Silymarin abrogates acrylamide‐induced oxidative stress‐mediated testicular toxicity via modulation of antioxidant mechanism, DNA damage, endocrine deficit and sperm quality in rats . Andrologia 54:9.
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Tahereh Etemadi, Hamid Reza Momeni, Niloufar Darbandi & Mohammad Hussein Abnosi. (2022) Silymarin modulates cadmium‐induced oxidative stress in human spermatozoa. Andrologia 54:8.
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Essa Daham. JalloobRusul HeiderAbdulamir A. Al ZahidIman Jawad. JaberAdnan Mansour. JasimMohsin MohsinRawaa RawaaKareem KareemAmeer Ridha. DirwalDheyaa Ali.Neamah. (2022) Characterization and Synthesis of Milk Thistle Nanoparticles to overcome Oxidative Stress Induce Testicular damage in male rats. Research Journal of Pharmacy and Technology, pages 1664-1670.
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Amina Talbi, Kamel Khelili, Feriel Remita & Cherif Abdennour. (2022) The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat. Brazilian Journal of Pharmaceutical Sciences 58.
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Samaneh Akbar Gharehbagh, Javad Tolouei Azar & Mazdak Razi. (2021) ROS and metabolomics-mediated autophagy in rat's testicular tissue alter after exercise training; Evidence for exercise intensity and outcomes. Life Sciences 277, pages 119585.
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Mahsa Aeeni, Mazdak Razi, Alireza Alizadeh & Arash Alizadeh. (2021) The molecular mechanism behind insulin protective effects on testicular tissue of hyperglycemic rats. Life Sciences 277, pages 119394.
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Poupak Soudmand, Asghar Tofighi, Javad Tolouei Azar, Mazdak Razi & Firouz Ghaderi Pakdel. (2021) Different continuous exercise training intensities induced effect on sertoli-germ cells metabolic interaction; implication on GLUT-1, GLUT-3 and MCT-4 transporting proteins expression level. Gene 783, pages 145553.
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Mazdak Razi, Marziyeh Tavalaee, Farshid Sarrafzadeh‐Rezaei, Aron Moazamian, Parviz Gharagozloo, Joël R. Drevet & Mohammad‐Hossein Nasr‐Eshafani. (2020) Varicocoele and oxidative stress: New perspectives from animal and human studies. Andrology 9:2, pages 546-558.
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Tahereh Etemadi, Hamid Reza Momeni & Ali Asghar Ghafarizadeh. (2020) Impact of silymarin on cadmium‐induced apoptosis in human spermatozoa. Andrologia 52:11.
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Rozita Azarniad, Mazdak Razi, Shapour Hasanzadeh & Hassan Malekinejad. (2020) Experimental diabetes negatively affects the spermatogonial stem cells’ self‐renewal by suppressing GDNF network interactions. Andrologia 52:9.
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Hajar Oghbaei, Gholamreza Hamidian, Mohammad Reza Alipour, Shahriar Alipour & Rana Keyhanmanesh. (2020) The effect of prolonged dietary sodium nitrate treatment on the hypothalamus-pituitary-gonadal axis and testicular structure and function in streptozotocin-induced diabetic male rats. Food & Function 11:3, pages 2451-2465.
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Hamed Rezaei‐Agdam, Sana Moshari, Elaheh Nahari, Aram Minas, Zeynab Daliri, Mahsa Hallaj & Mazdak Razi. (2019) Zeta and hyaluronic acid assessments, novel sperm selection procedures, in animal model for male infertility. Andrologia 51:11.
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Karna, Choi, Kim, Kim & Park. (2019) The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat. International Journal of Molecular Sciences 20:22, pages 5785.
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Hamed Najaran, Hassan Hassani Bafrani, Hamid Rashtbari, Fatemeh Izadpanah, Mohammad Reza Rajabi, Hamed Haddad Kashani & Abouzar Mohammadi. (2019) Evaluation of the serum sex hormones levels and alkaline phosphatase activity in rats’ testis after administering of berberine in experimental varicocele. Oriental Pharmacy and Experimental Medicine 19:2, pages 157-165.
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Hassan Hassani-Bafrani, Hamed Najaran, Mazdak Razi & Hamid Rashtbari. (2019) Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation. Andrologia 51:2, pages e13179.
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Hajar Oghbaei, Mohammad Reza Alipour, Gholamreza Hamidian, Mahdi Ahmadi, Vajihe Ghorbanzadeh & Rana Keyhanmanesh. (2018) Two months sodium nitrate supplementation alleviates testicular injury in streptozotocin-induced diabetic male rats. Experimental Physiology 103:12, pages 1603-1617.
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Sheyda Jouhari, Afsaneh Mohammadzadeh, Haleh Soltanghoraee, Zohreh Mohammadi, Shaheen Khazali, Ebrahim Mirzadegan, Niknam Lakpour, Farnaz Fatemi, Simin Zafardoust, Arash Mohazzab & Mohammad Mehdi Naderi. (2018) Effects of silymarin, cabergoline and letrozole on rat model of endometriosis. Taiwanese Journal of Obstetrics and Gynecology 57:6, pages 830-835.
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Turan Yaman, Ahmet Uyar, Mehmet Salih Kaya, Ömer Faruk Keles, Baris Atalay Uslu & Zabit Yener. (2018) Protective effects of silymarin on methotrexate-induced damages in rat testes. Brazilian Journal of Pharmaceutical Sciences 54:1.
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Sara Mazhari, Mazdak Razi & Rajabali Sadrkhanlou. (2018) Silymarin and celecoxib ameliorate experimental varicocele-induced pathogenesis: evidences for oxidative stress and inflammation inhibition. International Urology and Nephrology 50:6, pages 1039-1052.
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M. Amin, M. Razi, F. Sarrafzadeh-Rezaei, A. Shalizar Jalali & G. Najafi. (2018) Berberine inhibits experimental varicocele-induced cell cycle arrest via regulating cyclin D1, cdk4 and p21 proteins expression in rat testicles. Andrologia 50:4, pages e12984.
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Hamid Rashtbari, Mazdak Razi, Hassan Hassani-Bafrani & Hamed Najaran. (2018) Berberine reinforces Sertoli cells niche and accelerates spermatogonial stem cells renewal in experimentally-induced varicocele condition in rats. Phytomedicine 40, pages 68-78.
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Youssef A. Attia, Rawia S. Hamed, Fulvia Bovera, Abd El-Hamid E. Abd El-Hamid, Mohammed A. Al-Harthi & Hossam A. Shahba. (2017) Semen quality, antioxidant status and reproductive performance of rabbits bucks fed milk thistle seeds and rosemary leaves. Animal Reproduction Science 184, pages 178-186.
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S. Gholirad, M. Razi & H. Hassani Bafrani. (2017) Tracing of zinc and iron in experimentally induced varicocele: correlation with oxidative, nitrosative and carbonyl stress. Andrologia 49:6, pages e12687.
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Yanwu Jin, Xin Zhao, He Zhang, Qingsong Li, Guodong Lu & Xiaogang Zhao. (2016) Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury. Experimental and Therapeutic Medicine 12:2, pages 1135-1140.
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Hajar Khosravanian, Mazdak Razi, Farah Farokhi & Narges Khosravanian. (2015) Simultaneous Administration of Dexamethasone and Vitamin E Reversed Experimental Varicocele-induced Impact in testicular tissue in Rats; Correlation with Hsp70-2 Chaperone Expression. International braz j urol 41:4, pages 773-790.
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Narges Khosravanian, Mazdak Razi, Farah Farokhi & Hajar Khosravanian. (2014) Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp70-2 protein expression and ameliorated biochemical alterations. Journal of Assisted Reproduction and Genetics 31:3, pages 341-354.
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