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Systems Biology in Reproductive Medicine Volume 60, 2014 - Issue 2
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RESEARCH COMMUNICATIONS

Concentration-dependent Sildenafil citrate (Viagra) effects on ROS production, energy status, and human sperm function

Maria Inês SousaBiology of Reproduction and Stem Cell Group, CNC-Center for Neuroscience and Cell Biology, University of Coimbra;Department of Life Sciences, University of Coimbra
,
Sandra AmaralBiology of Reproduction and Stem Cell Group, CNC-Center for Neuroscience and Cell Biology, University of Coimbra
,
Renata Santos TavaresBiology of Reproduction and Stem Cell Group, CNC-Center for Neuroscience and Cell Biology, University of Coimbra;Department of Life Sciences, University of Coimbra
,
Carla PaivaBiology of Reproduction and Stem Cell Group, CNC-Center for Neuroscience and Cell Biology, University of Coimbra;PhD Programme in Experimental Biology and Biomedicine, CNC-Center for Neuroscience and Cell Biology, University of Coimbra;Institute for Interdisciplinary Research (IIIUC), University of Coimbra CoimbraPortugal
&
João Ramalho-SantosBiology of Reproduction and Stem Cell Group, CNC-Center for Neuroscience and Cell Biology, University of Coimbra;Department of Life Sciences, University of CoimbraCorrespondence[email protected]
Pages 72-79 | Received 29 May 2013, Accepted 27 Sep 2013, Published online: 18 Dec 2013

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Anne A. Adeyanju, Omolola R. Oyenihi, Oluwafemi O. Oguntibeju & Oreoluwa Ojomu. (2023) Sildenafil aggravates adriamycin-induced testicular toxicity in rats; a preliminary investigation. Drug and Chemical Toxicology 46:2, pages 219-225.
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Articles from other publishers (15)

Ibrahim M. Ibrahim Laila, Samar HassabAllah Kassem & Marwa Salah ElDin Mohamed Diab. (2023) Ameliorative effect of hesperidin against high dose sildenafil-induced liver and testicular oxidative stress and altered gene expression in male rats. Laboratory Animal Research 39:1.
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Taymour Mostafa, Moheiddin Alghobary, Noha S Hanafy & Ahmed Abosief. (2023) Oral phosphodiesterase type 5 inhibitors and male reproductive potential: an overview. Sexual Medicine Reviews 11:3, pages 240-252.
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Sara Escada-RebeloMaria Inês CristoJoão Ramalho-Santos & Sandra Amaral. (2022) Mitochondria-Targeted Compounds to Assess and Improve Human Sperm Function. Antioxidants & Redox Signaling 37:7-9, pages 451-480.
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Sawsan M.A. El‐Sheikh, Naglaa Z. Eleiwa, Ghada M. Khairy, Reda M. Abd El‐Aziz, Mohamed M.M. Metwally & Azza A.A. Galal. (2021) Comparative effect of administration and discontinuation of sildenafil and/or clomipramine on the hepatic, cardiac and testicular tissues of male rats. Andrologia 53:4.
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Renata S. Tavares, Sara Escada-Rebelo, Maria M. Soares, Andreia F. Silva, Teresa Almeida-Santos, Sandra Amaral, Ana Paula Sousa & João Ramalho-Santos. 2021. Mitochondrial Regulation. Mitochondrial Regulation 57 68 .
Athira Johnson, Shu-Chun Cheng, David Tsou & Zwe-Ling Kong. (2019) Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract. Biomedicine & Pharmacotherapy 112, pages 108684.
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Nagarajan Laleethambika, Venugopal Anila, Chandran Manojkumar, Ishvarya Muruganandam, Bupesh Giridharan, Thangarasu Ravimanickam & Vellingiri Balachandar. (2018) Diabetes and Sperm DNA Damage: Efficacy of Antioxidants. SN Comprehensive Clinical Medicine 1:1, pages 49-59.
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Sandra Amaral, Renata S. Tavares, Sara Escada-Rebelo, Andreia F. Silva & João Ramalho-Santos. 2018. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants. Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants 185 203 .
Gabriella Avellino, Didi Theva & Robert D. Oates. (2017) Common urologic diseases in older men and their treatment: how they impact fertility. Fertility and Sterility 107:2, pages 305-311.
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Erma Z. Drobnis & Ajay K. NangiaErma Z. Drobnis & Ajay K. Nangia. 2017. Impacts of Medications on Male Fertility. Impacts of Medications on Male Fertility 29 38 .
J M D Portela, R S Tavares, P C Mota, J Ramalho-Santos & S Amaral. (2015) High glucose concentrations per se do not adversely affect human sperm function in vitro. REPRODUCTION 150:1, pages 77-84.
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Mary K. Samplaski & Ajay K. Nangia. (2015) Adverse effects of common medications on male fertility. Nature Reviews Urology 12:7, pages 401-413.
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Renata S. Tavares, Sandra Amaral, Carla Paiva, Marta Baptista & João Ramalho-Santos. (2015) In vitro exposure to the organochlorine p,p′-DDE affects functional human sperm parameters. Chemosphere 120, pages 443-446.
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Kumiko Nakata, Naoki Yamashita, Yoshihiro Noda & Ikuroh Ohsawa. (2015) Stimulation of human damaged sperm motility with hydrogen molecule. Medical Gas Research 5:1, pages 2.
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Steve Tardif, Oladipo A. Madamidola, Sean G. Brown, Lorna Frame, Linda Lefièvre, Paul G. Wyatt, Christopher L.R. Barratt & Sarah J. Martins Da Silva. (2014) Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity. Human Reproduction 29:10, pages 2123-2135.
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