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Research Article

Increased iron level in motor cortex of amyotrophic lateral sclerosis patients: An in vivo MR study

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Pages 357-361 | Received 06 Sep 2013, Accepted 17 Mar 2014, Published online: 09 May 2014

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Qionghua Sun, Fei Yang, Hongfen Wang, Fang Cui, Yanran Li, Siyuan Li, Yuting Ren, Wenjie Lan, Mao Li, Wenjia Zhu, Xiaosun Sun, Zhengqing He, Xue Zhao, Li Yang & Xusheng Huang. (2019) Elevated serum ferritin level as a predictor of reduced survival in patients with sporadic amyotrophic lateral sclerosis in China: a retrospective study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:3-4, pages 186-191.
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Yifang Bao, Yan Chen, Sirong Piao, Bin Hu, Liqin Yang, Haiqing Li, Daoying Geng & Yuxin Li. (2022) Iron quantitative analysis of motor combined with bulbar region in M1 cortex may improve diagnosis performance in ALS. European Radiology 33:2, pages 1132-1142.
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Anjan Bhattarai, Gary F. Egan, Paul Talman, Phyllis Chua & Zhaolin Chen. (2021) Magnetic Resonance Iron Imaging in Amyotrophic Lateral Sclerosis. Journal of Magnetic Resonance Imaging 55:5, pages 1283-1300.
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Flore Gouel, Kelly Timmerman, Philippe Gosset, Cedric Raoul, Mary Dutheil, Aurélie Jonneaux, Guillaume Garçon, Caroline Moreau, Veronique Danel-Brunaud, James Duce, Thierry Burnouf, Jean-Christophe Devedjian & David Devos. (2022) Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis. Biomaterials 280, pages 121311.
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Parsa Ravanfar, Samantha M. Loi, Warda T. Syeda, Tamsyn E. Van Rheenen, Ashley I. Bush, Patricia Desmond, Vanessa L. Cropley, Darius J. R. Lane, Carlos M. Opazo, Bradford A. Moffat, Dennis Velakoulis & Christos Pantelis. (2021) Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases. Frontiers in Neuroscience 15.
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Valeria Elisa Contarino, Giorgio Conte, Claudia Morelli, Francesca Trogu, Elisa Scola, Sonia Francesca Calloni, Luis Carlos Sanmiguel Serpa, Chunlei Liu, Vincenzo Silani & Fabio Triulzi. (2020) Toward a marker of upper motor neuron impairment in amyotrophic lateral sclerosis: A fully automatic investigation of the magnetic susceptibility in the precentral cortex. European Journal of Radiology 124, pages 108815.
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Benjamin Roeben, Carlo Wilke, Benjamin Bender, Ulf Ziemann & Matthis Synofzik. (2019) The motor band sign in ALS: presentations and frequencies in a consecutive series of ALS patients. Journal of the Neurological Sciences 406, pages 116440.
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Marie Catherine Boll, Oscar René Marrufo Meléndez, Camilo Rios, Jesus Maciel Zenil & Yara de Alba. (2019) Is the Hypointensity in Motor Cortex the Hallmark of Amyotrophic Lateral Sclerosis?. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 46:2, pages 166-173.
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Archana Prasad, Vidhya Bharathi, Vishwanath Sivalingam, Amandeep Girdhar & Basant K. Patel. (2019) Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis. Frontiers in Molecular Neuroscience 12.
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Xian-Le Bu, Yang Xiang & Yansu Guo. 2019. Brain Iron Metabolism and CNS Diseases. Brain Iron Metabolism and CNS Diseases 145 152 .
Jixu Yu, Nian Wang, Faying Qi, Xianjun Wang, Qiyi Zhu, Yucheng Lu, Huiling Zhang, Fengyuan Che & Wei Li. (2018) Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis. Biomedical Reports.
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Emmanuel C. Obusez, Mark Lowe, Se-Hong Oh, Irene Wang, Jennifer Bullen, Paul Ruggieri, Virginia Hill, Daniel Lockwood, Todd Emch, Doksu Moon, Gareth Loy, Jonathan Lee, Matthew Kiczek, Manoj Massand, Volodymyr Statsevych, Todd Stultz & Stephen E. Jones. (2018) 7T MR of intracranial pathology: Preliminary observations and comparisons to 3T and 1.5T. NeuroImage 168, pages 459-476.
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Hironobu Endo, Kenji Sekiguchi, Hitoshi Shimada, Takehiro Ueda, Hisatomo Kowa, Fumio Kanda & Tatsushi Toda. (2018) Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study. Journal of Neurology 265:3, pages 552-561.
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Ferdinand Schweser, Marilena Preda & Robert Zivadinov. 2018. Preclinical MRI. Preclinical MRI 205 234 .
Zhi Dong Zhou & Eng-King Tan. (2017) Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases. Molecular Neurodegeneration 12:1.
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Fengyuan Che, Guangying Wang, Jixu Yu, Xianjun Wang, Yucheng Lu, Qingxi Fu, Quanping Su, Jianzhang Jiang & Yifeng Du. (2017) Effects of epigallocatechin-3-gallate on iron metabolism in spinal cord motor neurons. Molecular Medicine Reports 16:3, pages 3010-3014.
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G. Grolez, C. Moreau, V. Danel-Brunaud, C. Delmaire, R. Lopes, P. F. Pradat, M. M. El Mendili, L. Defebvre & D. Devos. (2016) The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review. BMC Neurology 16:1.
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Shingo Kakeda, Tetsuya Yoneda, Satoru Ide, Mari Miyata, Tomoyo Hashimoto, Koichiro Futatsuya, Keita Watanabe, Atsushi Ogasawara, Junji Moriya, Toru Sato, Kazumasa Okada, Takenori Uozumi, Hiroaki Adachi & Yukunori Korogi. (2016) Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results. European Radiology 26:11, pages 4173-4183.
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Giorgio Biasiotto, Diego Di Lorenzo, Silvana Archetti & Isabella Zanella. (2015) Iron and Neurodegeneration: Is Ferritinophagy the Link?. Molecular Neurobiology 53:8, pages 5542-5574.
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R. Sheelakumari, M. Madhusoodanan, A. Radhakrishnan, G. Ranjith & B. Thomas. (2016) A Potential Biomarker in Amyotrophic Lateral Sclerosis: Can Assessment of Brain Iron Deposition with SWI and Corticospinal Tract Degeneration with DTI Help?. American Journal of Neuroradiology 37:2, pages 252-258.
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Pan Chen, Mahfuzur Rahman Miah & Michael Aschner. (2016) Metals and Neurodegeneration. F1000Research 5, pages 366.
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Jeffrey R Liddell. (2015) Targeting mitochondrial metal dyshomeostasis for the treatment of neurodegeneration. Neurodegenerative Disease Management 5:4, pages 345-364.
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Afonso Celso Pedrotti Liberato, Victor Hugo Rocha Marussi, José Luiz Pedroso, Acary Souza Bulle Oliveira, Orlando G. Barsottini & Lázaro Luiz Faria do Amaral. (2015) Low signal intensity of motor cortex in SWI sequence: a radiological marker for motor neuron disease?. Arquivos de Neuro-Psiquiatria 73:4, pages 362-363.
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