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Scandinavian Journal of Urology Volume 50, 2016 - Issue 3

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Original Article

Intravesical instillation of onabotulinum toxin A embedded in inert hydrogel in the treatment of idiopathic overactive bladder: A double-blind randomized pilot study

Jan KrhutDepartment of Urology, University Hospital, Ostrava, Czech Republic; Correspondence[email protected]

Marie NavratilovaDepartment of Obstetrics and Gynecology, University Hospital, Ostrava, Czech Republic;

Radek SykoraDepartment of Urology, University Hospital, Ostrava, Czech Republic;

Michaela JurakovaDepartment of Obstetrics and Gynecology, University Hospital, Ostrava, Czech Republic;

Marcel GärtnerDepartment of Obstetrics and Gynecology, University Hospital, Ostrava, Czech Republic;

David MikaDepartment of Urology, University Hospital, Ostrava, Czech Republic;

Lubomir PavliskaDepartment for Science and Research, University Hospital, Ostrava, Czech Republic;

Peter ZvaraDepartment of Surgical Studies, Ostrava University, Ostrava, Czech Republic

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Pages 200-205 | Received 22 Jun 2015, Accepted 13 Nov 2015, Published online: 12 Jan 2016

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https://doi.org/10.3109/21681805.2015.1121406
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Fawzy Farag, Vasileios I. Sakalis, Serenella Monagas Arteaga, Néha Sihra, Markos Karavitakis, Salvador Arlandis, Kari Bø, Hanny Cobussen-Boekhorst, Elisabetta Costantini, Monica de Heide, Jan Groen, Benoit Peyronnet, Veronique Phé, Mary-Lynne van Poelgeest-Pomfret, Tine W.L. van den Bos, Huub van der Vaart, Christopher K. Harding, Marie Carmela Lapitan, Muhammad Imran Omar & Arjun K. Nambiar. (2023) What Are the Short-term Benefits and Potential Harms of Therapeutic Modalities for the Management of Overactive Bladder Syndrome in Women? A Review of Evidence Under the Auspices of the European Association of Urology, Female Non-neurogenic Lower Urinary Tract Symptoms Guidelines Panel. European Urology 84:3, pages 302-312.
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Mohammad Sajjad Rahnama’i, Aida Javan Balegh Marand, Dick Janssen, Hadi Mostafaei, Sotirios Gatsos, Sakineh Hajebrahimi, Apostolos Apostolidis & Rajesh Taneja. (2023) Botulinum Toxin Therapy for Bladder Pain Syndrome/Interstitial Cystitis. Current Bladder Dysfunction Reports 18:2, pages 147-153.
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Anirban Ganguly, Shachi Tyagi, Christopher Chermansky, Anthony Kanai, Jonathan Beckel, Mamoru Hashimoto, Kang Jun Cho, Michael Chancellor, Jonathan Kaufman, Naoki Yoshimura & Pradeep Tyagi. (2023) Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options. Drugs & Aging 40:3, pages 241-261.
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Adrianna Wierzbicka, Marek Krakos, Piotr Wilczek & Dorota Bociaga. (2022) A comprehensive review on hydrogel materials in urology: Problems, methods, and new opportunities. Journal of Biomedical Materials Research Part B: Applied Biomaterials 111:3, pages 730-756.
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Limin Liao & Helmut Madersbacher. 2023. Handbook of Neurourology. Handbook of Neurourology 901 913 .

Sotirios Gatsos & Apostolos Apostolidis. 2023. Handbook of Neurourology. Handbook of Neurourology 411 415 .

Limin Liao & Helmut Madersbacher. 2022. Handbook of Neurourology. Handbook of Neurourology 1 13 .

Qinggang Liu & Limin Liao. (2022) Nano-BTA: A New Strategy for Intravesical Delivery of Botulinum Toxin A. International Neurourology Journal 26:2, pages 92-101.
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Gao Yunfeng, Lai Fei, Liu Junbo, Yang Dingyuan & Huang Chaoyou. (2022) An indirect comparison meta-analysis of noninvasive intravesical instillation and intravesical injection of botulinum toxin-A in bladder disorders. International Urology and Nephrology 54:3, pages 479-491.
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Hodan Ibrahim, Jacquie Maignel, Fraser Hornby, Donna Daly & Matthew Beard. (2022) BoNT/A in the Urinary Bladder—More to the Story Than Silencing of Cholinergic Nerves. Toxins 14:1, pages 53.
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Sotirios Gatsos & Apostolos Apostolidis. 2022. Handbook of Neurourology. Handbook of Neurourology 1 8 .

Jia-Fong Jhang & Hann-Chorng Kuo. (2021) Novel Applications of Non-Invasive Intravesical Botulinum Toxin a Delivery in the Treatment of Functional Bladder Disorders. Toxins 13:5, pages 359.
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Zhijun Lin, Hanze Hu, Bolong Liu, Yanyan Chen, Yu Tao, Xiangfu Zhou & Mingqiang Li. (2021) Biomaterial-assisted drug delivery for interstitial cystitis/bladder pain syndrome treatment. Journal of Materials Chemistry B 9:1, pages 23-34.
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Hong Chen, Bin Wang, Qin Li, Juan Zhou, Rui Li & Ye Zhang. (2020) Intravesical dexmedetomidine instillation reduces postoperative catheter-related bladder discomfort in male patients under general anesthesia: a randomized controlled study. BMC Anesthesiology 20:1.
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Po-Yen Chen, Wei-Chia Lee, Hung-Jen Wang & Yao-Chi Chuang. (2020) Therapeutic Efficacy of onabotulinumtoxinA Delivered Using Various Approaches in Sensory Bladder Disorder. Toxins 12:2, pages 75.
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Qin-Qin Gong, Yu-Qiong Xu, Jun Xu, Xiao-Yan Ding & Chong Guo. (2020) Meta-Analysis of Randomized Controlled Trials Using Botulinum Toxin A at Different Dosages for Urinary Incontinence in Patients With Overactive Bladder. Frontiers in Pharmacology 10.
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Ricardo Palmerola & Benjamin Brucker. 2020. Female Pelvic Surgery. Female Pelvic Surgery 255 282 .

Christopher Chermansky, Brigitte Schurch, Mohammad S. Rahnama'i, Marcio A. Averbeck, Sachin Malde, Vito Mancini, Francoise Valentini & Arun Sahai. (2019) How can we better manage drug‐resistant OAB/DO? ICI‐RS 2018. Neurourology and Urodynamics 38:S5.
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M. Martin Jensen, Wanjian Jia, Austin J. Schults, Kyle J. Isaacson, Douglas Steinhauff, Bryant Green, B. Zachary, Joseph Cappello, Hamidreza Ghandehari & Siam Oottamasathien. (2019) Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome. Biomaterials 217, pages 119293.
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Hyun Young Lee, Seung Whan Doo, Won Jae Yang, Yun Seob Song, Hwa Yeon Sun, Eli Jongchan Nho, Bora Lee & Jae Heon Kim. (2019) Efficacy and Safety of Noninvasive Intravesical Instillation of Onabotulinum Toxin-A for Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome: Systematic Review and Meta-analysis. Urology 125, pages 50-57.
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Apostolos Apostolidis. 2019. Neurourology. Neurourology 299 302 .

Melissa T. Sanford & David A. Ginsberg. 2019. Contemporary Pharmacotherapy of Overactive Bladder. Contemporary Pharmacotherapy of Overactive Bladder 177 204 .

Alice Crane, Sudhir Isharwal & Hui Zhu. (2018) Current Therapeutic Strategies in Clinical Urology. Molecular Pharmaceutics 15:8, pages 3010-3019.
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Elena Fonfria, Jacquie Maignel, Stephane Lezmi, Vincent Martin, Andrew Splevins, Saif Shubber, Mikhail Kalinichev, Keith Foster, Philippe Picaut & Johannes Krupp. (2018) The Expanding Therapeutic Utility of Botulinum Neurotoxins. Toxins 10:5, pages 208.
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Yishai H. Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok & Kobi Stav. (2018) Safety and Feasibility of Intravesical Instillation of Botulinum Toxin-A in Hydrogel-based Slow-release Delivery System in Patients With Interstitial Cystitis-Bladder Pain Syndrome: A Pilot Study. Urology 114, pages 60-65.
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Intravesical instillation of onabotulinum toxin A embedded in inert hydrogel in the treatment of idiopathic overactive bladder: A double-blind randomized pilot study

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Intravesical instillation of onabotulinum toxin A embedded in inert hydrogel in the treatment of idiopathic overactive bladder: A double-blind randomized pilot study

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