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ORIGINAL ARTICLE

Advanced bile acid-based multi-compartmental microencapsulated pancreatic β-cells integrating a polyelectrolyte-bile acid formulation, for diabetes treatment

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Pages 588-595 | Received 13 Sep 2014, Accepted 29 Sep 2014, Published online: 30 Oct 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami. (2021) The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Design, Development and Therapy 15, pages 4423-4434.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2020) Bio Micro-Nano Technologies of Antioxidants Optimised Their Pharmacological and Cellular Effects, ex vivo, in Pancreatic β-Cells. Nanotechnology, Science and Applications 13, pages 1-9.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Umar Shah, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Alginate-based drug oral targeting using bio-micro/nano encapsulation technologies. Expert Opinion on Drug Delivery 17:10, pages 1361-1376.
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Armin Mooranian, Nassim Zamani, Giuseppe Luna, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2019) Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model. Pharmaceutical Development and Technology 24:10, pages 1272-1277.
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Armin Mooranian, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2018) The effect of molecular weights of microencapsulating polymers on viability of mouse-cloned pancreatic β-cells: biomaterials, osmotic forces and potential applications in diabetes treatment. Pharmaceutical Development and Technology 23:2, pages 145-150.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) The impact of allylamine-bile acid combinations on cell delivery microcapsules in diabetes. Journal of Microencapsulation 33:6, pages 569-574.
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Articles from other publishers (36)

Susbin R Wagle, Corina M Ionescu, Bozica Kovacevic, Melissa Jones, Thomas Foster, Patrick Lim, Michael Lewkowicz, Maja Ðanić, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2023) Pharmaceutical characterization of probucol bile acid–lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies. Nanomedicine 18:12, pages 923-940.
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Prakriti Siwakoti, Claire Rennie, Yanan Huang, Jiao Jiao Li, Bernard E Tuch, Lana McClements & Xiaoxue Xu. (2022) Challenges with Cell-based Therapies for Type 1 Diabetes Mellitus. Stem Cell Reviews and Reports 19:3, pages 601-624.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Momir Mikov, Karmen Stankov, Magdy Elnashar & Hani Al-Salami. (2023) Low-dose nano-gel incorporated with bile acids enhanced pharmacology of surgical implants. Therapeutic Delivery 14:1, pages 17-29.
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Claire Rennie, Yanan Huang, Prakriti Siwakoti, Ziqing Du, Matthew Padula, Guochen Bao, Bernard E Tuch, Xiaoxue Xu & Lana McClements. (2023) In vitro evaluation of a hybrid drug-delivery nanosystem for fibrosis prevention in cell therapy for Type 1 diabetes . Nanomedicine 18:1, pages 53-66.
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Wee Ling Koh, Thomas Foster, Armin Mooranian & Hani Al-Salami. (2022) Applications of bile acids as biomaterials-based modulators, in biomedical science and microfluidics. Therapeutic Delivery 13:12, pages 591-604.
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Bozica Kovacevic, Melissa Jones, Corina Ionescu, Daniel Walker, Susbin Wagle, Jacqueline Chester, Thomas Foster, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2022) The emerging role of bile acids as critical components in nanotechnology and bioengineering: Pharmacology, formulation optimizers and hydrogel-biomaterial applications. Biomaterials 283, pages 121459.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov & Hani Al-Salami. (2022) Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma. Biomedicines 10:1, pages 111.
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Armin Mooranian, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems. Biomolecules 12:1, pages 73.
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Armin Mooranian, Melissa Jones, Daniel Walker, Corina IonescuMihaelaMihaela, Susbin WagleRajRaj, Božica Kovačević, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2022) 'In vitro' assessments of microencapsulated viable cells as a result of primary bile acid-encapsulated formulation for inflammatory disorders. Scripta Medica 53:2, pages 103-115.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2022) Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem. Therapeutic Delivery 13:1, pages 51-65.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Momir Mikov & Hani Al-Salami. (2021) Artificial Cell Encapsulation for Biomaterials and Tissue Bio-Nanoengineering: History, Achievements, Limitations, and Future Work for Potential Clinical Applications and Transplantation. Journal of Functional Biomaterials 12:4, pages 68.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov & Hani Al-Salami. (2021) Polyelectrolytes Formulated with Primary Unconjugated Bile Acid Optimised Pharmacology of Bio-Engineered Implant. Pharmaceutics 13:10, pages 1713.
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Armin Mooranian, Louise Carey, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Jacqueline Chester, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) The Effects of Accelerated Temperature-Controlled Stability Systems on the Release Profile of Primary Bile Acid-Based Delivery Microcapsules. Pharmaceutics 13:10, pages 1667.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Maja Danic, Momir Mikov, Crispin Dass & Hani Al-Salami. (2021) Chenodeoxycholic Acid Pharmacology in Biotechnology and Transplantable Pharmaceutical Applications for Tissue Delivery: An Acute Preclinical Study. Cells 10:9, pages 2437.
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Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Louise Carey, Ryusuke Takechi, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Pharmacological and Biological Study of Microencapsulated Probucol-Secondary Bile Acid in a Diseased Mouse Model. Pharmaceutics 13:8, pages 1223.
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Armin Mooranian, Thomas Foster, Corina M. Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnston, Elaine Wong, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2021) Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways. Pharmaceutics 13:8, pages 1184.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies. Nanomaterials 11:7, pages 1861.
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Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology. Pharmaceutics 13:7, pages 1041.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Bozica Kovacevic, Frank Arfuso & Hani Al-Salami. (2020) Modulatory Nano/Micro Effects of Diabetes Development on Pharmacology of Primary and Secondary Bile Acids Concentrations. Current Diabetes Reviews 16:8, pages 900-909.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations. Pharmaceutics 12:8, pages 708.
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Susbin Raj Wagle, Daniel Walker, Bozica Kovacevic, Ahmed Gedawy, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian & Hani Al-Salami. (2020) Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies. Scientific Reports 10:1.
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Armin Mooranian, Nassim Zamani, Corina M. Ionescu, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Božica Kovačević & Hani Al-Salami. (2020) Oral gavage of nano-encapsulated conjugated acrylic acid-bile acid formulation in type 1 diabetes altered pharmacological profile of bile acids, and improved glycaemia and suppressed inflammation. Pharmacological Reports 72:2, pages 368-378.
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Armin Mooranian, Susbin Raj Wagle, Bozica Kovacevic, Ryu Takechi, John Mamo, Virginie Lam, Gerald F. Watts, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Hesham Al-Sallami & Hani Al-Salami. (2020) Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study. Scientific Reports 10:1.
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Sangeetha Mathavan, Nigel Chen-Tan, Frank Arfuso & Hani Al-Salami. (2018) Morphological, Stability, and Hypoglycemic Effects of New Gliclazide-Bile Acid Microcapsules for Type 1 Diabetes Treatment: the Microencapsulation of Anti-diabetics Using a Microcapsule-Stabilizing Bile Acid. AAPS PharmSciTech 19:7, pages 3009-3018.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Influence of Biotechnological Processes, Speed of Formulation Flow and Cellular Concurrent Stream-Integration on Insulin Production from β-cells as a Result of Co-Encapsulation with a Highly Lipophilic Bile Acid. Cellular and Molecular Bioengineering 11:1, pages 65-75.
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Svetlana Golocorbin-Kon, Jelena Calasan, Boris Milijasevic, Sasa Vukmirovic, Mladena Lalic-Popovic, Momir Mikov & Hani Al-Salami. (2017) High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect. European Journal of Drug Metabolism and Pharmacokinetics 42:6, pages 1005-1011.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic β cells. Therapeutic Delivery 8:10, pages 833-842.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) New Biotechnological Microencapsulating Methodology Utilizing Individualized Gradient-Screened Jet Laminar Flow Techniques for Pancreatic β-Cell Delivery: Bile Acids Support Cell Energy-Generating Mechanisms. Molecular Pharmaceutics 14:8, pages 2711-2718.
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Armin Mooranian, Ryu Tackechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Innovative Microcapsules for Pancreatic β-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis. Pharmaceutical Research 34:6, pages 1217-1223.
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Armin Mooranian, Rebecca Negrulj, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2016) Biological Assessments of Encapsulated Pancreatic β-Cells: Their Potential Transplantation in Diabetes. Cellular and Molecular Bioengineering 9:4, pages 530-537.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Primary Bile Acid Chenodeoxycholic Acid-Based Microcapsules to Examine β-cell Survival and the Inflammatory Response. BioNanoScience 6:2, pages 103-109.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Alginate-deoxycholic Acid Interaction and Its Impact on Pancreatic Β-Cells and Insulin Secretion and Potential Treatment of Type 1 Diabetes. Journal of Pharmaceutical Innovation 11:2, pages 156-161.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) The Influence of Stabilized Deconjugated Ursodeoxycholic Acid on Polymer-Hydrogel System of Transplantable NIT-1 Cells. Pharmaceutical Research 33:5, pages 1182-1190.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Flow vibration-doubled concentric system coupled with low ratio amine to produce bile acid-macrocapsules of β-cells. Therapeutic Delivery 7:3, pages 171-178.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2015) The incorporation of water-soluble gel matrix into bile acid-based microcapsules for the delivery of viable β-cells of the pancreas, in diabetes treatment: biocompatibility and functionality studies. Drug Delivery and Translational Research 6:1, pages 17-23.
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Armin Mooranian, Rebecca Negrulj, Frank Arfuso & Hani Al-Salami. (2015) The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study. Drug Delivery and Translational Research 5:5, pages 511-522.
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