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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 44, 2016 - Issue 6
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ORIGINAL ARTICLE

The role of the bile acid chenodeoxycholic acid in the targeted oral delivery of the anti-diabetic drug gliclazide, and its applications in type 1 diabetes

Sangeetha MathavanBiotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University, Perth WA, Australia
,
Nigel Chen-TanFaculty of Science and Engineering, Curtin University, Perth WA, Australia
,
Frank ArfusoCurtin Health Innovation Research Institute, Biosciences Research Precinct, School of Biomedical Sciences, Curtin University, Perth WA, Australia
&
Hani Al-SalamiBiotechnology and Drug Development Research Laboratory, School of Pharmacy, Curtin Health Innovation Research Institute, Biosciences Research Precinct, School of Pharmacy, Curtin University, Perth WA, AustraliaCorrespondence[email protected]
Pages 1508-1519 | Received 10 Mar 2015, Accepted 02 Jun 2015, Published online: 25 Jul 2015

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Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami. (2021) The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Design, Development and Therapy 15, pages 4423-4434.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Umar Shah, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Alginate-based drug oral targeting using bio-micro/nano encapsulation technologies. Expert Opinion on Drug Delivery 17:10, pages 1361-1376.
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Articles from other publishers (23)

Jin Ma, Cong Wang, Tieying Yin, Yang Jiang, Wanjun Yu, Xiaoyu Zhang, Qin Qin, Hua Yang & Dechuan Zhang. (2023) Preparation and in Vitro Property Research of Cholic Acid Nanoparticles with Dual Functions of Hemostasis and Antibacterial. Iranian Journal of Pharmaceutical Research In Press:In Press.
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Abdulrahman A. Almehizia, Ahmed M. Naglah, Mohamed A. Al-Omar, Mashooq A. Bhat, Fhdah S. Alanazi, Fatimah A. Alotaibi, Asma S. Al-Wasidi, Moamen S. Refat & Abdel Majid A. Adam. (2023) Spectral Characterization and Antimicrobial Activity of Chenodeoxycholic Acid Complexes with Zn(II), Mg(II), and Ca(II) Ions. Crystals 13:8, pages 1166.
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Armin Mooranian, Melissa Jones, Daniel Walker, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells. Nanomaterials 12:4, pages 647.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov & Hani Al-Salami. (2022) Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma. Biomedicines 10:1, pages 111.
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Armin Mooranian, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Single-Cellular Biological Effects of Cholesterol-Catabolic Bile Acid-Based Nano/Micro Capsules as Anti-Inflammatory Cell Protective Systems. Biomolecules 12:1, pages 73.
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Armin Mooranian, Melissa Jones, Daniel Walker, Corina IonescuMihaelaMihaela, Susbin WagleRajRaj, Božica Kovačević, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2022) 'In vitro' assessments of microencapsulated viable cells as a result of primary bile acid-encapsulated formulation for inflammatory disorders. Scripta Medica 53:2, pages 103-115.
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Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2022) Pharmaceutical formulation and polymer chemistry for cell encapsulation applied to the creation of a lab-on-a-chip bio-microsystem. Therapeutic Delivery 13:1, pages 51-65.
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Armin Mooranian, Louise Carey, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Jacqueline Chester, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) The Effects of Accelerated Temperature-Controlled Stability Systems on the Release Profile of Primary Bile Acid-Based Delivery Microcapsules. Pharmaceutics 13:10, pages 1667.
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Jung Seok Lee, Patrick Han, Rabib Chaudhury, Shihan Khan, Sean Bickerton, Michael D. McHugh, Hyun Bong Park, Alyssa L. Siefert, Gerald Rea, José M. Carballido, David A. Horwitz, Jason Criscione, Karlo Perica, Robert Samstein, Ragy Ragheb, Dongin Kim & Tarek M. Fahmy. (2021) Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin. Nature Biomedical Engineering 5:9, pages 983-997.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Maja Danic, Momir Mikov, Crispin Dass & Hani Al-Salami. (2021) Chenodeoxycholic Acid Pharmacology in Biotechnology and Transplantable Pharmaceutical Applications for Tissue Delivery: An Acute Preclinical Study. Cells 10:9, pages 2437.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Marcus D. Atlas & Hani Al-Salami. (2021) Probucol Pharmacological and Bio-Nanotechnological Effects on Surgically Transplanted Graft Due to Powerful Anti-Inflammatory, Anti-Fibrotic and Potential Bile Acid Modulatory Actions. Pharmaceutics 13:8, pages 1304.
Crossref
Armin Mooranian, Melissa Jones, Corina Mihaela Ionescu, Daniel Walker, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) Advancements in Assessments of Bio-Tissue Engineering and Viable Cell Delivery Matrices Using Bile Acid-Based Pharmacological Biotechnologies. Nanomaterials 11:7, pages 1861.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations. Pharmaceutics 12:8, pages 708.
Crossref
Susbin Raj Wagle, Daniel Walker, Bozica Kovacevic, Ahmed Gedawy, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian & Hani Al-Salami. (2020) Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies. Scientific Reports 10:1.
Crossref
Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2020) Histological effects of pharmacologically active human bile acid nano/micro-particles in Type-1 diabetes. Therapeutic Delivery 11:3, pages 157-171.
Crossref
Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2020) A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds. Saudi Pharmaceutical Journal 28:2, pages 165-171.
Crossref
Linxia Xiao, Jialin Xu, Qi Weng, Leilei Zhou, Mengke Wang, Miao Liu & Qingyong Li. (2020) Mechanism of a Novel Camptothecin-Deoxycholic Acid Derivate Induced Apoptosis against Human Liver Cancer HepG2 Cells and Human Colon Cancer HCT116 Cells. Recent Patents on Anti-Cancer Drug Discovery 14:4, pages 370-382.
Crossref
Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2019) Formulation buoyancy of nanoencapsulated gliclazide using primary, conjugated and deconjugated bile acids. Therapeutic Delivery 10:9, pages 573-583.
Crossref
G. Kaur, M. Arora & M.N.V. Ravi Kumar. (2019) Oral Drug Delivery Technologies—A Decade of Developments. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 529-543.
Crossref
Sangeetha Mathavan, Nigel Chen-Tan, Frank Arfuso & Hani Al-Salami. (2018) Morphological, Stability, and Hypoglycemic Effects of New Gliclazide-Bile Acid Microcapsules for Type 1 Diabetes Treatment: the Microencapsulation of Anti-diabetics Using a Microcapsule-Stabilizing Bile Acid. AAPS PharmSciTech 19:7, pages 3009-3018.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Influence of Biotechnological Processes, Speed of Formulation Flow and Cellular Concurrent Stream-Integration on Insulin Production from β-cells as a Result of Co-Encapsulation with a Highly Lipophilic Bile Acid. Cellular and Molecular Bioengineering 11:1, pages 65-75.
Crossref
Svetlana Golocorbin-Kon, Jelena Calasan, Boris Milijasevic, Sasa Vukmirovic, Mladena Lalic-Popovic, Momir Mikov & Hani Al-Salami. (2017) High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect. European Journal of Drug Metabolism and Pharmacokinetics 42:6, pages 1005-1011.
Crossref
Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon & Hani Al-Salami. (2017) Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects. European Journal of Pharmaceutical Sciences 106, pages 1-9.
Crossref

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