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ResearchArticle

Multicompartmental, multilayered probucol microcapsules for diabetes mellitus: Formulation characterization and effects on production of insulin and inflammation in a pancreatic β-cell line

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Pages 1642-1653 | Received 02 May 2015, Accepted 01 Jul 2015, Published online: 17 Sep 2015

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Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami. (2021) The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Design, Development and Therapy 15, pages 4423-4434.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2020) Bio Micro-Nano Technologies of Antioxidants Optimised Their Pharmacological and Cellular Effects, ex vivo, in Pancreatic β-Cells. Nanotechnology, Science and Applications 13, pages 1-9.
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Armin Mooranian, Nassim Zamani, Giuseppe Luna, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2019) Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model. Pharmaceutical Development and Technology 24:10, pages 1272-1277.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Bozica Kovacevic, Frank Arfuso & Hani Al-Salami. (2018) Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 748-754.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2018) Novel nano-encapsulation of probucol in microgels: scanning electron micrograph characterizations, buoyancy profiling, and antioxidant assay analyses. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 741-747.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Edan Johnston, Momir Mikov, Karmen Stankov, Magdy Elnashar & Hani Al-Salami. (2023) Low-dose nano-gel incorporated with bile acids enhanced pharmacology of surgical implants. Therapeutic Delivery 14:1, pages 17-29.
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Armin Mooranian, Melissa Jones, Daniel Walker, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Thomas Foster, Edan Johnston, Jafri Kuthubutheen, Daniel Brown, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2022) Pharmacological Dose-Effect Profiles of Various Concentrations of Humanised Primary Bile Acid in Encapsulated Cells. Nanomaterials 12:4, pages 647.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov & Hani Al-Salami. (2022) Taurine Grafted Micro-Implants Improved Functions without Direct Dependency between Interleukin-6 and the Bile Acid Lithocholic Acid in Plasma. Biomedicines 10:1, pages 111.
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Zhen Li, Zengkun Qian, Jingjing Zhou, Wenjuan Zhu, Zheng Mao & Fan Cui. (2021) microRNA-206 Regulates Pancreatic- β -Cell Function via Targeting Insulin-Like Growth Factor 1 . Journal of Biomaterials and Tissue Engineering 11:11, pages 2254-2261.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Sanja Kojic, Goran Stojanovic, Momir Mikov & Hani Al-Salami. (2021) Polyelectrolytes Formulated with Primary Unconjugated Bile Acid Optimised Pharmacology of Bio-Engineered Implant. Pharmaceutics 13:10, pages 1713.
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Armin Mooranian, Louise Carey, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Thomas Foster, Jacqueline Chester, Edan Johnston, Momir Mikov & Hani Al-Salami. (2021) The Effects of Accelerated Temperature-Controlled Stability Systems on the Release Profile of Primary Bile Acid-Based Delivery Microcapsules. Pharmaceutics 13:10, pages 1667.
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Thomas Foster, Corina Ionescu, Daniel Walker, Melissa Jones, Susbin Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Chemotherapy-induced hearing loss: the applications of bio-nanotechnologies and bile acid-based delivery matrices. Therapeutic Delivery 12:10, pages 723-737.
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Armin Mooranian, Corina Mihaela Ionescu, Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Melissa Jones, Jacqueline Chester, Thomas Foster, Edan Johnston, Momir Mikov, Marcus D. Atlas & Hani Al-Salami. (2021) Probucol Pharmacological and Bio-Nanotechnological Effects on Surgically Transplanted Graft Due to Powerful Anti-Inflammatory, Anti-Fibrotic and Potential Bile Acid Modulatory Actions. Pharmaceutics 13:8, pages 1304.
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Susbin Raj Wagle, Bozica Kovacevic, Corina Mihaela Ionescu, Daniel Walker, Melissa Jones, Louise Carey, Ryusuke Takechi, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) Pharmacological and Biological Study of Microencapsulated Probucol-Secondary Bile Acid in a Diseased Mouse Model. Pharmaceutics 13:8, pages 1223.
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Armin Mooranian, Thomas Foster, Corina M. Ionescu, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnston, Elaine Wong, Marcus D. Atlas, Momir Mikov & Hani Al-Salami. (2021) Enhanced Bilosomal Properties Resulted in Optimum Pharmacological Effects by Increased Acidification Pathways. Pharmaceutics 13:8, pages 1184.
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Jacqueline Chester, Edan Johnston, Daniel Walker, Melissa Jones, Corina Mihaela Ionescu, Susbin Raj Wagle, Božica Kovacevic, Daniel Brown, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2021) A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology. Pharmaceutics 13:7, pages 1041.
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Tengjiao Qu, Yahao Mou, Jiao Dai, Xiaoli Zhang, Mengzhu Li, Shiyan Gu & Zuoshun He. (2021) Changes and relationship of N6-methyladenosine modification and long non-coding RNAs in oxidative damage induced by cadmium in pancreatic β-cells. Toxicology Letters 343, pages 56-66.
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Jieli Lu, Shuangyuan Wang, Mian Li, Zhengnan Gao, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang, Ruixin Liu, Ruying Hu, Lixin Shi, Ruizhi Zheng, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Guixia Wang, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Donghui Li, Shenghan Lai, Yiming Mu, Lulu Chen, Jiajun Zhao, Guowang Xu, Guang Ning, Yufang Bi & Weiqing Wang. (2021) Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes Among Normoglycemic Chinese Adults: Findings From the 4C Study. Diabetes Care 44:2, pages 499-510.
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Melissa Jones, Daniel Walker, Corina Mihaela Ionescu, Bozica Kovacevic, Susbin Raj Wagle, Armin Mooranian, Daniel Brown & Hani Al-Salami. (2020) Microencapsulation of Coenzyme Q10 and bile acids using ionic gelation vibrational jet flow technology for oral delivery. Therapeutic Delivery 11:12, pages 791-805.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Bozica Kovacevic, Frank Arfuso & Hani Al-Salami. (2020) Modulatory Nano/Micro Effects of Diabetes Development on Pharmacology of Primary and Secondary Bile Acids Concentrations. Current Diabetes Reviews 16:8, pages 900-909.
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Susbin Raj Wagle, Bozica Kovacevic, Daniel Walker, Corina Mihaela Ionescu, Melissa Jones, Goran Stojanovic, Sanja Kojic, Armin Mooranian & Hani Al-Salami. (2020) Pharmacological and Advanced Cell Respiration Effects, Enhanced by Toxic Human-Bile Nano-Pharmaceuticals of Probucol Cell-Targeting Formulations. Pharmaceutics 12:8, pages 708.
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Armin Mooranian, Nassim Zamani, Corina M. Ionescu, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Božica Kovačević & Hani Al-Salami. (2020) Oral gavage of nano-encapsulated conjugated acrylic acid-bile acid formulation in type 1 diabetes altered pharmacological profile of bile acids, and improved glycaemia and suppressed inflammation. Pharmacological Reports 72:2, pages 368-378.
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Sangeetha Mathavan, Corina M Ionescu, Bozica Kovacevic, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Crispin R Dass & Hani Al-Salami. (2020) Histological effects of pharmacologically active human bile acid nano/micro-particles in Type-1 diabetes. Therapeutic Delivery 11:3, pages 157-171.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic & Hani Al-Salami. (2020) A second-generation micro/nano capsules of an endogenous primary un-metabolised bile acid, stabilized by Eudragit-alginate complex with antioxidant compounds. Saudi Pharmaceutical Journal 28:2, pages 165-171.
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Armin Mooranian, Susbin Raj Wagle, Bozica Kovacevic, Ryu Takechi, John Mamo, Virginie Lam, Gerald F. Watts, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Hesham Al-Sallami & Hani Al-Salami. (2020) Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study. Scientific Reports 10:1.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Bozica Kovacevic, Frank Arfuso & Hani Al-Salami. (2019) Probucol-poly(meth)acrylate-bile acid nanoparticles increase IL-10, and primary bile acids in prediabetic mice. Therapeutic Delivery 10:9, pages 563-571.
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Armin Mooranian, Nassim Zamani, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Magdy Elnashar, Frank Arfuso & Hani Al-Salami. (2019) An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques. PLOS ONE 14:4, pages e0214984.
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Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2019) Stability and biological testing of taurine-conjugated bile acid antioxidant microcapsules for diabetes treatment. Therapeutic Delivery 10:2, pages 99-106.
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Victor Navarro-Tableros, Yonathan Gomez, Maria Felice Brizzi & Giovanni Camussi. 2020. Cell Biology and Translational Medicine, Volume 6. Cell Biology and Translational Medicine, Volume 6 179 220 .
Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso & Hani Al-Salami. (2018) Eudragit ® -based microcapsules of probucol with a gut-bacterial processed secondary bile acid . Therapeutic Delivery 9:11, pages 811-821.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, John Mamo, Hesham Al-Sallami & Hani Al-Salami. (2018) The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects. Drug Delivery and Translational Research 8:3, pages 543-551.
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Hong Liu & Mingming Cai. (2018) Effect of probucol on hemodynamics, rheology and blood lipid of diabetic retinopathy. Experimental and Therapeutic Medicine.
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Albert Espona-Noguera, Jesús Ciriza, Alberto Cañibano-Hernández, Luis Fernandez, Ignacio Ochoa, Laura Saenz del Burgo & Jose Luis Pedraz. (2018) Tunable injectable alginate-based hydrogel for cell therapy in Type 1 Diabetes Mellitus. International Journal of Biological Macromolecules 107, pages 1261-1269.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Influence of Biotechnological Processes, Speed of Formulation Flow and Cellular Concurrent Stream-Integration on Insulin Production from β-cells as a Result of Co-Encapsulation with a Highly Lipophilic Bile Acid. Cellular and Molecular Bioengineering 11:1, pages 65-75.
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Svetlana Golocorbin-Kon, Jelena Calasan, Boris Milijasevic, Sasa Vukmirovic, Mladena Lalic-Popovic, Momir Mikov & Hani Al-Salami. (2017) High-Loading Dose of Microencapsulated Gliclazide Formulation Exerted a Hypoglycaemic Effect on Type 1 Diabetic Rats and Incorporation of a Primary Deconjugated Bile Acid, Diminished the Hypoglycaemic Antidiabetic Effect. European Journal of Drug Metabolism and Pharmacokinetics 42:6, pages 1005-1011.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic β cells. Therapeutic Delivery 8:10, pages 833-842.
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Armin Mooranian, Rebecca Negrulj, Ryu Takechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) New Biotechnological Microencapsulating Methodology Utilizing Individualized Gradient-Screened Jet Laminar Flow Techniques for Pancreatic β-Cell Delivery: Bile Acids Support Cell Energy-Generating Mechanisms. Molecular Pharmaceutics 14:8, pages 2711-2718.
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Sangeetha Mathavan, Momir Mikov, Svetlana Golocorbin-Kon & Hani Al-Salami. (2017) Diabetes development increased concentrations of the conjugated bile acid, taurocholic acid in serum, while treatment with microencapsulated-taurocholic acid exerted no hypoglycaemic effects. European Journal of Pharmaceutical Sciences 106, pages 1-9.
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J C L Mamo, V Lam, C Giles, S H Coulson, N Fimognari, A Mooranian, H Al-Salami & R Takechi. (2017) Antihypertensive agents do not prevent blood–brain barrier dysfunction and cognitive deficits in dietary-induced obese mice. International Journal of Obesity 41:6, pages 926-934.
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Armin Mooranian, Ryu Tackechi, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2017) Innovative Microcapsules for Pancreatic β-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis. Pharmaceutical Research 34:6, pages 1217-1223.
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Armin Mooranian, Rebecca Negrulj, Emma Jamieson, Grant Morahan & Hani Al-Salami. (2016) Biological Assessments of Encapsulated Pancreatic β-Cells: Their Potential Transplantation in Diabetes. Cellular and Molecular Bioengineering 9:4, pages 530-537.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Primary Bile Acid Chenodeoxycholic Acid-Based Microcapsules to Examine β-cell Survival and the Inflammatory Response. BioNanoScience 6:2, pages 103-109.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Alginate-deoxycholic Acid Interaction and Its Impact on Pancreatic Β-Cells and Insulin Secretion and Potential Treatment of Type 1 Diabetes. Journal of Pharmaceutical Innovation 11:2, pages 156-161.
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Armin Mooranian, Rebecca Negrulj & Hani Al-Salami. (2016) Flow vibration-doubled concentric system coupled with low ratio amine to produce bile acid-macrocapsules of β-cells. Therapeutic Delivery 7:3, pages 171-178.
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Armin Mooranian, Rebecca Negrulj, Hani Al-Salami, Grant Morahan & Emma Jamieson. (2016) Designing anti-diabetic β-cells microcapsules using polystyrenic sulfonate, polyallylamine, and a tertiary bile acid: Morphology, bioenergetics, and cytokine analysis. Biotechnology Progress 32:2, pages 501-509.
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