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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 44, 2016 - Issue 7
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Review Article

Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA)

Behzad Mansooria Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;b Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranCorrespondence[email protected]
,
Ali Mohammadia Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;c Department of genetic, East Azarbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran
,
Solmaz Shir Janga Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
&
Behzad Baradarana Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Pages 1589-1596 | Received 22 Jun 2015, Accepted 29 Sep 2015, Published online: 26 Oct 2015

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Mahdi Jafarlou, Dariush Shanehbandi, Parvin Dehghan, Behzad Mansoori, F. Othman & Behzad Baradaran. (2018) Enhancement of chemosensitivity by simultaneously silencing of Mcl-1 and Survivin genes using small interfering RNA in human myelomonocytic leukaemia. Artificial Cells, Nanomedicine, and Biotechnology 46:8, pages 1792-1798.
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Sahar Esmailzadeh, Behzad Mansoori, Ali Mohammadi & Behzad Baradaran. (2017) Regulatory roles of micro-RNAs in T cell autoimmunity. Immunological Investigations 46:8, pages 864-879.
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Behzad Mansoori, Ali Mohammadi, Solmaz Shirjang & Behzad Baradaran. (2016) HMGI-C suppressing induces P53/caspase9 axis to regulate apoptosis in breast adenocarcinoma cells. Cell Cycle 15:19, pages 2585-2592.
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Articles from other publishers (25)

Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim & Jung-Yong Yeh. (2023) Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges. Journal of Biomedical Science 30:1.
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Chandrasekharan Rajalekshmi Dhanya, Aarcha Shanmugha Mary & Maya Madhavan. (2022) Aptamer‐siRNA chimeras: Promising tools for targeting HER2 signaling in cancer . Chemical Biology & Drug Design 101:5, pages 1162-1180.
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Emine Şalva, Suna Özbaş, Saadet Alan, Naziye Özkan, Ceyda Ekentok‐Atıcı, Levent Kabasakal & Jülide Akbuğa. (2022) Combination therapy with chitosan/siRNA nanoplexes targeting PDGF‐D and PDGFR‐β reveals anticancer effect in breast cancer. The Journal of Gene Medicine 25:2.
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Cristina de la Torre, Pablo Játiva, Inmaculada Posadas, Darío Manzanares, José L. Jiménez Blanco, Carmen Ortiz Mellet, José Manuel García Fernández & Valentín Ceña. (2022) A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells. Pharmaceutics 14:11, pages 2424.
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Young Gyu Kang, Jaejin KimKyeongmin LeeJeong Yong ChoePooja DuaDong Ki Lee. (2022) RIG-I-Mediated Innate Immune Stimulation by Chemically Synthesized Long Double-Stranded RNAs Is Structure and Sequence Dependent. Nucleic Acid Therapeutics 32:4, pages 321-332.
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JinHua He, NaiTe Xi, ZePing Han, WenFeng Luo, Jian Shen, ShengBo Wang, JianHao Li, ZhongHui Guo & HanWei Cheng. (2022) The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer. Frontiers in Endocrinology 13.
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Danielle de Brito e Cunha, Ana Frederico, Tamiris Azamor, Juliana Melgaço, Patricia da Costa Neves, Ana Bom, Tatiana Tilli & Sotiris Missailidis. (2022) Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug. Pharmaceuticals 15:5, pages 575.
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Beomseok Son, Tae Rim Kim, Jun Hong Park, Sung-Il Yun, Hanjoo Choi, Ji Woo Choi, ChanHyeok Jeon & Han-Oh Park. (2022) SAMiRNA Targeting Amphiregulin Alleviate Total-Body-Irradiation-Induced Renal Fibrosis. Radiation Research 197:5.
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Divya Kaushal, Swati Gupta & Yashwant V. Pathak. 2022. Macrophage Targeted Delivery Systems. Macrophage Targeted Delivery Systems 469 487 .
Ebru TEMİZ, İsmail KOYUNCU, Shameem SAADAT, Özgür YÜKSEKDAĞ & Yazan AWARD. (2021) Exploring the Antiproliferative Mechanisms of Urtica dioica L. extract in Human Promyelocytic Leukemia Cell Lineİnsan Promiyelositik Lösemi Hücre Hattında Isırgan Ekstraktının Antiproliferatif Mekanizmalarının Araştırılması. Harran Üniversitesi Tıp Fakültesi Dergisi 18:3, pages 468-474.
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Ali Bishani & Elena L. Chernolovskaya. (2021) Activation of Innate Immunity by Therapeutic Nucleic Acids. International Journal of Molecular Sciences 22:24, pages 13360.
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Patrick Iversen, Sandra Bixler, Christopher D. Kane & Travis K. Warren. 2021. Antiviral Discovery for Highly Pathogenic Emerging Viruses. Antiviral Discovery for Highly Pathogenic Emerging Viruses 61 90 .
Chinmoy K. Bose. (2021) siRNA and Ovarian Cancer. Indian Journal of Gynecologic Oncology 19:4.
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An-Katrien Minnaert, Helena Vanluchene, Rein Verbeke, Ine Lentacker, Stefaan C. De Smedt, Koen Raemdonck, Niek N. Sanders & Katrien Remaut. (2021) Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across. Advanced Drug Delivery Reviews 176, pages 113900.
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Seung Seob Son, Soohyun Hwang, Jun Hong Park, Youngho Ko, Sung-Il Yun, Ji-Hye Lee, Beomseok Son, Tae Rim Kim, Han-Oh Park & Eun Young Lee. (2021) In vivo silencing of amphiregulin by a novel effective Self-Assembled-Micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals. Scientific Reports 11:1.
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George Kasotakis, Ekaterina Kintsurashvili, Manuel D. Galvan, Christopher Graham, J. Todd Purves, Suresh Agarwal, David L. Corcoran, Bruce A. Sullenger, Scott M. Palmer & Daniel G. Remick. (2020) Histone Deacetylase 7 Inhibition in a Murine Model of Gram-Negative Pneumonia-Induced Acute Lung Injury. Shock 53:3, pages 344-351.
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Mikhail I. Zharkov, Marina A. Zenkova, Valentin V. Vlassov & Elena L. Chernolovskaya. (2019) Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA. Frontiers in Oncology 9.
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Miguel Hueso, Angela Casas, Adrian Mallén, Laura de Ramón, Nuria Bolaños, Cristian Varela, Josep M. Cruzado, Joan Torras & Estanislao Navarro. (2019) The double edge of anti-CD40 siRNA therapy: It increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE−/− mice. Journal of Inflammation 16:1.
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Ivan V. Chernikov, Valentin V. Vlassov & Elena L. Chernolovskaya. (2019) Current Development of siRNA Bioconjugates: From Research to the Clinic. Frontiers in Pharmacology 10.
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Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Dariush Shanehbandi, Ahad Mokhtarzadeh & Behzad Baradaran. (2018) Small interfering RNA–mediated gene suppression as a therapeutic intervention in hepatocellular carcinoma. Journal of Cellular Physiology 234:4, pages 3263-3276.
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Pei Ning, Zhihong Zheng, Jude Juventus Aweya, Defu Yao, Shengkang Li, Hongyu Ma, Fan Wang & Yueling Zhang. (2018) Litopenaeus vannamei notch affects lipopolysaccharides induced reactive oxygen species. Developmental & Comparative Immunology 81, pages 74-82.
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Sahar Esmailzadeh, Behzad Mansoori, Ali Mohammadi, Dariush Shanehbandi & Behzad Baradaran. (2016) siRNA-Mediated Silencing of HMGA2 Induces Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma. Journal of Gastrointestinal Cancer 48:2, pages 156-163.
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Sadaf Davudian, Behzad Mansoori, Neda Shajari, Ali Mohammadi & Behzad Baradaran. (2016) BACH1, the master regulator gene: A novel candidate target for cancer therapy. Gene 588:1, pages 30-37.
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Behzad Mansoori, Ali Mohammadi, Samira Goldar, Dariush shanehbandi, Leila Mohammadnejad, Elham Baghbani, Tohid Kazemi, Saeed Kachalaki & Behzad Baradaran. (2016) Silencing of High Mobility Group Isoform I-C (HMGI-C) Enhances Paclitaxel Chemosensitivity in Breast Adenocarcinoma Cells (MDA-MB-468). Advanced Pharmaceutical Bulletin 6:2, pages 171-177.
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Ali Mohammadi, Behzad Mansoori, Mahyar Aghapour, Pooneh Chokhachi Baradaran, Neda Shajari, Sadaf Davudian, Shima Salehi & Behzad Baradaran. (2016) The Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2/M Phase. Journal of Gastrointestinal Cancer 47:2, pages 187-195.
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