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Infectious Diseases Volume 47, 2015 - Issue 10
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CASE REPORT

Hypofibrinogenemia induced by tigecycline: a potentially life-threatening coagulation disorder

Nikolaos Sabanis From the Nephrological Department, General Hospital of Pella, Edessa, Greece
,
Eleni PaschouDepartment of General Practice and Family Medicine, General Hospital of Pella, Edessa, GreeceCorrespondence[email protected]
,
Eleni GavriilakiMedical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
,
Asterios KalaitzoglouMedical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
&
Sotirios Vasileiou From the Nephrological Department, General Hospital of Pella, Edessa, Greece
Pages 743-746 | Received 21 Feb 2015, Accepted 20 Apr 2015, Published online: 08 May 2015

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Zhaolin Li, Qiaojun Zeng, Shuwan Xu, Yuewei Li, Tiantian Tang, Jianting Shi, Xueming Song, Wenman He, Liang Chen, Guirong Liu, Boying Gao, Jianming Zheng, Linjie Huang, Ming Chen & Shanping Jiang. (2023) Development and Validation of a Nomogram for Predicting Tigecycline-Related Coagulopathy: A Retrospective Cohort Study. Infection and Drug Resistance 16, pages 423-434.
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Haibo Lei, Xiang Liu, Zuojun Li & Chunjiang Wang. (2023) Analysis of the clinical characteristics of tigecycline-induced hypofibrinogenemia. Journal of Chemotherapy 35:4, pages 292-297.
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Yu Huang, Libin Chen, Handuo Su, Zhenwei Huang, Xiaoyi Li & Shubao Huang. (2022) Tigecycline treatment causes a decrease in peripheral blood platelet. Journal of Chemotherapy 0:0, pages 1-5.
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Gianpaolo Perletti, Alberto Trinchieri, Konstantinos Stamatiou & Vittorio Magri. (2022) Safety considerations with new antibacterial approaches for chronic bacterial prostatitis. Expert Opinion on Drug Safety 21:2, pages 171-182.
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Jia Liu, Yingying Yan & Fan Zhang. (2021) Risk Factors for Tigecycline-Associated Hypofibrinogenemia. Therapeutics and Clinical Risk Management 17, pages 325-332.
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Sara Akalay, Thomas Vanassche & Paul De Munter. (2021) Tigecycline-induced life-threatening coagulopathy in a patient with a Mycobacterium abscess: a case report and step-by-step diagnostic approach. Acta Clinica Belgica 76:5, pages 410-414.
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Damla Akdağ, Meltem Işıkgöz-Taşbakan, Hüsnü Pullukcu, Hilal Sipahi & Oğuz Reşat Sipahi. (2020) Tigecycline versus INR increase; more than expected?. Expert Opinion on Drug Safety 19:3, pages 335-337.
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Hakeam A. Hakeam, Zainab Al Duhailib, Nawal Salahuddin & Tarek Amin. (2018) Impact of tigecycline versus imipenem–cilastatin on fibrinogen levels following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized-controlled study. Journal of Chemotherapy 30:4, pages 224-232.
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Articles from other publishers (25)

Xiaoxuan Yang, Lu Jin, Xuemei Luo, Shurun An, Min Wang, Huaijun Zhu, Yujie Zhou & Hang Liu. (2023) Pharmacokinetic/Pharmacodynamic Target Attainment of Tigecycline in Patients with Hepatic Impairment in a Real-World Setting. Therapeutic Drug Monitoring Publish Ahead of Print.
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Chuwen Lin, Miaoqin Tan, Dongmei Wang, Chunping Gu, Yongming Wu & Shengnan Wang. (2023) Safety of Tigecycline in Patients on Antithrombotic Therapy: A Single-Center Retrospective Study. Pharmacology 108:6, pages 540-549.
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Mingxing Guo, Jinwei Liang, Dandan Li, Ying Zhao, Wanyi Xu, Lei Wang & Xiangli Cui. (2022) Coagulation dysfunction events associated with tigecycline: a real-world study from FDA adverse event reporting system (FAERS) database. Thrombosis Journal 20:1.
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Tingting Jiang, Xuhui Huang, Qinghua Liu, Hangwei Feng, Yiting Huang, Jian Lin, Long Huang, Shufang Chen, Yingfeng Zhuang & Cuilian Weng. (2022) Risk Factors for Tigecycline‐Associated Hepatotoxicity in Patients in the Intensive Care Units of 2 Tertiary Hospitals: A Retrospective Study. The Journal of Clinical Pharmacology 62:11, pages 1426-1434.
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Bing Leng, Chengwu Shen, Tiantian Gao, Kai Zhao, Xuemei Zhao, Yujin Guo, Jiyong Wu, Jing Yang, Wei Fang, Jicheng Zhang, Yahui Zhang, Chao Sun, Lei Duan, Jing Huang, Yougang Qi & Genquan Yan. (2022) Incidence, characteristics and risk factors of hypofibrinogenemia associated with tigecycline: A multicenter retrospective study in China. Frontiers in Pharmacology 13.
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Sajad Yaghoubi, Angelina Olegovna Zekiy, Marcela Krutova, Mehrdad Gholami, Ebrahim Kouhsari, Mohammad Sholeh, Zahra Ghafouri & Farajolah Maleki. (2021) Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review. European Journal of Clinical Microbiology & Infectious Diseases 41:7, pages 1003-1022.
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Dongmei Wang, Chuwen Lin, Chunping Gu, Yongming Wu & Shengnan Wang. (2022) Tigecycline-Associated Coagulopathy: A Single-Center Retrospective Analysis. Pharmacology 107:9-10, pages 524-536.
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Müge AYHAN, Ferda CAN, Selma KARAAHMETOĞLU & Rahmet GÜNER. (2021) Hypofibrinogenemia caused by tigecycline use in a patient with acute cholecystitis: a case report and review of the literature. The European Research Journal 7:6, pages 667-671.
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Xiaoping Shi, Chengchun Zuo, Lingling Yu, Donghui Lao, Xiaoyu Li, Qing Xu & Qianzhou Lv. (2021) Real-World Data of Tigecycline-Associated Drug-Induced Liver Injury Among Patients in China: A 3-year Retrospective Study as Assessed by the Updated RUCAM. Frontiers in Pharmacology 12.
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Benedikt Treml, Sasa Rajsic, Tobias Hell, Dietmar Fries & Mirjam Bachler. (2021) Progression of Fibrinogen Decrease during High Dose Tigecycline Therapy in Critically Ill Patients: A Retrospective Analysis. Journal of Clinical Medicine 10:20, pages 4702.
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Qian Zhang, Jine Wang, Hui Liu, Wang Ma, Suming Zhou & Jing Zhou. (2020) Risk factors for tigecycline‐induced hypofibrinogenaemia. Journal of Clinical Pharmacy and Therapeutics 45:6, pages 1434-1441.
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David Campany-Herrero, Maria Larrosa-Garcia, Pilar Lalueza-Broto, Lucas Rivera-Sánchez, Juan Espinosa-Pereiro, Jaume Mestre-Torres & Carles Pigrau-Serrallach. (2020) Tigecycline-associated hypofibrinogenemia in a real-world setting. International Journal of Clinical Pharmacy 42:4, pages 1184-1189.
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Juan Hu, Yong-hong Xiao, Yi Zheng, Yang-xiao Lai, Xue-ling Fang & Qiang Fang. (2020) Clinical characteristics and risk factors of tigecycline-associated hypofibrinogenaemia in critically ill patients. European Journal of Clinical Pharmacology 76:7, pages 913-922.
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Hakeam A. Hakeam & Zainab Al Duhailib. (2020) Tigecycline-induced coagulopathy: a literature review. International Journal of Clinical Pharmacy 42:3, pages 846-847.
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Anna Brandtner, Mirjam Bachler, Dietmar Fries, Martin Hermann, Jacqueline Ruehlicke, Vilmos Fux, Andrea Griesmacher, Christian Niederwanger, Tobias Hell & Benedikt Treml. (2020) Tigecycline Interferes with Fibrinogen Polymerization Independent of Peripheral Interactions with the Coagulation System. Antibiotics 9:2, pages 84.
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Qiaomei Fan, Wei Huang, Yayun Weng, Xianze Xie & Zheng Shi. (2020) Hypofibrinogenemia induced by high-dose tigecycline—case report and review of literature. Medicine 99:43, pages e22638.
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Jian Liu, Yiqing Liu, Shengjun Liu, Qin Zhang, Jiexin Zheng, Yiwen Niu & Xuefeng Wang. (2019) Hypocoagulation induced by broad-spectrum antibiotics in extensive burn patients. Burns & Trauma 7.
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Nannan Cui, Hongliu Cai, Zhitao Li, Yuting Lu, Guobin Wang & Anwei Lu. (2019) Tigecycline-induced coagulopathy: a literature review. International Journal of Clinical Pharmacy 41:6, pages 1408-1413.
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Bing Leng, Yuan Chao Xue, Wen Zhang, Tian tian Gao, Gen quan Yan & Hui Tang. (2019) A Retrospective Analysis of the Effect of Tigecycline on Coagulation Function. Chemical and Pharmaceutical Bulletin 67:3, pages 258-264.
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Jinhong Gong, Dan Su, Jingjing Shang, Hai Yu, Guantao Du, Ying Lin, Zhiqiang Sun & Guangjun Liu. (2019) Efficacy and safety of high-dose tigecycline for the treatment of infectious diseases. Medicine 98:38, pages e17091.
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Pei-Chun Wu & Chien-Chih Wu. (2018) Tigecycline-associated hypofibrinogenemia: A case report and review of the literature. IDCases 11, pages 56-57.
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Xiaoqin Wu, Ping Zhao, Liang Dong & Xiuhong Zhang. (2017) A case report of patient with severe acute cholangitis with tigecycline treatment causing coagulopathy and hypofibrinogenemia. Medicine 96:49, pages e9124.
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Hanae Makita, Keiki Nagaharu, Manami Teramoto, Yuji Bessho, Takanori Yamaguchi, Ryugo Ito & Keiki Kawakami. (2017) Severe Coagulopathy Associated with Tigecycline for the <i>Achromobacter Xylosoxydans</i> Bacteremia in a Patient with Follicular Lymphoma濾胞性リンパ腫治療中に発症した<i>Achromobacter xylosoxidans</i>菌血症に対しtigecyclineを使用し凝固障害を来たした1例. Nihon Naika Gakkai Zasshi 106:8, pages 1626-1631.
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. (2016) Tigecycline. Reactions Weekly 1599:1, pages 212-212.
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Yeong Jin JeongByeongzu GhanhJi Wan LeeJinoh ParkTae-Bum KimYou Sook ChoHee-Bom MoonHyouk-Soo Kwon. (2016) Rapid-onset of severe tigecycline-induced coagulopathy in drug reaction with eosinophilia and systemic symptom syndrome. Allergy, Asthma & Respiratory Disease 4:1, pages 74.
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