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Research Article

The Role of Endogenous Thiols in Intrinsic Radioprotection

Pages 361-368 | Published online: 17 Feb 2011

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D. Becker, S. Summerfield, S. Gillich & M.D. Sevilla. (1994) Influence of Oxygen on the Repair of Direct Radiation Damage to DNA by Thiols in Model Systems. International Journal of Radiation Biology 65:5, pages 537-548.
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G. Sölen. (1993) Radioprotective Effect of N-acetylcysteine in Vitro Using the Induction of DNA Breaks as End-point. International Journal of Radiation Biology 64:4, pages 359-366.
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S. Awad, G.B. Henderson, A. Cerami & K.D. Held. (1992) Effects of Trypanothione on the Biological Activity of Irradiated Transforming DNA. International Journal of Radiation Biology 62:4, pages 401-407.
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K.M. Prise, S. Davies, M.R.L. Stratford & B.D. Michael. (1992) The Role of Non-protein Sulphydryls in Determining the Chemical Repair Rates of Free Radical Precursors of DNA Damage and Cell Killing in Chinese Hamster V79 Cells. International Journal of Radiation Biology 62:3, pages 297-306.
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D. Ewing, D.S. Guilfoil & M.B. Ohm. (1991) Do Intracellular Thiol or Peroxidase Levels Block Radiation Sensitization by Nitrous Oxide in Some E. Coli Strains?. International Journal of Radiation Biology 59:1, pages 153-164.
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Dietrich Schulte-Frohlinde. (1989) The Effect of Oxygen and Thiols on the Radiation Damage of DNA. Free Radical Research Communications 6:2-3, pages 181-183.
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M.F. Dennis, M.R.L. Stratford, P. Wardman & R.R. Watfa. (1989) Increase in Intracellular Cysteine after Exposure to Dithiothreitol: Implications in Radiobiology. International Journal of Radiation Biology 56:6, pages 877-883.
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Walter A. Prütz, John Butler, Edward J. Land & A. John Swallow. (1989) The Role of Sulphur Peptide Functions in Free Radical Transfer: A Pulse Radiolysis Study. International Journal of Radiation Biology 55:4, pages 539-556.
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M. Shahid Akhlaq, Heinz-peter Schuchmann & Clemens Von Sonntag. (1987) The Reverse of the ‘Repair’ Reaction of Thiols: H-abstraction at Carbon by Thiyl Radicals. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 51:1, pages 91-102.
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Margareta R. Edgren. (1987) Nuclear Glutathione and Oxygen Enhancement of Radiosensitivity. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 51:1, pages 3-6.
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J.W. Hülsewede & D. Schulte-Frohlinde. (1986) Radiation Protection of E. Coli Strains by Cysteamine in the Presence of Oxygen. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:5, pages 861-869.
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D. Schulte-Frohlinde, G. Behrens & A. Önal. (1986) Lifetime of Peroxyl Radicals of Poly(U), Poly(A) and Single-and Double-Stranded DNA and the Rate of Their Reaction with Thiols. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 50:1, pages 103-110.
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Amrita K. Cheema, Yaoxiang Li, Michael Girgis, Meth Jayatilake, Madison Simas, Stephen Y. Wise, Ayodele O. Olabisi, Thomas M. Seed & Vijay K. Singh. (2019) Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation. Scientific Reports 9:1.
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Thulasi G. Pillai & P. Uma Devi. (2013) Mushroom beta glucan: Potential candidate for post irradiation protection. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 751:2, pages 109-115.
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M. Langenbacher, R.J. Abdel-Jalil, W. Voelter, M. Weinmann & S.M. Huber. (2013) In vitro hypoxic cytotoxicity and hypoxic radiosensitizationHypoxische Zytotoxizität und Strahlensensibilisierung in vitro. Strahlentherapie und Onkologie 189:3, pages 246-255.
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Janakiraman Shanthakumar, Arumugam Karthikeyan, Venkata Reddy Bandugula & Nagarajan Rajendra Prasad. (2012) Ferulic acid, a dietary phenolic acid, modulates radiation effects in Swiss albino mice. European Journal of Pharmacology 691:1-3, pages 268-274.
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G. Kanimozhi, N. Rajendra Prasad, S. Ramachandran & K.V. Pugalendi. (2012) Umbelliferone protects whole-body irradiated Swiss albino mice: Study on animal survival, tissue antioxidant status and DNA damage. Biomedicine & Preventive Nutrition 2:3, pages 186-192.
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B. Nageshwar Rao, B.S. Satish Rao, B. Kiran Aithal & M.R. Sunil Kumar. (2009) Radiomodifying and anticlastogenic effect of Zingerone on Swiss albino mice exposed to whole body gamma radiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 677:1-2, pages 33-41.
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Geetanjali Pujari, Andrea Berni, Fabrizio Palitti & A. Chatterjee. (2009) Influence of glutathione levels on radiation-induced chromosomal DNA damage and repair in human peripheral lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 675:1-2, pages 23-28.
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N. Rajendra Prasad, M. Srinivasan, K.V. Pugalendi & Venugopal P. Menon. (2006) Protective effect of ferulic acid on γ-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 603:2, pages 129-134.
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David W. Hedley, Trudey Nicklee, Fernando Moreno-Merlo, Melania Pintilie, Anthony Fyles, Michael Milosevic & Richard P. Hill. (2005) Relations between non–protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma. International Journal of Radiation Oncology*Biology*Physics 61:1, pages 137-144.
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K Kumpawat, S Deb, S Ray & A Chatterjee. (2003) Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 538:1-2, pages 1-12.
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Beatriz Mazar Barnett & Enzo R. Muñoz. (1998) Genetic damage induced by methylglyoxal and methylglyoxal plus X-rays in Drosophila melanogaster germinal cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 421:1, pages 37-43.
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Graham Stevens, Michael Joiner, Barbara Joiner, Helen Johns & Juliana Denekamp. (1995) Radiosensitization of mouse skin by oxygen and depletion of glutathione. International Journal of Radiation Oncology*Biology*Physics 33:2, pages 399-408.
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P. Bhanumathi, E.D. Saleesh & D.M. Vasudevan. (1994) WR-1065 as a chemoprotector in Adriamycin chemotherapy. Cancer Letters 81:2, pages 171-175.
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Ganesh Chandra Jagetia, Preenu Sunil Jacob & M.N.A. Rao. (1994) (E)4-[4-N,N-dimethylaminophenyl]but-3-en-2-one (DMAP) treatment inhibits the radiation-induced micronucleus formation in bone marrow of BALB/c mice. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 306:1, pages 71-80.
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Louise K. Hosking, Richard D.H. Whelan, Sharon A. Shellard, Philip Bedford & Bridget T. Hill. (1990) An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines. Biochemical Pharmacology 40:8, pages 1833-1842.
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Edward A. Bump & J.Martin Brown. (1990) Role of glutathione in the radiation response of mammalian cells invitro and in vivo. Pharmacology & Therapeutics 47:1, pages 117-136.
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Marlis Frankenberg-Schwager. (1989) Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiotherapy and Oncology 14:4, pages 307-320.
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Brian Ketterer. (1988) Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 202:2, pages 343-361.
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O. Vos & W.S.D. Roos-Verhey. (1988) Endogenous versus exogenous thiols in radioprotection. Pharmacology & Therapeutics 39:1-3, pages 169-177.
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Robert C. Fahey. (1988) Protection of DNA by thiols. Pharmacology & Therapeutics 39:1-3, pages 101-108.
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Catherine K. Luk & Robert M. Sutherland. (1987) Nutrient modification of proliferation and radiation response in EMT6/RO spheroids. International Journal of Radiation Oncology*Biology*Physics 13:6, pages 885-895.
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John C. Livesey & Donald J. Reed. 1987. 285 353 .
Theodore L. Phillips, James B. Mitchell, William de Graff, Anthony Russo & Eli Glatstein. (1986) Variation in sensitizing efficiency for SR 2508 in human cells dependent on glutathione content. International Journal of Radiation Oncology*Biology*Physics 12:9, pages 1627-1635.
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Lyle A. Dethlefsen, John E. Biaglow, V.M. Peck & D.N. Ridinger. (1986) Toxic effects of extended glutathione depletion by buthionine sulfoximine on murine mammary carcinoma cells. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1157-1160.
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Edward P. Clark. (1986) Thiol-induced biochemical modification of chemo- and radioresponses. International Journal of Radiation Oncology*Biology*Physics 12:7, pages 1121-1126.
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