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Modern Rheumatology Volume 16, 2006 - Issue 3
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ORIGINAL ARTICLE

Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage

Katsuaki KanbeDepartment of Orthopaedic Surgery, Tokyo Women’s Medical University, Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, JapanCorrespondence[email protected]
,
Kazuhiko InoueDepartment of Orthopaedic Surgery, Tokyo Women’s Medical University, Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan
,
Charlie XiangNIH, Bethesda, MD, USA
&
Qian ChenBrown Medical School/Rhode Island Hospital, Providence, RI, USA
Pages 131-136 | Received 03 Oct 2005, Accepted 24 Feb 2006, Published online: 02 Jan 2014

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Jingming Zhou, Xiaochun Wei & Lei Wei. (2014) Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration disease. Connective Tissue Research 55:4, pages 257-261.
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Articles from other publishers (25)

Natalie Rogers & Qing-Jun Meng. (2023) Tick tock, the cartilage clock. Osteoarthritis and Cartilage 31:11, pages 1425-1436.
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Lekau Dintwa, Clare E. Hughes & Emma J. Blain. (2023) Importance of mechanical cues in regulating musculoskeletal circadian clock rhythmicity: Implications for articular cartilage. Physiological Reports 11:15.
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Ze Du, Xuanhe You, Diwei Wu, Shishu Huang & Zongke Zhou. (2022) Rhythm disturbance in osteoarthritis. Cell Communication and Signaling 20:1.
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Stephanie Wang, David W. Dai, Elinor Lee & Tisha S. Wang. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 466 474 .
M. Abdulhadi Alagha, Judit Vágó, Éva Katona, Roland Takács, Daan van der Veen, Róza Zákány & Csaba Matta. (2020) A Synchronized Circadian Clock Enhances Early Chondrogenesis. CARTILAGE 13:2_suppl, pages 53S-67S.
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Xiaopeng Song, Hui Bai, Xinghua Meng, Jianhua Xiao & Li Gao. (2021) Drivers of phenotypic variation in cartilage: Circadian clock genes. Journal of Cellular and Molecular Medicine 25:16, pages 7593-7601.
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Honor Morris, Cátia F Gonçalves, Michal Dudek, Judith Hoyland & Qing-Jun Meng. (2021) Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc. Annals of the Rheumatic Diseases 80:7, pages 828-839.
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Raewyn C Poulsen, James I Hearn & Nicola Dalbeth. (2021) The circadian clock: a central mediator of cartilage maintenance and osteoarthritis development?. Rheumatology 60:7, pages 3048-3057.
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Elizabeth S. Silagi, Ernestina Schipani, Irving M. Shapiro & Makarand V. Risbud. (2021) The role of HIF proteins in maintaining the metabolic health of the intervertebral disc. Nature Reviews Rheumatology 17:7, pages 426-439.
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Francesco Dernie & Daniel Adeyoju. (2021) A matter of time: Circadian clocks in osteoarthritis and the potential of chronotherapy. Experimental Gerontology 143, pages 111163.
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Shaowei Wang, Mengbo Zhu, Xiaochun Wei & Lei Wei. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 652 657 .
R. Akagi, Y. Akatsu, K.M. Fisch, O. Alvarez-Garcia, T. Teramura, Y. Muramatsu, M. Saito, T. Sasho, A.I. Su & M.K. Lotz. (2017) Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes. Osteoarthritis and Cartilage 25:6, pages 943-951.
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Nan Yang & Qing-Jun Meng. (2016) Circadian Clocks in Articular Cartilage and Bone. Journal of Biological Rhythms 31:5, pages 415-427.
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Francis Berenbaum & Qing-Jun Meng. (2016) The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond. Nature Reviews Rheumatology 12:9, pages 508-516.
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Wei YangXiaomin KangJiali LiuHuixia LiZhengmin MaXinxin JinZhuang QianTianping XieNa QinDongxu FengWenjie PanQian Chen, Hongzhi SunShufang Wu. (2016) Clock Gene Bmal1 Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1. Endocrinology 157:8, pages 3096-3107.
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Jonathan A.R. Gordon, Janet L. Stein, Jennifer J. Westendorf & Andre J. van Wijnen. (2015) Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease. Bone 81, pages 739-745.
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Chih-Chung Liu, Li-Jen Su, Wei-Yuan Tsai, Hsiao-Lun Sun, Hoong-Chien Lee & Chih-Shung Wong. (2015) Hylan G-F 20 attenuates posttraumatic osteoarthritis progression: Association with upregulated expression of the circardian gene NPAS2. Life Sciences 141, pages 20-24.
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Nicole Gossan, Ray Boot-Handford & Qing-Jun Meng. (2014) Ageing and osteoarthritis: a circadian rhythm connection. Biogerontology 16:2, pages 209-219.
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Simon R. Tew, Benjamin T. McDermott, Rory B. Fentem, Mandy J. Peffers & Peter D. Clegg. (2014) Transcriptome‐Wide Analysis of Messenger RNA Decay in Normal and Osteoarthritic Human Articular Chondrocytes. Arthritis & Rheumatology 66:11, pages 3052-3061.
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Michal DudekQing-Jun Meng. (2014) Running on time: the role of circadian clocks in the musculoskeletal system. Biochemical Journal 463:1, pages 1-8.
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Nicole Gossan, Leo Zeef, James Hensman, Alun Hughes, John F. Bateman, Lynn Rowley, Christopher B. Little, Hugh D. Piggins, Magnus Rattray, Raymond P. Boot‐Handford & Qing‐Jun Meng. (2013) The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis. Arthritis & Rheumatism 65:9, pages 2334-2345.
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Francis Berenbaum. (2013) Editorial: Osteoarthritis: When Chondrocytes Don't Wake Up on Time. Arthritis & Rheumatism 65:9, pages 2233-2235.
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Karen A. Roddy, Patrick J. Prendergast & Paula Murphy. (2011) Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos. PLoS ONE 6:2, pages e17526.
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T. Wei, N.H. Kulkarni, Q.Q. Zeng, L.M. Helvering, X. Lin, F. Lawrence, L. Hale, M.G. Chambers, C. Lin, A. Harvey, Y.L. Ma, R.L. Cain, J. Oskins, M.A. Carozza, D.D. Edmondson, T. Hu, R.R. Miles, T.P. Ryan, J.E. Onyia & P.G. Mitchell. (2010) Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis and Cartilage 18:7, pages 992-1000.
Crossref
Lixin Qi & Samuel Y. Boateng. (2006) The circadian protein Clock localizes to the sarcomeric Z-disk and is a sensor of myofilament cross-bridge activity in cardiac myocytes. Biochemical and Biophysical Research Communications 351:4, pages 1054-1059.
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