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Modern Rheumatology Volume 16, 2006 - Issue 5
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CASE REPORT

Leflunomide-related acute interstitial pneumonia in two patients with rheumatoid arthritis: autopsy findings with a mosaic pattern of acute and organizing diffuse alveolar damage

Sae OchiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
,
Masayoshi HarigaiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;Department of Pharmacovigilance, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan;Clinical Research Center, Tokyo Medical and Dental University Hospital, Tokyo, Japan
,
Fumitaka MizoguchiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
,
Hideyuki IwaiDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
,
Hiroyuki HagiyamaDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
,
Teruaki OkaDepartment of Pathology, Kanto Central Hospital of the Mutual Aid Association of Public School Teachers, Tokyo, Japan
&
Nobuyuki MiyasakaDepartment of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, JapanCorrespondence[email protected]
 show all
Pages 316-320 | Received 11 May 2006, Accepted 15 Jun 2006, Published online: 02 Jan 2014

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Read on this site (5)

Shigeko Inokuma. (2011) Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury. Expert Opinion on Drug Safety 10:4, pages 603-611.
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Kumi Shidara, Daisuke Hoshi, Eisuke Inoue, Toru Yamada, Ayako Nakajima, Atsuo Taniguchi, Masako Hara, Shigeki Momohara, Naoyuki Kamatani & Hisashi Yamanaka. (2010) Incidence of and risk factors for interstitial pneumonia in patients with rheumatoid arthritis in a large Japanese observational cohort, IORRA. Modern Rheumatology 20:3, pages 280-286.
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Sae Ochi, Ken Taniguchi & Masakazu Nagashima. (2009) Leflunomide-induced polymyositis in a patient with rheumatoid arthritis. Modern Rheumatology 19:4, pages 443-446.
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Xingdong Jian, Guangran Guo, Yanjun Ruan, Dawei Lin & Xingfu Li. (2008) Severe Cutaneous Adverse Drug Reaction to Leflunomide: A Report of Two Cases. Cutaneous and Ocular Toxicology 27:1, pages 5-9.
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Yasuhiko Toyokawa, Isamu Kingetsu, Chiho Yasuda, Jun Yasuda, Ken Yoshida, Daitaro Kurosaka & Akio Yamada. (2007) Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. Modern Rheumatology 17:5, pages 436-440.
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Marianna M. Henry & Terry L. Noah. 2019. Kendig's Disorders of the Respiratory Tract in Children. Kendig's Disorders of the Respiratory Tract in Children 876 885.e6 .
Meghna Jani, William G. Dixon & Eric L. Matteson. 2018. Lung Disease in Rheumatoid Arthritis. Lung Disease in Rheumatoid Arthritis 121 161 .
Su‑Xian Zhou, Dong‑Mei Huo, Xiao‑Yun He, Ping Yu, Yan‑Hua Xiao, Chun‑Lin Ou, Ren-Mei Jiang, Dan Li & Hao Li. (2017) High glucose/lysophosphatidylcholine levels stimulate extracellular matrix deposition in diabetic nephropathy via platelet‑activating factor receptor. Molecular Medicine Reports.
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B. Huret, S. Boulanger, L. Benhamed, X. Deprez & D. Caparros. (2017) Pyopneumothorax au cours d’une polyarthrite rhumatoïde. Revue des Maladies Respiratoires 34:9, pages 1011-1015.
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Dam Kim, Soo-Kyung Cho, Chan-Bum Choi, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Tae-Hwan Kim, Tae-Jong Kim, Hye-Soon Lee, Joo-Hyun Lee, Jisoo Lee, Shin-Seok Lee, Dae-Hyun Yoo, Bo Young Yoon, Jin Woo Song, Sang-Cheol Bae & Yoon-Kyoung Sung. (2017) Impact of interstitial lung disease on mortality of patients with rheumatoid arthritis. Rheumatology International 37:10, pages 1735-1745.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 498 511 .
Aryeh Fischer & Kevin K. Brown. 2015. Orphan Lung Diseases. Orphan Lung Diseases 419 434 .
Camille Roubille & Boulos Haraoui. (2014) Interstitial lung diseases induced or exacerbated by DMARDS and biologic agents in rheumatoid arthritis: A systematic literature review. Seminars in Arthritis and Rheumatism 43:5, pages 613-626.
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Aryeh Fischer & Roland M. du Bois. 2012. Diffuse Lung Disease. Diffuse Lung Disease 217 237 .
. 2010. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs 371 667 .
S P.Y. Wong, C M. Chu, C H. Kan, H S. Tsui & W L. Ng. (2009) Successful Treatment of Leflunomide-Induced Acute Pneumonitis With Cholestyramine Wash-Out Therapy. JCR: Journal of Clinical Rheumatology 15:8, pages 389-392.
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Sae Ochi, Ken Taniguchi & Masakazu Nagashima. (2009) Leflunomide-induced polymyositis in a patient with rheumatoid arthritis. Modern Rheumatology 19:4, pages 443-446.
Crossref
Makoto Sasaki, Yasushi Isobe, Yutaka Tsukune, Shimpei Kawahara, Yasuharu Hamano, Jun Ando, Junichi Tomomatsu, Miyuki Tsutsui & Koichi Sugimoto. (2009) Thalidomide may induce interstitial pneumonia preferentially in Japanese patients. European Journal of Haematology 82:1, pages 73-74.
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Ildiko Fanny Horvath, Antonia Szanto, Zoltan Csiki, Peter Szodoray & Margit Zeher. (2008) Intrapulmonary Rheumatoid Nodules in a Patient with Long-Standing Rheumatoid Arthritis Treated with Leflunomide. Pathology & Oncology Research 14:1, pages 101-104.
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Takeshi Otsuka, Takako Koyama, Ryoko Ohtani, Hiroaki Niiro, Seiji Yoshizawa, Mine Harada & Shigeko Inokuma. (2007) Leflunomide-induced lung injury that developed after its withdrawal, coinciding with peripheral blood lymphocyte count decrease. Modern Rheumatology 18:1, pages 96-99.
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Yasuhiko Toyokawa, Isamu Kingetsu, Chiho Yasuda, Jun Yasuda, Ken Yoshida, Daitaro Kurosaka & Akio Yamada. (2007) Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. Modern Rheumatology 17:5, pages 436-440.
Crossref
R. Stokes PeeblesJr.Jr. & Martin L. Moore. (2007) A Mechanistic Advance in Understanding RSV Pathogenesis, but Still a Long Way from Therapy. American Journal of Respiratory Cell and Molecular Biology 37:4, pages 375-377.
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