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Modern Rheumatology Volume 17, 2007 - Issue 2
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ORIGINAL ARTICLE

A relationship between pharmacokinetics (PK) and the efficacy of infliximab for patients with rheumatoid arthritis: characterization of infliximab-resistant cases and PK-based modified therapy

Shunsuke MoriDepartment of Rheumatology, Clinical Research Center for Rheumatic Disease, National Kumamoto Saishunsou Hospital,2659 Suya, Kohshi 861-1196, JapanCorrespondence[email protected]
Pages 83-91 | Received 04 Sep 2006, Accepted 01 Nov 2006, Published online: 02 Jan 2014

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Won Park, Sang Joon Lee, Jihye Yun & Dae Hyun Yoo. (2015) Comparison of the pharmacokinetics and safety of three formulations of infliximab (CT-P13, EU-approved reference infliximab and the US-licensed reference infliximab) in healthy subjects: a randomized, double-blind, three-arm, parallel-group, single-dose, Phase I study. Expert Review of Clinical Immunology 11:sup1, pages 25-31.
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Shunsuke Mori. (2012) Additional use of tacrolimus after switching to tocilizumab therapy in patients with primary lack of efficacy of infliximab therapy for rheumatoid arthritis. Modern Rheumatology 22:6, pages 947-950.
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Shunsuke Mori & Yukitaka Ueki. (2011) Primary lack of efficacy of infliximab therapy for rheumatoid arthritis: pharmacokinetic characterization and assessment of switching to tocilizumab. Modern Rheumatology 21:6, pages 628-636.
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Garrett Lawlor & Alan C Moss. (2009) Cause for controversy? Infliximab in the treatment of ulcerative colitis: an update. Clinical and Experimental Gastroenterology 2, pages 149-161.
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Rene Westhovens, Piotr Wiland, Marek Zawadzki, Delina Ivanova, Alfredo Berrocal Kasay, Elias Chalouhi El-Khouri, Éva Balázs, Sergii Shevchuk, Larisa Eliseeva, Mykola Stanislavchuk, Roman Yatsyshyn, Paweł Hrycaj, Janusz Jaworski, Vyacheslav Zhdan, Jakub Trefler, Pavel Shesternya, Sang Joon Lee, Sung Hyun Kim, Jee Hye Suh, Seul Gi Lee, Noo Ri Han & Dae Hyun Yoo. (2021) Efficacy, pharmacokinetics and safety of subcutaneous versus intravenous CT-P13 in rheumatoid arthritis: a randomized phase I/III trial. Rheumatology 60:5, pages 2277-2287.
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Ping Ji, Nikolay Nikolov, Sally Seymour, Rachel Glaser, Yupeng Ren, Liang Li, Anshu Marathe, Yunzhao Ren, Jianmeng Chen, Lei He, Dipak Pisal, Shalini Wickramaratne Senarath Yapa, Yaning Wang & Chandrahas Sahajwalla. (2019) A Novel Pharmacokinetic Bridging Strategy to Support a Change in the Route of Administration for Biologics. Journal of Pharmaceutical Sciences 108:7, pages 2490-2499.
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Tan Zhang, Guihong Chen, Chang Liu, Li’an Zu, Qi Wang, Yitong Wang, Jie Lv, Youzhong An, Lihou Dong, Huiyang Cheng, Shengbin Ren, Qian Wang, Qingshan Zheng, Haifeng Song & Yi Fang. (2018) A Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of Proposed Biosimilar GB242 and Reference Infliximab in Healthy Subjects. BioDrugs 33:1, pages 93-100.
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Kevin D. Pile, Garry G. Graham, Stephen M. Mahler & Richard O. Day. 2019. Nijkamp and Parnham's Principles of Immunopharmacology. Nijkamp and Parnham's Principles of Immunopharmacology 709 750 .
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Eli D. Ehrenpreis. (2017) Pharmacokinetic Effects of Antidrug Antibodies Occurring in Healthy Subjects After a Single Dose of Intravenous Infliximab. Drugs in R&D 17:4, pages 607-613.
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Christophe PassotMieke F. Pouw, Denis MullemanTheodora Bejan-AngoulvantGilles PaintaudErwin DreesenDavid Ternant. (2017) Therapeutic Drug Monitoring of Biopharmaceuticals May Benefit From Pharmacokinetic and Pharmacokinetic–Pharmacodynamic Modeling. Therapeutic Drug Monitoring 39:4, pages 322-326.
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Dario Sorrentino, Vu Nguyen, Carl Henderson & Adegabenga Bankole. (2016) Therapeutic Drug Monitoring and Clinical Outcomes in Immune Mediated Diseases. Inflammatory Bowel Diseases 22:10, pages 2527-2537.
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Songmao Zheng, Weirong Wang & Honghui Zhou. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 22 .
Chamaida Plasencia, Teresa Jurado, Alejandro Villalba, Diana Peitedado, Maria Teresa López Casla, Laura Nuño, María Gema Bonilla, Ana Martínez-Feito, Emilio Martín-Mola, Dora Pascual-Salcedo & Alejandro Balsa. (2015) Effect of Infliximab Dose Increase in Rheumatoid Arthritis at Different Trough Concentrations: A Cohort Study in Clinical Practice Conditions. Frontiers in Medicine 2.
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David Ternant, Emilie Ducourau, Piéra Fuzibet, Céline Vignault, Hervé Watier, Thierry Lequerré, Xavier Le Loët, Olivier Vittecoq, Philippe Goupille, Denis Mulleman & Gilles Paintaud. (2015) Pharmacokinetics and concentration–effect relationship of adalimumab in rheumatoid arthritis. British Journal of Clinical Pharmacology 79:2, pages 286-297.
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Maarten L. Zandvliet, Jine S. van Bezooijen, Mariska A. Bos, Errol P. Prens, Martijn van Doorn, Ilona Bijen, Marco W. J. Schreurs, Vincent H. J. van der Velden, Birgit C. P. Koch & Teun van Gelder. (2013) Monitoring Antigen-Specific Biologics. Therapeutic Drug Monitoring 35:5, pages 588-594.
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Henit Yanai & Stephen B Hanauer. (2011) Assessing Response and Loss of Response to Biological Therapies in IBD. American Journal of Gastroenterology 106:4, pages 685-698.
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Ron J. Keizer, Alwin D.R. Huitema, Jan H.M. Schellens & Jos H. Beijnen. (2010) Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies. Clinical Pharmacokinetics 49:8, pages 493-507.
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Denis Mulleman, Delphine Chu Miow Lin, Emilie Ducourau, Patrick Emond, David Ternant, Charlotte Magdelaine-Beuzelin, Jean-Pierre Valat, Gilles Paintaud & Philippe Goupille. (2010) Trough Infliximab Concentrations Predict Efficacy and Sustained Control of Disease Activity in Rheumatoid Arthritis. Therapeutic Drug Monitoring 32:2, pages 232-236.
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Christopher R. Gibson, Punam Sandhu & William D. Hanley. 2009. Therapeutic Monoclonal Antibodies. Therapeutic Monoclonal Antibodies 439 460 .
Ulrich Klotz, Alexander Teml & Matthias Schwab. (2007) Clinical Pharmacokinetics and Use??of??Infliximab. Clinical Pharmacokinetics 46:8, pages 645-660.
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