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Modern Rheumatology Volume 17, 2007 - Issue 3
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ORIGINAL ARTICLE

Mizoribine therapy for patients with lupus nephritis: the association between peak mizoribine concentration and clinical efficacy

Takeshi KurodaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, JapanCorrespondence[email protected]
,
Shintaro HiroseDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Naohito TanabeDivision of Health Promotion, Niigata University Graduate School of Medical and Dental Sciences,Niigata, Japan
,
Hiroe SatoDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Takeshi NakatsueDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Jyunya AjiroDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Yoko WadaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Syuichi MurakamiDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Hisashi HasegawaDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Satoshi ItoDepartment of Internal Medicine, University of Tsukuba,Tsukuba, Japan
,
Minoru SakatsumeDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
,
Masaaki NakanoDepartment of Medical Technology, School of Health Sciences, Faculty of Medicine, Niigata University,Niigata, Japan
&
Fumitake GejyoDivision of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences,1-757, Asahimachi-dori, Niigata 951-8510, Japan
 show all
Pages 206-212 | Received 11 Sep 2006, Accepted 05 Feb 2007, Published online: 02 Jan 2014

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Eiko Nishi, Hideto Kameda, Hiroe Ogawa, Hayato Nagasawa, Hirofumi Takei, Ayumi Okuyama, Takahiko Kurasawa, Tsuneo Kondo, Koji Nishimura, Yuichiro Shirai, Ryota Sakai, Tatsuya Ito, Tsutomu Takeuchi & Koichi Amano. (2013) Efficacy of weekly mizoribine pulse therapy in refractory lupus nephritis. Modern Rheumatology 23:1, pages 97-103.
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Akira Onishi, Daisuke Sugiyama, Go Tsuji, Takashi Nakazawa, Yoshinori Kogata, Kosaku Tsuda, Ikuko Naka, Keisuke Nishimura, Kenta Misaki, Chiyo Kurimoto, Hiroki Hayashi, Goichi Kageyama, Jun Saegusa, Takeshi Sugimoto, Seiji Kawano, Shunichi Kumagai & Akio Morinobu. (2013) Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study. Modern Rheumatology 23:1, pages 89-96.
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Hideo Ohtsubo, Sanae Ohkura, Masaki Akimoto, Yoshiya Arishima, Nobuhiko Sunahara, Tomomaro Izumihara, Nobutaka Eiraku, Tamami Yoshitama & Takemasa Matsuda. (2012) An investigation of the correlation between blood concentration of mizoribine and its efficacy in treatment of rheumatoid arthritis based on indices of drug survival and improvement in DAS28-CRP. Modern Rheumatology 22:6, pages 837-843.
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Keita Nishimura, Jinju Nishino, Akira Kouchi, Naotsugu Nakamura, Shin Nakajima, Isamu Yokoe, Hitomi Haraoka & Takashi Matsushita. (2011) Efficacy and safety of single-dose mizoribine for patients with rheumatoid arthritis: results at 6 months after switching from a multiple-dose regimen without a change in total daily dose. Modern Rheumatology 21:2, pages 158-163.
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Takeshi Kuroda, Daisuke Kobayashi, Hiroe Sato, Akihisa Oyanagi, Yoko Wada, Syuichi Murakami, Masaaki Nakano & Ichiei Narita. (2010) Mizoribine therapy in a patient with lupus nephritis: the association between mizoribine concentration and peritoneal dialysis. Modern Rheumatology 20:3, pages 296-300.
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Tsuyoshi Kasama, Kuninobu Wakabayashi, Tsuyoshi Odai, Takeo Isozaki, Mizuho Matsunawa, Nobuyuki Yajima, Yusuke Miwa, Masao Negishi & Hirotsugu Ide. (2009) Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate. Modern Rheumatology 19:4, pages 395-400.
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Masanobu Horikoshi, Satoshi Ito, Mizue Ishikawa, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Taichi Hayashi, Daisuke Goto, Isao Matsumoto & Takayuki Sumida. (2009) Efficacy of mizoribine pulse therapy in patients with rheumatoid arthritis who show a reduced or insufficient response to infliximab. Modern Rheumatology 19:3, pages 229-234.
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Shunsuke Mori & Kenji Ebihara. (2008) A sudden onset of diabetic ketoacidosis and acute pancreatitis after introduction of mizoribine therapy in a patient with rheumatoid arthritis. Modern Rheumatology 18:6, pages 634-638.
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Yasunori Tsubouchi, Wataru Fukuda, Yutaka Kawahito, Masataka Kohno, Makoto Wada, Hidetaka Ishino, Masahide Hamaguchi, Aihiro Yamamoto, Masatoshi Kadoya, Mikiko Niimi & Toshikazu Yoshikawa. (2008) A case of lupus nephritis improved after appropriately adjusting the dosage of mizoribine. Modern Rheumatology 18:1, pages 91-95.
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Articles from other publishers (11)

Zheng-Kun Xia, Yuan-Fu Gao, Li-Ping Rong, Xi-Qiang Dang, Qian Shen, Xiao-Yun Jiang, Zhu-Wen Yi & Hong Xu. (2019) Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China. World Journal of Pediatrics 15:3, pages 262-269.
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Taketsugu Hama, Koichi Nakanishi, Kenji Ishikura, Shuichi Ito, Hidefumi Nakamura, Mayumi Sako, Mari Saito-Oba, Kandai Nozu, Yuko Shima, Kazumoto Iijima & Norishige Yoshikawa. (2018) Study protocol: high-dose mizoribine with prednisolone therapy in short-term relapsing steroid-sensitive nephrotic syndrome to prevent frequent relapse (JSKDC05 trial). BMC Nephrology 19:1.
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Hidetoshi Kagawa, Tsutomu Hiromasa, Ryutaro Yamanaka, Reika Hayashi, Yoko Tsunashima, Tatsuyuki Inoue & Ken-ei Sada. (2018) The first year results of mizoribine/tacrolimus-based multitarget treatment for consecutive patients with lupus nephritis. Clinical and Experimental Nephrology 22:6, pages 1371-1378.
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L. Liu, B. Ren, H. Zhang, J. Li, Q. Fu, J. Jiang, S. Deng, J. Qiu, G. Chen, J. Fei, L. Chen & C. Wang. (2018) Population Pharmacokinetic Analysis of Mizoribine in Chinese Renal Transplant Recipients. Transplantation Proceedings 50:8, pages 2392-2397.
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Keiji Hirai, Susumu Ookawara, Taisuke Kitano, Haruhisa Miyazawa, Kiyonori Ito, Yuichirou Ueda, Yoshio Kaku, Taro Hoshino, Honami Mori, Izumi Yoshida, Kenji Kubota, Yasuyoshi Yamaji, Tetsuro Takeda, Yoshikazu Nakamura, Kaoru Tabei & Yoshiyuki Morishita. (2017) Efficacy and safety of adding mizoribine to standard treatment in patients with immunoglobulin A nephropathy: A randomized controlled trial. Kidney Research and Clinical Practice 36:2, pages 159-166.
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Hisashi Kaneda, Masaki Shimizu, Kazuhide Ohta, Katsumi Ushijima, Yoshimitsu Gotoh, Kenichi Satomura, Takuhito Nagai, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Mari Takaai, Yukiya Hashimoto & Osamu Uemura. (2015) Population pharmacokinetics of mizoribine in pediatric patients with kidney disease. Clinical and Experimental Nephrology 20:5, pages 757-763.
Crossref
Hiroshi Tanaka, Kazushi Tsuruga & Taddatsu Imaizumi. (2015) Mizoribine in the treatment of pediatric-onset glomerular disease. World Journal of Pediatrics 11:2, pages 108-112.
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Tetsuji Sawada. (2011) 5. Leflunomide and Mizoribine.. Nihon Naika Gakkai Zasshi 100:10, pages 2929-2935.
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Tsutomu OHTSUKA. (2010) Combinational effect of low-dose oral corticosteroid and mizoribine for ulcerative colitis in a patient with systemic sclerosis. The Journal of Dermatology 37:1, pages 71-74.
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Tsuyoshi Kasama, Kuninobu Wakabayashi, Tsuyoshi Odai, Takeo Isozaki, Mizuho Matsunawa, Nobuyuki Yajima, Yusuke Miwa, Masao Negishi & Hirotsugu Ide. (2009) Effects of low-dose mizoribine pulse therapy in combination with methotrexate in rheumatoid arthritis patients with an insufficient response to methotrexate. Modern Rheumatology 19:4, pages 395-400.
Crossref
Yasunori Tsubouchi, Wataru Fukuda, Yutaka Kawahito, Masataka Kohno, Makoto Wada, Hidetaka Ishino, Masahide Hamaguchi, Aihiro Yamamoto, Masatoshi Kadoya, Mikiko Niimi & Toshikazu Yoshikawa. (2007) A case of lupus nephritis improved after appropriately adjusting the dosage of mizoribine. Modern Rheumatology 18:1, pages 91-95.
Crossref

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