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Modern Rheumatology Volume 18, 2008 - Issue 5
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Review Article

Proposals for leflunomide use to avoid lung injury in patients with rheumatoid arthritis

Shigeko InokumaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
,
Takeo SatoStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Rheumatology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, JapanCorrespondence[email protected]
,
Akira SagawaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Sagawa Akira Rheumatology Clinic, Sapporo, Japan
,
Takemasa MatsudaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;The Center for Rheumatic Diseases, Kagoshima Red Cross Hospital, Kagoshima, Japan
,
Tamiko TakemuraStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan
,
Takeshi OhtsukaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Internal Medicine, Munakata Medical Association Hospital, Fukuoka, Japan
,
Yukihiko SaekiStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Division of Allergy and Clinical Immunology, National Hospital Organization, Osaka-Minami Medical Center, Osaka, Japan
,
Tsutomu TakeuchiStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Division of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University, Saitama, Japan
&
Tetsuji SawadaStudy Committee for Leflunomide-Induced Lung Injury, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0011, Japan;Department of Allergy and Rheumatology, University of Tokyo School of Medicine, Tokyo, Japan
 show all
Pages 442-446 | Received 07 Dec 2007, Accepted 11 Mar 2008, Published online: 02 Jan 2014

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Shigeko Inokuma. (2011) Leflunomide-induced interstitial pneumonitis might be a representative of disease-modifying antirheumatic drug-induced lung injury. Expert Opinion on Drug Safety 10:4, pages 603-611.
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Akira Hashiramoto, Kazuko Shiozawa, Yasushi Tanaka, Takashi Yamane, Miki Murata, Chihiro Tanaka, Yasuhiro Terashima, Kozo Koyama, Natsuko Nakagawa, Shuji Abe, Rhosuke Yoshihara, Yasuhiro Saegusa, Ken Tsumiyama, Koichiro Komai, Yoshitada Sakai & Shunichi Shiozawa. (2009) Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose. Modern Rheumatology 19:6, pages 637-642.
Read now
Kou Katayama & Takeo Matsuno. (2009) Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients. Modern Rheumatology 19:5, pages 513-521.
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Articles from other publishers (13)

KWANGSEOK YANG, MASAKAZU MATSUSHITA & NAOTO TAMURA. (2020) Methotrexate and Oral Antirheumatic Drugs. Juntendo Medical Journal 66:1, pages 27-33.
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Li-Ta Keng, Mong-Wei Lin, Hsien-Neng Huang & Kuei-Pin Chung. (2016) Diffuse alveolar damage in a patient with rheumatoid arthritis under prolonged leflunomide treatment. Medicine 95:26, pages e4044.
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Kenjiro FUKUSHIMA, Nozomi EGUCHI, Koichi OHNO, Hideyuki KANEMOTO, Masashi TAKAHASHI, Hirotaka IGARASHI, Aki OHMI, Ko NAKASHIMA & Hajime TSUJIMOTO. (2016) Efficacy of leflunomide for treatment of refractory inflammatory colorectal polyps in 15 Miniature Dachshunds. Journal of Veterinary Medical Science 78:2, pages 265-269.
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Boulos Haraoui. 2015. Rheumatology. Rheumatology 451 458 .
Glen S. Hazlewood, Pooneh Akhavan, Orit Schieir, Deborah Marshall, George Tomlinson, Vivian Bykerk & Claire Bombardier. (2014) Adding a ?GRADE? to the quality appraisal of rheumatoid arthritis guidelines identifies limitations beyond AGREE-II. Journal of Clinical Epidemiology 67:11, pages 1274-1285.
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Kazuhiko Nakagawa, Shoji Kudoh, Yuichiro Ohe, Takeshi Johkoh, Masahiko Ando, Naoya Yamazaki, Akihiro Seki, Shinya Takemoto & Masahiro Fukuoka. (2012) Postmarketing Surveillance Study of Erlotinib in Japanese Patients With Non–Small-Cell Lung Cancer (NSCLC): An Interim Analysis of 3488 Patients (POLARSTAR). Journal of Thoracic Oncology 7:8, pages 1296-1303.
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Tetsuji Sawada. (2011) 5. Leflunomide and Mizoribine.. Nihon Naika Gakkai Zasshi 100:10, pages 2929-2935.
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J.K. Aronson. 2011. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 815 839 .
T Namba, K-I Tanaka, Y Ito, T Hoshino, M Matoyama, N Yamakawa, Y Isohama, A Azuma & T Mizushima. (2010) Induction of EMT-like phenotypes by an active metabolite of leflunomide and its contribution to pulmonary fibrosis. Cell Death & Differentiation 17:12, pages 1882-1895.
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Sara A. Colopy, Theresa A. Baker & Peter Muir. (2010) Efficacy of leflunomide for treatment of immune-mediated polyarthritis in dogs: 14 cases (2006–2008). Journal of the American Veterinary Medical Association 236:3, pages 312-318.
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Akira Hashiramoto, Kazuko Shiozawa, Yasushi Tanaka, Takashi Yamane, Miki Murata, Chihiro Tanaka, Yasuhiro Terashima, Kozo Koyama, Natsuko Nakagawa, Shuji Abe, Rhosuke Yoshihara, Yasuhiro Saegusa, Ken Tsumiyama, Koichiro Komai, Yoshitada Sakai & Shunichi Shiozawa. (2009) Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose. Modern Rheumatology 19:6, pages 637-642.
Crossref
T. Sato, S. Inokuma, A. Sagawa, T. Matsuda, T. Takemura, T. Otsuka, Y. Saeki, T. Takeuchi & T. Sawada. (2009) Factors associated with fatal outcome of leflunomide-induced lung injury in Japanese patients with rheumatoid arthritis. Rheumatology 48:10, pages 1265-1268.
Crossref
Kou Katayama & Takeo Matsuno. (2009) Long-term efficacy of leflunomide on disease activity and inhibition of joint damage: retrospective comparison with methotrexate for Japanese rheumatoid arthritis patients. Modern Rheumatology 19:5, pages 513-521.
Crossref

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