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Modern Rheumatology Volume 19, 2009 - Issue 1
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CASE REPORT

A case report of a patient with refractory adult-onset Still’s disease who was successfully treated with tocilizumab over 6 years

Hideko NakaharaLaboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan;NTT West Osaka Hospital, 2-6-40 Karasugatsuji, Tennoji-ku, Osaka, Osaka 543-8922, Japan
,
Toru MimaLaboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan
,
Naoko Yoshio-HoshinoLaboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, Japan
,
Masato MatsushitaDivision of Rheumatology, National Hospital Organization, Osaka Minami Medical Center, 2-1 Kidohigashi-cho, Kawachinagano, Osaka 586-8521, Japan
,
Jun HashimotoDepartment of Orthopaedics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
&
Norihiro NishimotoLaboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565-0871, JapanCorrespondence[email protected]
Pages 69-72 | Received 25 Apr 2008, Accepted 22 Jul 2008, Published online: 02 Jan 2014

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Hyoun-Ah Kim & Chang-Hee Suh. (2017) An update: current and prospective treatments for adult-onset Still’s disease. Expert Opinion on Orphan Drugs 5:5, pages 421-429.
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Anjali Shetty, Rebekah Hanson, Peter Korsten, Munir Shawagfeh, Shiva Arami, Suncica Volkov, Olga Vila, William Swedler, Abdel Naser Shunaigat, Sameer Smadi, Ray Sawaqed, David Perkins, Shiva Shahrara & Nadera J Sweiss. (2014) Tocilizumab in the treatment of rheumatoid arthritis and beyond. Drug Design, Development and Therapy 8, pages 349-364.
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Toshio Tanaka, Atsushi Ogata & Masashi Narazaki. (2010) Tocilizumab for the treatment of rheumatoid arthritis. Expert Review of Clinical Immunology 6:6, pages 843-854.
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Rodney Tehrani, Rochella A Ostrowski, Richard Hariman & Walter M. Jay. (2009) Review of Biologic Therapies. Neuro-Ophthalmology 33:6, pages 286-299.
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Articles from other publishers (25)

Shijia Rao, Lemuel Shui-Lun Tsang, Ming Zhao, Wei Shi & Qianjin Lu. (2022) Adult-onset Still’s disease: A disease at the crossroad of innate immunity and autoimmunity. Frontiers in Medicine 9.
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M. Delplanque, J. Pouchot, S. Ducharme-Bénard, B.J Fautrel, A. Benyamine, L. Daniel, T. Gendre, G. Grateau & S. Georgin-Lavialle. (2020) AA amyloidosis secondary to adult onset Still's disease: About 19 cases. Seminars in Arthritis and Rheumatism 50:1, pages 156-165.
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Sheng Li, Siting Zheng, Shunli Tang, Yunlei Pan, Shan Zhang, Hong Fang & Jianjun Qiao. (2019) Autoinflammatory Pathogenesis and Targeted Therapy for Adult-Onset Still’s Disease. Clinical Reviews in Allergy & Immunology 58:1, pages 71-81.
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Asami Masui-Ito, Ryuji Okamoto, Kaoru Ikejiri, Mika Fujimoto, Muneyoshi Tanimura, Shiro Nakamori, Tomohiro Murata, Eiji Ishikawa, Norikazu Yamada, Hiroshi Imai & Masaaki Ito. (2017) Tocilizumab for uncontrollable systemic inflammatory response syndrome complicating adult-onset Still disease. Medicine 96:29, pages e7596.
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Xavier Vandemergel & Frédéric Vandergheynst. (2016) Efficacy of Low-Dose Tocilizumab on Relapsing Adult-Onset Still’s Disease. Acta Medica (Hradec Kralove, Czech Republic) 59:1, pages 22-25.
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Daisuke Kobayashi, Satoshi Ito, Akira Murasawa, Ichiei Narita & Kiyoshi Nakazono. (2015) Two Cases of Adult-onset Still's Disease Treated with Tocilizumab that Achieved Tocilizumab-free Remission. Internal Medicine 54:20, pages 2675-2679.
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Alexandre Thibault Jacques Maria, Alain Le Quellec, Christian Jorgensen, Isabelle Touitou, Sophie Rivière & Philippe Guilpain. (2014) Adult onset Still's disease (AOSD) in the era of biologic therapies: Dichotomous view for cytokine and clinical expressions. Autoimmunity Reviews 13:11, pages 1149-1159.
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Mathieu Gerfaud-Valentin, Yvan Jamilloux, Jean Iwaz & Pascal Sève. (2014) Adult-onset Still's disease. Autoimmunity Reviews 13:7, pages 708-722.
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Lilia Andrade-Ortega, Fedra Irazoque-Palazuelos, Sandra Mu?oz-L?pez & Victor M. Rosales-Don Pablo. (2014) Efficacy of Tocilizumab in Refractory Adult-Onset Still's Disease; Report of 2 Cases. Reumatolog?a Cl?nica (English Edition) 10:3, pages 199-200.
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Lilia Andrade-Ortega, Fedra Irazoque-Palazuelos, Sandra Mu?oz-L?pez & Victor M. Rosales-Don Pablo. (2014) Eficacia de tocilizumab en enfermedad de Still del adulto refractaria; a prop?sito de 2 casos. Reumatolog?a Cl?nica 10:3, pages 199-200.
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C. Iking-Konert, P. Bartz-Bazzanella, D. Falagan, M.W. Hofman, A. Schwarting & T. D?rner. (2013) Interleukin-6-Blockade als potenzielles therapeutisches Target bei entz?ndlich-rheumatischen ErkrankungenInterleukin-6 inhibition as a potential therapeutic target in rheumatic diseases. Zeitschrift f?r Rheumatologie 73:3, pages 269-276.
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Paola Cipriani, Piero Ruscitti, Francesco Carubbi, Ilenia Pantano, Vasiliki Liakouli, Onorina Berardicurti & Roberto Giacomelli. (2013) Tocilizumab for the treatment of adult-onset Still’s disease: results from a case series. Clinical Rheumatology 33:1, pages 49-55.
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Toshio Tanaka, Atsushi OgataMasashi Narazaki. (2013) Tocilizumab: An Updated Review of Its Use in the Treatment of Rheumatoid Arthritis and Its Application for Other Immune-Mediated Diseases. Clinical Medicine Insights: Therapeutics 5, pages CMT.S9282.
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Hubert de Boysson, J?rome F?vrier, Am?lie Nicolle, Christophe Auzary & Lo?k Geffray. (2012) Tocilizumab in the treatment of the adult-onset Still's disease: current clinical evidence. Clinical Rheumatology 32:1, pages 141-147.
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Masaki Shimizu, Yasuo Nakagishi, Kazuko Kasai, Yuichi Yamasaki, Mari Miyoshi, Syuji Takei & Akihiro Yachie. (2012) Tocilizumab masks the clinical symptoms of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The diagnostic significance of interleukin-18 and interleukin-6. Cytokine 58:2, pages 287-294.
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Toshio Tanaka & Tadamitsu Kishimoto. (2012) Immunotherapeutic implication of IL-6 blockade. Immunotherapy 4:1, pages 87-105.
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Toshio Tanaka, Masashi Narazaki & Tadamitsu Kishimoto. (2011) Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases. FEBS Letters 585:23, pages 3699-3709.
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Toshio Tanaka, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata & Atsushi Kumanogoh. (2011) Tocilizumab, a humanized anti‐interleukin‐6 receptor antibody, for the treatment of autoimmune disorders. Drug Development Research 72:8, pages 717-732.
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Youssef Sekkach, Mohamed Elqatni, Abdessadek El Khattabi, Jamal Fatihi, Salaheddine Hammi, Mohamed Badaoui, Naoual Elomri, Fadoua Mekouar, Taoufik Amezyane, Ali Abouzahir & Driss Ghafir. (2011) Les antagonistes de l?interleukine-6 (tocilizumab) dans la maladie de still r?fractaire de l?adulte. La Presse M?dicale 40:7-8, pages e333-e337.
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. (2011) Current World Literature. Current Opinion in Rheumatology 23:3, pages 317-324.
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Miho Murakami & Norihiro Nishimoto. (2011) The value of blocking IL-6 outside of rheumatoid arthritis: current perspective. Current Opinion in Rheumatology 23:3, pages 273-277.
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Xavier Pu?chal, Michel DeBandt, Jean-Marie Berthelot, Maxime Breban, Jean-Jacques Dubost, Olivier Fain, Jean-Emmanuel Kahn, Laurence Lequen, Ma?t? Longy-Boursier, Aleth Perdriger, Thierry Schaeverbeke, Eric Toussirot & Jean Sibilia. (2011) Tocilizumab in refractory adult Still's disease. Arthritis Care & Research 63:1, pages 155-159.
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Dennis J. Cada, Terri L. Levien & Danial E. Baker. (2010) Tocilizumab. Hospital Pharmacy 45:6, pages 484-495.
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Hiromichi Tamaki, Hisanori Shimizu, Eiji Hiraoka, Eishi Uechi, Mitsumasa Kishimoto, Kenichi Yamaguchi & Masato Okada. (2009) Marked effect and steroid-sparing ability of anakinra on a patient with refractory adult-onset Still’s disease. Modern Rheumatology 20:2, pages 200-204.
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Yuko Takahashi, Hisako Ochi, Atsushi Yanai, Hiroyuki Yamashita, Kenji Itoh & Akio Mimori. (2010) Successful Tocilizumab Therapy for Adult Onset Still's Disease with Intractable Conditions Over Ten Years.. Nihon Naika Gakkai Zasshi 99:1, pages 130-132.
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