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Original Article

Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions

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Pages 222-232 | Received 09 Dec 2009, Accepted 26 Jan 2010, Published online: 02 Jan 2014

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O. Shovman, Y. Shoenfeld & P. Langevitz. (2014) Tocilizumab-induced neutropenia in rheumatoid arthritis patients with previous history of neutropenia: case series and review of literature. Immunologic Research 61:1-2, pages 164-168.
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Tomas Söderman, Claes Olerud, Adel Shalabi, Kamran Alavi & Anders Sundin. (2014) Static and dynamic CT imaging of the cervical spine in patients with rheumatoid arthritis. Skeletal Radiology 44:2, pages 241-248.
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Alejandro Souto, Eva Salgado, Jos? Ram?n Maneiro, Antonio Mera, Loreto Carmona & Juan J. G?mez-Reino. (2015) Lipid Profile Changes in Patients With Chronic Inflammatory Arthritis Treated With Biologic Agents and Tofacitinib in Randomized Clinical Trials: A Systematic Review and Meta-Analysis. Arthritis & Rheumatology 67:1, pages 117-127.
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Crossref
Cheng Zhang, Xi Zhang & Xing-Hua Chen. (2014) Inhibition of the Interleukin-6 Signaling Pathway: A Strategy to Induce Immune Tolerance. Clinical Reviews in Allergy & Immunology 47:2, pages 163-173.
Crossref
Dinny Wallis. (2014) Infection risk and biologics. Current Opinion in Rheumatology 26:4, pages 404-409.
Crossref
Oscar Epis, Emilio Filippucci, Andrea Delle Sedie, Anna De Matthaeis & Eleonora Bruschi. (2013) Clinical and ultrasound evaluation of the response to tocilizumab treatment in patients with rheumatoid arthritis: a case series. Rheumatology International 34:5, pages 737-742.
Crossref
Sohita Dhillon. (2013) Intravenous Tocilizumab: A Review of Its Use in Adults with Rheumatoid Arthritis. BioDrugs 28:1, pages 75-106.
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Shuji Ohta, Tomomi Tsuru, Kimio Terao, Seiji Mogi, Midori Suzaki, Eisuke Shono, Yoshimasa Ishida, Eriko Tarumi & Masato Imai. (2013) Mechanism‐based approach using a biomarker response to evaluate tocilizumab subcutaneous injection in patients with rheumatoid arthritis with an inadequate response to synthetic DMARDs (MATSURI study). The Journal of Clinical Pharmacology 54:1, pages 109-119.
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Jutatip Guptarak, Sheshali Wanchoo, Julieann Durham-Lee, Yewen Wu, Dragoslava Zivadinovic, Adriana Paulucci-Holthauzen & Olivera Nesic. (2013) Inhibition of IL-6 signaling: A novel therapeutic approach to treating spinal cord injury pain. Pain 154:7, pages 1115-1128.
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Janna A. van Diepen, Jimmy F.P. Berb?e, Louis M. Havekes & Patrick C.N. Rensen. (2013) Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis 228:2, pages 306-315.
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Medha Barbhaiya & Daniel H. Solomon. (2013) Rheumatoid arthritis and cardiovascular disease. Current Opinion in Rheumatology 25:3, pages 317-324.
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Toshio Tanaka, Atsushi OgataMasashi Narazaki. (2013) Tocilizumab: An Updated Review of Its Use in the Treatment of Rheumatoid Arthritis and Its Application for Other Immune-Mediated Diseases. Clinical Medicine Insights: Therapeutics 5, pages CMT.S9282.
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Jin Ha LeeJae Hee Cheon. (2013) Natural Course of Crohn's Disease and Novel Treatment Drugs. Korean Journal of Medicine 85:6, pages 578.
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Atsushi Kaneko. (2013) Tocilizumab in rheumatoid arthritis: efficacy, safety and its place in therapy. Therapeutic Advances in Chronic Disease 4:1, pages 15-21.
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Rachel Byng-Maddick & Michael Ehrenstein. (2012) Infections in biological agents used in rheumatic disease. British Journal of Hospital Medicine 73:9, pages 517-520.
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Jean‐Frédéric Boyer, Vanina Bongard, Alain Cantagrel, Bénédicte Jamard, Jacques‐Eric Gottenberg, Xavier Mariette, Jean‐luc Davignon, Jean Ferrières, Jean‐Bernard Ruidavets, Jean Dallongeville, Dominique Arveiler, Anne Cambon‐Thomsen & Arnaud Constantin. (2012) Link between traditional cardiovascular risk factors and inflammation in patients with early arthritis: Results from a French Multicenter Cohort. Arthritis Care & Research 64:6, pages 872-880.
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Veronika R. Lang, Matthias Englbrecht, J?rgen Rech, Hubert N?sslein, Karin Manger, Florian Schuch, Hans-Peter Tony, Martin Fleck, Bernhard Manger, Georg Schett & Jochen Zwerina. (2012) Risk of infections in rheumatoid arthritis patients treated with tocilizumab. Rheumatology 51:5, pages 852-857.
Crossref
C.I. Daïen & P. Fesler. (2012) La polyarthrite rhumatoïde : une maladie cardiovasculaire ?. Annales de Cardiologie et d'Angéiologie 61:2, pages 111-117.
Crossref
. (2012) The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. The Lancet 379:9822, pages 1214-1224.
Crossref
Atsushi OgataToru HiranoYoshihiro HishitaniToshio Tanaka. (2012) Safety and Efficacy of Tocilizumab for the Treatment of Rheumatoid Arthritis. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 5, pages CMAMD.S7371.
Crossref
Jeffrey D. Greenberg, Victoria Furer & Michael E. Farkouh. (2011) Cardiovascular safety of biologic therapies for the treatment of RA. Nature Reviews Rheumatology 8:1, pages 13-21.
Crossref
Kenji Okumura, Fumihiro Shoji, Masaki Yoshida, Atsushi Mizuta, Ichiro Makino & Hidefumi Higashi. (2011) Severe sepsis caused by Aeromonas hydrophila in a patient using tocilizumab: a case report. Journal of Medical Case Reports 5:1.
Crossref
Toshio Tanaka, Keisuke Hagihara, Yoshihito Shima, Masashi Narazaki, Atsushi Ogata & Atsushi Kumanogoh. (2011) Tocilizumab, a humanized anti‐interleukin‐6 receptor antibody, for the treatment of autoimmune disorders. Drug Development Research 72:8, pages 717-732.
Crossref
Robert S. Woodrick & Eric M. Ruderman. (2011) Safety of biologic therapy in rheumatoid arthritis. Nature Reviews Rheumatology 7:11, pages 639-652.
Crossref
Catuxa Prado, Banesa de Paz, Jesús Gómez, Patricia López, Javier Rodríguez-Carrio & Ana Suárez. (2011) Glucocorticoids enhance Th17/Th1 imbalance and signal transducer and activator of transcription 3 expression in systemic lupus erythematosus patients. Rheumatology 50:10, pages 1794-1801.
Crossref
AN Malaviya & Nigil Haroon. (2011) Infections associated with the use of biologic response modifiers in rheumatic diseases: a critical appraisal. Indian Journal of Rheumatology 6:1, pages 99-112.
Crossref
Masakatsu Yanagimachi, Takuya Naruto, Takuma Hara, Masako Kikuchi, Ryoki Hara, Takako Miyamae, Tomoyuki Imagawa, Masaaki Mori, Tetsuji Kaneko, Satoshi Morita, Hiroaki Goto & Shumpei Yokota. (2011) Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis. British Journal of Clinical Pharmacology 71:2, pages 237-243.
Crossref

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